Angewandte Chemie,
Год журнала:
2024,
Номер
136(31)
Опубликована: Май 20, 2024
Abstract
Dithioacetals
are
heavily
used
in
organic,
material
and
medical
chemistries,
exhibit
huge
potential
to
synthesize
degradable
or
recyclable
polymers.
However,
the
current
synthetic
approaches
of
dithioacetals
polydithioacetals
overwhelmingly
dependent
on
external
catalysts
organic
solvents.
Herein,
we
disclose
a
catalyst‐
solvent‐free
acetal‐thiol
click‐like
reaction
for
synthesizing
polydithioacetals.
High
conversion,
higher
than
acid
catalytic
reaction,
can
be
achieved.
universality
was
confirmed
by
monitoring
reactions
linear
cyclic
acetals
(including
renewable
bio‐sourced
furan‐acetal)
with
aliphatic
aromatic
thiols,
mechanism
monomolecular
nucleophilic
substitution
(S
N
1)
auto‐protonation
(activation)
thiol
clarified
combining
experiments
density
functional
theory
computation.
Subsequently,
utilize
this
readily
By
simple
heating
stirring,
w
~110
kDa
were
synthesized
from
acetal
dithiol,
depolymerization
into
macrocyclic
dithioacetal
repolymerization
polydithioacetal
achieved;
through
reactive
extrusion,
semi‐interpenetrating
polymer
dynamic
network
excellent
mechanical
properties
continuous
reprocessability
prepared
poly(vinyl
butyral)
pentaerythritol
tetrakis(3‐mercaptopropionate).
This
green
high‐efficient
synthesis
method
is
beneficial
sustainable
development
chemistry.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 8, 2025
Cancer
is
a
major
killer
threatening
modern
human
health
and
leading
cause
of
death
worldwide.
Due
to
the
heterogeneity
complexity
cancer,
traditional
treatments
have
limited
effectiveness.
To
address
this
problem,
an
increasing
number
researchers
medical
professionals
are
working
develop
new
ways
treat
cancer.
Bacteria
chemotaxis
that
can
target
colonize
tumor
tissue,
as
well
activate
anti-tumor
immune
responses,
which
makes
them
ideal
for
biomedical
applications.
With
rapid
development
nanomedicine
synthetic
biology
technologies,
bacteria
extensively
used
carriers
drug
delivery
tumors,
holds
promise
overcoming
limitations
conventional
cancer
treatment
regimens.
This
paper
summarizes
examples
anti-cancer
drugs
delivered
by
bacterial
carriers,
their
strengths
weaknesses.
Further,
we
emphasize
carrier
systems
in
clinical
translation.
Advanced Materials,
Год журнала:
2024,
Номер
36(21)
Опубликована: Фев. 24, 2024
Engineered
bacteria
are
widely
used
in
cancer
treatment
because
live
facultative/obligate
anaerobes
can
selectively
proliferate
at
tumor
sites
and
reach
hypoxic
regions,
thereby
causing
nutritional
competition,
enhancing
immune
responses,
producing
anticancer
microbial
agents
situ
to
suppress
growth.
Despite
the
unique
advantages
of
bacteria-based
biotherapy,
insufficient
efficiency
limits
its
application
complete
ablation
malignant
tumors.
The
combination
nanomedicine
engineered
has
attracted
increasing
attention
owing
their
striking
synergistic
effects
treatment.
that
function
as
natural
vehicles
effectively
deliver
nanomedicines
sites.
Moreover,
provide
an
opportunity
enhance
by
modulating
TME
substrates
support
nanomedicine-mediated
reactions.
Nanomedicine
exhibits
excellent
optical,
magnetic,
acoustic,
catalytic
properties,
plays
important
role
promoting
bacteria-mediated
biotherapies.
therapy
comprehensively
summarized
this
review.
Attention
is
paid
not
only
fabrication
nanobiohybrid
composites,
but
also
interpromotion
mechanism
between
therapy.
Additionally,
recent
advances
bacteria-synergized
multimodal
therapies
highlighted.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(31)
Опубликована: Май 20, 2024
Dithioacetals
are
heavily
used
in
organic,
material
and
medical
chemistries,
exhibit
huge
potential
to
synthesize
degradable
or
recyclable
polymers.
However,
the
current
synthetic
approaches
of
dithioacetals
polydithioacetals
overwhelmingly
dependent
on
external
catalysts
organic
solvents.
Herein,
we
disclose
a
catalyst-
solvent-free
acetal-thiol
click-like
reaction
for
synthesizing
polydithioacetals.
High
conversion,
higher
than
acid
catalytic
reaction,
can
be
achieved.
universality
was
confirmed
by
monitoring
reactions
linear
cyclic
acetals
(including
renewable
bio-sourced
furan-acetal)
with
aliphatic
aromatic
thiols,
mechanism
monomolecular
nucleophilic
substitution
(S
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(25), С. 31950 - 31965
Опубликована: Июнь 11, 2024
Ulcerative
colitis
(UC)
is
a
recurrent
chronic
mucosal
inflammation
disease
whose
most
significant
pathological
characteristics
are
intestinal
and
damaged
barrier
induced
by
reactive
oxygen/nitrogen
species,
abnormal
immune
microenvironment,
microecological
imbalance.
Oral
probiotics
living
therapy
for
diseases,
but
their
clinical
application
hindered
poor
bacterial
biological
activity
insufficient
retention.
Here,
we
developed
targeted
oral
formulation,
functionalized
probiotic
Lf@MPB,
with
Lactobacillus
fermentum
(Lf)
as
the
core
modified
melanin
nanoparticles
(MNPs)
on
its
surface
through
click
reaction
of
tricarboxyphenylboronic
acid
synergistic
UC.
In
vitro
experiments
showed
that
Lf@MPB
not
only
possessed
strong
free
radical
scavenging
ability,
reduced
cellular
mitochondrial
polarization,
inhibited
apoptosis
also
significantly
enhanced
viability
Lf
in
simulated
gastrointestinal
fluid.
Fluorescence
imaging
vivo
revealed
high
accumulation
at
site
dextran
sulfate
sodium-induced
UC
mice.
Moreover,
results
demonstrated
effectively
alleviated
oxidative
stress
inflammatory
response
restored
barrier.
addition,
16S
rRNA
gene
sequencing
verified
could
increase
abundance
diversity
microbial
communities
optimize
composition
to
inhibit
progression
This
work
combines
effective
antioxidant
anti-inflammatory
strategies
administration
provide
promising
alternative
treatment.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
19(4), С. 100943 - 100943
Опубликована: Июль 14, 2024
Inflammatory
bowel
diseases
(IBD)
significantly
contribute
to
high
mortality
globally
and
negatively
affect
patients'
qualifications
of
life.
The
gastrointestinal
tract
has
unique
anatomical
characteristics
physiological
environment
limitations.
Moreover,
certain
natural
or
synthetic
anti-inflammatory
drugs
are
associated
with
poor
targeting,
low
drug
accumulation
at
the
lesion
site,
other
side
effects,
hindering
them
from
exerting
their
therapeutic
effects.
Colon-targeted
delivery
systems
represent
attractive
alternatives
as
novel
carriers
for
IBD
treatment.
This
review
mainly
discusses
treatment
status
IBD,
obstacles
delivery,
design
strategies
colon-targeted
systems,
perspectives
on
existing
complementary
therapies.
based
recent
reports,
we
summarized
mechanism
delivery.
Finally,
addressed
challenges
future
directions
facilitate
exploitation
advanced
nanomedicine
therapy.
Nano Letters,
Год журнала:
2024,
Номер
24(50), С. 16132 - 16142
Опубликована: Дек. 6, 2024
Immunotherapy
is
revolutionizing
oncology,
but
its
therapeutic
efficiency
still
limited
by
the
off-target
toxicities
and
poor
antitumor
immune
responses.
By
integrating
drug-loaded
nanoparticles
(DMnSH)
with
unique
metabolic
traits
of
Veillonella
parvula
(Vei),
a
probiotic–nanomedicine
conjugate
Vei@DMnSH
biohybrid
elaborately
designed
for
enhanced
cancer
chemo-immunotherapy.
Specifically,
can
accumulate
in
hypoxic
tumor
sites
simultaneously
consume
lactate
cysteine
to
reverse
lactate-associated
immunosuppression
impede
biosynthesis
GSH.
In
addition,
DMnSH
will
rapidly
deplete
intracellular
GSH
disassemble
release
DOX
Mn2+.
Accompanied
two-pronged
depletion,
Mn2+-mediated
Fenton-like
reaction
effectively
generate
oxidative
hydroxyl
radicals
induce
heavy
redox
imbalance.
Combined
effect
DOX,
robust
immunogenic
cell
death
provoked
subsequently
activates
adaptive
immunity
suppression
rate
over
82%,
synergistically
enhancing
outcomes
