Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Июнь 13, 2024
Combination
therapy
with
oral
administration
of
several
active
ingredients
is
a
popular
clinical
treatment
for
cancer.
However,
the
traditional
method
has
poor
convenience,
less
safety,
and
low
efficiency
patients.
The
combination
pharmaceutical
techniques
advanced
material
conversion
methods
can
provide
new
solutions
to
this
issue.
In
research,
kind
hybrid
film
was
created
via
coaxial
electrospraying,
followed
by
casting
process.
films
were
composed
Reglan
5-fluorouracil
(5-FU)-loaded
cellulose
acetate
(CA)
core-shell
particles
in
polyvinylpyrrolidone
(PVP)
matrix.
Microscopic
observations
these
demonstrated
solid
cross
section
loaded
particles.
X-ray
diffraction
Fourier-transform
infrared
tests
verified
that
5-FU
showed
amorphous
states
fine
compatibilities
polymeric
matrices,
i.e.,
PVP
CA,
respectively.
vitro
dissolution
indicated
able
desired
asynchronous
dual-drug
delivery,
fast
release
Reglan,
sustained
5-FU.
controlled
mechanisms
shown
be
an
erosion
mechanism
typical
Fickian
diffusion
protocols
reported
herein
pioneer
approach
fabricating
biomaterials
multiple
drugs,
each
its
own
behavior,
synergistic
cancer
treatment.
Journal of Functional Biomaterials,
Год журнала:
2022,
Номер
13(4), С. 289 - 289
Опубликована: Дек. 9, 2022
Electrospinning
is
an
advanced
technology
for
the
preparation
of
drug-carrying
nanofibers
that
has
demonstrated
great
advantages
in
biomedical
field.
Electrospun
nanofiber
membranes
are
widely
used
field
drug
administration
due
to
their
such
as
large
specific
surface
area
and
similarity
extracellular
matrix.
Different
electrospinning
technologies
can
be
prepare
different
structures,
those
with
a
monolithic
structure,
core–shell
Janus
or
porous
structure.
It
also
possible
controlled-release
functions,
sustained
release,
delayed
biphasic
targeted
release.
This
paper
elaborates
on
drug-loaded
using
various
concludes
mechanisms
behind
controlled
release
drugs.
Polymers,
Год журнала:
2023,
Номер
15(4), С. 921 - 921
Опубликована: Фев. 12, 2023
Electrospun
porous
nanofibers
have
gained
a
lot
of
interest
recently
in
various
fields
because
their
adjustable
structure,
high
specific
surface
area,
and
large
number
active
sites,
which
can
further
enhance
the
performance
materials.
This
paper
provides
an
overview
common
polymers,
preparation,
applications
electrospun
nanofibers.
Firstly,
polymers
commonly
used
to
construct
structures
main
pore-forming
methods
by
electrospinning,
namely
template
method
phase
separation
method,
are
introduced.
Secondly,
recent
air
purification,
water
treatment,
energy
storage,
biomedicine,
food
packaging,
sensor,
sound
wave
absorption,
flame
retardant,
heat
insulation
reviewed.
Finally,
challenges
possible
research
directions
for
future
study
discussed.
Sustained
release
is
highly
desired
for
"efficacious,
safe
and
convenient"
drug
delivery,
particularly
those
anticancer
molecules
with
toxicity.
In
this
study,
a
modified
coaxial
electrospraying
process
was
developed
to
coat
hydrophobic
lipid,
i.e.,
stearic
acid
(SA),
on
composites
composed
of
the
tamoxifen
citrate
(TC)
insoluble
polymeric
matrix
ethylcellulose
(EC).
Compared
electrosprayed
TC-EC
composite
microparticles
M1,
SA-coated
hybrid
M2
were
able
provide
an
improved
TC
sustained-release
profile.
The
30%
90%
loaded
time
periods
extended
3.21
h
19.43
M2,
respectively,
which
significantly
longer
than
provided
by
M1
(0.88
9.98
h,
respectively).
morphology,
inner
structure,
physical
state,
compatibility
components
particles
disclosed
through
SEM,
TEM,
XRD,
FTIR.
Based
analyses,
mechanism
multiple
factors
co-acting
suggested,
include
reasonable
selections
organizations
lipid
excipient,
blank
SA
shell
loading,
regularly
round
shape,
also
high
density.
reported
protocols
pioneered
brand-new
manner
developing
sustained
delivery
hybrids
combination
cellulose
gels
using
electrospraying.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(3)
Опубликована: Май 1, 2024
Abstract
The
shapes
of
micro‐
and
nano‐products
have
profound
influences
on
their
functional
performances,
which
has
not
received
sufficient
attention
during
the
past
several
decades.
Electrohydrodynamic
atomization
(EHDA)
techniques,
mainly
include
electrospinning
electrospraying,
are
facile
in
manipulate
products'
shapes.
In
this
review,
generated
using
EHDA
for
modifying
drug
release
profiles
reviewed.
These
linear
nanofibers,
round
micro‐/nano‐particles,
beads‐on‐a‐string
hybrids.
They
can
be
further
divided
into
different
kinds
sub‐shapes,
explored
providing
desired
pulsatile
release,
sustained
biphasic
delayed
pH‐sensitive
release.
Additionally,
resulted
from
organizations
electrospun
nanofibers
discussed
delivery,
inner
structures
considered
together
developing
novel
delivery
systems.
future,
related
shape–performance
relationships
at
nanoscale,
besides
size,
structure
structure–performance
relationships,
would
play
important
roles
promoting
developments
field.
This
article
is
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Macromolecular Materials and Engineering,
Год журнала:
2023,
Номер
309(4)
Опубликована: Ноя. 23, 2023
Abstract
In
this
study,
three
kinds
of
electrohydrodynamic
atomization
(EHDA)
processes
(electrospraying,
electrospinning,
and
coaxial
electrospinning)
are
implemented
to
create
hydroxypropyl
methylcellulose
(HPMC)
based
ultra‐thin
products
for
providing
the
fast
dissolution
a
poorly
water‐soluble
drug
ketoprofen
(KET).
An
EHDA
apparatus,
characterized
by
novel
spinneret,
is
homemade
conducting
processes.
The
types
electrospun
nanofibers
E1,
electrosprayed
microparticles
E2,
core‐shell
E3.
SEM
TEM
results
indicate
that
they
have
anticipated
morphologies
inner
structures.
X‐ray
diffraction
Fourier
Transform
Infrared
verify
KET
mainly
amorphous
in
all
composites
due
its
fine
compatibility
with
HPMC.
vitro
tests
demonstrate
rapid
release
performances
has
an
order
E3>E1>E2≫KET
powders.
mechanisms
suggested
advantages
compared.
super
performance
E3
furnishing
attributed
synergistic
action
small
size
(of
shell
thickness),
high
porosity,
state
drug,
solubility
nanostructures
can
support
development
nano
delivery
systems
(DDSs)
through
tailoring
spatial
distribution
molecules
within
products.
Biomolecules,
Год журнала:
2023,
Номер
13(1), С. 184 - 184
Опубликована: Янв. 16, 2023
Herbal
medicine
has
a
long
history
of
medical
efficacy
with
low
toxicity,
side
effects
and
good
biocompatibility.
However,
the
bioavailability
extract
raw
herbs
bioactive
compounds
is
poor
because
their
water
solubility.
In
order
to
overcome
solubility
issues,
electrospinning
technology
can
offer
delivery
alternative
resolve
them.
The
electrospun
fibers
have
advantages
high
specific
surface
area,
porosity,
excellent
mechanical
strength
flexible
structures.
At
same
time,
various
natural
synthetic
polymer-bound
mimic
extracellular
matrix
applications
in
different
fields.
this
paper,
development
polymers
used
for
incorporating
herbal
into
nanofibers
are
reviewed.
Finally,
recent
progress
these
biomedical
(drug
delivery,
wound
dressing,
tissue
engineering)
food
fields
along
future
prospects
discussed.
Pharmaceutics,
Год журнала:
2023,
Номер
15(11), С. 2561 - 2561
Опубликована: Окт. 31, 2023
Polymers
are
the
backbone
of
drug
delivery.
Electrospinning
has
greatly
enriched
strategies
that
have
been
explored
for
developing
novel
delivery
systems
using
polymers
during
past
two
decades.
In
this
study,
four
different
kinds
polymers,
i.e.,
water-soluble
polymer
poly
(vinyl
alcohol)
(PVA),
insoluble
poly(ε-caprolactone)
(PCL),
Eudragit
RL100
(ERL100)
and
pH-sensitive
S100
(ES100)
were
successfully
converted
into
types
tri-layer
tri-polymer
core-shell
fibers
through
bi-fluid
coaxial
electrospinning.
During
process,
model
metronidazole
(MTD)
was
loaded
shell
working
fluid,
which
an
emulsion.
The
micro-formation
mechanism
from
emulsion
electrospinning
proposed.
Scanning
electron
microscope
transmission
evaluations
verified
linear
morphology
resultant
their
obvious
multiple-chamber
structures.
X-ray
diffraction
Fourier
transform
infrared
spectroscopy
measurements
demonstrated
MTD
presented
in
amorphous
state
compatible
with
three
polymeric
matrices.
vitro
dissolution
tests
could
act
a
synergistic
manner
prolonged
sustained-release
profile
gut.
controlled-release
mechanisms
suggested
detail.
protocols
reported
here
pioneer
new
route
creating
structure
both
aqueous
organic
solvents,
strategy
advanced
sophisticated
profiles.
