Development of New Chitosan-Based Complex with Bioactive Molecules for Regenerative Medicine DOI Creative Commons
Natasha Maurmann, Gabriela Moraes Machado, Rafaela Hartmann Kasper

et al.

Future Pharmacology, Journal Year: 2024, Volume and Issue: 4(4), P. 873 - 891

Published: Dec. 16, 2024

Background/Objectives: The development of new materials incorporating bioactive molecules for tissue regeneration is a growing area interest. objective this study was to develop complex specifically designed bone and skin engineering, combining chitosan, ascorbic acid-2-magnesium phosphate (ASAP), β-tricalcium (β-TCP). Methods: Chitosan the complexes chitosan/ASAP chitosan/ASAP/β-TCP were prepared in membrane form, macerated particulate format, then subjected characterization through Fourier transform infrared (FTIR) spectroscopy, optical scanning electron microscopy (SEM), zeta potential, thermogravimetric analysis (TGA), differential calorimetry (DSC). Cell viability evaluated 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay with fluorescein diacetate (FDA) propidium iodide (PI) staining stem cells obtained from deciduous teeth. Statistical analyses performed using variance (ANOVA), followed by Tukey’s test. Results: FTIR results indicated characteristic bands chitosan group complexation between ASAP, β-TCP. Microscopic revealed polydisperse distribution micrometric particles. Zeta potential measurements demonstrated reduction surface charge upon addition ASAP β-TCP matrix. TGA DSC further three components successful formation cross-linked structure Stem cultured biomaterials their biocompatibility. significant increase cell groups compared control. Conclusions: Therefore, regeneration, while formulation showed promise as biomaterial due presence phosphate.

Language: Английский

Recent study on biodegradable hydrogels for agriculture application: a review DOI

Wan Amirah Najwa Wan Anuar,

Ros Azlinawati Ramli, Morsi Mahmoud

et al.

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 115679 - 115679

Published: Feb. 1, 2025

Language: Английский

Citations

2
A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials DOI Creative Commons
Hoon Choi, Wan-Sun Choi,

Jin-Oh Jeong

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 693 - 693

Published: Oct. 25, 2024

Hydrogels are known for their high water retention capacity and biocompatibility have become essential materials in tissue engineering drug delivery systems. This review explores recent advancements hydrogel technology, focusing on innovative types such as self-healing, tough, smart, hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited applications dynamic biomedical environments. Tough designed with enhanced mechanical properties, enabling use load-bearing cartilage regeneration. Smart respond external stimuli, including changes pH, temperature, electromagnetic fields, ideal controlled release tailored specific medical needs. Hybrid made from both natural synthetic polymers, combine bioactivity resilience, which is particularly valuable complex tissues. Despite these innovations, challenges optimizing biocompatibility, adjusting degradation rates, scaling up production remain. provides an in-depth analysis emerging technologies, highlighting transformative potential while outlining future directions development applications.

Language: Английский

Citations

10
Preparation and Drug Release Behavior Study of Intelligent pH-Responsive Sodium Alginate/κ-Carrageenan Polysaccharide-based Hydrogels DOI

Jiaying Ren,

Jiarui Jin,

Yuze Wang

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105975 - 105975

Published: Jan. 1, 2025

Language: Английский

Citations

1
Advances in Materials Science for Precision Melanoma Therapy: Nanotechnology-Enhanced Drug Delivery Systems DOI Creative Commons
Sivakumar S. Moni, Jobran M. Moshi, Sabine Matou‐Nasri

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 296 - 296

Published: Feb. 24, 2025

Melanoma, a highly aggressive form of skin cancer, poses major therapeutic challenge due to its metastatic potential, resistance conventional therapies, and the complexity tumor microenvironment (TME). Materials science nanotechnology advances have led using nanocarriers such as liposomes, dendrimers, polymeric nanoparticles, metallic nanoparticles transformative solutions for precision melanoma therapy. This review summarizes findings from Web Science, PubMed, EMBASE, Scopus, Google Scholar highlights role in overcoming treatment barriers. Nanoparticles facilitate passive active targeting through mechanisms enhanced permeability retention (EPR) effect functionalization with tumor-specific ligands, thereby improving accuracy drug delivery reducing systemic toxicity. Stimuli-responsive systems multi-stage further improve overcome challenges poor penetration resistance. Emerging platforms combine diagnostic imaging delivery, paving way personalized medicine. However, there are still issues scalability, biocompatibility, regulatory compliance. comprehensive potential integrating genetics proteomics, scalable, patient-specific therapies. These interdisciplinary innovations promise redefine provide safer, more effective, accessible treatments. Continued research is essential bridge gap between evidence-based scientific clinical applications.

Language: Английский

Citations

1
Mineral nanoparticles and nanocomposite hydrogels with osteoinductive properties for bone regeneration DOI Creative Commons

Cho‐E Choi,

Arghya Paul

Published: March 17, 2025

Mineral nanoparticles and osteoinductive biomaterials are essential in advancing bone regeneration by addressing skeletal conditions injuries that compromise structural integrity functionality. These stimulate the differentiation of precursor cells into osteoblasts, creating biocompatible environments conducive to tissue regeneration. Among most promising innovations, mineral-based nanocomposite hydrogels have emerged as effective strategies for enhancing potential. This review explores diverse types biomaterials, including natural sources, synthetic compounds, hybrid designs incorporate mineralized nanoparticles. Emphasis is placed on polymeric delivery platforms these materials, highlighting their dual role supports bioactive agents promote osteogenesis. Challenges such immune rejection, biodegradability, mechanical stability, short vivo residence time critically discussed, alongside impact clinical translation. By presenting a comprehensive analysis mechanisms, applications, limitations, this identifies opportunities integrating with emerging fields like immunology biomechanics. Ultimately, work aims provide actionable insights advance development novel, clinically relevant solutions improve patient outcomes address growing global need repair

Language: Английский

Citations

1
Advanced Hydrogel Systems for Local Anesthetic Delivery: Toward Prolonged and Targeted Pain Relief DOI Creative Commons

Jin-Oh Jeong,

Min-Joo Kim,

Seonwook Kim

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 131 - 131

Published: Feb. 12, 2025

Local anesthetics (LAs) have been indispensable in clinical pain management, yet their limitations, such as short duration of action and systemic toxicity, necessitate improved delivery strategies. Hydrogels, with biocompatibility, tunable properties, ability to modulate drug release, extensively explored platforms for enhancing LA efficacy safety. This narrative review explores the historical development LAs, physicochemical applications, providing a foundation understanding integration hydrogels anesthetic delivery. Advances thermoresponsive, stimuli-responsive, multifunctional demonstrated significant potential prolonging analgesia reducing exposure preclinical studies, while early findings highlight feasibility thermoresponsive hydrogel formulations. Despite these advancements, challenges burst mechanical instability, regulatory considerations remain critical barriers translation. Emerging innovations, including nanocomposite hydrogels, biofunctionalized matrices, smart materials, offer solutions limitations. Future research should focus on optimizing formulations, expanding validation, integrating advanced fabrication technologies 3D printing artificial intelligence-driven design enhance personalized management. By bridging materials science pharmacology, this provides comprehensive perspective current trends future directions hydrogel-based systems.

Language: Английский

Citations

0
Development of ecofriendly, biodegradable electrically conductive double-layer bio-hydrogel nanocomposite for sustainable medical device applications DOI Creative Commons
Zohre Jafari Vafa, Ehsan Nazarzadeh Zare‬,

Mohammad Reza Fadavi Eslam

et al.

Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(2)

Published: Feb. 17, 2025

Language: Английский

Citations

0
Post-Stroke Recovery: A Review of Hydrogel-Based Phytochemical Delivery Systems DOI Creative Commons

Irina Musa,

Alexandra Daniela Rotaru-Zavaleanu,

Veronica Sfredel

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 260 - 260

Published: April 1, 2025

Stroke remains a leading cause of disability worldwide, underscoring the urgent need for novel and innovative therapeutic strategies to enhance neuroprotection, support regeneration, improve functional recovery. Previous research has shown that phytochemicals such as curcumin, tannic acid, gallic ginsenosides, resveratrol, isorhamnetin display extensive neuroprotective properties, including antioxidant, anti-inflammatory, anti-apoptotic effects. These natural compounds could also promote neurogenesis, angiogenesis, preservation blood–brain barrier. Despite their promising bioactivities, clinical application is often limited by poor solubility, bioavailability, suboptimal pharmacokinetics. Hydrogels offer solution encapsulating controlling gradual release these directly at site injury. Recent advancements in hydrogel formulations, constructed from biopolymers functionalized using nanotechnological approaches, significantly stability, targeted delivery phytochemicals. Controlled profiles pH-sensitive environment-responsive hydrogels ensure compounds’ effects are optimally timed with individual critical stages post-stroke repair. Moreover, scaffolds tailored material properties biocompatibility can create favorable microenvironment, reducing secondary inflammation, enhancing tissue potentially improving cognitive outcomes following stroke. This review explores potential integrating within hydrogel-based systems specifically designed The design synthesis biocompatible, biodegradable especially applications discussed. Lastly, we emphasize additional robust translatable preclinical studies.

Language: Английский

Citations

0
Hydrogel Performance in Boosting Plant Resilience to Water Stress—A Review DOI Creative Commons
Gamareldawla H.D. Agbna,

Syed Javaid Zaidi

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 276 - 276

Published: April 7, 2025

Hydrogels have emerged as a transformative technology in agriculture, offering significant potential to enhance crop resilience, improve water use efficiency, and promote sustainable farming practices. These three-dimensional polymeric networks can absorb retain water, making them particularly valuable regions facing scarcity unpredictable rainfall patterns. This review examines the types, properties, applications of hydrogels highlighting their role improving soil moisture retention, enhancing nutrient delivery by, increasing yield. The discussion extends economic environmental implications hydrogel use, including reduce irrigation costs by minimize erosion. also explores latest innovations technology, such smart biodegradable alternatives, which offer new possibilities for precision agriculture sustainability. Despite promising benefits, challenges higher cost synthetic hydrogels, impact, performance variability across different types remain. Addressing these requires multidisciplinary approach that integrates advancements material science, agronomy, policy. future outlook is optimistic, with ongoing research poised refine expand diverse agricultural systems. By leveraging capabilities achieve increase productivity, ensure food security, move towards more resilient landscape.

Language: Английский

Citations

0
Global Research and Emerging Trend of Superabsorbent Hydrogel Applied to Agriculture Based on Visual Analysis DOI

Zhiwen Li,

Yuankai Zhou, Tian Qin

et al.

Water Air & Soil Pollution, Journal Year: 2025, Volume and Issue: 236(6)

Published: April 21, 2025

Language: Английский

Citations

0