Review of factors affecting virus inactivation in aerosols and droplets
Journal of The Royal Society Interface,
Год журнала:
2024,
Номер
21(215)
Опубликована: Июнь 1, 2024
The
inactivation
of
viruses
in
aerosol
particles
(aerosols)
and
droplets
depends
on
many
factors,
but
the
precise
mechanisms
are
not
known.
system
involves
complex
physical
biochemical
interactions.
We
reviewed
literature
to
establish
current
knowledge
about
these
identify
gaps.
identified
168
relevant
papers
grouped
results
by
following
factors:
virus
type
structure,
or
droplet
size,
temperature,
relative
humidity
(RH)
evaporation,
chemical
composition
droplet,
pH
atmospheric
composition.
These
factors
influence
dynamic
microenvironment
surrounding
a
virion
thus
may
affect
its
inactivation.
Results
indicate
that
experience
biphasic
decay
as
carrier
aerosols
undergo
evaporation
equilibrate
with
air,
their
final
state
(liquid,
semi-solid
solid)
RH.
Virus
stability,
RH
temperature
interrelated,
effects
multifaceted
still
completely
understood.
Studies
impact
stability
have
raised
new
questions
require
further
exploration.
frequent
practice
studying
large
culture
media
limit
our
understanding
for
transmission,
so
we
encourage
use
physiologically
size
future
research.
Язык: Английский
Unanswered questions on the airborne transmission of COVID-19
Environmental Chemistry Letters,
Год журнала:
2023,
Номер
21(2), С. 725 - 739
Опубликована: Янв. 6, 2023
Язык: Английский
Building parameters linked with indoor transmission of SARS-CoV-2
Environmental Research,
Год журнала:
2023,
Номер
238, С. 117156 - 117156
Опубликована: Сен. 15, 2023
Язык: Английский
Therapeutic Efficacy of Nanocarrier‐Mediated Inhalable Gene Transfection for Lung Cancer
ChemistrySelect,
Год журнала:
2024,
Номер
9(37)
Опубликована: Окт. 1, 2024
Abstract
Lung
cancer
is
now
the
leading
cause
of
cancer‐related
mortality,
eclipsing
all
other
forms,
and
lung
malignancies,
non‐small
cell
(NSCLC)
makes
up
around
85%.
Recently,
use
vectors
in
gene
therapy
besides
chemotherapy
to
treat
malignancies
brought
on
by
mutations
has
gained
prominence.
Therapeutic
molecule
inhalation
a
direct
approach
lung‐targeted
medication
delivery
with
low
nonspecific
toxicity
limited
drug
exposure.
Treatment
for
immunotherapy
can
be
aided
inhalable
nanomedicine
through
advanced
mechanisms.
Viral
nonviral
vectors,
such
as
lipid‐based
nanoparticles,
polymeric
inorganic
have
drawn
lot
interest
their
ability
increase
effects
decrease
side
effects.
Nanocarriers
significant
impact
targeted
delivery,
bioavailability,
stability,
residence
target
areas.
The
inhaled
pulmonary
approach,
when
combined
nanomedicine,
will
offer
noninvasive
successful
way
taking
physiological
properties
lung.
authors
majorly
used
data
from
PubMed
Google
Scholar
obtain
relevant
information
required
article.
In
general,
this
review
concentrates
usage
various
nanocarriers,
which
might
serve
an
inspiration
creation
deployment
more
potent
genetic
treatment
cancer.
Язык: Английский
Salt Supersaturation as an Accelerator of Influenza A Virus Inactivation in 1 μL Droplets
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(42), С. 18856 - 18869
Опубликована: Окт. 11, 2024
Influenza
A
virus
(IAV)
spreads
through
exhaled
aerosol
particles
and
larger
droplets.
Estimating
the
stability
of
IAV
is
challenging
depends
on
factors
such
as
respiratory
matrix
drying
kinetics.
Here,
we
combine
kinetic
experiments
millimeter-sized
saline
droplets
with
a
biophysical
model
to
quantify
impact
NaCl
stability.
We
show
that
inactivation
determined
by
concentration,
which
increases
during
water
evaporation
then
decreases
again
when
efflorescence
occurs.
When
in
air
relative
humidity
RH
=
30%,
follows
an
inverted
sigmoidal
curve,
occurring
most
rapidly
concentration
exceeds
20
mol/(kg
H2O)
immediately
prior
efflorescence.
Efflorescence
reduces
molality
saturated
conditions,
resulting
significantly
reduced
rate.
demonstrate
rate
k
exponentially
molality,
after
solution
reaches
equilibrium,
proceeds
at
first-order
Introducing
sucrose,
organic
cosolute,
attenuates
via
two
mechanisms:
first
decreasing
phase
second
protective
effect
against
NaCl-induced
inactivation.
For
both
pure
sucrose-containing
droplets,
our
ResAM
accurately
simulates
used
only
inactivating
factor.
This
study
highlights
role
provides
mechanistic
basis
for
observed
rates.
Язык: Английский
Salt supersaturation as accelerator of influenza A virus inactivation in 1-μl droplets
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 21, 2023
Influenza
A
virus
(IAV)
spreads
through
exhaled
aerosol
particles
and
larger
droplets.
Estimating
the
stability
of
IAV
is
challenging
depends
on
factors
such
as
respiratory
matrix
drying
kinetics.
Here,
we
combine
kinetic
experiments
millimeter-sized
saline
droplets
with
a
biophysical
model
to
quantify
impact
NaCl
stability.
We
show
that
inactivation
determined
by
concentration,
which
increases
during
water
evaporation
then
decreases
again
when
efflorescence
occurs.
When
in
air
relative
humidity
RH
=
30%,
follows
an
inverted
sigmoidal
curve,
occurring
most
rapidly
concentration
exceeds
20
molal
immediately
prior
efflorescence.
Efflorescence
reduces
molality
saturated
conditions,
resulting
significantly
reduced
rate.
demonstrate
rate
k
exponentially
molality,
after
solution
reaches
equilibrium,
proceeds
at
first-order
Introducing
sucrose,
organic
co-solute,
attenuates
via
two
mechanisms,
firstly
decreasing
phase,
secondly
protective
effect
against
NaCl-induced
inactivation.
For
both
pure
sucrose-containing
droplets,
our
ResAM
accurately
simulates
used
only
inactivating
factor.
This
study
highlights
role
provides
mechanistic
basis
for
observed
rates.
Язык: Английский
A Pilot Study of Aerosolization of Infectious Murine Norovirus in an Experimental Setup
Food and Environmental Virology,
Год журнала:
2024,
Номер
16(3), С. 329 - 337
Опубликована: Май 2, 2024
Язык: Английский
Microfluidic platform for coupled studies of freezing behavior and final effloresced particle morphology in Snomax ® containing aqueous droplets
Aerosol Science and Technology,
Год журнала:
2023,
Номер
58(4), С. 427 - 439
Опубликована: Июль 12, 2023
Aerosol
physicochemical
mixing
state,
defined
as
the
chemical,
phase,
and
internal
structure
of
a
population
aerosols,
is
complex
under-characterized
regarding
its
role
in
atmosphere.
The
compositional
microphysical
properties
aerosol
particle
strongly
impact
atmospheric
processes,
including
water
uptake
ice
nucleation
(IN)
activities.
However,
relationship
between
IN
activity
microphysics
remains
underdeveloped,
activity,
composition,
morphology
size
are
highly
intercorrelated.
In
this
article,
we
demonstrate
efficacy
microfluidic
static
well
trap
device
for
testing
both
effloresced
residual
same
droplet.
We
link
cationic
composition
with
droplets
containing
sodium
chloride,
calcium
biological
nucleating
(INP)
Snomax.
Finally,
show
decoupling
within
droplet
chemical
systems
studied
here.
Язык: Английский
Evaluating the Effect of Climate on Viral Respiratory Diseases Among Children Using AI
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(23), С. 7474 - 7474
Опубликована: Дек. 9, 2024
:
Respiratory
viral
infections
(RVIs)
exhibit
seasonal
patterns
influenced
by
biological,
ecological,
and
climatic
factors.
Weather
variables
such
as
temperature,
humidity,
wind
impact
the
transmission
of
droplet-borne
viruses,
potentially
affecting
disease
severity.
However,
role
climate
in
predicting
complications
pediatric
RVIs
remains
unclear,
particularly
context
climate-change-driven
extreme
weather
events.
Язык: Английский