Evaluating the Effect of Climate on Viral Respiratory Diseases Among Children Using AI DOI Open Access
Mikhail Krivonosov, Ekaterina Pazukhina, Alexey Zaikin

и другие.

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(23), С. 7474 - 7474

Опубликована: Дек. 9, 2024

: Respiratory viral infections (RVIs) exhibit seasonal patterns influenced by biological, ecological, and climatic factors. Weather variables such as temperature, humidity, wind impact the transmission of droplet-borne viruses, potentially affecting disease severity. However, role climate in predicting complications pediatric RVIs remains unclear, particularly context climate-change-driven extreme weather events.

Язык: Английский

Review of factors affecting virus inactivation in aerosols and droplets DOI Creative Commons
Alexandra Longest, Nicole C. Rockey, Seema S. Lakdawala

и другие.

Journal of The Royal Society Interface, Год журнала: 2024, Номер 21(215)

Опубликована: Июнь 1, 2024

The inactivation of viruses in aerosol particles (aerosols) and droplets depends on many factors, but the precise mechanisms are not known. system involves complex physical biochemical interactions. We reviewed literature to establish current knowledge about these identify gaps. identified 168 relevant papers grouped results by following factors: virus type structure, or droplet size, temperature, relative humidity (RH) evaporation, chemical composition droplet, pH atmospheric composition. These factors influence dynamic microenvironment surrounding a virion thus may affect its inactivation. Results indicate that experience biphasic decay as carrier aerosols undergo evaporation equilibrate with air, their final state (liquid, semi-solid solid) RH. Virus stability, RH temperature interrelated, effects multifaceted still completely understood. Studies impact stability have raised new questions require further exploration. frequent practice studying large culture media limit our understanding for transmission, so we encourage use physiologically size future research.

Язык: Английский

Процитировано

9

Unanswered questions on the airborne transmission of COVID-19 DOI Open Access
Zhaolin Gu, Jie Han, Liyuan Zhang

и другие.

Environmental Chemistry Letters, Год журнала: 2023, Номер 21(2), С. 725 - 739

Опубликована: Янв. 6, 2023

Язык: Английский

Процитировано

12

Building parameters linked with indoor transmission of SARS-CoV-2 DOI
Jacqueline Horne, Nicholas Dunne,

Nirmala Singh

и другие.

Environmental Research, Год журнала: 2023, Номер 238, С. 117156 - 117156

Опубликована: Сен. 15, 2023

Язык: Английский

Процитировано

7

Therapeutic Efficacy of Nanocarrier‐Mediated Inhalable Gene Transfection for Lung Cancer DOI
Poulami Sarkar,

M. Rizwan Sardar,

Olivia Sen

и другие.

ChemistrySelect, Год журнала: 2024, Номер 9(37)

Опубликована: Окт. 1, 2024

Abstract Lung cancer is now the leading cause of cancer‐related mortality, eclipsing all other forms, and lung malignancies, non‐small cell (NSCLC) makes up around 85%. Recently, use vectors in gene therapy besides chemotherapy to treat malignancies brought on by mutations has gained prominence. Therapeutic molecule inhalation a direct approach lung‐targeted medication delivery with low nonspecific toxicity limited drug exposure. Treatment for immunotherapy can be aided inhalable nanomedicine through advanced mechanisms. Viral nonviral vectors, such as lipid‐based nanoparticles, polymeric inorganic have drawn lot interest their ability increase effects decrease side effects. Nanocarriers significant impact targeted delivery, bioavailability, stability, residence target areas. The inhaled pulmonary approach, when combined nanomedicine, will offer noninvasive successful way taking physiological properties lung. authors majorly used data from PubMed Google Scholar obtain relevant information required article. In general, this review concentrates usage various nanocarriers, which might serve an inspiration creation deployment more potent genetic treatment cancer.

Язык: Английский

Процитировано

2

Salt Supersaturation as an Accelerator of Influenza A Virus Inactivation in 1 μL Droplets DOI
Aline Schaub, Beiping Luo, Shannon C. David

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер 58(42), С. 18856 - 18869

Опубликована: Окт. 11, 2024

Influenza A virus (IAV) spreads through exhaled aerosol particles and larger droplets. Estimating the stability of IAV is challenging depends on factors such as respiratory matrix drying kinetics. Here, we combine kinetic experiments millimeter-sized saline droplets with a biophysical model to quantify impact NaCl stability. We show that inactivation determined by concentration, which increases during water evaporation then decreases again when efflorescence occurs. When in air relative humidity RH = 30%, follows an inverted sigmoidal curve, occurring most rapidly concentration exceeds 20 mol/(kg H2O) immediately prior efflorescence. Efflorescence reduces molality saturated conditions, resulting significantly reduced rate. demonstrate rate k exponentially molality, after solution reaches equilibrium, proceeds at first-order Introducing sucrose, organic cosolute, attenuates via two mechanisms: first decreasing phase second protective effect against NaCl-induced inactivation. For both pure sucrose-containing droplets, our ResAM accurately simulates used only inactivating factor. This study highlights role provides mechanistic basis for observed rates.

Язык: Английский

Процитировано

2

Salt supersaturation as accelerator of influenza A virus inactivation in 1-μl droplets DOI Creative Commons
Aline Schaub, Beiping Luo, Shannon C. David

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Дек. 21, 2023

Influenza A virus (IAV) spreads through exhaled aerosol particles and larger droplets. Estimating the stability of IAV is challenging depends on factors such as respiratory matrix drying kinetics. Here, we combine kinetic experiments millimeter-sized saline droplets with a biophysical model to quantify impact NaCl stability. We show that inactivation determined by concentration, which increases during water evaporation then decreases again when efflorescence occurs. When in air relative humidity RH = 30%, follows an inverted sigmoidal curve, occurring most rapidly concentration exceeds 20 molal immediately prior efflorescence. Efflorescence reduces molality saturated conditions, resulting significantly reduced rate. demonstrate rate k exponentially molality, after solution reaches equilibrium, proceeds at first-order Introducing sucrose, organic co-solute, attenuates via two mechanisms, firstly decreasing phase, secondly protective effect against NaCl-induced inactivation. For both pure sucrose-containing droplets, our ResAM accurately simulates used only inactivating factor. This study highlights role provides mechanistic basis for observed rates.

Язык: Английский

Процитировано

5

A Pilot Study of Aerosolization of Infectious Murine Norovirus in an Experimental Setup DOI Creative Commons
Roderik Purhonen, Nina S. Atanasova, Julija Salokas

и другие.

Food and Environmental Virology, Год журнала: 2024, Номер 16(3), С. 329 - 337

Опубликована: Май 2, 2024

Язык: Английский

Процитировано

1

Microfluidic platform for coupled studies of freezing behavior and final effloresced particle morphology in Snomax ® containing aqueous droplets DOI Creative Commons
Margaret L. House, Cari S. Dutcher

Aerosol Science and Technology, Год журнала: 2023, Номер 58(4), С. 427 - 439

Опубликована: Июль 12, 2023

Aerosol physicochemical mixing state, defined as the chemical, phase, and internal structure of a population aerosols, is complex under-characterized regarding its role in atmosphere. The compositional microphysical properties aerosol particle strongly impact atmospheric processes, including water uptake ice nucleation (IN) activities. However, relationship between IN activity microphysics remains underdeveloped, activity, composition, morphology size are highly intercorrelated. In this article, we demonstrate efficacy microfluidic static well trap device for testing both effloresced residual same droplet. We link cationic composition with droplets containing sodium chloride, calcium biological nucleating (INP) Snomax. Finally, show decoupling within droplet chemical systems studied here.

Язык: Английский

Процитировано

3

Evaluating the Effect of Climate on Viral Respiratory Diseases Among Children Using AI DOI Open Access
Mikhail Krivonosov, Ekaterina Pazukhina, Alexey Zaikin

и другие.

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(23), С. 7474 - 7474

Опубликована: Дек. 9, 2024

: Respiratory viral infections (RVIs) exhibit seasonal patterns influenced by biological, ecological, and climatic factors. Weather variables such as temperature, humidity, wind impact the transmission of droplet-borne viruses, potentially affecting disease severity. However, role climate in predicting complications pediatric RVIs remains unclear, particularly context climate-change-driven extreme weather events.

Язык: Английский

Процитировано

0