Innovative designs of 3D scaffolds for bone tissue regeneration: Understanding principles and addressing challenges
European Polymer Journal,
Год журнала:
2024,
Номер
215, С. 113251 - 113251
Опубликована: Июнь 19, 2024
Meeting
the
escalating
demands
in
biomedical
applications
has
spurred
creation
of
diverse
scaffolds,
where
selection
materials
and
manufacturing
techniques
stands
as
a
linchpin
fostering
bone
tissue
formation.
These
scaffolds
provide
fundamental
structural
framework
that
supports
cell
growth
differentiation.
It
is
vital
for
repair,
addressing
various
biological
requisites
such
biocompatibility,
biodegradability,
mechanical
properties
becomes
imperative.
This
comprehensive
review
discusses
recent
advancements
3D
tailored
specifically
engineering
applications.
Stereolithography,
fused
deposition
modelling,
selective
laser
sintering,
binder
jetting,
electron
beam
melting,
bioprinting
(including
laser-based,
inkjet
extrusion
bioprinting)
are
meticulously
explored.
Focusing
on
their
respective
applications,
limitations,
well
advantages
disadvantages
within
context
regeneration.
Furthermore,
article
underscores
pivotal
role
material
potential
solution
to
address
challenges
associated
with
grafts.
emphasizes
need
nuanced
understanding
significant
considerations
regardless
type
when
designing
or
evaluating
suitability
integration
into
expansive
realm
engineering.
Язык: Английский
Fiber-based Biomaterial Scaffolds for Cell Support towards the Production of Cultivated Meat
Acta Biomaterialia,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Dermal Substitutes for Clinical Management of Severe Burn Injuries: Current and Future Perspectives
Advanced Therapeutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 23, 2025
Abstract
Despite
significant
advances
in
recent
decades,
severe
burns
remain
a
formidable
challenge,
with
high
morbidity
and
mortality
rates.
The
immunocompromised
state
following
burn
injuries,
compounded
by
the
loss
of
protective
skin
barrier,
increases
risk
bacterial
colonization
invasion.
Without
appropriate
management,
infections
patients
can
progress
to
sepsis,
life‐threatening
complication.
Current
care
often
fails
achieve
optimal
tissue
regeneration
infection
prevention,
necessitating
combination
different
approaches.
Developing
innovative
safer
strategies
mitigate
is
essential
for
improving
patient
outcomes.
This
review
provides
updated
insights
into
various
biomaterials
tailored
managing
burns,
offering
comprehensive
summary
emerging
technologies
potential
clinical
application.
Additionally,
an
in‐depth
discussion
on
current
research
areas
that
warrant
further
investigation
presented.
Potential
avenues
next‐generation
dermal
substitutes
aimed
at
preventing
wound
are
then
explored.
Язык: Английский
Electroconductive Gelatin/Alginate/ Graphene Hydrogel Based Scaffold for Neural Tissue Repair
Macromolecular Materials and Engineering,
Год журнала:
2024,
Номер
310(1)
Опубликована: Ноя. 27, 2024
Abstract
A
composite
polymeric
scaffold
of
gelatin/alginate
/graphene
is
fabricated
through
freeze‐drying
technique.
Initially,
a
hydrogel
system
comprised
(1:1)
prepared,
and
then
the
effect
different
amounts
graphene
carboxyl
nanosheets
(1,1.5,
2,
2.5
wt.%)
on
resultant
structural
properties
are
thoroughly
evaluated.
The
swelling
ratio,
biodegradability,
electrical
mechanical
bio‐composite
hydrogels
controlled
by
manipulating
concentration
graphene‐COOH.
significant
increase
in
conductivity
observed
with
addition
2.5%
graphene‐COOH,
increased
from
8.525
×
10
−7
±
0.01
S
cm
−1
to
7.644
−4
0.04
.
Also,
biocomposite
exhibited
compressive
tensile
strength
ranging
25
382
KPa
11.4
148
an
simplicity,
low
cost,
tunable
properties,
optimal
presented
this
study
highlight
its
potential
as
nerve
tissue
replacement.
Язык: Английский