Frontiers in Medicine,
Journal Year:
2023,
Volume and Issue:
10
Published: Aug. 14, 2023
The
wide
and
rapid
spread
of
the
COVID-19
pandemic
has
placed
an
unanticipated
burden
on
global
healthcare
sector.
This
necessitated
a
swift
response
from
international
community
to
reach
solution.
Efforts
were
made
in
parallel
develop
preventative
therapeutic
modalities.
Since
then,
drug
repurposing
blossomed
as
potentially
resolution
included
various
agents
with
anti-viral
anti-inflammatory
properties.
Corticosteroids,
being
potent
agents,
have
been
under
extensive
investigation.
Various
trials
recorded
beneficial
outcome
corticosteroids
decreasing
mortality
morbidity
COVID-19.
With
high
pace
escalating
events,
quality
study
design
clinical
are
varied.
Therefore,
this
aims
explore
role
disease.
It
inspects
molecular,
pharmacologic,
proof
behind
theory.
Sustainability,
Journal Year:
2021,
Volume and Issue:
13(15), P. 8654 - 8654
Published: Aug. 3, 2021
This
study
aims
to
investigate
the
relationships
between
COVID-19
phobia
experienced
by
school
administrators
and
their
work–family
conflict,
family–work
life
satisfaction.
descriptive
research,
designed
according
relational
survey
model,
was
conducted
with
participation
of
356
administrators.
The
data
were
collected
through
online
questionnaires,
then
t-test,
ANOVA,
correlation
analysis,
simple
linear
regression
analysis
employed
for
statistical
analyses.
results
revealed
that
female
greater
levels
than
male
peers
is
felt
more
intensely
in
psychological
social
sub-dimensions.
However,
administrators’
satisfaction
significantly
higher
those
In
current
study,
it
determined
younger
age
group
family–work/work–family
conflict
from
other
groups.
this
a
positive
moderate
relationship
both
conflict.
findings
offer
significant
implications
policy
makers
education,
showing
importance
developing
strategies
will
reduce
effects
pandemic
sustainable
efficient
employee
performance.
Journal of Medical Virology,
Journal Year:
2022,
Volume and Issue:
94(12), P. 5790 - 5801
Published: Aug. 13, 2022
SARS-CoV-2
Omicron
variant
seemed
to
cause
milder
disease
compared
previous
predominated
variants.
We
aimed
conduct
a
meta-analysis
assess
the
pooled
proportion
of
nonsevere
and
asymptomatic
infection
among
COVID-19
patients
infected
with
Delta.
searched
PubMed,
Embase,
Web
Science,
China
National
Knowledge
Infrastructure
(CNKI)
databases.
included
studies
from
November
1,
2021,
April
18,
2022,
Delta
October
2020,
June
30,
2022.
Studies
without
corresponding
data,
less
than
50
patients,
or
obviously
biased
concerning
main
outcome
were
excluded.
Meta-analysis
was
performed
in
R
4.2.0
"meta"
package.
Subgroup
analyses
conducted
by
study
group
vaccination
status.
The
25.5%
(95%
confidence
interval
[CI]
17.0%-38.2%)
97.9%
CI
97.1%-98.7%),
significantly
higher
those
8.4%
4.4%-16.2%)
91.4%
87.0%-96.0%).
During
wave,
children
adolescents
had
infection,
SOTR
elderly
lower
disease,
booster
dose
contributed
both
disease.
This
estimates
caused
other
predominant
result
has
important
implications
for
future
policy
making.
Periodontology 2000,
Journal Year:
2024,
Volume and Issue:
94(1), P. 257 - 414
Published: Feb. 1, 2024
Abstract
Exosomes
are
the
smallest
subset
of
extracellular
signaling
vesicles
secreted
by
most
cells
with
ability
to
communicate
other
tissues
and
cell
types
over
long
distances.
Their
use
in
regenerative
medicine
has
gained
tremendous
momentum
recently
due
their
be
utilized
as
therapeutic
options
for
a
wide
array
diseases/conditions.
Over
5000
publications
currently
being
published
yearly
on
this
topic,
number
is
only
expected
dramatically
increase
novel
strategies
continue
developed.
Today
exosomes
have
been
applied
numerous
contexts
including
neurodegenerative
disorders
(Alzheimer's
disease,
central
nervous
system,
depression,
multiple
sclerosis,
Parkinson's
post‐traumatic
stress
disorders,
traumatic
brain
injury,
peripheral
nerve
injury),
damaged
organs
(heart,
kidney,
liver,
stroke,
myocardial
infarctions,
ovaries),
degenerative
processes
(atherosclerosis,
diabetes,
hematology
musculoskeletal
degeneration,
osteoradionecrosis,
respiratory
disease),
infectious
diseases
(COVID‐19,
hepatitis),
procedures
(antiaging,
bone
regeneration,
cartilage/joint
osteoarthritis,
cutaneous
wounds,
dental
dermatology/skin
erectile
dysfunction,
hair
regrowth,
intervertebral
disc
repair,
spinal
cord
vascular
regeneration),
cancer
therapy
(breast,
colorectal,
gastric
osteosarcomas),
immune
function
(allergy,
autoimmune
regulation,
inflammatory
diseases,
lupus,
rheumatoid
arthritis).
This
scoping
review
first
its
kind
aimed
at
summarizing
extensive
potential
broad
range
disorders.
Journal of Medical Virology,
Journal Year:
2022,
Volume and Issue:
95(1)
Published: Dec. 2, 2022
Severe
acute
respiratorysyndrome
coronavirus-2
(SARS-CoV-2)
pandemic
spread
rapidly
and
this
scenario
is
concerning
worldwide,
presenting
more
than
590
million
coronavirus
disease
2019
cases
6.4
deaths.
The
emergence
of
novel
lineages
carrying
several
mutations
in
the
spike
protein
has
raised
additional
public
health
concerns
worldwide
during
pandemic.
present
study
review
summarizes
temporal
spreading
molecular
evolution
SARS-CoV-2
clades
variants
worldwide.
evaluation
these
data
important
for
understanding
evolutionary
histories
SARSCoV-2
lineages,
allowing
us
to
identify
origins
each
lineage
virus
responsible
one
biggest
pandemics
history.
A
total
2897
whole-genome
sequences
with
available
information
from
country
sampling
date
(December
August
2022),
were
obtained
evaluated
by
Bayesian
approach.
results
demonstrated
that
time
most
recent
common
ancestor
(tMRCA)
Asia
was
2019-12-26
(highest
posterior
density
95%
[HPD95%]:
2019-12-18;
2019-12-29),
Oceania
2020-01-24
(HPD95%:
2020-01-15;
2020-01-30),
Africa
2020-02-27
2020-02-21;
2020-03-04),
Europe
2020-02-20;
2020-03-06),
North
America
2020-03-12
2020-03-05;
2020-03-18),
South
2020-03-15
2020-03-09;
2020-03-28).
Between
December
June
2020,
11
detected
(20I
[Alpha]
19A,
19B,
20B,
20C,
20A,
20D,
20E
[EU1],
20F,
20H
[Beta]).
From
July
4
identified
(20J
[Gamma,
V3],
21
C
[Epsilon],
21D
[Eta],
21G
[Lambda]).
January
2021,
3
Delta
variant
(21A,
21I,
21J).
two
detected,
21J)
Omicron
(21K,
21L,
22B,
22C).
2022,
(21I
22A)
detected.
Finally,
between
(22B,
22C,
22D).
Clade
19A
first
(Wuhan
strain)
origin
2019-12-16
2019-12-15;
2019-12-25);
20I
(Alpha)
2020-11-24
2020-11-15;
2021-12-02);
(Beta)
2020-11-25
2020-11-13;
2020-11-29);
20J
(Gamma)
2020-12-21
2020-11-05;
2021-01-15);
21A
(Delta)
2020-09-20
2020-05-17;
2021-02-03);
21J
2021-02-26
(2020-11-02;
2021-04-24);
21M
(Omicron)
2021-01-25
2020-09-16;
2021-08-08);
21K
2021-07-30
2021-05-30;
2021-10-19);
21L
2021-10-03
2021-04-16;
2021-12-23);
22B
2022-01-25
2022-01-10;
2022-02-05);
2021-12-20
2021-05-16;
2021-12-31).
Currently,
predominates
clade
branching
into
(22A,
Phylogeographic
showed
Alpha
originated
United
Kingdom,
Beta
Africa,
Gamma
Brazil,
India,
Mu
Colombia,
Epsilon
States
America,
Lambda
Peru.
COVID-19
had
a
significant
impact
on
global
provides
an
overview
(from
Wuhan
strain
currently
circulating
Omicron).
Life,
Journal Year:
2022,
Volume and Issue:
12(2), P. 194 - 194
Published: Jan. 28, 2022
The
COVID-19
pandemic
has
had
a
significant
global
impact,
with
more
than
280,000,000
people
infected
and
5,400,000
deaths.
use
of
personal
protective
equipment
the
anti-SARS-CoV-2
vaccination
campaigns
have
reduced
infection
death
rates
worldwide.
However,
recent
increase
in
been
observed
associated
appearance
SARS-CoV-2
variants,
including
recently
described
lineage
B.1.617.2
(Delta
variant)
B.1.1.529/BA.1
(Omicron
variant).
These
new
variants
put
effectiveness
international
at
risk,
outbreaks
throughout
world.
This
emergence
due
to
multiple
predisposing
factors,
molecular
characteristics
virus,
geographic
environmental
conditions,
impact
social
determinants
health
that
favor
genetic
diversification
SARS-CoV-2.
We
present
literature
review
on
most
information
available
analyzed
biological,
geographical,
sociocultural
factors
development
these
variants.
Finally,
we
evaluate
surveillance
strategies
for
early
detection
prevent
their
distribution
outside
regions.
Viruses,
Journal Year:
2023,
Volume and Issue:
15(4), P. 995 - 995
Published: April 18, 2023
Mpox
(previously
known
as
monkeypox)
is
an
infectious
viral
illness
caused
by
the
mpox
virus
(MPXV),
orthopoxvirus
that
belongs
to
family
Poxviridae.
The
symptoms
of
in
humans
are
similar
those
smallpox,
although
mortality
rate
lower.
In
recent
years,
concern
over
a
potential
global
pandemic
has
increased
due
reports
spreading
across
Africa
and
other
parts
world.
Prior
this
discovery,
was
rare
zoonotic
disease
restricted
endemic
regions
Western
Central
Africa.
sudden
emergence
MPXV
cases
multiple
raised
concerns
about
its
natural
evolution.
This
review
aims
provide
overview
previously
available
information
MPXV,
including
genome,
morphology,
hosts
reservoirs,
virus–host
interaction
immunology,
well
perform
phylogenetic
analysis
on
genomes,
with
emphasis
evolution
genome
new
emerge.
Diagnostics,
Journal Year:
2023,
Volume and Issue:
13(3), P. 559 - 559
Published: Feb. 2, 2023
Since
the
beginning
of
coronavirus
disease
2019
(COVID-19)
pandemic,
there
have
been
multiple
peaks
SARS-CoV-2
(severe
acute
respiratory
syndrome
virus
2)
infection,
mainly
due
to
emergence
new
variants,
each
with
a
set
mutations
in
viral
genome,
which
led
changes
pathogenicity,
transmissibility,
and
morbidity.
The
Omicron
variant
is
most
recent
concern
(VOC)
emerge
was
recognized
by
World
Health
Organization
(WHO)
on
26
November
2021.
lineage
phylogenetically
distinct
from
earlier
including
previously
dominant
Delta
variant.
reverse
transcription–polymerase
chain
reaction
(RT–PCR)
test,
rapid
antigen
assays,
chest
computed
tomography
(CT)
scans
can
help
diagnose
Furthermore,
many
agents
are
expected
therapeutic
benefits
for
those
infected
variant,
TriSb92,
molnupiravir,
nirmatrelvir,
their
combination,
corticosteroids,
interleukin-6
(IL-6)
receptor
blockers.
Despite
being
milder
than
previous
threatens
lives,
particularly
among
unvaccinated,
its
higher
infectivity.
Mounting
evidence
has
reported
common
clinical
manifestations
be
fever,
runny
nose,
sore
throat,
severe
headache,
fatigue.
This
review
summarizes
essential
features
history,
manifestations,
diagnosis,
management,
effectiveness
existing
vaccines
against
this
VOC.
