Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses

Nature reviews. Immunology, Год журнала: 2022, Номер 23(3), С. 189 - 199

Опубликована: Сен. 27, 2022

Язык: Английский

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Exploring the Interrelationship between COVID-19 Phobia, Work–Family Conflict, Family–Work Conflict, and Life Satisfaction among School Administrators for Advancing Sustainable Management

Sustainability, Год журнала: 2021, Номер 13(15), С. 8654 - 8654

Опубликована: Авг. 3, 2021

This study aims to investigate the relationships between COVID-19 phobia experienced by school administrators and their work–family conflict, family–work life satisfaction. descriptive research, designed according relational survey model, was conducted with participation of 356 administrators. The data were collected through online questionnaires, then t-test, ANOVA, correlation analysis, simple linear regression analysis employed for statistical analyses. results revealed that female greater levels than male peers is felt more intensely in psychological social sub-dimensions. However, administrators’ satisfaction significantly higher those In current study, it determined younger age group family–work/work–family conflict from other groups. this a positive moderate relationship both conflict. findings offer significant implications policy makers education, showing importance developing strategies will reduce effects pandemic sustainable efficient employee performance.

Язык: Английский

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Proportion of asymptomatic infection and nonsevere disease caused by SARS‐CoV‐2 Omicron variant: A systematic review and analysis

Journal of Medical Virology, Год журнала: 2022, Номер 94(12), С. 5790 - 5801

Опубликована: Авг. 13, 2022

SARS-CoV-2 Omicron variant seemed to cause milder disease compared previous predominated variants. We aimed conduct a meta-analysis assess the pooled proportion of nonsevere and asymptomatic infection among COVID-19 patients infected with Delta. searched PubMed, Embase, Web Science, China National Knowledge Infrastructure (CNKI) databases. included studies from November 1, 2021, April 18, 2022, Delta October 2020, June 30, 2022. Studies without corresponding data, less than 50 patients, or obviously biased concerning main outcome were excluded. Meta-analysis was performed in R 4.2.0 "meta" package. Subgroup analyses conducted by study group vaccination status. The 25.5% (95% confidence interval [CI] 17.0%-38.2%) 97.9% CI 97.1%-98.7%), significantly higher those 8.4% 4.4%-16.2%) 91.4% 87.0%-96.0%). During wave, children adolescents had infection, SOTR elderly lower disease, booster dose contributed both disease. This estimates caused other predominant result has important implications for future policy making.

Язык: Английский

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Understanding exosomes: Part 2—Emerging leaders in regenerative medicine

Periodontology 2000, Год журнала: 2024, Номер 94(1), С. 257 - 414

Опубликована: Фев. 1, 2024

Abstract Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with ability to communicate other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due their be utilized as therapeutic options for a wide array diseases/conditions. Over 5000 publications currently being published yearly on this topic, number is only expected dramatically increase novel strategies continue developed. Today exosomes have been applied numerous contexts including neurodegenerative disorders (Alzheimer's disease, central nervous system, depression, multiple sclerosis, Parkinson's post‐traumatic stress disorders, traumatic brain injury, peripheral nerve injury), damaged organs (heart, kidney, liver, stroke, myocardial infarctions, ovaries), degenerative processes (atherosclerosis, diabetes, hematology musculoskeletal degeneration, osteoradionecrosis, respiratory disease), infectious diseases (COVID‐19, hepatitis), procedures (antiaging, bone regeneration, cartilage/joint osteoarthritis, cutaneous wounds, dental dermatology/skin erectile dysfunction, hair regrowth, intervertebral disc repair, spinal cord vascular regeneration), cancer therapy (breast, colorectal, gastric osteosarcomas), immune function (allergy, autoimmune regulation, inflammatory diseases, lupus, rheumatoid arthritis). This scoping review first its kind aimed at summarizing extensive potential broad range disorders.

Язык: Английский

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Flavonoids in Ampelopsis grossedentata as covalent inhibitors of SARS-CoV-2 3CLpro: Inhibition potentials, covalent binding sites and inhibitory mechanisms

International Journal of Biological Macromolecules, Год журнала: 2021, Номер 187, С. 976 - 987

Опубликована: Июль 30, 2021

Язык: Английский

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Molecular evolution of SARS‐CoV‐2 from December 2019 to August 2022

Journal of Medical Virology, Год журнала: 2022, Номер 95(1)

Опубликована: Дек. 2, 2022

Severe acute respiratorysyndrome coronavirus-2 (SARS-CoV-2) pandemic spread rapidly and this scenario is concerning worldwide, presenting more than 590 million coronavirus disease 2019 cases 6.4 deaths. The emergence of novel lineages carrying several mutations in the spike protein has raised additional public health concerns worldwide during pandemic. present study review summarizes temporal spreading molecular evolution SARS-CoV-2 clades variants worldwide. evaluation these data important for understanding evolutionary histories SARSCoV-2 lineages, allowing us to identify origins each lineage virus responsible one biggest pandemics history. A total 2897 whole-genome sequences with available information from country sampling date (December August 2022), were obtained evaluated by Bayesian approach. results demonstrated that time most recent common ancestor (tMRCA) Asia was 2019-12-26 (highest posterior density 95% [HPD95%]: 2019-12-18; 2019-12-29), Oceania 2020-01-24 (HPD95%: 2020-01-15; 2020-01-30), Africa 2020-02-27 2020-02-21; 2020-03-04), Europe 2020-02-20; 2020-03-06), North America 2020-03-12 2020-03-05; 2020-03-18), South 2020-03-15 2020-03-09; 2020-03-28). Between December June 2020, 11 detected (20I [Alpha] 19A, 19B, 20B, 20C, 20A, 20D, 20E [EU1], 20F, 20H [Beta]). From July 4 identified (20J [Gamma, V3], 21 C [Epsilon], 21D [Eta], 21G [Lambda]). January 2021, 3 Delta variant (21A, 21I, 21J). two detected, 21J) Omicron (21K, 21L, 22B, 22C). 2022, (21I 22A) detected. Finally, between (22B, 22C, 22D). Clade 19A first (Wuhan strain) origin 2019-12-16 2019-12-15; 2019-12-25); 20I (Alpha) 2020-11-24 2020-11-15; 2021-12-02); (Beta) 2020-11-25 2020-11-13; 2020-11-29); 20J (Gamma) 2020-12-21 2020-11-05; 2021-01-15); 21A (Delta) 2020-09-20 2020-05-17; 2021-02-03); 21J 2021-02-26 (2020-11-02; 2021-04-24); 21M (Omicron) 2021-01-25 2020-09-16; 2021-08-08); 21K 2021-07-30 2021-05-30; 2021-10-19); 21L 2021-10-03 2021-04-16; 2021-12-23); 22B 2022-01-25 2022-01-10; 2022-02-05); 2021-12-20 2021-05-16; 2021-12-31). Currently, predominates clade branching into (22A, Phylogeographic showed Alpha originated United Kingdom, Beta Africa, Gamma Brazil, India, Mu Colombia, Epsilon States America, Lambda Peru. COVID-19 had a significant impact on global provides an overview (from Wuhan strain currently circulating Omicron).

Язык: Английский

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Emergence of SARS-CoV-2 Variants in the World: How Could This Happen?

Life, Год журнала: 2022, Номер 12(2), С. 194 - 194

Опубликована: Янв. 28, 2022

The COVID-19 pandemic has had a significant global impact, with more than 280,000,000 people infected and 5,400,000 deaths. use of personal protective equipment the anti-SARS-CoV-2 vaccination campaigns have reduced infection death rates worldwide. However, recent increase in been observed associated appearance SARS-CoV-2 variants, including recently described lineage B.1.617.2 (Delta variant) B.1.1.529/BA.1 (Omicron variant). These new variants put effectiveness international at risk, outbreaks throughout world. This emergence due to multiple predisposing factors, molecular characteristics virus, geographic environmental conditions, impact social determinants health that favor genetic diversification SARS-CoV-2. We present literature review on most information available analyzed biological, geographical, sociocultural factors development these variants. Finally, we evaluate surveillance strategies for early detection prevent their distribution outside regions.

Язык: Английский

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Mpox Virus: Its Molecular Evolution and Potential Impact on Viral Epidemiology

Viruses, Год журнала: 2023, Номер 15(4), С. 995 - 995

Опубликована: Апрель 18, 2023

Mpox (previously known as monkeypox) is an infectious viral illness caused by the mpox virus (MPXV), orthopoxvirus that belongs to family Poxviridae. The symptoms of in humans are similar those smallpox, although mortality rate lower. In recent years, concern over a potential global pandemic has increased due reports spreading across Africa and other parts world. Prior this discovery, was rare zoonotic disease restricted endemic regions Western Central Africa. sudden emergence MPXV cases multiple raised concerns about its natural evolution. This review aims provide overview previously available information MPXV, including genome, morphology, hosts reservoirs, virus–host interaction immunology, well perform phylogenetic analysis on genomes, with emphasis evolution genome new emerge.

Язык: Английский

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Acute disseminated encephalomyelitis (ADEM) following COVID-19 vaccination: A systematic review

Journal of Clinical Neuroscience, Год журнала: 2023, Номер 111, С. 57 - 70

Опубликована: Март 22, 2023

Язык: Английский

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SARS-CoV-2 Omicron (B.1.1.529) Variant: A Challenge with COVID-19

Diagnostics, Год журнала: 2023, Номер 13(3), С. 559 - 559

Опубликована: Фев. 2, 2023

Since the beginning of coronavirus disease 2019 (COVID-19) pandemic, there have been multiple peaks SARS-CoV-2 (severe acute respiratory syndrome virus 2) infection, mainly due to emergence new variants, each with a set mutations in viral genome, which led changes pathogenicity, transmissibility, and morbidity. The Omicron variant is most recent concern (VOC) emerge was recognized by World Health Organization (WHO) on 26 November 2021. lineage phylogenetically distinct from earlier including previously dominant Delta variant. reverse transcription–polymerase chain reaction (RT–PCR) test, rapid antigen assays, chest computed tomography (CT) scans can help diagnose Furthermore, many agents are expected therapeutic benefits for those infected variant, TriSb92, molnupiravir, nirmatrelvir, their combination, corticosteroids, interleukin-6 (IL-6) receptor blockers. Despite being milder than previous threatens lives, particularly among unvaccinated, its higher infectivity. Mounting evidence has reported common clinical manifestations be fever, runny nose, sore throat, severe headache, fatigue. This review summarizes essential features history, manifestations, diagnosis, management, effectiveness existing vaccines against this VOC.

Язык: Английский

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