Translation The University of Toledo Journal of Medical Sciences,
Год журнала:
2024,
Номер
12(1)
Опубликована: Янв. 29, 2024
Cyanobacterial
Harmful
Algal
Blooms
(CyanoHABs)
occur
when
colonies
of
photosynthetic
bacteria
called
cyanobacteria
grow
out
control,
usually
in
warm,
nutrient-rich,
slow-moving
waters.
They
are
becoming
increasingly
prevalent
around
the
world
and
release
harmful
toxins
cyanotoxins
into
bodies
water,
which
negatively
affect
human
ecological
health.
One
such
cyanotoxin
is
microcystin,
with
microcystin-leucine
arginine
(MC-LR)
being
most
widespread.
Exposure
to
MC-LR
inhibits
serine
threonine
protein
phosphatase
1
2A
humans,
causing
a
myriad
health
problems.
Fortunately,
certain
naturally
occurring
may
be
able
degrade
reverse
its
effects.
Mice
were
separated
five
experimental
groups
based
on
three
types
pre-treatments
(control
drinking
water/vehicle,
probiotic-supplemented
heat-inactivated
water)
as
well
two
exposures
(microcystin-LR
water/vehicle).
RNA
was
extracted
from
kidneys
for
sequencing
because
exacerbates
kidney
disease.
Gene
expression
data
analyzed
3
Pod
Reports,
an
R
package
that
produces
three-part
report
consisting
Set
Enrichment
Analysis
(GSEA),
EnrichR,
integrative
LINCS
(iLINCS).
exposure
associated
upregulated
cellular
respiration
metabolism
pathways
downregulated
transcription
pathways.
Probiotic
pre-treatment
combined
lipoprotein
particle
ribosome
Overall,
probiotic
mixture
corrected
transcriptional
profile
resulting
exposure.
Future
high
yield
could
targeted
therapeutic
benefit
include
VEGFR
inhibitors
increased
renal
indicator
genes
EGFR.
Toxins,
Год журнала:
2025,
Номер
17(2), С. 53 - 53
Опубликована: Янв. 24, 2025
Due
to
cyanobacterial
toxin
(cyanotoxin)
contamination
issues
in
2018,
the
city
of
Salem,
Oregon,
issued
a
33-day
do-not-drink
advisory
for
vulnerable
people
among
200,000
residents.
After
incident,
state
Oregon
put
place
drinking
water
rules
require
routine
testing
raw
water,
as
well
finished
cases
where
cyanotoxin
concentrations
exceeded
trigger
values.
The
United
States
Environmental
Protection
Agency
(EPA)
total
microcystins
health
level
(HAL)
small
children
is
0.3
µg/L.
This
equivalent
minimum
reporting
(MRL)
EPA
Method
546.
Consequently,
there
was
no
ability
provide
early
warnings
via
using
method.
In
this
study,
we
performed
comparison
precision
and
accuracy
enzyme-linked
immunosorbent
assay
(ELISA)
described
method
more
sensitive
assay,
Streptavidin-enhanced
Sensitivity
(SAES)
assay.
Based
on
these
studies
quantitation
limit
determinations
confirmations,
Office
Ground
Water
Drinking
(OGWDW)
has
concluded
SAES
kit
meets
requirements
With
an
MRL
that
one-third
original
concentration,
new
provides
but
critical
window
identifying
warnings.
Challenges
remain
with
providing
due
variability
bloom
dynamics;
however,
allowed
lower
susceptible
systems,
thereby
additional
warning.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101466 - 101466
Опубликована: Янв. 8, 2025
The
proliferation
of
microplastics
(μP)
in
aquatic
environments
poses
a
significant
threat
to
ecosystem
health,
with
repercussions
extending
organisms
and
potentially
human
health.
In
this
study,
we
investigated
the
efficacy
novel
biosurfactant-microplastic
(BSμP)
hybrid
reducing
vivo
green
bio-toxicity
induced
by
oxidative
stress
apoptosis
zebrafish
(Danio
rerio).
Microplastics,
ubiquitous
environments,
were
hybridised
Biosurfactant
evaluate
their
potential
mitigating
effects.
A
stable
BSμP
was
formed
zeta
-10.3
±
1.5
mV.
Exposure
embryos
μP
resulted
increased
markers,
including
elevated
levels
reactive
oxygen
species
apoptosis,
as
evidenced
expression
apoptotic
markers
morphological
changes
embryonic
zebrafish.
However,
significantly
ameliorated
observed
toxic
effects
reduced
activity.
This
effect
deduced
intrinsic
hybridisation,
which
likely
mitigated
bioavailability
toxicity
molecular
interaction
metabolic
proteins
like
Sod1
p53
through
less
accumulation
internalisation.
Overall,
our
findings
highlight
promising
approach
for
ecological
impacts
microplastic
pollution.
Journal of Surfactants and Detergents,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 22, 2025
Abstract
Bacterial
resistance
to
conventional
antibiotics
has
become
a
massive
problem
for
healthcare
systems.
This
could
result
in
serious
consequences
treating
bacterial
infections,
including
treatment
failure.
In
turn,
drug
promoted
the
development
of
more
effective
antibacterial
agents.
Niosomes
are
considered
efficient
agents
enhancement
activity
antibiotics.
Herein,
Coumarin‐triazole
hybrid
(CAT)
niosomes
were
developed
and
evaluated
against
extensively
drug‐resistant
Salmonella
enterica
(XDR
S.
).
The
Cefixime‐loaded
CAT
niosomal
vesicle
average
particle
size
was
342
±
3
nm,
with
zeta
potential
−28
2.0
mV.
vesicles
showed
prominent
entrapment
efficiency
74%
3%.
A
blood
hemolytic
assay
revealed
no
hemolysis
occurred.
exhibited
reduced
cytotoxic
effect
NIH/3T3
normal
mouse
fibroblast
cells,
at
maximum
concentration
1000
μg/mL.
However,
MIC
50
empty
Cefixime
loaded
XDR
observed
250
125
μgmL
−1
,
respectively,
indicating
that
lowered
by
two‐fold.
Topographical
atomic
force
microscopy
(AFM)
images
exposure
efficiently
damaged
cell
membrane
resulting
leaking
scattering.
Experimental Gerontology,
Год журнала:
2025,
Номер
201, С. 112705 - 112705
Опубликована: Фев. 6, 2025
Osteoporosis
(OP)
and
osteopenia
are
metabolic
bone
disorders
associated
with
increased
fragility
fracture
risk.
While
lipid
accumulation
products
(LAP)
emerging
as
potential
markers
of
health,
their
prognostic
significance
in
patients
OP
or
remains
unclear.
The
objective
this
study
is
to
elucidate
the
relationship
between
all-cause
well
cardiovascular
mortality
individuals
diagnosed
either
condition.
Data
from
2007-2018
National
Health
Nutrition
Examination
Survey
(NHANES)
were
retrospectively
analyzed.
Kaplan-Meier
survival
curves,
multivariable
Cox
proportional
hazards
regression,
restricted
cubic
spline
plots
used
evaluate
association
LAP
outcomes
osteopenia.
Subgroup
threshold
analyses
also
conducted.
This
included
4959
osteopenia,
followed
over
a
comprehensive
duration
12
years,
during
which
800
instances
194
deaths
attributed
diseases
documented.
A
linear
negative
correlation
was
identified
both
among
Notably,
at
an
level
3.69,
risk
ratio
reached
1,
indicating
transition
high
low.
revealed
more
pronounced
mortality.
Our
significant
product
osteoporosis
