Environmental Research, Год журнала: 2024, Номер 266, С. 120504 - 120504
Опубликована: Дек. 3, 2024
Язык: Английский
Environment International, Год журнала: 2024, Номер 183, С. 108432 - 108432
Опубликована: Янв. 1, 2024
Micro- and nanoplastics (MNPs), emerging as pervasive environmental pollutants, present multifaceted threats to diverse ecosystems. This review critically examines the ability of MNPs traverse biological barriers in fish, leading their accumulation gonadal tissues subsequent reproductive toxicity. A focal concern is potential transgenerational harm, where offspring not directly exposed exhibit toxic effects. Characterized by extensive specific surface areas marked hydrophobicity, readily adsorb concentrate other contaminants, potentially intensifying comprehensive analysis aims provide profound insights into repercussions on fish health progeny, highlighting intricate interplay between pollutants. We delve mechanisms MNPs-induced toxicity, including histopathologic alterations, oxidative stress, disruptions hypothalamic-pituitary-gonadal axis. The also underscores urgency for future research explore size-specific dynamics long-term implications chronic exposure. Understanding these aspects crucial assessing ecological risks posed formulating strategies safeguard aquatic life.
Язык: Английский
Процитировано
22
TrAC Trends in Analytical Chemistry, Год журнала: 2023, Номер 170, С. 117477 - 117477
Опубликована: Дек. 6, 2023
Язык: Английский
Процитировано
41
Toxics, Год журнала: 2024, Номер 12(3), С. 178 - 178
Опубликована: Фев. 26, 2024
The escalating prevalence of microplastics and nanoplastics in aquatic environments is a major challenge affecting the behavior reproductive health organisms while posing potential risks to human ecosystems. This review focuses on neurobehavioral changes toxicity MNPs zebrafish their relationships. At same time, caused by were studied, synergistic effects interaction these pollutants with other environmental contaminants explored. In addition, zebrafish, as model organism, provide valuable insights into subtle but important behavior, which critical for understanding success, suggesting that behavioral can serve an early biomarker toxicity. based classical endocrine disruptor models research methods, current status was reviewed, further indicated parameters be used effective rapid tool evaluate MNPs. However, methods rapidly assessing are still area exploration. To address limitations challenges scope research, this outlines future directions aim improving our impacts work aims inform targeted policies advance public strategies growing pollution.
Язык: Английский
Процитировано
14
Life, Год журнала: 2024, Номер 14(5), С. 640 - 640
Опубликована: Май 17, 2024
The aquatic environment encompasses a wide variety of pollutants, from plastics to drug residues, pesticides, food compounds, and other by-products, improper disposal waste is the main cause accumulation toxic substances in water. Monitoring, assessing, attempting control effects contaminants are necessary essential protect thus human animal health, study ecotoxicology has become topical. In this respect, zebrafish used as model organisms bioaccumulation, toxicity, influence environmental pollutants due their structural, functional, material advantages. There many similarities between metabolism physiological structures humans, nervous system structure, blood–brain barrier function, social behavior characteristics that make them an ideal for studying neurotoxicity. aim was highlight neurotoxicity nanoplastics, microplastics, fipronil, deltamethrin, rotenone behavioral, histological, oxidative status changes produced exposed them.
Язык: Английский
Процитировано
12
Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117883 - 117883
Опубликована: Фев. 1, 2025
Microplastics (MPs) are emerging contaminants characterized by persistence, cross-media transport, and complex pollutant interactions, posing serious ecotoxicological risks to ecosystems human health. Effective MPs management requires multi-faced, long-term, strategies involving targeted sampling, quantitative detection, comprehensive risk assessments, all of which entail significant resource investment. Despite advancements in remediation technologies, a holistic governance framework integrating these innovations remains underdeveloped. This review synthesizes current knowledge on MPs, elaborating their diverse morphologies, degradation pathways, role as vectors for toxic substances. State-of-the-art extraction techniques evaluated this article, including micropore adsorption using nanocomposites, alongside the incorporation advanced analytical tools such spectroscopic methods, electron microscopy, bioinformatics augment environmental forensics. also underscores necessity formulating robust global policies regulate pollution discusses potential biodegradation thermal sustainable solutions removal. By promoting an interdisciplinary approach, advocates coordinated response, science, policy frameworks, waste mitigate escalating impact well-being.
Язык: Английский
Процитировано
2
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Март 25, 2025
Lead nanoparticles (PbNPs) in air pollution pose a significant threat to human health, especially due their neurotoxic effects. In this study, we exposed mice lead(II) oxide (PbONPs) inhalation chambers mimic real-life exposure and assess impact on the brain. PbONPs caused formation of Hirano bodies pathological changes related neurodegenerative disorders through cytoskeletal disruptions without induction inflammation. Damage astrocytic endfeet capillary endothelial cells indicated compromised blood-brain barrier (BBB), allowing enter Additionally, NPs were detected along olfactory pathway, including fila olfactoria, suggesting that at least proportion PbNPs brain directly by passing epithelium. PbNP severely damaged apical parts epithelial cells, loss microtubules ciliary distal segments. Inhalation led rapid accumulation lead brain, while more soluble nitrate did not accumulate significantly until 11 weeks exposure. induced disruption BBB multiple levels, ranging from ultrastructural functional impairments barrier; however, they induce systemic inflammation The clearance ability remove Pb was very low for both types NPs, with effects persisting even after long period. Cation-binding proteins (ZBTB20 calbindin1) distributed unevenly strongest signal located hippocampus, which exhibited greatest defects nuclear architecture, indicating area is most sensitive structure also altered PI3K/Akt/mTOR signaling tau phosphorylation hippocampus inhibition GSK-3 inhibitor rescued negative effect intracellular calcium level trigeminal ganglion cultures. zebrafish larvae, affected locomotor activity reduced levels medium enhanced PbONP animal mobility, increasing lethality. These findings suggest dysregulation are key factors PbNP-induced neurotoxicity, providing potential targets therapeutic intervention prevent following
Язык: Английский
Процитировано
1
Frontiers in Physiology, Год журнала: 2023, Номер 14
Опубликована: Ноя. 23, 2023
Skin pigmentation abnormalities, ranging from aesthetic concerns to severe hyperpigmentation disease, have profound implications for individuals’ psychological and economic wellbeing. The intricate etiology of our evolving comprehension its underlying mechanisms underscore the need robust animal models. Zebrafish, renowned their transparent embryos genetic parallels humans, been spotlighted as a pivotal model skin studies. This review offers concise overview zebrafish attributes, highlighting shared melanin production pathways with humans. We systematically dissect diverse strategies craft models abnormal pigmentation, spanning physical, chemical, interventions, while critically appraising merits constraints each approach. Additionally, we elucidate metrics employed gauge efficacy these Concluding, cast visionary gaze on prospective breakthroughs in domain, aiming steer forthcoming efforts refined research.
Язык: Английский
Процитировано
14
Advances in Clinical Toxicology, Год журнала: 2024, Номер 9(1), С. 1 - 14
Опубликована: Янв. 1, 2024
Background: Traditional toxicity testing emphasizes animal models with growing concerns regarding predictive capacity, throughput and ethics. Rapid innovation surrounding human cell platforms, bioengineered tissues, omics techniques computational tools offers more modern alternatives aligned expanding knowledge of chemical biological pathways. These disruptive approaches promise immense potential to transform next-generation safety assessment drug development pipelines. Purpose: This review provides clinical researchers an updated, comprehensive perspective across evolving areas focus in new methods analysis latest advances translational context. Main Body: We survey progress two- three-dimensional cultures recapitulating tissue/organ complexity impossible conventional assays. Complementing this, modeling integrates structure-activity relationships, physicochemical properties physiological interactions predict pharmacokinetics silico. Expanding model organisms add further dimensionality demographic relevance. High-throughput imaging technologies unravel mechanisms illuminate biomarkers undetectable by standard measures. Specialized show high addressing toxicodynamic intricacies within disease contexts like diabetes NAFLD. Evaluating traditional medicines phytochemicals likewise represents area growth well-suited for contemporary platforms. Future outlook weighs remarkable advantages reducing demands, enabling precision toxicology links medicine overhauling core risk frameworks. Conclusion: intends catalyze discourse on strategic optimization priorities roadmaps towards fully unlocking the yet still emerging public health these poising transformation sciences centered human-focused models.
Язык: Английский
Процитировано
6
Chemosphere, Год журнала: 2024, Номер 357, С. 142026 - 142026
Опубликована: Апрель 12, 2024
Язык: Английский
Процитировано
6
Aquatic Toxicology, Год журнала: 2024, Номер 272, С. 106977 - 106977
Опубликована: Май 27, 2024
Язык: Английский
Процитировано
5