Applied Surface Science, Journal Year: 2024, Volume and Issue: 687, P. 162211 - 162211
Published: Dec. 27, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129682 - 129682
Published: Jan. 22, 2024
Language: Английский
Citations
26
Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 123 - 123
Published: Feb. 7, 2025
Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.
Language: Английский
Citations
8
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216093 - 216093
Published: July 25, 2024
Language: Английский
Citations
16
Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 615 - 615
Published: Jan. 30, 2025
Royal jelly and medical grade honey are traditionally used in treating wounds infections, although their effectiveness is often variable insufficient. To overcome limitations, we created novel amphiphiles by modifying the main reparative antimicrobial components, queen bee acid (hda) 10-hydroxyl-decanoic (hdaa), through peptide bonding with specific tripeptides. Our molecular design incorporated amphiphile targets as being biocompatible wound healing, biodegradable, non-toxic, hydrogelable, prohealing, antimicrobial. The amphiphilic molecules were designed a hda(hdaa)-aa1-aa2-aa3 structural model rational selection criteria for each moiety, prepared via Rink/Fmoc-tBu-based solid-phase synthesis, structurally verified NMR LC–MS/MS. We tested several among those containing moieties of hda or hdaa isoleucine–leucine–aspartate (ILD-amidated) IL-lysine (ILK-NH2). These tests conducted to evaluate prohealing hydrogel properties. observation hydrogelation hydrogel-rheology showed that they can form hydrogels stable elastic moduli injectable shear-thinning properties, which suitable cell tissue repair regeneration. disc-diffusion assay demonstrated hdaa-ILK-NH2 markedly inhibited Staphylococcus aureus. Future research needed comprehensively properties these modified from
Language: Английский
Citations
2
Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 194 - 194
Published: March 12, 2025
Honey has long been recognized for its medicinal properties, particularly in wound healing. Recent advancements material science have led to the development of honey-containing hydrogels, combining natural healing properties honey with versatile characteristics hydrogel matrices. These hydrogels offer numerous advantages, including high moisture retention, biocompatibility, and controlled release bioactive compounds, making them highly effective applications. Hydrogels hold significant potential advancing medical applications, cutaneous injuries. The diverse honey, antimicrobial, anti-inflammatory, anti-eschar effects, shown promise accelerating tissue regeneration. According studies, they are maintaining a good swelling ratio index, Water Vapour Transmission Rate (WVTR), contact angle, tensile elongation at break, vitro biodegradation rate, viscosity porosity analysis, lowering bacterial infections, encouraging rapid regeneration notable FTIR peaks SEM average pore sizes. However, limitations such as low bioavailability inefficiencies direct application reduce their therapeutic effectiveness site. Integrating into can help preserve mechanisms while enhancing ability facilitate skin recovery. This review explores underlying management presents an extensive analysis reported literature over past eight years. It emphasizes physicochemical mechanical honey-incorporated promoting regeneration, supported by evidence from both vivo studies. While honey-based therapies demonstrated promising outcomes animal clinical studies remain limited. Despite that, honey’s incorporation systems, however, offers potent fusion contemporary technology qualities, marking substantial breakthrough treatment.
Language: Английский
Citations
2
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(15), P. 3745 - 3764
Published: Jan. 1, 2024
Hydrogels, as an emerging biomaterial, have found extensive use in the healing of wounds due to their distinctive physicochemical structure and functional properties. Moreover, hydrogels can be made match a range therapeutic requirements for materials used wound through specific modifications. This review provides step-by-step explanation processes involved cutaneous healing, including hemostasis, inflammation, proliferation, reconstitution, along with investigation factors that impact these processes. Furthermore, thorough analysis is conducted on various stages process at which are implemented, anti-infection measures, encouraging regeneration, scar reduction, monitoring. Next, latest progress multifunctional methods achieve functions discussed depth categorized elucidation. Finally, perspectives challenges associated clinical applications discussed.
Language: Английский
Citations
5
Health Science Reports, Journal Year: 2024, Volume and Issue: 7(7)
Published: July 1, 2024
The difficulty in treating chronic wounds due to the prolonged inflammation stage has affected a staggering 6.5 million people, accompanied by 25 billion USD annually United States alone. A 1.9% rise wound prevalence among Medicare beneficiaries was reported from 2014 2019. Besides, global care market values were anticipated increase 20.18 2022 30.52 2030, suggesting an expected financial burdens. lack of feasibility using traditional dry dressings sparks hydrogel development as alternative approach tackling wounds. Since ancient times, honey been used treat wounds, including burns, and ongoing studies have also demonstrated its wound-healing capabilities on cellular animal models. However, fluidity low mechanical strength necessitate incorporation other polymers. Therefore, this review aims unravel characteristics natural (chitosan gelatin) synthetic (polyvinyl alcohol polyethylene glycol) polymers be incorporated hydrogel.
Language: Английский
Citations
5
Polymers, Journal Year: 2023, Volume and Issue: 15(22), P. 4407 - 4407
Published: Nov. 14, 2023
Hydrogel-based drug delivery systems are of interest to researchers for many reasons, such as biocompatibility, high diversity, and the possibility administration from different routes. Despite these advantages, there challenges, controlling release rate their mechanical properties during manufacturing systems. For this reason, is a need production development with scientific strategy. quality by design (QbD) approach used This approach, identifying most effective factors in pharmaceutical products them, results product desired least number errors. In review article, an attempt made discuss application method applying hydrogel-based So that systems, according type system, what target characteristics should be considered (QTPP) factors, material (CMA) or process parameters (CPP), taken into account reach critical attributes (CQA).
Language: Английский
Citations
10
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: March 7, 2025
Diabetes is a widespread metabolic disorder that presents considerable challenges in its management. Recent advancements biomaterial research have shed light on innovative approaches for the treatment of diabetes. This review examines role biomaterials diabetes diagnosis and treatment, as well their application managing diabetic wounds. By evaluating recent developments alongside future obstacles, highlights promising potential care, underscoring importance enhancing patient outcomes refining methodologies.
Language: Английский
Citations
0
Polymers, Journal Year: 2025, Volume and Issue: 17(9), P. 1129 - 1129
Published: April 22, 2025
Chronic wounds, particularly those associated with conditions like diabetes, present significant challenges in healthcare due to prolonged healing and high susceptibility infections. This study investigates the development of injectable hydrogels composed genipin-crosslinked gelatin Kelulut honey (KH) as novel biomaterials for wound applications. Hydrogels were prepared varying concentrations (w/v) (9% 10%) KH (0.1% 0.5%), genipin (0.1%) acting a crosslinker. The physicochemical properties extensively evaluated, including swelling ratio, water vapor transmission rate (WVTR), contact angle, porosity, enzymatic degradation, surface roughness. results showed that incorporation significantly enhanced hydrogels, 9GE_0.1KH formulation demonstrating ratio 742.07 ± 89.61% compared 500% control 9GE formulation. WVTR values KH-incorporated ranged from 1670.60 236.87 g/m2h 2438.92 190.90 g/m2h, which within ideal range (1500–2500 g/m2h) healing. Contact angle measurements indicated improved hydrophilicity, showing 42.14° 7.52° 60° 11.66° 10GE Biodegradation rates slightly higher KH-modified (0.079 0.006 mg/h 9GE_0.1KH), but all remained acceptable limits. These findings suggest gelatin-KH offer promising scaffold potential applications tissue engineering three-dimensional (3D) bioprinting technologies.
Language: Английский
Citations
0