Crosstalk between ROS-inflammatory gene expression axis in the progression of lung disorders
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 28, 2024
Язык: Английский
Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 27, 2025
Abstract
Background
The
small
intestine
harbors
a
rich
array
of
intestinal
intraepithelial
lymphocytes
(IELs)
that
interact
with
structural
cells
to
collectively
sustain
gut
immune
homeostasis.
Dysregulation
homeostasis
was
implicated
in
the
pathogenesis
multiple
autoimmune
diseases,
however,
whether
this
is
disrupted
lupus
background
remains
unclear.
Methods
We
performed
single-cell
RNA
sequencing
(scRNA-seq)
analyses
elucidate
and
milieu
epithelium
MRL/Lpr
mice
(Lpr
mice)
MRL/Mpj
control
(Mpj
mice).
Comprehensive
including
unsupervised
clustering,
trajectories,
cellular
communication
were
performed.
primary
findings
from
scRNA-seq
further
validated
by
quantitative
polymerase
chain
reaction
(qPCR),
flow
cytometry,
vivo
experiments
selenium
supplementation.
Results
observed
significant
reduction
CD8αα
+
IELs,
accompanied
marked
increase
CD8αβ
IELs
Lpr
mice.
Additionally,
subsets
CD8
exhibiting
significantly
enhanced
effector
functions
found
be
markedly
enriched
Intercellular
patterns
within
epithelial
specifically
altered
Moreover,
revealed
decreased
TCRγδ
T
(γδT)
associated
reduced
aryl-hydrocarbon
receptor
repressor
(
AHRR
)
expression
subsequent
oxidative
stress
ferroptosis
Antioxidant
effectively
reversed
loss
γδT
mice,
improved
barrier,
alleviated
symptoms.
Conclusions
Our
high-resolution
atlas
enhances
understanding
provides
new
insights
into
mediated
dysregulation.
Язык: Английский
Nutrition, Lifestyle, and Environmental Factors in Lung Homeostasis and Respiratory Health
Nutrients,
Год журнала:
2025,
Номер
17(6), С. 954 - 954
Опубликована: Март 9, 2025
The
lungs
play
a
vital
role
in
maintaining
homeostasis
by
facilitating
gas
exchange
and
serving
as
structural
immune
barrier.
External
factors,
including
nutrition,
lifestyle,
environmental
exposures,
profoundly
influence
normal
lung
function
contribute
to
the
development,
progression,
prognosis
of
various
respiratory
diseases.
Deficiencies
key
micronutrients,
such
vitamins
A,
D,
C,
well
omega-3
fatty
acids,
can
impair
integrity
epithelial
lining,
compromising
lungs’
defense
mechanisms
increasing
susceptibility
injury
disease.
Obesity
physical
inactivity
further
disrupt
inducing
changes
chest
wall
promoting
pro-inflammatory
state.
Environmental
pollutants
worsen
oxidative
damage
activate
inflammatory
pathways.
Addressing
these
modifiable
factors
through
interventions
dietary
optimization,
activity
programs,
strategies
reduce
exposure
offers
promising
avenues
for
preserving
preventing
disease
progression.
This
review
examines
molecular
pathways
which
influences
impact
homeostasis.
Язык: Английский
Particulate Matter Exposure and Viral Infections: Relevance to Highly Polluted Settings such as Ulaanbaatar, Mongolia
Current Environmental Health Reports,
Год журнала:
2025,
Номер
12(1)
Опубликована: Апрель 23, 2025
Язык: Английский
A comprehensive review of ferroptosis in environmental pollutants-induced chronic obstructive pulmonary disease
The Science of The Total Environment,
Год журнала:
2024,
Номер
957, С. 177534 - 177534
Опубликована: Ноя. 15, 2024
Язык: Английский
Blue light photobiomodulation induced osteosarcoma cell death by facilitating ferroptosis and eliciting an incomplete tumor cell stress response
Journal of Photochemistry and Photobiology B Biology,
Год журнала:
2024,
Номер
258, С. 113003 - 113003
Опубликована: Авг. 3, 2024
Язык: Английский
Cardiovascular disease burden linked to particulate matter pollution in Latin America and the Caribbean: Insights from GBD 2021 and socio-demographic index analysis
Public Health,
Год журнала:
2024,
Номер
238, С. 53 - 58
Опубликована: Ноя. 29, 2024
Язык: Английский
Urban aerosol particulate matter promotes cellular senescence through mitochondrial ROS-mediated Akt/Nrf2 downregulation in human retinal pigment epithelial cells
Free Radical Research,
Год журнала:
2024,
Номер
unknown, С. 1 - 13
Опубликована: Дек. 8, 2024
Urban
aerosol
particulate
matter
(UPM)
is
widespread
in
the
environment,
and
its
concentration
continues
to
increase.
Several
recent
studies
have
reported
that
UPM
results
premature
cellular
senescence,
but
few
investigated
molecular
basis
of
UPM-induced
senescence
retinal
pigment
epithelial
(RPE)
cells.
In
this
study,
we
primarily
evaluated
protective
function
nuclear
factor
erythroid
2-related
2
(Nrf2)
human
RPE
ARPE-19
The
findings
indicated
exposure
substantially
induced
cells,
as
observed
by
increased
β-galactosidase
activity,
expression
levels
senescence-associated
marker
proteins,
phenotypes.
Such
associated
with
mitochondrial
oxidative
stress-mediated
phosphatidylinositol
3'-kinase/Akt/Nrf2
downregulation.
Sulforaphane-mediated
Nrf2
activation
upregulation
phosphorylated
suppressed
decrease
target
antioxidant
gene,
NAD(P)H
quinone
oxidoreductase
1,
under
UPM,
which
notably
prevented
cells
from
senescence.
By
contrast,
knockdown
exacerbated
promoted
stress.
Collectively,
our
demonstrate
regulatory
role
suggest
a
potential
target.
Язык: Английский