GPR84 regulates pulmonary inflammation by modulating neutrophil functions

Acta Pharmacologica Sinica, Год журнала: 2023, Номер 44(8), С. 1665 - 1675

Опубликована: Апрель 4, 2023

Acute lung injury (ALI) is an acute, progressive hypoxic respiratory failure that could develop into acute distress syndrome (ARDS) with very high mortality rate. ALI believed to be caused by uncontrolled inflammation, and multiple types of immune cells, especially neutrophils, are critically involved in the development ALI. The treatment for ALI/ARDS limited, a better understanding pathogenesis new therapies urgently needed. Here we discover GPR84, medium chain fatty acid receptor, plays critical roles regulating neutrophil functions. GPR84 highly upregulated cells isolated from bronchoalveolar lavage fluid LPS-induced mice. deficiency or blockage significantly ameliorated mice inflammation reducing neutrophils infiltration oxidative stress. Further studies reveal activation strongly induced reactive oxygen species production stimulating Lyn, AKT ERK1/2 assembly NADPH oxidase. These results important role functions suggest potential drug target

Язык: Английский

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Interventions for Improving Long COVID-19 Symptomatology: A Systematic Review

Viruses, Год журнала: 2022, Номер 14(9), С. 1863 - 1863

Опубликована: Авг. 24, 2022

Although the understanding of several aspects long COVID-19 syndrome is increasing, there limited literature regarding treatment these signs and symptoms. The aim our systematic review was to understand which therapies have proved effective against symptoms COVID-19.

Язык: Английский

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Can COVID-19 Vaccines Induce Premature Non-Communicable Diseases: Where Are We Heading to?

Vaccines, Год журнала: 2023, Номер 11(2), С. 208 - 208

Опубликована: Янв. 17, 2023

According to the WHO, as of January 2023, more than 850 million cases and over 6.6 deaths from COVID-19 have been reported worldwide. Currently, death rate has reduced due decreased pathogenicity new SARS-CoV-2 variants, but major factor in rates is administration 12.8 billion vaccine doses globally. While vaccines are saving lives, serious side effects after vaccinations for several premature non-communicable diseases (NCDs). However, adverse events low number. The scientific community must investigate entire spectrum COVID-19-vaccine-induced complications so that necessary safety measures can be taken, current re-engineered avoid or minimize their effects. We describe depth severe metabolic, mental, neurological disorders; cardiovascular, renal, autoimmune diseases, reproductive health issues detected whether these causal incidental. In any case, it become clear benefits outweigh risks by a large margin. pre-existing conditions vaccinated individuals need taken into account prevention treatment events.

Язык: Английский

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SARS-CoV-2 and COVID-19: A Narrative Review

British Journal of Biomedical Science, Год журнала: 2022, Номер 79

Опубликована: Сен. 6, 2022

The World Health Organisation has reported that the viral disease known as COVID-19, caused by SARS-CoV-2, is leading cause of death a single infectious agent. This narrative review examines certain components pandemic: its origins, early clinical data, global and UK-focussed epidemiology, vaccination, variants, long COVID.

Язык: Английский

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Myocardial Infarction Following COVID-19 Vaccine Administration: Post Hoc, Ergo Propter Hoc?

Viruses, Год журнала: 2022, Номер 14(8), С. 1644 - 1644

Опубликована: Июль 27, 2022

Vaccination against coronavirus disease 2019 (COVID-19) is the safest and most effective strategy for controlling pandemic. However, some cases of acute cardiac events following vaccine administration have been reported, including myocarditis myocardial infarction (MI). While post-vaccine has widely discussed, information about MI scarce heterogenous, often lacking in histopathological pathophysiological details. We hereby present five (four men, mean age 64 years, range 50–76) sudden death secondary to tightly temporally related COVID-19 vaccination. In each case, comprehensive macro- microscopic pathological analyses were performed, post-mortem magnetic resonance, ascertain cause death. To investigate determinants MI, toxicological tryptase yielding negative results, while absence anti-platelet factor 4 antibodies ruled out vaccine-induced thrombotic thrombocytopenia. Finally, genetic testing disclosed that all subjects carriers at least one pro-thrombotic mutation. Although presented do not allow us establish any causative relation, they should foster further research possible link between vaccination, genotypes, cardiovascular events.

Язык: Английский

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Withdrawn: A systematic review of autopsy findings in deaths after COVID-19 vaccination

Forensic Science International, Год журнала: 2024, Номер unknown, С. 112115 - 112115

Опубликована: Июнь 1, 2024

The rapid development of COVID-19 vaccines, combined with a high number adverse event reports, have led to concerns over possible mechanisms injury including systemic lipid nanoparticle (LNP) and mRNA distribution, Spike protein-associated tissue damage, thrombogenicity, immune system dysfunction, carcinogenicity. aim this systematic review is investigate causal links between vaccine administration death using autopsies post-mortem analysis. We searched PubMed ScienceDirect for all published autopsy necropsy reports relating vaccination up until May 18th, 2023. All studies that included as an antecedent exposure were included. Because the state knowledge has advanced since time original publications, three physicians independently reviewed each case adjudicated whether or not was direct cause contributed significantly death. initially identified 678 and, after screening our inclusion criteria, 44 papers contained 325 cases one case. mean age 70.4 years. most implicated organ among cardiovascular (49%), followed by hematological (17%), respiratory (11%), multiple systems (7%). Three more affected in 21 cases. from 14.3 days. Most deaths occurred within week last administration. A total 240 (73.9%) directly due vaccination, which primary causes include sudden cardiac (35%), pulmonary embolism (12.5%), myocardial infarction (12%), VITT (7.9%), myocarditis (7.1%), multisystem inflammatory syndrome (4.6%), cerebral hemorrhage (3.8%). consistency seen known death, coupled confirmation physician adjudication, suggests there likelihood link vaccines Further urgent investigation required purpose clarifying findings.

Язык: Английский

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Clinical cardiovascular emergencies and the cellular basis of COVID-19 vaccination: from dream to reality?

International Journal of Infectious Diseases, Год журнала: 2022, Номер 124, С. 1 - 10

Опубликована: Сен. 6, 2022

Язык: Английский

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A Cross-Sectional Analysis of Self-Medication Patterns during the COVID-19 Pandemic in Ecuador

Medicina, Год журнала: 2022, Номер 58(11), С. 1678 - 1678

Опубликована: Ноя. 19, 2022

Background and Objectives: Drug consumption is a widely developed practice around the world. However, sometimes medicines are acquired with or without prescription, termed self-medication, which can have negative impacts on health of population. It has been observed that arrival coronavirus disease 2019 (COVID-19) pandemic, self-medicated drug figures increased in several countries. To describe patterns medication, use prevalence self-medication during COVID-19 pandemic inhabitants capital province Pichincha, Ecuador. Materials Methods: A descriptive, cross-sectional study was conducted based self-administered online questionnaire from April to June 2022, among residents Participants were invited through social networks (WhatsApp Facebook). total 401 surveys included this study. Consumption (prescription treatment with) evaluated, as well variables characterize way acquiring medicines. The Chi-square test used look for relationships between patterns, characteristics participants. Results: Most participants female (53.4%), 59.4% reported having had COVID-19. 244 (60.9%) consumed medications mostly purpose treating infection. About half (48.4%) self-medicated. most paracetamol (87.3%) ibuprofen (47.5%). Drugs informal sources information (TV, networks, advice) associated (p < 0.05). Conclusions: significant percentage over-the-counter (OTC) legal found persist after pandemic. Our findings highlight effects alternative forms other than medical personnel practices.

Язык: Английский

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COVID-19 mortality paradox (United States vs Africa): Mass vaccination vs early treatment

World Journal of Experimental Medicine, Год журнала: 2024, Номер 14(1)

Опубликована: Март 19, 2024

The coronavirus disease 2019 (COVID-19) mortality rate in 55 African countries is almost 4.5 times lower than the despite Africa having over 4.2 more people. This paradox also evident when comparing Nigeria, a heavily populated, poorly vaccinated and weakly mandated country to Israel, small, highly strictly country. Nigeria has 4 COVID Israel. In this Field of Vision perspective, I explain how evolved drawing upon my academic, clinical social experience. Since April 2020, I’ve developed been using Egyptian immune-modulatory Kelleni’s protocol manage COVID-19 patients including pediatric, geriatric, pregnant, immune-compromised other individuals suffering from multiple comorbidities. It’s unfortunate that severe acute respiratory syndrome 2 still evolving accompanied by deaths. However Africa, we’ve able live without anxiety or mandates throughout pandemic because we trust science adopted early treatment safe, effective repurposed drugs have saved majority patients. article represents an tale honor.

Язык: Английский

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Arrhythmias after SARS-CoV-2 Vaccination in Patients with a Cardiac Implantable Electronic Device: A Multicenter Study

Biomedicines, Год журнала: 2022, Номер 10(11), С. 2838 - 2838

Опубликована: Ноя. 7, 2022

One of the most concerning adverse events related to SARS-CoV-2 vaccination is arrhythmia. To ascertain relationship between and arrhythmic events, we studied occurrence arrhythmia in patients with cardiac implantable electronic devices (CIEDs) before after a vaccination. Patients CIEDs aged ≥18 who visited CIED clinic at King Chulalongkorn Memorial Hospital Vajira hospital from August 2021 February 2022 were included. Information about side effects was obtained. hundred eighty included our study, which compared incidence arrhythmias 14 days post-vaccination The median age 70 years. number received one, two, three doses vaccine 180, 88, 4, respectively. ChAdOx1 primary used institutes, accounting for 86% vaccinations. significantly associated 73% increase supraventricular tachycardia (SVT). In an adjusted model, factors SVT period, female sex, increasing BMI, chronic kidney disease, history atrial fibrillation. Increased ventricular (VA) episodes also decreasing but lesser degree than those episodes. No life-threatening noted this study. conclusion, implanted increased

Язык: Английский

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