Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114633 - 114633
Опубликована: Март 1, 2025
Язык: Английский
Journal of Controlled Release, Год журнала: 2023, Номер 362, С. 19 - 43
Опубликована: Авг. 24, 2023
Язык: Английский
Процитировано
53
Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(12), С. 5107 - 5120
Опубликована: Июнь 20, 2023
Oxidative stress injury and mitochondrial dysfunction are major obstacles to neurological functional recovery after ischemic stroke. The development of new approaches simultaneously diminish oxidative resist is urgently needed. Inspired by the overproduced reactive oxygen species (ROS) at neuron mitochondria, multifunctional nanoparticles with ROS-responsiveness mitochondrial-targeted (SPNPs) were engineered, achieving specific targeting delivery controllable drug release penumbra. Due nose-to-brain pathway, SPNPs which encapsulated in a thermo-sensitive gel intranasal administration directly delivered penumbra bypassing blood‒brain barrier (BBB) enhancing efficiency. potential for stroke treatment was systematically evaluated
Язык: Английский
Процитировано
50
Nano Today, Год журнала: 2024, Номер 55, С. 102147 - 102147
Опубликована: Янв. 18, 2024
Язык: Английский
Процитировано
32
Advanced Materials, Год журнала: 2024, Номер 36(24)
Опубликована: Март 6, 2024
Abstract The quest for effective and reliable methods of delivering medications, with the aim improving delivery therapeutic agent to intended location, has presented a demanding yet captivating field in biomedical research. concept smart drug systems is an evolving approach, serving as model directing drugs specific targets or sites. These have been developed specifically target regulate administration substances diverse array chronic conditions, including periodontitis, diabetes, cardiac diseases, inflammatory bowel rheumatoid arthritis, different cancers. Nevertheless, numerous comprehensive clinical trials are still required ascertain both immediate enduring impacts such nanosystems on human subjects. This review delves into benefits vehicles, aiming enhance comprehension their applicability addressing present medical requirements. Additionally, it touches upon current applications these stimuli‐reactive biomedicine outlines future development prospects.
Язык: Английский
Процитировано
25
Biomedicines, Год журнала: 2024, Номер 12(1), С. 187 - 187
Опубликована: Янв. 15, 2024
In recent years, the field of drug delivery has witnessed remarkable progress, driven by quest for more effective and precise therapeutic interventions. Among myriad strategies employed, integration aptamers as targeting moieties stimuli-responsive systems emerged a promising avenue, particularly in context anticancer therapy. This review explores cutting-edge advancements targeted drug-delivery systems, focusing on platforms enhanced spatial aptamer-based we delve into versatile applications aptamers, examining their conjugation with gold, silica, carbon materials. The synergistic interplay between these materials is discussed, emphasizing potential achieving delivery. Additionally, explore an emphasis Tumor microenvironment-responsive nanoparticles are elucidated, capacity to exploit dynamic conditions within cancerous tissues controlled release detailed. External strategies, including ultrasound-mediated, photo-responsive, magnetic-guided examined role effects. integrates diverse approaches precision medicine, showcasing revolutionize
Язык: Английский
Процитировано
18
Journal of Controlled Release, Год журнала: 2024, Номер 368, С. 518 - 532
Опубликована: Март 12, 2024
Язык: Английский
Процитировано
17
Regenerative Biomaterials, Год журнала: 2023, Номер 10
Опубликована: Янв. 1, 2023
Abstract Ferroptosis, a completely new form of regulated cell death, is mainly caused by an imbalance between oxidative damage and reductive protection has shown great anti-cancer potential. However, existing small-molecule ferroptosis inducers have various limitations, such as poor water solubility, drug resistance low targeting ability, hindering their clinical applications. Nanotechnology provides opportunities for ferroptosis-driven tumor therapy. Especially, stimuli-responsive nanomaterials stand out among others been widely researched because unique spatiotemporal control advantages. Therefore, it’s necessary to summarize the application those in ferroptosis. Here, we describe physiological feature illustrate current challenges induce cancer Then, that are classified elaborated according external internal stimuli. Finally, future perspectives field proposed. We hope this review facilitates paving way design intelligent nano-ferroptosis inducers.
Язык: Английский
Процитировано
39
International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 899 - 915
Опубликована: Фев. 1, 2023
Oxidative stress, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and adenosine signaling are factors associated with psoriatic inflammation. Topical delivery methotrexate (MTX) has become an option to overcome the side effects caused by systemic therapy in psoriasis, leading suppression NF-κB activation through boosting release. However, thickened skin is primary restriction against local drug delivery.In this study, a ROS responsive MTX prodrug (MTX-TK-HA) was synthesized feature CD44 mediated active targeting hyperproliferative keratinocytes. PLA-mPEG were formulated nano-precipitation method develop MTX-TK-HA/PLA-mPEG nanoassemblies. To achieve painless transdermal delivery, dissolving microneedle applied for direct loading these nanoassemblies micromolding technique. The particle size, zeta potential, ROS-responsiveness, permeability, mechanical strength arrays determined, respectively. Then, MTT assay, immunoblot analysis, ELISA flow cytometry, histological staining utilized thoroughly evaluate efficacy nanoassemblies-loaded microneedles imiquimod-induced mouse model.Nanoassemblies-loaded capable significantly penetrating epidermis mice. efficient topical achieved potent hyaluronic acid as dissolvable matrix arrays. CD44-mediated endocytosis enabled intracellular uptake keratinocytes, released from MTX-TK-HA stimuli, followed suppressing proliferation epidermal via pathway blockade.In model, loaded relieve inflammatory disorders regulation signaling. Our study offered rational design hydrophobic agents defined effective therapeutic psoriasis treatment.
Язык: Английский
Процитировано
28
Journal of the American Chemical Society, Год журнала: 2023, Номер 145(49), С. 26932 - 26946
Опубликована: Ноя. 21, 2023
The synergy of living microbial and small-molecular therapeutics has been widely explored for treating a variety diseases, while current combination strategies often suffer from low bioavailability, heterogeneous spatiotemporal distribution, premature drug release. Here, the use triggerable prodrug nanocoating is reported to enable on-demand activation treatment. As proof-of-concept study, reactive oxygen species-responsive aromatic thioacetal linker employed prepare cationic chitosan-drug conjugates, which can form on surface bacteria via electrostatic interaction. Following administration, wrapped be prevented in vivo insults by shielding effect co-delivered with conjugated spatiotemporally synchronous manner. Upon reaching lesion site, upgraded species trigger situ cleavage linker, resulting release linker-derived therapeutic cinnamaldehyde. Meanwhile, charge reversal achieved generation negatively charged thiolated chitosan induces dissociation nanocoating, leading bacteria. adequate combined at site exhibits superior synergistic treatment efficacy, as demonstrated an assessment using mouse model colitis. This work presents appealing approach combine advanced therapy diseases.
Язык: Английский
Процитировано
26
Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 234, С. 113758 - 113758
Опубликована: Янв. 18, 2024
Язык: Английский
Процитировано
15