Cadmium toxicity and autophagy: a review

BioMetals, Год журнала: 2024, Номер 37(3), С. 609 - 629

Опубликована: Янв. 26, 2024

Язык: Английский

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The impact of nanomaterials on autophagy across health and disease conditions

Cellular and Molecular Life Sciences, Год журнала: 2024, Номер 81(1)

Опубликована: Апрель 17, 2024

Abstract Autophagy, a catabolic process integral to cellular homeostasis, is constitutively active under physiological and stress conditions. The role of autophagy as defense response becomes particularly evident upon exposure nanomaterials (NMs), especially environmental nanoparticles (NPs) nanoplastics (nPs). This has positioned modulation at the forefront nanotechnology-based therapeutic interventions. While NMs can exploit enhance outcomes, they also trigger it pro-survival against NP-induced toxicity. Conversely, heightened may lead regulated cell death (RCD), in particular autophagic death, NP exposure. Thus, relationship between exhibits dual nature with Recognizing decoding these intricate patterns are essential for pioneering next-generation autophagy-regulating NMs. review delves into present-day potential autophagy-modulating NMs, shedding light on their status clinical trials, intervention applications discusses potency application early indicator NM Graphical

Язык: Английский

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Lysosomal genes contribute to Parkinson’s disease near agriculture with high intensity pesticide use

npj Parkinson s Disease, Год журнала: 2024, Номер 10(1)

Опубликована: Апрель 25, 2024

Abstract Parkinson’s disease (PD), the second most common neurodegenerative disorder, develops sporadically, likely through a combination of polygenic and environmental factors. Previous studies associate pesticide exposure genes involved in lysosomal function with PD risk. We evaluated frequency variants among patients from Parkinson’s, Environment, Genes (PEG) study ambient agricultural sources. 757 patients, primarily White European/non-Hispanic ancestry (75%), were screened for 85 using custom amplicon panel. Variant enrichment was calculated against Genome Aggregation Database (gnomAD). Enriched exonic prioritized by to cluster pesticides used on cotton severity progression subset 386 subdivided race/ethnicity. Gene analysis identified 36 26 PEG patients. Twelve (12/26, 46%) had multiple enriched and/or single variant present individuals, representing 61% (22/36) observed variation cohort. The majority (26/36, 72%) found contributing function, particularly autophagy, bioinformatically deemed functionally deleterious (31/36, 86%). conclude that, this study, associated notably exposed suggesting that altered may generate an underlying susceptibility developing exposure. Further gene-environment interactions targeting improve understanding risk individuals pesticides.

Язык: Английский

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Autophagy in Its (Proper) Context: Molecular Basis, Biological Relevance, Pharmacological Modulation, and Lifestyle Medicine

International Journal of Biological Sciences, Год журнала: 2024, Номер 20(7), С. 2532 - 2554

Опубликована: Янв. 1, 2024

Autophagy plays a critical role in maintaining cellular homeostasis and responding to various stress conditions by the degradation of intracellular components.In this narrative review, we provide comprehensive overview autophagy's molecular basis, biological significance, pharmacological modulation, its relevance lifestyle medicine.We delve into intricate mechanisms that govern autophagy, including macroautophagy, microautophagy chaperone-mediated autophagy.Moreover, highlight significance autophagy aging, immunity, metabolism, apoptosis, tissue differentiation systemic diseases, such as neurodegenerative or cardiovascular diseases cancer.We also discuss latest advancements modulation their potential implications clinical settings.Finally, explore intimate connection between factors emphasizing how nutrition, exercise, sleep patterns environmental can significantly impact autophagic process.The integration medicine research opens new avenues for promoting health longevity through personalized interventions.

Язык: Английский

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Acute exposure to fungicide fluazinam induces cell death in the midgut, oxidative stress and alters behavior of the stingless bee Partamona helleri (Hymenoptera: Apidae)

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 282, С. 116677 - 116677

Опубликована: Июль 5, 2024

Stingless bees (Hymenoptera: Meliponini) are pollinators of both cultivated and wild crop plants in the Neotropical region. However, they susceptible to pesticide exposure during foraging activities. The fungicide fluazinam is commonly applied bean sunflower cultivation flowering period, posing a potential risk stingless bee Partamona helleri, which serves as pollinator for these crops. In this study, we investigated impact acute oral (24 h) on survival, morphology cell death signaling pathways midgut, oxidative stress behavior P. helleri worker bees. Worker were exposed 24 h (field concentrations 0.5, 1.5 2.5 mg a.i. mL

Язык: Английский

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Is it time to revise the fighting strategy toward type 2 diabetes? Sex and pollution as new risk factors

Ageing Research Reviews, Год журнала: 2024, Номер 99, С. 102405 - 102405

Опубликована: Июль 4, 2024

Diabetes mellitus, a metabolic condition affecting around 537 million individuals worldwide, poses significant challenges, particularly among the elderly population. The etiopathogenesis of type 2 diabetes (T2D) depends on combination effects driven by advancing age, genetic background, and lifestyle habits, e.g. overnutrition. These factors influence development T2D differently in men women, with an obvious sexual dimorphism possibly underlying diverse clinical features disease different sexes. More recently, environmental pollution, estimated to cause 9 deaths every year, is emerging as novel risk factor for T2D. Indeed, exposure atmospheric pollutants such PM2.5, O3, NO2, Persistent Organic Pollutants (POP)s, along their bioaccumulation, associated obesity, 15 % excess case very high levels PM2.5. Similar data are available plasticizer molecules, bisphenol A phthalates, endocrine-disrupting chemicals. Even though causality still debated at this stage, preclinical evidence sustains ability multiple affect pancreatic function, promote insulin resistance, alter lipid metabolism, contributing onset progression. In addition, findings suggest possible role also plastic itself pioneeristic studies evidenced that micro- or nanoplastics (MNP)s, particles nano- range, cellular damage, senescence, inflammation, disturbances, leading resistance impaired glucose metabolism animal and/or vitro models. Here we synthesize recent knowledge relative association between air-related plastic-derived incidence T2D, discussing mechanistic links suggested literature. We then anticipate need future field candidate therapeutic strategies limiting pollution-induced damage models, SGLT-2 inhibitors. finally postulate guidelines prevention should consider pollution sex additional limit pandemic.

Язык: Английский

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Myostatin: a potential therapeutic target for metabolic syndrome

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Май 23, 2023

Metabolic syndrome is a complex metabolic disorder, its main clinical manifestations are obesity, hyperglycemia, hypertension and hyperlipidemia. Although has been the focus of research in recent decades, it proposed that occurrence development related to pathophysiological processes such as insulin resistance, adipose tissue dysfunction chronic inflammation, but there still lack favorable prevention treatment measures for syndrome. Multiple studies have shown myostatin (MSTN), member TGF-β family, involved hyperlipidemia, diabetes, (clinical syndrome), thus may be potential therapeutic target In this review, we describe transcriptional regulation receptor binding pathway MSTN, then introduce role MSTN regulating mitochondrial function autophagy, review progress Finally summarize some inhibitors under trial use inhibitor

Язык: Английский

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Enhancing Efficacy of Albumin-Bound Paclitaxel for Human Lung and Colorectal Cancers through Autophagy Receptor Sequestosome 1 (SQSTM1)/p62-Mediated Nanodrug Delivery and Cancer therapy

ACS Nano, Год журнала: 2023, Номер 17(19), С. 19033 - 19051

Опубликована: Сен. 22, 2023

Selective autophagy is a defense mechanism by which foreign pathogens and abnormal substances are processed to maintain cellular homeostasis. Sequestosome 1 (SQSTM1)/p62, vital selective receptor, recruits ubiquitinated cargo form autophagosomes for lysosomal degradation. Nab-PTX an albumin-bound paclitaxel nanoparticle used in clinical cancer therapy. However, the role of SQSTM1 regulating delivery efficacy nanodrugs remains unclear. Here we showed that plays crucial drug human lung colorectal cancers. induces phosphorylation at Ser403, facilitates its incorporation into nanoparticles, known as nanoparticulophagy. increased LC3-II protein expression, triggered autophagosome formation. enhanced recognition autophagosomes, were delivered lysosomes albumin degradation, thereby releasing PTX induce mitotic catastrophe apoptosis. Knockout downregulated Nab-PTX-induced catastrophe, apoptosis, tumor inhibition vitro vivo inhibited caspase 3 activation via p53-independent pathway. Ectopic expression transfection SQSTM1-GFP vector restored Nab-PTX. Importantly, highly expressed advanced tumors associated with poor overall survival patients. Targeting may provide important strategy improve nanodrug This study demonstrates cancers SQSTM1-mediated delivery.

Язык: Английский

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Role of circPSEN1 in carbon black and cadmium co-exposure induced autophagy-dependent ferroptosis in respiratory epithelial cells

Environmental Pollution, Год журнала: 2024, Номер 346, С. 123562 - 123562

Опубликована: Фев. 14, 2024

Язык: Английский

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Analysis of cytotoxicity and genotoxicity of diesel exhaust PM2.5 generated from diesel and dual natural gas-diesel engines

Environmental Toxicology and Pharmacology, Год журнала: 2025, Номер 114, С. 104638 - 104638

Опубликована: Янв. 5, 2025

Язык: Английский

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