Electroconductive Gelatin/Alginate/ Graphene Hydrogel Based Scaffold for Neural Tissue Repair DOI Creative Commons

Pegah Madaninasab,

Mahshid Mohammadi,

Sheyda Labbaf

et al.

Macromolecular Materials and Engineering, Journal Year: 2024, Volume and Issue: 310(1)

Published: Nov. 27, 2024

Abstract A composite polymeric scaffold of gelatin/alginate /graphene is fabricated through freeze‐drying technique. Initially, a hydrogel system comprised (1:1) prepared, and then the effect different amounts graphene carboxyl nanosheets (1,1.5, 2, 2.5 wt.%) on resultant structural properties are thoroughly evaluated. The swelling ratio, biodegradability, electrical mechanical bio‐composite hydrogels controlled by manipulating concentration graphene‐COOH. significant increase in conductivity observed with addition 2.5% graphene‐COOH, increased from 8.525 × 10 −7 ± 0.01 S cm −1 to 7.644 −4 0.04 . Also, biocomposite exhibited compressive tensile strength ranging 25 382 KPa 11.4 148 an simplicity, low cost, tunable properties, optimal presented this study highlight its potential as nerve tissue replacement.

Language: Английский

Innovative designs of 3D scaffolds for bone tissue regeneration: Understanding principles and addressing challenges DOI Creative Commons

Mohamed Selim,

Hamouda M. Mousa,

G. T. Abdel-Jaber

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 215, P. 113251 - 113251

Published: June 19, 2024

Meeting the escalating demands in biomedical applications has spurred creation of diverse scaffolds, where selection materials and manufacturing techniques stands as a linchpin fostering bone tissue formation. These scaffolds provide fundamental structural framework that supports cell growth differentiation. It is vital for repair, addressing various biological requisites such biocompatibility, biodegradability, mechanical properties becomes imperative. This comprehensive review discusses recent advancements 3D tailored specifically engineering applications. Stereolithography, fused deposition modelling, selective laser sintering, binder jetting, electron beam melting, bioprinting (including laser-based, inkjet extrusion bioprinting) are meticulously explored. Focusing on their respective applications, limitations, well advantages disadvantages within context regeneration. Furthermore, article underscores pivotal role material potential solution to address challenges associated with grafts. emphasizes need nuanced understanding significant considerations regardless type when designing or evaluating suitability integration into expansive realm engineering.

Language: Английский

Citations

20
Dermal Substitutes for Clinical Management of Severe Burn Injuries: Current and Future Perspectives DOI Creative Commons
Tuong-Van Vo Le, Hanif Haidari, Allison J. Cowin

et al.

Advanced Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract Despite significant advances in recent decades, severe burns remain a formidable challenge, with high morbidity and mortality rates. The immunocompromised state following burn injuries, compounded by the loss of protective skin barrier, increases risk bacterial colonization invasion. Without appropriate management, infections patients can progress to sepsis, life‐threatening complication. Current care often fails achieve optimal tissue regeneration infection prevention, necessitating combination different approaches. Developing innovative safer strategies mitigate is essential for improving patient outcomes. This review provides updated insights into various biomaterials tailored managing burns, offering comprehensive summary emerging technologies potential clinical application. Additionally, an in‐depth discussion on current research areas that warrant further investigation presented. Potential avenues next‐generation dermal substitutes aimed at preventing wound are then explored.

Language: Английский

Citations

0
Fiber-based Biomaterial Scaffolds for Cell Support towards the Production of Cultivated Meat DOI

Xinxin Li,

D. H. Sim,

Yushu Wang

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

2
Electroconductive Gelatin/Alginate/ Graphene Hydrogel Based Scaffold for Neural Tissue Repair DOI Creative Commons

Pegah Madaninasab,

Mahshid Mohammadi,

Sheyda Labbaf

et al.

Macromolecular Materials and Engineering, Journal Year: 2024, Volume and Issue: 310(1)

Published: Nov. 27, 2024

Abstract A composite polymeric scaffold of gelatin/alginate /graphene is fabricated through freeze‐drying technique. Initially, a hydrogel system comprised (1:1) prepared, and then the effect different amounts graphene carboxyl nanosheets (1,1.5, 2, 2.5 wt.%) on resultant structural properties are thoroughly evaluated. The swelling ratio, biodegradability, electrical mechanical bio‐composite hydrogels controlled by manipulating concentration graphene‐COOH. significant increase in conductivity observed with addition 2.5% graphene‐COOH, increased from 8.525 × 10 −7 ± 0.01 S cm −1 to 7.644 −4 0.04 . Also, biocomposite exhibited compressive tensile strength ranging 25 382 KPa 11.4 148 an simplicity, low cost, tunable properties, optimal presented this study highlight its potential as nerve tissue replacement.

Language: Английский

Citations

1