Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(3)
Опубликована: Май 1, 2024
Abstract
The
shapes
of
micro‐
and
nano‐products
have
profound
influences
on
their
functional
performances,
which
has
not
received
sufficient
attention
during
the
past
several
decades.
Electrohydrodynamic
atomization
(EHDA)
techniques,
mainly
include
electrospinning
electrospraying,
are
facile
in
manipulate
products'
shapes.
In
this
review,
generated
using
EHDA
for
modifying
drug
release
profiles
reviewed.
These
linear
nanofibers,
round
micro‐/nano‐particles,
beads‐on‐a‐string
hybrids.
They
can
be
further
divided
into
different
kinds
sub‐shapes,
explored
providing
desired
pulsatile
release,
sustained
biphasic
delayed
pH‐sensitive
release.
Additionally,
resulted
from
organizations
electrospun
nanofibers
discussed
delivery,
inner
structures
considered
together
developing
novel
delivery
systems.
future,
related
shape–performance
relationships
at
nanoscale,
besides
size,
structure
structure–performance
relationships,
would
play
important
roles
promoting
developments
field.
This
article
is
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Macromolecular Materials and Engineering,
Год журнала:
2023,
Номер
309(4)
Опубликована: Ноя. 23, 2023
Abstract
In
this
study,
three
kinds
of
electrohydrodynamic
atomization
(EHDA)
processes
(electrospraying,
electrospinning,
and
coaxial
electrospinning)
are
implemented
to
create
hydroxypropyl
methylcellulose
(HPMC)
based
ultra‐thin
products
for
providing
the
fast
dissolution
a
poorly
water‐soluble
drug
ketoprofen
(KET).
An
EHDA
apparatus,
characterized
by
novel
spinneret,
is
homemade
conducting
processes.
The
types
electrospun
nanofibers
E1,
electrosprayed
microparticles
E2,
core‐shell
E3.
SEM
TEM
results
indicate
that
they
have
anticipated
morphologies
inner
structures.
X‐ray
diffraction
Fourier
Transform
Infrared
verify
KET
mainly
amorphous
in
all
composites
due
its
fine
compatibility
with
HPMC.
vitro
tests
demonstrate
rapid
release
performances
has
an
order
E3>E1>E2≫KET
powders.
mechanisms
suggested
advantages
compared.
super
performance
E3
furnishing
attributed
synergistic
action
small
size
(of
shell
thickness),
high
porosity,
state
drug,
solubility
nanostructures
can
support
development
nano
delivery
systems
(DDSs)
through
tailoring
spatial
distribution
molecules
within
products.
Pharmaceutics,
Год журнала:
2023,
Номер
15(11), С. 2561 - 2561
Опубликована: Окт. 31, 2023
Polymers
are
the
backbone
of
drug
delivery.
Electrospinning
has
greatly
enriched
strategies
that
have
been
explored
for
developing
novel
delivery
systems
using
polymers
during
past
two
decades.
In
this
study,
four
different
kinds
polymers,
i.e.,
water-soluble
polymer
poly
(vinyl
alcohol)
(PVA),
insoluble
poly(ε-caprolactone)
(PCL),
Eudragit
RL100
(ERL100)
and
pH-sensitive
S100
(ES100)
were
successfully
converted
into
types
tri-layer
tri-polymer
core-shell
fibers
through
bi-fluid
coaxial
electrospinning.
During
process,
model
metronidazole
(MTD)
was
loaded
shell
working
fluid,
which
an
emulsion.
The
micro-formation
mechanism
from
emulsion
electrospinning
proposed.
Scanning
electron
microscope
transmission
evaluations
verified
linear
morphology
resultant
their
obvious
multiple-chamber
structures.
X-ray
diffraction
Fourier
transform
infrared
spectroscopy
measurements
demonstrated
MTD
presented
in
amorphous
state
compatible
with
three
polymeric
matrices.
vitro
dissolution
tests
could
act
a
synergistic
manner
prolonged
sustained-release
profile
gut.
controlled-release
mechanisms
suggested
detail.
protocols
reported
here
pioneer
new
route
creating
structure
both
aqueous
organic
solvents,
strategy
advanced
sophisticated
profiles.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Ноя. 15, 2023
Bacterial
prostatitis
is
a
challenging
condition
to
treat
with
traditional
dosage
forms.
Physicians
often
prescribe
variety
of
forms
different
administration
methods,
which
fail
provide
an
efficient
and
convenient
mode
drug
delivery.
The
aim
this
work
was
develop
new
type
hybrid
material
incorporating
both
electrosprayed
core-shell
microparticles
electrospun
nanofibers.
A
Chinese
medicine
(Ningmitai,
NMT)
Western
(ciprofloxacin,
CIP)
were
co-encapsulated
within
designed
be
released
in
separately
controlled
manner.
Utilizing
polyvinylpyrrolidone
(PVP)
as
hydrophilic
filament-forming
polymer
pH-sensitive
Eudragit
®
S100
(ES100)
the
particulate
polymeric
matrix,
combined
electrohydrodynamic
atomization
(EHDA)
method
comprising
coaxial
electrospraying
blending
electrospinning,
used
create
hybrids
single-step
straightforward
series
characterization
methods
conducted
analyze
working
process
its
final
products.
Scanning
electron
microscopy
transmission
revealed
that
EHDA
comprised
CIP-PVP
nanofibers
NMT-ES100
microparticles.
Multiple
confirmed
rapid
release
CIP
sustained
NMT.
antibacterial
experiments
indicated
exhibited
more
potent
effect
against
Escherichia
coli
dh5α
Bacillus
subtilis
Wb800
than
either
separate
or
amalgamation
fibrous
nanomedicine
micromedicine
can
expand
horizon
types
medicines.
integration
electrospinning
provides
approach
fabrication.
By
combining
soluble
polymers
hybrids,
we
ensure
sequential
NMT
for
potential
synergistic
therapy
bacterial
prostatitis.
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 789 - 789
Опубликована: Июль 3, 2024
Alginate
is
a
natural
polymer
with
good
biocompatible
properties
and
potential
polymeric
material
for
the
sustainable
development
replacement
of
petroleum
derivatives.
However,
non-spinnability
pure
alginate
solutions
has
hindered
expansion
applications.
With
continuous
electrospinning
technology,
synthetic
polymers,
such
as
PEO
PVA,
are
used
co-spinning
agents
to
increase
spinnability
alginate.
Moreover,
coaxial,
parallel
Janus,
tertiary
other
diverse
novel
electrospun
fiber
structures
prepared
by
multi-fluid
have
found
new
breakthrough
problem
poor
spinning
polymers.
Meanwhile,
effectively
achieve
multiple
release
modes
drugs.
The
powerful
combination
electrostatic
widely
in
many
biomedical
fields,
tissue
engineering,
regenerative
bioscaffolds,
drug
delivery,
research
fever
continues
climb.
This
particularly
true
controlled
delivery
aspect
review
provides
brief
overview
alginate,
introduces
advances
spinning,
highlights
progress
alginate-based
nanofibers
achieving
various
modes,
pulsed
release,
sustained
biphasic
responsive
targeted
release.
Green Chemistry,
Год журнала:
2024,
Номер
26(5), С. 2476 - 2504
Опубликована: Янв. 1, 2024
Hypercrosslinked
polymers
and
the
resultant
carbon
materials
are
promising
platforms
for
CO
2
capture
conversion,
because
of
their
high
specific
surface
areas,
modifiable
accessible
functionalities.
