Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101740 - 101740
Опубликована: Апрель 1, 2025
Язык: Английский
Phytotherapy Research, Год журнала: 2024, Номер 38(4), С. 2041 - 2076
Опубликована: Фев. 23, 2024
Abstract In recent years, heightened interest surrounds the exploration of natural phenols as potential agents for cancer therapy, specifically by inducing ferroptosis, a unique form regulated cell death characterized iron‐dependent lipid peroxidation. This review delves into roles key phenols, flavonoids, phenolic acids, curcumin, and stilbenes, in modulating ferroptosis their underlying mechanisms. Emphasizing significance amino acid, lipid, iron metabolism, study elucidates diverse pathways through which these regulate ferroptosis. Notably, well‐known polyphenol, exhibits multifaceted interactions with cellular components involved regulation, providing distinctive therapeutic avenue. Stilbenes, another class, demonstrate promising influencing metabolism processes, contributing to ferroptotic death. Understanding intricate interplay between not only illuminates complex regulatory networks but also unveils avenues novel therapies. Exploring compounds inducers presents strategy targeted treatment, capitalizing on delicate balance article synthesizes current knowledge, aiming stimulate further research context ferroptosis‐mediated therapy.
Язык: Английский
Процитировано
6
Current Medicinal Chemistry, Год журнала: 2024, Номер 31(32), С. 5199 - 5221
Опубликована: Янв. 12, 2024
Hepatocellular carcinoma (HCC) is the most prevalent form of liver cancer, accounting for 85-90% cancer cases and a leading cause cancer-related mortality worldwide. The major risk factors HCC include hepatitis C B viral infections, along with chronic diseases, such as cirrhosis, fibrosis, non-alcoholic steatohepatitis associated metabolic syndrome. Despite advancements in modern medicine, there continuous rise annual global incidence rate HCC, it estimated to reach >1 million by 2025. Emerging research phytomedicine chemotherapy has established anti-cancer potential phytochemicals, owing their diverse biological activities. In this review, we report phytochemicals that have been explored combating hepatocellular possess great be used an alternative or conjunction existing treatment modalities. An overview pre-clinical observations, mechanism action molecular targets some these also incorporated.
Язык: Английский
Процитировано
5
Phytotherapy Research, Год журнала: 2023, Номер 38(1), С. 280 - 304
Опубликована: Окт. 23, 2023
Abstract This review focuses on the potential ameliorative effects of polyphenolic compounds derived from human diet hepatic diseases. It discusses molecular mechanisms and recent advancements in clinical applications. Edible polyphenols have been found to play a therapeutic role, particularly liver injury, fibrosis, NAFLD/NASH, HCC. In regulation exhibit anti‐inflammatory antioxidant effects, primarily targeting TGF‐β, NF‐κB/TLR4, PI3K/AKT, Nrf2/HO‐1 signaling pathways. effectively reverse fibrotic process by inhibiting activation stellate cells (HSC). Furthermore, show efficacy against NAFLD/NASH lipid oxidation accumulation, mediated through AMPK, SIRT, PPARγ Moreover, several anti‐HCC activity suppressing tumor cell proliferation metastasis. inhibition involves blocking Akt Wnt signaling, as well epithelial‐mesenchymal transition (EMT). Additionally, trials nutritional evidence support notion that certain can improve disease associated metabolic disorders. However, further fundamental research are warranted validate dietary polyphenols.
Язык: Английский
Процитировано
11
International Journal of Pharmaceutics, Год журнала: 2023, Номер 650, С. 123670 - 123670
Опубликована: Дек. 4, 2023
Язык: Английский
Процитировано
11
Pharmacognosy Magazine, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
Background Activation of PRR11 contributes to the progression lung cancer and is related its methylation status. However, regulatory mechanism luteolin-zinc (Lu-Zn) on methylation-mediated under hypoxic conditions remains be explored.. Purpose This study aims investigate inhibitory effect Lu-Zn cells, regulation ferroptosis, role in hypoxia. Methods In vitro experiments were conducted evaluate focusing impact invasion, migration, ferroptosis. The expression levels PRR11, status, microRNA-6769b-3p (miR-6769b-3p) also analyzed. Results Under conditions, significantly inhibited invasion migration abilities cells promoted Additionally, reversed pro-cancer effects induced by PRR11. At molecular level, regulated miR-6769b-3p. Conclusion Our demonstrates that enhances reduces through leads inhibition downstream PI3K/AKT/mTOR signaling pathway, promoting ferroptosis exerting anti-lung effects.
Язык: Английский
Процитировано
0
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Год журнала: 2025, Номер unknown, С. 503853 - 503853
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2025, Номер 17(4), С. 616 - 616
Опубликована: Фев. 8, 2025
Polyphenols have been shown to be utilized as an effective treatment for cancer by acting a DNMT or HDAC inhibitor, reducing inflammatory processes, and causing cell cycle arrest. While there many studies demonstrating the anti-cancerous potential of individual polyphenols, are limited on combinatorial effects polyphenols. This review focuses how combinations different polyphenols can used chemotherapeutic option patients. Specifically, we examine three commonly polyphenols: curcumin, resveratrol, epigallocatechin gallate. These induce apoptosis, prevent colony formation migration, increase tumor suppression, reduce viability angiogenesis, create several epigenetic modifications. In addition, these were synergistic additive. Thus, findings suggest that using at appropriate concentrations better more efficacious against compared individually.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1752 - 1752
Опубликована: Фев. 19, 2025
Hypoxia-inducible factors (HIFs) are master regulators of cellular responses to low oxygen levels and modulate autophagy, a conserved process essential for maintaining homeostasis. Under hypoxic conditions, HIFs regulate the expression autophagy-related genes influence autophagic flux stress responses. Dysregulated hypoxia-induced autophagy promotes cancer cell survival, metabolism, metastasis, thereby contributing treatment resistance. Targeting HIF-mediated pathways or modulating processes offers potential improve traditional therapies overcome drug Pharmacological inhibitors either alone in combination with other treatments, may disrupt pro-survival mechanisms within tumor microenvironment. Further research is needed elucidate intricate interplay between HIF signaling machinery cells. Understanding these could pave way novel therapeutic strategies enhance outcomes combat This review highlights complex relationship development therapy, offering insights into how targeting patient outcomes.
Язык: Английский
Процитировано
0
Reference series in phytochemistry, Год журнала: 2025, Номер unknown, С. 1 - 28
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Russian Journal of General Chemistry, Год журнала: 2025, Номер 95(1), С. 239 - 252
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0