Electrospun Janus core (ethyl cellulose//polyethylene oxide) @ shell (hydroxypropyl methyl cellulose acetate succinate) hybrids for an enhanced colon-targeted prolonged drug absorbance

Advanced Composites and Hybrid Materials, Год журнала: 2023, Номер 6(6)

Опубликована: Окт. 17, 2023

Язык: Английский

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Electrosprayed Stearic-Acid-Coated Ethylcellulose Microparticles for an Improved Sustained Release of Anticancer Drug

Gels, Год журнала: 2023, Номер 9(9), С. 700 - 700

Опубликована: Авг. 29, 2023

Sustained release is highly desired for "efficacious, safe and convenient" drug delivery, particularly those anticancer molecules with toxicity. In this study, a modified coaxial electrospraying process was developed to coat hydrophobic lipid, i.e., stearic acid (SA), on composites composed of the tamoxifen citrate (TC) insoluble polymeric matrix ethylcellulose (EC). Compared electrosprayed TC-EC composite microparticles M1, SA-coated hybrid M2 were able provide an improved TC sustained-release profile. The 30% 90% loaded time periods extended 3.21 h 19.43 M2, respectively, which significantly longer than provided by M1 (0.88 9.98 h, respectively). morphology, inner structure, physical state, compatibility components particles disclosed through SEM, TEM, XRD, FTIR. Based analyses, mechanism multiple factors co-acting suggested, include reasonable selections organizations lipid excipient, blank SA shell loading, regularly round shape, also high density. reported protocols pioneered brand-new manner developing sustained delivery hybrids combination cellulose gels using electrospraying.

Язык: Английский

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Engineered shapes using electrohydrodynamic atomization for an improved drug delivery

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2024, Номер 16(3)

Опубликована: Май 1, 2024

Abstract The shapes of micro‐ and nano‐products have profound influences on their functional performances, which has not received sufficient attention during the past several decades. Electrohydrodynamic atomization (EHDA) techniques, mainly include electrospinning electrospraying, are facile in manipulate products' shapes. In this review, generated using EHDA for modifying drug release profiles reviewed. These linear nanofibers, round micro‐/nano‐particles, beads‐on‐a‐string hybrids. They can be further divided into different kinds sub‐shapes, explored providing desired pulsatile release, sustained biphasic delayed pH‐sensitive release. Additionally, resulted from organizations electrospun nanofibers discussed delivery, inner structures considered together developing novel delivery systems. future, related shape–performance relationships at nanoscale, besides size, structure structure–performance relationships, would play important roles promoting developments field. This article is categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies

Язык: Английский

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Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites

Macromolecular Materials and Engineering, Год журнала: 2023, Номер 309(4)

Опубликована: Ноя. 23, 2023

Abstract In this study, three kinds of electrohydrodynamic atomization (EHDA) processes (electrospraying, electrospinning, and coaxial electrospinning) are implemented to create hydroxypropyl methylcellulose (HPMC) based ultra‐thin products for providing the fast dissolution a poorly water‐soluble drug ketoprofen (KET). An EHDA apparatus, characterized by novel spinneret, is homemade conducting processes. The types electrospun nanofibers E1, electrosprayed microparticles E2, core‐shell E3. SEM TEM results indicate that they have anticipated morphologies inner structures. X‐ray diffraction Fourier Transform Infrared verify KET mainly amorphous in all composites due its fine compatibility with HPMC. vitro tests demonstrate rapid release performances has an order E3>E1>E2≫KET powders. mechanisms suggested advantages compared. super performance E3 furnishing attributed synergistic action small size (of shell thickness), high porosity, state drug, solubility nanostructures can support development nano delivery systems (DDSs) through tailoring spatial distribution molecules within products.

Язык: Английский

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Tri-Layer Core–Shell Fibers from Coaxial Electrospinning for a Modified Release of Metronidazole

Pharmaceutics, Год журнала: 2023, Номер 15(11), С. 2561 - 2561

Опубликована: Окт. 31, 2023

Polymers are the backbone of drug delivery. Electrospinning has greatly enriched strategies that have been explored for developing novel delivery systems using polymers during past two decades. In this study, four different kinds polymers, i.e., water-soluble polymer poly (vinyl alcohol) (PVA), insoluble poly(ε-caprolactone) (PCL), Eudragit RL100 (ERL100) and pH-sensitive S100 (ES100) were successfully converted into types tri-layer tri-polymer core-shell fibers through bi-fluid coaxial electrospinning. During process, model metronidazole (MTD) was loaded shell working fluid, which an emulsion. The micro-formation mechanism from emulsion electrospinning proposed. Scanning electron microscope transmission evaluations verified linear morphology resultant their obvious multiple-chamber structures. X-ray diffraction Fourier transform infrared spectroscopy measurements demonstrated MTD presented in amorphous state compatible with three polymeric matrices. vitro dissolution tests could act a synergistic manner prolonged sustained-release profile gut. controlled-release mechanisms suggested detail. protocols reported here pioneer new route creating structure both aqueous organic solvents, strategy advanced sophisticated profiles.

Язык: Английский

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A combined electrohydrodynamic atomization method for preparing nanofiber/microparticle hybrid medicines

Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 11

Опубликована: Ноя. 15, 2023

Bacterial prostatitis is a challenging condition to treat with traditional dosage forms. Physicians often prescribe variety of forms different administration methods, which fail provide an efficient and convenient mode drug delivery. The aim this work was develop new type hybrid material incorporating both electrosprayed core-shell microparticles electrospun nanofibers. A Chinese medicine (Ningmitai, NMT) Western (ciprofloxacin, CIP) were co-encapsulated within designed be released in separately controlled manner. Utilizing polyvinylpyrrolidone (PVP) as hydrophilic filament-forming polymer pH-sensitive Eudragit ® S100 (ES100) the particulate polymeric matrix, combined electrohydrodynamic atomization (EHDA) method comprising coaxial electrospraying blending electrospinning, used create hybrids single-step straightforward series characterization methods conducted analyze working process its final products. Scanning electron microscopy transmission revealed that EHDA comprised CIP-PVP nanofibers NMT-ES100 microparticles. Multiple confirmed rapid release CIP sustained NMT. antibacterial experiments indicated exhibited more potent effect against Escherichia coli dh5α Bacillus subtilis Wb800 than either separate or amalgamation fibrous nanomedicine micromedicine can expand horizon types medicines. integration electrospinning provides approach fabrication. By combining soluble polymers hybrids, we ensure sequential NMT for potential synergistic therapy bacterial prostatitis.

Язык: Английский

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A novel electrospun nanofiber system with PEGylated paclitaxel nanocrystals enhancing the transmucus permeability and in situ retention for an efficient cervicovaginal cancer therapy

International Journal of Pharmaceutics, Год журнала: 2023, Номер 650, С. 123660 - 123660

Опубликована: Дек. 9, 2023

Язык: Английский

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Integrated Janus nanofibers enabled by a co-shell solvent for enhancing icariin delivery efficiency

International Journal of Pharmaceutics, Год журнала: 2024, Номер 658, С. 124180 - 124180

Опубликована: Май 4, 2024

Язык: Английский

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Improved synergistic anticancer action of quercetin and tamoxifen citrate supported by an electrospun complex nanostructure

Materials & Design, Год журнала: 2024, Номер 238, С. 112657 - 112657

Опубликована: Янв. 10, 2024

A tri-fluid electrospinning process was successfully developed to prepare tri-chamber complex nanofibers. The core–shell and Janus structure were combined form a delicate complicated architecture for solving the problem of co-administration quercetin tamoxifen citrate, improving oral bioavailability, enhancing their synergistic anti-breast cancer actions. Scanning electron microscope, transmission microscope confocal fluorescent microscopy images showed designed Fourier transform infrared X-ray diffraction analyses verified that model drugs polymeric excipients had good compatibility presented in an amorphous state. vitro release study certified nanofibers facilitated rapid compared with crude drug (90% versus 38%) delayed sustained citrate at same time interval (decreased by 1.88 times). vivo pharmacokinetic pharmacodynamic analysis could result increased bioavailability enhanced anticancer action citrate. findings proved new medicated delivery system advanced dual-, time-, target-specific profiles using electrospun nanostructure.

Язык: Английский

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Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Фев. 5, 2024

Diabetic wounds are a significant subset of chronic characterized by elevated levels inflammatory cytokines, matrix metalloproteinases (MMPs), and reactive oxygen species (ROS). They also associated with impaired angiogenesis, persistent infection, high likelihood hospitalization, leading to substantial economic burden for patients. In severe cases, amputation or even mortality may occur. foot ulcers (DFUs) common complication diabetes, up 25% diabetic patients being at risk developing over their lifetime, more than 70% ultimately requiring amputation. Electrospun scaffolds exhibit structural similarity the extracellular (ECM), promoting adhesion, growth, migration fibroblasts, thereby facilitating formation new skin tissue wound site. The composition size electrospun can be easily adjusted, enabling controlled drug release through fiber structure modifications. porous nature these facilitates gas exchange absorption exudate. Furthermore, surface readily modified impart specific functionalities, making electrospinning nanofiber highly promising treatment wounds. This article provides concise overview healing process in normal pathological mechanisms underlying wounds, including complications such as ulcers. It explores advantages treatment. Additionally, it summarizes findings from various studies on use different types reviews methods loading onto scaffolds. These advancements broaden horizon effectively treating

Язык: Английский

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