Abstract
Male
genitourinary
dysfunction
causes
serious
physical
or
mental
distress,
such
as
infertility
and
psychological
harm,
which
leads
to
impaired
quality
of
life.
Current
conventional
treatments
involving
drug
therapy,
surgical
repair,
tissue
grafting
have
a
limited
effect
on
recovering
the
function
fertility
organs.
To
address
these
limitations,
various
biomaterials
been
explored,
with
collagen-based
materials
increasingly
gaining
attention
for
reconstructing
male
system
due
their
superior
biocompatibility,
biodegradability,
low
antigenicity,
biomimetic
3D
matrix
characteristics,
hemostatic
efficacy,
regeneration
capabilities.
This
review
covers
recent
biomedical
applications
including
treatment
erectile
dysfunction,
premature
ejaculation,
penile
girth
enlargement,
prostate
cancer,
Peyronie's
disease,
chronic
kidney
etc.
Although
there
are
relatively
few
clinical
trials,
promising
results
existing
studies
animal
models
reveal
bright
future
in
diseases.
Graphic
Gels,
Год журнала:
2024,
Номер
10(11), С. 693 - 693
Опубликована: Окт. 25, 2024
Hydrogels
are
known
for
their
high
water
retention
capacity
and
biocompatibility
have
become
essential
materials
in
tissue
engineering
drug
delivery
systems.
This
review
explores
recent
advancements
hydrogel
technology,
focusing
on
innovative
types
such
as
self-healing,
tough,
smart,
hybrid
hydrogels,
each
engineered
to
overcome
the
limitations
of
conventional
hydrogels.
Self-healing
hydrogels
can
autonomously
repair
structural
damage,
making
them
well-suited
applications
dynamic
biomedical
environments.
Tough
designed
with
enhanced
mechanical
properties,
enabling
use
load-bearing
cartilage
regeneration.
Smart
respond
external
stimuli,
including
changes
pH,
temperature,
electromagnetic
fields,
ideal
controlled
release
tailored
specific
medical
needs.
Hybrid
made
from
both
natural
synthetic
polymers,
combine
bioactivity
resilience,
which
is
particularly
valuable
complex
tissues.
Despite
these
innovations,
challenges
optimizing
biocompatibility,
adjusting
degradation
rates,
scaling
up
production
remain.
provides
an
in-depth
analysis
emerging
technologies,
highlighting
transformative
potential
while
outlining
future
directions
development
applications.
Gels,
Год журнала:
2025,
Номер
11(4), С. 276 - 276
Опубликована: Апрель 7, 2025
Hydrogels
have
emerged
as
a
transformative
technology
in
agriculture,
offering
significant
potential
to
enhance
crop
resilience,
improve
water
use
efficiency,
and
promote
sustainable
farming
practices.
These
three-dimensional
polymeric
networks
can
absorb
retain
water,
making
them
particularly
valuable
regions
facing
scarcity
unpredictable
rainfall
patterns.
This
review
examines
the
types,
properties,
applications
of
hydrogels
highlighting
their
role
improving
soil
moisture
retention,
enhancing
nutrient
delivery
by,
increasing
yield.
The
discussion
extends
economic
environmental
implications
hydrogel
use,
including
reduce
irrigation
costs
by
minimize
erosion.
also
explores
latest
innovations
technology,
such
smart
biodegradable
alternatives,
which
offer
new
possibilities
for
precision
agriculture
sustainability.
Despite
promising
benefits,
challenges
higher
cost
synthetic
hydrogels,
impact,
performance
variability
across
different
types
remain.
Addressing
these
requires
multidisciplinary
approach
that
integrates
advancements
material
science,
agronomy,
policy.
future
outlook
is
optimistic,
with
ongoing
research
poised
refine
expand
diverse
agricultural
systems.
By
leveraging
capabilities
achieve
increase
productivity,
ensure
food
security,
move
towards
more
resilient
landscape.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 296 - 296
Опубликована: Фев. 24, 2025
Melanoma,
a
highly
aggressive
form
of
skin
cancer,
poses
major
therapeutic
challenge
due
to
its
metastatic
potential,
resistance
conventional
therapies,
and
the
complexity
tumor
microenvironment
(TME).
Materials
science
nanotechnology
advances
have
led
using
nanocarriers
such
as
liposomes,
dendrimers,
polymeric
nanoparticles,
metallic
nanoparticles
transformative
solutions
for
precision
melanoma
therapy.
This
review
summarizes
findings
from
Web
Science,
PubMed,
EMBASE,
Scopus,
Google
Scholar
highlights
role
in
overcoming
treatment
barriers.
Nanoparticles
facilitate
passive
active
targeting
through
mechanisms
enhanced
permeability
retention
(EPR)
effect
functionalization
with
tumor-specific
ligands,
thereby
improving
accuracy
drug
delivery
reducing
systemic
toxicity.
Stimuli-responsive
systems
multi-stage
further
improve
overcome
challenges
poor
penetration
resistance.
Emerging
platforms
combine
diagnostic
imaging
delivery,
paving
way
personalized
medicine.
However,
there
are
still
issues
scalability,
biocompatibility,
regulatory
compliance.
comprehensive
potential
integrating
genetics
proteomics,
scalable,
patient-specific
therapies.
These
interdisciplinary
innovations
promise
redefine
provide
safer,
more
effective,
accessible
treatments.
Continued
research
is
essential
bridge
gap
between
evidence-based
scientific
clinical
applications.
Mineral
nanoparticles
and
osteoinductive
biomaterials
are
essential
in
advancing
bone
regeneration
by
addressing
skeletal
conditions
injuries
that
compromise
structural
integrity
functionality.
These
stimulate
the
differentiation
of
precursor
cells
into
osteoblasts,
creating
biocompatible
environments
conducive
to
tissue
regeneration.
Among
most
promising
innovations,
mineral-based
nanocomposite
hydrogels
have
emerged
as
effective
strategies
for
enhancing
potential.
This
review
explores
diverse
types
biomaterials,
including
natural
sources,
synthetic
compounds,
hybrid
designs
incorporate
mineralized
nanoparticles.
Emphasis
is
placed
on
polymeric
delivery
platforms
these
materials,
highlighting
their
dual
role
supports
bioactive
agents
promote
osteogenesis.
Challenges
such
immune
rejection,
biodegradability,
mechanical
stability,
short
vivo
residence
time
critically
discussed,
alongside
impact
clinical
translation.
By
presenting
a
comprehensive
analysis
mechanisms,
applications,
limitations,
this
identifies
opportunities
integrating
with
emerging
fields
like
immunology
biomechanics.
Ultimately,
work
aims
provide
actionable
insights
advance
development
novel,
clinically
relevant
solutions
improve
patient
outcomes
address
growing
global
need
repair
Gels,
Год журнала:
2025,
Номер
11(4), С. 260 - 260
Опубликована: Апрель 1, 2025
Stroke
remains
a
leading
cause
of
disability
worldwide,
underscoring
the
urgent
need
for
novel
and
innovative
therapeutic
strategies
to
enhance
neuroprotection,
support
regeneration,
improve
functional
recovery.
Previous
research
has
shown
that
phytochemicals
such
as
curcumin,
tannic
acid,
gallic
ginsenosides,
resveratrol,
isorhamnetin
display
extensive
neuroprotective
properties,
including
antioxidant,
anti-inflammatory,
anti-apoptotic
effects.
These
natural
compounds
could
also
promote
neurogenesis,
angiogenesis,
preservation
blood–brain
barrier.
Despite
their
promising
bioactivities,
clinical
application
is
often
limited
by
poor
solubility,
bioavailability,
suboptimal
pharmacokinetics.
Hydrogels
offer
solution
encapsulating
controlling
gradual
release
these
directly
at
site
injury.
Recent
advancements
in
hydrogel
formulations,
constructed
from
biopolymers
functionalized
using
nanotechnological
approaches,
significantly
stability,
targeted
delivery
phytochemicals.
Controlled
profiles
pH-sensitive
environment-responsive
hydrogels
ensure
compounds’
effects
are
optimally
timed
with
individual
critical
stages
post-stroke
repair.
Moreover,
scaffolds
tailored
material
properties
biocompatibility
can
create
favorable
microenvironment,
reducing
secondary
inflammation,
enhancing
tissue
potentially
improving
cognitive
outcomes
following
stroke.
This
review
explores
potential
integrating
within
hydrogel-based
systems
specifically
designed
The
design
synthesis
biocompatible,
biodegradable
especially
applications
discussed.
Lastly,
we
emphasize
additional
robust
translatable
preclinical
studies.
Gels,
Год журнала:
2025,
Номер
11(2), С. 131 - 131
Опубликована: Фев. 12, 2025
Local
anesthetics
(LAs)
have
been
indispensable
in
clinical
pain
management,
yet
their
limitations,
such
as
short
duration
of
action
and
systemic
toxicity,
necessitate
improved
delivery
strategies.
Hydrogels,
with
biocompatibility,
tunable
properties,
ability
to
modulate
drug
release,
extensively
explored
platforms
for
enhancing
LA
efficacy
safety.
This
narrative
review
explores
the
historical
development
LAs,
physicochemical
applications,
providing
a
foundation
understanding
integration
hydrogels
anesthetic
delivery.
Advances
thermoresponsive,
stimuli-responsive,
multifunctional
demonstrated
significant
potential
prolonging
analgesia
reducing
exposure
preclinical
studies,
while
early
findings
highlight
feasibility
thermoresponsive
hydrogel
formulations.
Despite
these
advancements,
challenges
burst
mechanical
instability,
regulatory
considerations
remain
critical
barriers
translation.
Emerging
innovations,
including
nanocomposite
hydrogels,
biofunctionalized
matrices,
smart
materials,
offer
solutions
limitations.
Future
research
should
focus
on
optimizing
formulations,
expanding
validation,
integrating
advanced
fabrication
technologies
3D
printing
artificial
intelligence-driven
design
enhance
personalized
management.
By
bridging
materials
science
pharmacology,
this
provides
comprehensive
perspective
current
trends
future
directions
hydrogel-based
systems.
