Urban aerosol particulate matter promotes cellular senescence through mitochondrial ROS-mediated Akt/Nrf2 downregulation in human retinal pigment epithelial cells DOI
Beom Su Park, EunJin Bang, Hyun Hwangbo

et al.

Free Radical Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: Dec. 8, 2024

Urban aerosol particulate matter (UPM) is widespread in the environment, and its concentration continues to increase. Several recent studies have reported that UPM results premature cellular senescence, but few investigated molecular basis of UPM-induced senescence retinal pigment epithelial (RPE) cells. In this study, we primarily evaluated protective function nuclear factor erythroid 2-related 2 (Nrf2) human RPE ARPE-19 The findings indicated exposure substantially induced cells, as observed by increased β-galactosidase activity, expression levels senescence-associated marker proteins, phenotypes. Such associated with mitochondrial oxidative stress-mediated phosphatidylinositol 3'-kinase/Akt/Nrf2 downregulation. Sulforaphane-mediated Nrf2 activation upregulation phosphorylated suppressed decrease target antioxidant gene, NAD(P)H quinone oxidoreductase 1, under UPM, which notably prevented cells from senescence. By contrast, knockdown exacerbated promoted stress. Collectively, our demonstrate regulatory role suggest a potential target.

Language: Английский

Crosstalk between ROS-inflammatory gene expression axis in the progression of lung disorders DOI
Sumel Ashique, Neeraj Mishra, Shubhrajit Mantry

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Language: Английский

Citations

6
Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus DOI Creative Commons
Qiaolin Wang,

Yutong Wu,

Lianlian Ouyang

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 27, 2025

Abstract Background The small intestine harbors a rich array of intestinal intraepithelial lymphocytes (IELs) that interact with structural cells to collectively sustain gut immune homeostasis. Dysregulation homeostasis was implicated in the pathogenesis multiple autoimmune diseases, however, whether this is disrupted lupus background remains unclear. Methods We performed single-cell RNA sequencing (scRNA-seq) analyses elucidate and milieu epithelium MRL/Lpr mice (Lpr mice) MRL/Mpj control (Mpj mice). Comprehensive including unsupervised clustering, trajectories, cellular communication were performed. primary findings from scRNA-seq further validated by quantitative polymerase chain reaction (qPCR), flow cytometry, vivo experiments selenium supplementation. Results observed significant reduction CD8αα + IELs, accompanied marked increase CD8αβ IELs Lpr mice. Additionally, subsets CD8 exhibiting significantly enhanced effector functions found be markedly enriched Intercellular patterns within epithelial specifically altered Moreover, revealed decreased TCRγδ T (γδT) associated reduced aryl-hydrocarbon receptor repressor ( AHRR ) expression subsequent oxidative stress ferroptosis Antioxidant effectively reversed loss γδT mice, improved barrier, alleviated symptoms. Conclusions Our high-resolution atlas enhances understanding provides new insights into mediated dysregulation.

Language: Английский

Citations

0
Nutrition, Lifestyle, and Environmental Factors in Lung Homeostasis and Respiratory Health DOI Open Access
Athanasios Pouptsis, Rosa Zaragozá, Elena R. García‐Trevijano

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 954 - 954

Published: March 9, 2025

The lungs play a vital role in maintaining homeostasis by facilitating gas exchange and serving as structural immune barrier. External factors, including nutrition, lifestyle, environmental exposures, profoundly influence normal lung function contribute to the development, progression, prognosis of various respiratory diseases. Deficiencies key micronutrients, such vitamins A, D, C, well omega-3 fatty acids, can impair integrity epithelial lining, compromising lungs’ defense mechanisms increasing susceptibility injury disease. Obesity physical inactivity further disrupt inducing changes chest wall promoting pro-inflammatory state. Environmental pollutants worsen oxidative damage activate inflammatory pathways. Addressing these modifiable factors through interventions dietary optimization, activity programs, strategies reduce exposure offers promising avenues for preserving preventing disease progression. This review examines molecular pathways which influences impact homeostasis.

Language: Английский

Citations

0
Particulate Matter Exposure and Viral Infections: Relevance to Highly Polluted Settings such as Ulaanbaatar, Mongolia DOI
Jargalsaikhan Galsuren, Davaalkham Dambadarjaa, Robert M. Tighe

et al.

Current Environmental Health Reports, Journal Year: 2025, Volume and Issue: 12(1)

Published: April 23, 2025

Language: Английский

Citations

0
A comprehensive review of ferroptosis in environmental pollutants-induced chronic obstructive pulmonary disease DOI
Xiaoqing Jiang, Zhenyu Peng,

Baimei He

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 957, P. 177534 - 177534

Published: Nov. 15, 2024

Language: Английский

Citations

2
Blue light photobiomodulation induced osteosarcoma cell death by facilitating ferroptosis and eliciting an incomplete tumor cell stress response DOI
Jiali Yang, Qiqi Fu, Hui Jiang

et al.

Journal of Photochemistry and Photobiology B Biology, Journal Year: 2024, Volume and Issue: 258, P. 113003 - 113003

Published: Aug. 3, 2024

Language: Английский

Citations

0
Cardiovascular disease burden linked to particulate matter pollution in Latin America and the Caribbean: Insights from GBD 2021 and socio-demographic index analysis DOI
Oliver Mendoza‐Cano,

Andrés Vázquez-Yáñez,

Xóchitl Trujillo

et al.

Public Health, Journal Year: 2024, Volume and Issue: 238, P. 53 - 58

Published: Nov. 29, 2024

Language: Английский

Citations

0
Urban aerosol particulate matter promotes cellular senescence through mitochondrial ROS-mediated Akt/Nrf2 downregulation in human retinal pigment epithelial cells DOI
Beom Su Park, EunJin Bang, Hyun Hwangbo

et al.

Free Radical Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: Dec. 8, 2024

Urban aerosol particulate matter (UPM) is widespread in the environment, and its concentration continues to increase. Several recent studies have reported that UPM results premature cellular senescence, but few investigated molecular basis of UPM-induced senescence retinal pigment epithelial (RPE) cells. In this study, we primarily evaluated protective function nuclear factor erythroid 2-related 2 (Nrf2) human RPE ARPE-19 The findings indicated exposure substantially induced cells, as observed by increased β-galactosidase activity, expression levels senescence-associated marker proteins, phenotypes. Such associated with mitochondrial oxidative stress-mediated phosphatidylinositol 3'-kinase/Akt/Nrf2 downregulation. Sulforaphane-mediated Nrf2 activation upregulation phosphorylated suppressed decrease target antioxidant gene, NAD(P)H quinone oxidoreductase 1, under UPM, which notably prevented cells from senescence. By contrast, knockdown exacerbated promoted stress. Collectively, our demonstrate regulatory role suggest a potential target.

Language: Английский

Citations

0