bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2022,
Номер
unknown
Опубликована: Ноя. 7, 2022
Abstract
Pervasive
SARS-CoV-2
infections
in
humans
have
led
to
multiple
transmission
events
captive
animals.
While
has
a
potential
broad
wildlife
host
range,
most
documented
date
are
found
single
species,
the
white-tailed
deer.
The
extent
of
exposure
among
species
and
factors
that
influence
risk
remain
unknown.
We
sampled
23
for
examined
effects
urbanization
human
use
on
seropositivity.
Here,
we
document
positive
detections
RNA
six
including
deer
mouse,
Virginia
opossum,
raccoon,
groundhog,
Eastern
cottontail,
red
bat.
In
addition,
sites
with
high
activity
had
three
times
higher
seroprevalence
than
low
human-use
areas.
detected
genomic
sequences
from
nine
individuals
which
were
assigned
seven
Pango
lineages
Omicron
variant.
close
match
variants
circulating
at
time
suggests
least
recent
human-to-animal
events.
Our
data
support
been
widespread
communities
areas
may
serve
as
points
contact
cross-species
transmission.
Proceedings of the National Academy of Sciences,
Год журнала:
2022,
Номер
119(6)
Опубликована: Янв. 25, 2022
Significance
The
results
provide
strong
evidence
of
extensive
SARS-CoV-2
infection
white-tailed
deer,
a
free-living
wild
animal
species
with
widespread
distribution
across
North,
Central,
and
South
America.
analysis
shows
deer
resulted
from
multiple
spillovers
humans,
followed
by
efficient
deer-to-deer
transmission.
discovery
indicates
their
establishment
as
potential
reservoir
hosts
for
SARS-CoV-2,
finding
important
implications
the
ecology,
long-term
persistence,
evolution
virus,
including
spillback
to
humans.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Июль 10, 2023
Abstract
SARS-CoV-2
is
a
zoonotic
virus
with
documented
bi-directional
transmission
between
people
and
animals.
Transmission
of
from
humans
to
free-ranging
white-tailed
deer
(
Odocoileus
virginianus
)
poses
unique
public
health
risk
due
the
potential
for
reservoir
establishment
where
variants
may
persist
evolve.
We
collected
8,830
respiratory
samples
across
Washington,
D.C.
26
states
in
United
States
November
2021
April
2022.
obtained
391
sequences
identified
34
Pango
lineages
including
Alpha,
Gamma,
Delta,
Omicron
variants.
Evolutionary
analyses
showed
these
viruses
originated
at
least
109
independent
spillovers
humans,
which
resulted
39
cases
subsequent
local
deer-to-deer
three
spillover
back
humans.
Viruses
repeatedly
adapted
recurring
amino
acid
substitutions
spike
other
proteins.
Overall,
our
findings
suggest
that
multiple
were
introduced,
became
enzootic,
co-circulated
deer.
Annual Review of Animal Biosciences,
Год журнала:
2023,
Номер
11(1), С. 1 - 31
Опубликована: Фев. 15, 2023
Over
the
past
three
decades,
coronavirus
(CoV)
diseases
have
impacted
humans
more
than
any
other
emerging
infectious
disease.
The
recent
emergence
of
severe
acute
respiratory
syndrome
2
(SARS-CoV-2),
causative
agent
COVID-19
(coronavirus
disease
2019),
has
resulted
in
huge
economic
disruptions
and
loss
human
lives.
SARS-CoV-2
genome
was
found
to
mutate
rapidly
due
sustained
transmission
potentially
animals,
resulting
variants
concern
(VOCs)
that
threaten
global
health.
However,
primary
difficulties
are
filling
current
knowledge
gaps
terms
origin
modalities
for
these
viruses.
Because
many
CoVs
threatening
health
suspected
a
zoonotic
origin,
identifying
animal
hosts
implicated
spillover
or
spillback
events
would
be
beneficial
pandemic
management
prevent
future
outbreaks.
In
this
review,
wesummarize
models,
reservoirs,
cross-species
CoVs.
Finally,
we
comment
on
potential
sources
Omicron
VOCs
new
recombinants
currently
under
investigation.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июль 29, 2024
Pervasive
SARS-CoV-2
infections
in
humans
have
led
to
multiple
transmission
events
animals.
While
has
a
potential
broad
wildlife
host
range,
most
documented
been
captive
animals
and
single
species,
the
white-tailed
deer.
The
full
extent
of
exposure
among
communities
factors
that
influence
risk
remain
unknown.
We
sampled
23
species
for
examined
effects
urbanization
human
use
on
seropositivity.
Here,
we
document
positive
detections
RNA
six
including
deer
mouse,
Virginia
opossum,
raccoon,
groundhog,
Eastern
cottontail,
red
bat
between
May
2022-September
2023
across
Washington,
D.C.,
USA.
In
addition,
found
sites
with
high
activity
had
three
times
higher
seroprevalence
than
low
human-use
areas.
obtained
genomic
sequences
from
nine
individuals
which
were
assigned
seven
Pango
lineages
Omicron
variant.
close
match
variants
circulating
at
time
suggests
least
recent
human-to-animal
events.
Our
data
support
widespread
areas
may
serve
as
points
contact
cross-species
transmission.
Journal of Medical Virology,
Год журнала:
2022,
Номер
95(1)
Опубликована: Сен. 19, 2022
Severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2)
is
the
causative
agent
of
novel
coronavirus
disease
(COVID-19)
pandemic,
which
has
caused
serious
challenges
for
public
health
systems
worldwide.
Due
to
close
relationship
between
animals
and
humans,
confirmed
transmission
from
humans
numerous
animal
species
been
reported.
Understanding
cross-species
SARS-CoV-2
infection
dynamics
in
different
crucial
control
COVID-19
protect
health.
In
this
review,
possible
origins
naturally
susceptible
are
discussed.
Furthermore,
review
categorizes
by
families,
so
as
better
understand
animals.
Viruses,
Год журнала:
2022,
Номер
14(12), С. 2770 - 2770
Опубликована: Дек. 12, 2022
There
is
mounting
evidence
of
SARS-CoV-2
spillover
from
humans
into
many
domestic,
companion,
and
wild
animal
species.
Research
indicates
that
have
infected
white-tailed
deer,
deer-to-deer
transmission
has
occurred,
indicating
deer
could
be
a
wildlife
reservoir
source
novel
variants.
We
examined
the
hypothesis
Omicron
variant
actively
asymptomatically
infecting
free-ranging
New
York
City.
Between
December
2021
February
2022,
155
on
Staten
Island,
York,
were
anesthetized
for
gross
abnormalities
illnesses.
Paired
nasopharyngeal
swabs
blood
samples
collected
analyzed
presence
RNA
antibodies.
Of
135
serum
samples,
19
(14.1%)
indicated
exposure,
11
reacted
most
strongly
to
wild-type
B.1
lineage.
71
swabs,
8
positive
(4
4
Delta).
Two
animals
had
active
infections
robust
neutralizing
antibodies,
revealing
reinfection
or
early
seroconversion
in
deer.
Variants
concern
continue
circulate
among
may
reinfect
US
populations,
establish
enzootic
cycles
wild:
this
warrants
coordinated
One
Health
response,
proactively
surveil,
identify,
curtail
variants
before
they
can
spill
back
humans.
Emerging Microbes & Infections,
Год журнала:
2022,
Номер
11(1), С. 662 - 675
Опубликована: Фев. 2, 2022
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
is
responsible
for
a
global
pandemic
that
has
had
significant
impacts
on
human
health
and
economies
worldwide.
SARS-CoV-2
highly
transmissible
the
cause
of
disease
2019
in
humans.
A
wide
range
animal
species
have
also
been
shown
to
be
susceptible
by
experimental
and/or
natural
infections.
Sheep
are
commonly
farmed
domestic
ruminant
not
thoroughly
investigated
their
susceptibility
SARS-CoV-2.
Therefore,
we
performed
vitro
vivo
studies
which
consisted
infection
ruminant-derived
cells
challenge
sheep
investigate
Our
results
showed
sheep-derived
kidney
support
replication.
Furthermore,
demonstrated
limited
with
viral
RNA
shed
nasal
oral
swabs
at
1
3-days
post
(DPC);
was
detected
tract
lymphoid
tissues
4
8
DPC.
Sero-reactivity
observed
some
principal
infected
but
contact
sentinels,
indicating
transmission
co-mingled
naïve
efficient;
however,
sentinel
animals
21
used
inoculum
consisting
mixture
two
isolates,
representatives
ancestral
lineage
B.1.1.7-like
alpha
variant
concern,
study
competition
virus
strains.
indicate
show
low
outcompeted
strain.
Cellular and Molecular Immunology,
Год журнала:
2023,
Номер
21(2), С. 134 - 143
Опубликована: Дек. 25, 2023
Abstract
Numerous
pathogens
can
infect
the
olfactory
tract,
yet
pandemic
caused
by
SARS-CoV-2
has
strongly
emphasized
importance
of
mucosa
as
an
immune
barrier.
Situated
in
nasal
passages,
is
directly
exposed
to
environment
sense
airborne
odorants;
however,
this
also
means
it
serve
a
direct
route
entry
from
outside
world
into
brain.
As
result,
olfactotropic
infections
have
serious
consequences,
including
dysfunction
system,
CNS
invasion,
dissemination
lower
respiratory
and
transmission
between
individuals.
Recent
research
shown
that
distinctive
response
needed
protect
neuronal
mucosal
tissue.
A
better
understanding
innate,
adaptive,
structural
barriers
develop
effective
therapeutics
vaccines
against
microbes
such
SARS-CoV-2.
Here,
we
summarize
ramifications
infection
mucosa,
review
subsequent
response,
discuss
important
areas
future
for
immunity
infectious
disease.
The ISME Journal,
Год журнала:
2023,
Номер
17(4), С. 549 - 560
Опубликована: Янв. 23, 2023
Abstract
Exploring
wild
reservoirs
of
pathogenic
viruses
is
critical
for
their
long-term
control
and
predicting
future
pandemic
scenarios.
Here,
a
comparative
in
vitro
infection
analysis
was
first
performed
on
83
cell
cultures
derived
from
55
mammalian
species
using
pseudotyped
bearing
S
proteins
SARS-CoV-2,
SARS-CoV,
MERS-CoV.
Cell
Thomas’s
horseshoe
bats,
king
green
monkeys,
ferrets
were
found
to
be
highly
susceptible
MERS-CoV
viruses.
Moreover,
five
variants
(del69-70,
D80Y,
S98F,
T572I,
Q675H),
that
beside
spike
receptor-binding
domain
can
significantly
alter
the
host
tropism
SARS-CoV-2.
An
examination
phylogenetic
signals
transduction
rates
revealed
closely
related
taxa
generally
have
similar
susceptibility
but
not
SARS-CoV
SARS-CoV-2
Additionally,
we
discovered
expression
95
genes,
e.g.,
PZDK1
APOBEC3,
commonly
associated
with
MERS-CoV,
This
study
provides
basic
documentation
susceptibility,
variants,
molecules
underlie
cross-species
transmission
these
coronaviruses.
