Cadmium toxicity and autophagy: a review

BioMetals, Journal Year: 2024, Volume and Issue: 37(3), P. 609 - 629

Published: Jan. 26, 2024

Language: Английский

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The impact of nanomaterials on autophagy across health and disease conditions

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: April 17, 2024

Abstract Autophagy, a catabolic process integral to cellular homeostasis, is constitutively active under physiological and stress conditions. The role of autophagy as defense response becomes particularly evident upon exposure nanomaterials (NMs), especially environmental nanoparticles (NPs) nanoplastics (nPs). This has positioned modulation at the forefront nanotechnology-based therapeutic interventions. While NMs can exploit enhance outcomes, they also trigger it pro-survival against NP-induced toxicity. Conversely, heightened may lead regulated cell death (RCD), in particular autophagic death, NP exposure. Thus, relationship between exhibits dual nature with Recognizing decoding these intricate patterns are essential for pioneering next-generation autophagy-regulating NMs. review delves into present-day potential autophagy-modulating NMs, shedding light on their status clinical trials, intervention applications discusses potency application early indicator NM Graphical

Language: Английский

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Lysosomal genes contribute to Parkinson’s disease near agriculture with high intensity pesticide use

npj Parkinson s Disease, Journal Year: 2024, Volume and Issue: 10(1)

Published: April 25, 2024

Abstract Parkinson’s disease (PD), the second most common neurodegenerative disorder, develops sporadically, likely through a combination of polygenic and environmental factors. Previous studies associate pesticide exposure genes involved in lysosomal function with PD risk. We evaluated frequency variants among patients from Parkinson’s, Environment, Genes (PEG) study ambient agricultural sources. 757 patients, primarily White European/non-Hispanic ancestry (75%), were screened for 85 using custom amplicon panel. Variant enrichment was calculated against Genome Aggregation Database (gnomAD). Enriched exonic prioritized by to cluster pesticides used on cotton severity progression subset 386 subdivided race/ethnicity. Gene analysis identified 36 26 PEG patients. Twelve (12/26, 46%) had multiple enriched and/or single variant present individuals, representing 61% (22/36) observed variation cohort. The majority (26/36, 72%) found contributing function, particularly autophagy, bioinformatically deemed functionally deleterious (31/36, 86%). conclude that, this study, associated notably exposed suggesting that altered may generate an underlying susceptibility developing exposure. Further gene-environment interactions targeting improve understanding risk individuals pesticides.

Language: Английский

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Autophagy in Its (Proper) Context: Molecular Basis, Biological Relevance, Pharmacological Modulation, and Lifestyle Medicine

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(7), P. 2532 - 2554

Published: Jan. 1, 2024

Autophagy plays a critical role in maintaining cellular homeostasis and responding to various stress conditions by the degradation of intracellular components.In this narrative review, we provide comprehensive overview autophagy's molecular basis, biological significance, pharmacological modulation, its relevance lifestyle medicine.We delve into intricate mechanisms that govern autophagy, including macroautophagy, microautophagy chaperone-mediated autophagy.Moreover, highlight significance autophagy aging, immunity, metabolism, apoptosis, tissue differentiation systemic diseases, such as neurodegenerative or cardiovascular diseases cancer.We also discuss latest advancements modulation their potential implications clinical settings.Finally, explore intimate connection between factors emphasizing how nutrition, exercise, sleep patterns environmental can significantly impact autophagic process.The integration medicine research opens new avenues for promoting health longevity through personalized interventions.

Language: Английский

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Acute exposure to fungicide fluazinam induces cell death in the midgut, oxidative stress and alters behavior of the stingless bee Partamona helleri (Hymenoptera: Apidae)

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 282, P. 116677 - 116677

Published: July 5, 2024

Stingless bees (Hymenoptera: Meliponini) are pollinators of both cultivated and wild crop plants in the Neotropical region. However, they susceptible to pesticide exposure during foraging activities. The fungicide fluazinam is commonly applied bean sunflower cultivation flowering period, posing a potential risk stingless bee Partamona helleri, which serves as pollinator for these crops. In this study, we investigated impact acute oral (24 h) on survival, morphology cell death signaling pathways midgut, oxidative stress behavior P. helleri worker bees. Worker were exposed 24 h (field concentrations 0.5, 1.5 2.5 mg a.i. mL

Language: Английский

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Is it time to revise the fighting strategy toward type 2 diabetes? Sex and pollution as new risk factors

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102405 - 102405

Published: July 4, 2024

Diabetes mellitus, a metabolic condition affecting around 537 million individuals worldwide, poses significant challenges, particularly among the elderly population. The etiopathogenesis of type 2 diabetes (T2D) depends on combination effects driven by advancing age, genetic background, and lifestyle habits, e.g. overnutrition. These factors influence development T2D differently in men women, with an obvious sexual dimorphism possibly underlying diverse clinical features disease different sexes. More recently, environmental pollution, estimated to cause 9 deaths every year, is emerging as novel risk factor for T2D. Indeed, exposure atmospheric pollutants such PM2.5, O3, NO2, Persistent Organic Pollutants (POP)s, along their bioaccumulation, associated obesity, 15 % excess case very high levels PM2.5. Similar data are available plasticizer molecules, bisphenol A phthalates, endocrine-disrupting chemicals. Even though causality still debated at this stage, preclinical evidence sustains ability multiple affect pancreatic function, promote insulin resistance, alter lipid metabolism, contributing onset progression. In addition, findings suggest possible role also plastic itself pioneeristic studies evidenced that micro- or nanoplastics (MNP)s, particles nano- range, cellular damage, senescence, inflammation, disturbances, leading resistance impaired glucose metabolism animal and/or vitro models. Here we synthesize recent knowledge relative association between air-related plastic-derived incidence T2D, discussing mechanistic links suggested literature. We then anticipate need future field candidate therapeutic strategies limiting pollution-induced damage models, SGLT-2 inhibitors. finally postulate guidelines prevention should consider pollution sex additional limit pandemic.

Language: Английский

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Analysis of cytotoxicity and genotoxicity of diesel exhaust PM2.5 generated from diesel and dual natural gas-diesel engines

Environmental Toxicology and Pharmacology, Journal Year: 2025, Volume and Issue: 114, P. 104638 - 104638

Published: Jan. 5, 2025

Language: Английский

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Possible role of autophagy in microbial volatile pollutant-induced starch degradation and expression of hypoxia responsive genes

Environmental Pollution, Journal Year: 2025, Volume and Issue: 367, P. 125663 - 125663

Published: Jan. 9, 2025

Language: Английский

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Environmental Health Is Overlooked in Longevity Research

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 421 - 421

Published: March 31, 2025

Aging is a multifactorial process influenced by genetic predisposition and lifestyle choices. Environmental exposures are too often overlooked. pollutants—ranging from airborne particulate matter heavy metals to endocrine disruptors microplastics—accelerate biological aging. Oxidative stress major molecular initiating event, driving inflammation toxicity across levels. We detail the mechanisms which pollutants enhance reactive oxygen species (ROS) production. This oxidative inflicts damage on DNA, proteins, lipids, accelerating telomere shortening, dysregulating autophagy, ultimately epigenetic age acceleration. For instance, exposure polycyclic aromatic hydrocarbons, benzene, pesticides has been associated with increased DNA methylation age. Early-life factors such as tobacco alcohol consumption further contribute accelerated The cumulative loss of healthy life years caused these can conceivably reach between 5 10 per person. Addressing pollutant-induced aging through regulatory measures, changes, therapeutic interventions essential mitigate their detrimental impacts, extending healthspan improving quality in populations.

Language: Английский

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Lycium barbarum polysaccharide protects BMSCs against cadmium-induced suppression of osteogenic differentiation by modulating autophagy

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 295, P. 118148 - 118148

Published: April 1, 2025

Language: Английский

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