Pharmaceutical Medicine, Год журнала: 2024, Номер unknown
Опубликована: Окт. 14, 2024
Язык: Английский
International Journal of Pharmaceutics, Год журнала: 2024, Номер 652, С. 123856 - 123856
Опубликована: Янв. 26, 2024
Язык: Английский
Процитировано
26
AAPS PharmSciTech, Год журнала: 2025, Номер 26(1)
Опубликована: Янв. 9, 2025
Язык: Английский
Процитировано
2
Molecules, Год журнала: 2025, Номер 30(5), С. 1181 - 1181
Опубликована: Март 6, 2025
Nano-drug delivery systems provide targeted solutions for addressing various drug challenges, leveraging nanotechnology to enhance solubility and permeability. Liposomes, explored several decades, face hurdles, especially in oral delivery. Bile-acid stabilized vesicles (bilosomes) are flexible lipid vesicles, composed of phospholipids or other surfactants, along with amphiphilic bile salts, they show superior stability pharmacokinetic behavior comparison conventional vesicular (liposomes niosomes). Bilosomes skin penetration, fluidize the stratum corneum, improve stability. In applications, bilosomes overcome drawbacks, offering improved bioavailability, controlled release, reduced side effects. Vaccines using demonstrate efficacy, intranasal, inhalation, ocular, buccal applications delivery, targeted, efficient, activities. Formulations vary based on active substances optimization techniques, showcasing versatility potential across diverse routes. Therefore, aim this comprehensive review was critically explore state-of-the-art therapeutic applications.
Язык: Английский
Процитировано
2
Applied Sciences, Год журнала: 2024, Номер 14(7), С. 2926 - 2926
Опубликована: Март 30, 2024
Over the past few decades, notable advancements have been made in field of transdermal drug delivery systems (TDDSs), presenting a promising alternative to conventional oral administration. This comprehensive review aims enhance understanding this method by examining various techniques, skin’s role as barrier TDDS, factors affecting skin diffusion, and current challenges TDDSs. The primary focus analysis centers on TDDSs utilizing hydrogels. A thorough exploration hydrogel fundamentals, encompassing structure, properties, synthesis, is provided underscore importance hydrogels carriers delivery. concluding section delves into strategies for hydrogel-based delivery, addressing exploring future directions.
Язык: Английский
Процитировано
10
Journal of Controlled Release, Год журнала: 2024, Номер 366, С. 668 - 683
Опубликована: Янв. 18, 2024
Язык: Английский
Процитировано
9
Phytomedicine, Год журнала: 2024, Номер 133, С. 155917 - 155917
Опубликована: Июль 29, 2024
Язык: Английский
Процитировано
9
BioNanoScience, Год журнала: 2025, Номер 15(2)
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
1
Nano Materials Science, Год журнала: 2024, Номер unknown
Опубликована: Июль 1, 2024
Despite relevant advances, the pharmaceutical industry continues to strive with limited adaptability, moisture management, and discomfort caused by existing wound dressings. Adding these challenges are bioavailability pharmacokinetics of common (bio)therapeutics, overall leading unmet clinical demands, safety concerns, poor patient compliance. Ionogels, a versatile class materials comprising ionic liquids (ILs) confined in an organic or inorganic solid network, have been proposed overcome drawbacks. They demonstrated ability enhance antimicrobial mechanical properties resulting while allowing remarkable improvements drug solubility their delivery targeted sites. Nowadays, investigations trials still required fully leverage potential ionogels for human applications. However, recent FDA approval New Drug Application MRX-5LBT®, transdermal system, opens promising perspectives toward translation ionogels. This review focuses on advances achieved design applications, viz. topical formulations promote healing activity, as platforms improve (solubility bioavailability), at specific sites controlled release behaviour.
Язык: Английский
Процитировано
6
Drug Delivery and Translational Research, Год журнала: 2024, Номер unknown
Опубликована: Окт. 21, 2024
Abstract Transdermal drug delivery (TDD) using electrically assisted microneedle (MN) systems has emerged as a promising alternative to traditional administration routes. This review explores recent advancements in this technology across various therapeutic applications. Integrating iontophoresis (IP) and electroporation (EP) with MN shown significant potential improving treatment outcomes for conditions. Studies demonstrate their effectiveness enhancing vaccine DNA delivery, diabetes management, increasing efficacy dermatological The also exhibited promise delivering nonsteroidal anti-inflammatory drugs (NSAIDs), treating multiple sclerosis, advancing obesity cancer therapy. These offer improved permeation, targeted enhanced effects. While challenges remain, including safety concerns technological limitations, ongoing research focuses on optimizing these broader clinical future of technologies TDD appears promising, personalized medicine, smart monitoring systems, expanded Graphical
Язык: Английский
Процитировано
6
Drug Delivery and Translational Research, Год журнала: 2023, Номер 14(6), С. 1393 - 1431
Опубликована: Ноя. 30, 2023
Язык: Английский
Процитировано
16