Ganoderma lucidum polysaccharide hydrogel accelerates diabetic wound healing by regulating macrophage polarization

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 260, С. 129682 - 129682

Опубликована: Янв. 22, 2024

Язык: Английский

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Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings

Gels, Год журнала: 2025, Номер 11(2), С. 123 - 123

Опубликована: Фев. 7, 2025

Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.

Язык: Английский

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Biopolymer-based hydrogels for biomedical applications: Bioactivity and wound healing properties

Coordination Chemistry Reviews, Год журнала: 2024, Номер 518, С. 216093 - 216093

Опубликована: Июль 25, 2024

Язык: Английский

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Molecular Modification of Queen Bee Acid and 10-Hydroxydecanoic Acid with Specific Tripeptides: Rational Design, Organic Synthesis, and Assessment for Prohealing and Antimicrobial Hydrogel Properties

Molecules, Год журнала: 2025, Номер 30(3), С. 615 - 615

Опубликована: Янв. 30, 2025

Royal jelly and medical grade honey are traditionally used in treating wounds infections, although their effectiveness is often variable insufficient. To overcome limitations, we created novel amphiphiles by modifying the main reparative antimicrobial components, queen bee acid (hda) 10-hydroxyl-decanoic (hdaa), through peptide bonding with specific tripeptides. Our molecular design incorporated amphiphile targets as being biocompatible wound healing, biodegradable, non-toxic, hydrogelable, prohealing, antimicrobial. The amphiphilic molecules were designed a hda(hdaa)-aa1-aa2-aa3 structural model rational selection criteria for each moiety, prepared via Rink/Fmoc-tBu-based solid-phase synthesis, structurally verified NMR LC–MS/MS. We tested several among those containing moieties of hda or hdaa isoleucine–leucine–aspartate (ILD-amidated) IL-lysine (ILK-NH2). These tests conducted to evaluate prohealing hydrogel properties. observation hydrogelation hydrogel-rheology showed that they can form hydrogels stable elastic moduli injectable shear-thinning properties, which suitable cell tissue repair regeneration. disc-diffusion assay demonstrated hdaa-ILK-NH2 markedly inhibited Staphylococcus aureus. Future research needed comprehensively properties these modified from

Язык: Английский

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A Comprehensive Review of Honey-Containing Hydrogel for Wound Healing Applications

Gels, Год журнала: 2025, Номер 11(3), С. 194 - 194

Опубликована: Март 12, 2025

Honey has long been recognized for its medicinal properties, particularly in wound healing. Recent advancements material science have led to the development of honey-containing hydrogels, combining natural healing properties honey with versatile characteristics hydrogel matrices. These hydrogels offer numerous advantages, including high moisture retention, biocompatibility, and controlled release bioactive compounds, making them highly effective applications. Hydrogels hold significant potential advancing medical applications, cutaneous injuries. The diverse honey, antimicrobial, anti-inflammatory, anti-eschar effects, shown promise accelerating tissue regeneration. According studies, they are maintaining a good swelling ratio index, Water Vapour Transmission Rate (WVTR), contact angle, tensile elongation at break, vitro biodegradation rate, viscosity porosity analysis, lowering bacterial infections, encouraging rapid regeneration notable FTIR peaks SEM average pore sizes. However, limitations such as low bioavailability inefficiencies direct application reduce their therapeutic effectiveness site. Integrating into can help preserve mechanisms while enhancing ability facilitate skin recovery. This review explores underlying management presents an extensive analysis reported literature over past eight years. It emphasizes physicochemical mechanical honey-incorporated promoting regeneration, supported by evidence from both vivo studies. While honey-based therapies demonstrated promising outcomes animal clinical studies remain limited. Despite that, honey’s incorporation systems, however, offers potent fusion contemporary technology qualities, marking substantial breakthrough treatment.

Язык: Английский

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A comprehensive exploration of hydrogel applications in multi-stage skin wound healing

Biomaterials Science, Год журнала: 2024, Номер 12(15), С. 3745 - 3764

Опубликована: Янв. 1, 2024

Hydrogels, as an emerging biomaterial, have found extensive use in the healing of wounds due to their distinctive physicochemical structure and functional properties. Moreover, hydrogels can be made match a range therapeutic requirements for materials used wound through specific modifications. This review provides step-by-step explanation processes involved cutaneous healing, including hemostasis, inflammation, proliferation, reconstitution, along with investigation factors that impact these processes. Furthermore, thorough analysis is conducted on various stages process at which are implemented, anti-infection measures, encouraging regeneration, scar reduction, monitoring. Next, latest progress multifunctional methods achieve functions discussed depth categorized elucidation. Finally, perspectives challenges associated clinical applications discussed.

Язык: Английский

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Incorporation of natural and synthetic polymers into honey hydrogel for wound healing: A review

Health Science Reports, Год журнала: 2024, Номер 7(7)

Опубликована: Июль 1, 2024

The difficulty in treating chronic wounds due to the prolonged inflammation stage has affected a staggering 6.5 million people, accompanied by 25 billion USD annually United States alone. A 1.9% rise wound prevalence among Medicare beneficiaries was reported from 2014 2019. Besides, global care market values were anticipated increase 20.18 2022 30.52 2030, suggesting an expected financial burdens. lack of feasibility using traditional dry dressings sparks hydrogel development as alternative approach tackling wounds. Since ancient times, honey been used treat wounds, including burns, and ongoing studies have also demonstrated its wound-healing capabilities on cellular animal models. However, fluidity low mechanical strength necessitate incorporation other polymers. Therefore, this review aims unravel characteristics natural (chitosan gelatin) synthetic (polyvinyl alcohol polyethylene glycol) polymers be incorporated hydrogel.

Язык: Английский

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Application of the Quality by Design Concept (QbD) in the Development of Hydrogel-Based Drug Delivery Systems

Polymers, Год журнала: 2023, Номер 15(22), С. 4407 - 4407

Опубликована: Ноя. 14, 2023

Hydrogel-based drug delivery systems are of interest to researchers for many reasons, such as biocompatibility, high diversity, and the possibility administration from different routes. Despite these advantages, there challenges, controlling release rate their mechanical properties during manufacturing systems. For this reason, is a need production development with scientific strategy. quality by design (QbD) approach used This approach, identifying most effective factors in pharmaceutical products them, results product desired least number errors. In review article, an attempt made discuss application method applying hydrogel-based So that systems, according type system, what target characteristics should be considered (QTPP) factors, material (CMA) or process parameters (CPP), taken into account reach critical attributes (CQA).

Язык: Английский

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State-of-the-Art Advances and Current Applications of Gel-Based Membranes

Gels, Год журнала: 2024, Номер 10(1), С. 39 - 39

Опубликована: Янв. 1, 2024

Gel-based membranes, a fusion of polymer networks and liquid components, have emerged as versatile tools in variety technological domains thanks to their unique structural functional attributes. Historically rooted basic filtration tasks, recent advancements synthetic strategies increased the mechanical strength, selectivity, longevity these membranes. This review summarizes evolution, emphasizing breakthroughs that positioned them at forefront cutting-edge applications. They potential for desalination pollutant removal water treatment processes, delivering efficiency often surpasses conventional counterparts. The biomedical field has embraced drug delivery tissue engineering, capitalizing on biocompatibility tunable properties. Additionally, pivotal role energy storage gel electrolytes batteries fuel cells underscores adaptability. However, despite monumental progress gel-based membrane research, challenges persist, particularly scalability long-term stability. synthesis provides an overview state-of-the-art applications membranes discusses overcome current limitations, laying foundation future innovations this dynamic field.

Язык: Английский

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Dual network composite hydrogels with robust antibacterial and antifouling capabilities for efficient wound healing

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(20), С. 4909 - 4921

Опубликована: Янв. 1, 2024

Wound dressings play a critical role in the wound healing process; however, conventional often address singular functions, lacking versatility meeting diverse requirements. Herein, dual-network, multifunctional hydrogels (PSA/CS-GA) have been designed and synthesized through one-pot approach. The

Язык: Английский

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