Therapeutic Potential of Microneedle Assisted Drug Delivery for Wound Healing: Current State of the Art, Challenges, and Future Perspective

AAPS PharmSciTech, Год журнала: 2025, Номер 26(1)

Опубликована: Янв. 8, 2025

Язык: Английский

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Treatment avenues for age-related macular degeneration: Breakthroughs and bottlenecks

Ageing Research Reviews, Год журнала: 2024, Номер 98, С. 102322 - 102322

Опубликована: Май 8, 2024

Язык: Английский

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Exploring the oncogenic and tumor-suppressive roles of Circ-ADAM9 in cancer

Pathology - Research and Practice, Год журнала: 2024, Номер 256, С. 155257 - 155257

Опубликована: Март 13, 2024

Язык: Английский

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Microneedle patches: the next frontier in cardiovascular care

Drug Delivery and Translational Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Язык: Английский

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Dissolving microneedles for brain delivery: Recent advances and challenges

Drug Discovery Today, Год журнала: 2025, Номер unknown, С. 104330 - 104330

Опубликована: Март 1, 2025

Язык: Английский

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Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Авг. 13, 2024

Abstract The eye, a complex organ isolated from the systemic circulation, presents significant drug delivery challenges owing to its protective mechanisms, such as blood-retinal barrier and corneal impermeability. Conventional administration methods often fail sustain therapeutic levels may compromise patient safety compliance. Polysaccharide-based microneedles (PSMNs) have emerged transformative solution for ophthalmic delivery. However, comprehensive review of PSMNs in ophthalmology has not been published date. In this review, we critically examine synergy between polysaccharide chemistry microneedle technology enhancing ocular We provide thorough analysis PSMNs, summarizing design principles, fabrication processes, addressed during fabrication, including improving comfort also describe recent advances performance various both research clinical scenarios. Finally, current regulatory frameworks market barriers that are relevant commercial advancement final perspective on area.

Язык: Английский

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Harnessing the role of microneedles as sensors: current status and future perspectives

Drug Discovery Today, Год журнала: 2024, Номер 29(7), С. 104030 - 104030

Опубликована: Май 17, 2024

Язык: Английский

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Microneedle-mediated drug delivery for neurological diseases

International Journal of Pharmaceutics, Год журнала: 2024, Номер 661, С. 124400 - 124400

Опубликована: Июнь 29, 2024

Язык: Английский

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Development of Microneedles for Antimicrobial Drug Delivery: A Comprehensive Review on Applications in Wound Infection Management

Small Science, Год журнала: 2024, Номер unknown

Опубликована: Июль 21, 2024

Microneedles (MNs) have emerged as a promising transdermal antimicrobial delivery system, providing precise and localized drug while complemented with noninvasiveness patient compliance. Currently, the topical application of antimicrobials restricts drugs to critical areas wound bed, largely due barriers posed by necrotic tissue, scab formation, bacterial biofilms, which severely diminish bioavailability therapeutics. MNs enabled efficient targeted overcome many chronic challenges. Over past decade, significant progress has been made develop unique properties tailored for vaccines, anticancer, antimicrobials. As ongoing research continues refine MN design, material properties, formulations, potential revolutionizing efficacy, experience, therapeutic outcomes remains at forefront scientific research. In this review, insights are provided into latest progress, current developments, diverse applications delivery. Herein, translational is highlighted perspective on challenges associated clinical translation provided. Furthermore, review aids in identifying gaps empowering contributing future implementation cutting‐edge systems effectively tackle resistance.

Язык: Английский

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Microneedle patch with pure drug tips for delivery of liraglutide: pharmacokinetics in rats and minipigs

Drug Delivery and Translational Research, Год журнала: 2024, Номер unknown

Опубликована: Апрель 15, 2024

Язык: Английский

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