Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Дек. 9, 2024
Colorectal cancer (CRC) is a leading cause of cancer-related deaths globally. The heterogeneity the tumor microenvironment significantly influences patient prognosis, while diversity cells shapes its unique characteristics. A comprehensive analysis molecular profile crucial for identifying novel targets drug sensitivity and uncovering pathophysiological mechanisms underlying CRC.
Язык: Английский
Molecules, Год журнала: 2023, Номер 29(1), С. 35 - 35
Опубликована: Дек. 20, 2023
Spiders (Araneae), having thrived for over 300 million years, exhibit remarkable diversity, with 47,000 described species and an estimated 150,000 in existence. Evolving intricate venom, spiders are nature’s skilled predators. While only a small fraction of pose threat to humans, their venoms contain complex compounds, holding promise as drug leads. Spider primarily serve immobilize prey, achieved through neurotoxins targeting ion channels. Peptides constitute major part these venoms, displaying diverse pharmacological activities, making them appealing development. Moreover, spider-venom peptides have emerged valuable tools exploring human disease mechanisms. This review focuses on the roles spider survival strategies dual significance pharmaceutical research tools. By integrating recent discoveries, it provides comprehensive overview peptides, targets, bioactivities, relevance medical research.
Язык: Английский
Процитировано
9
Pharmaceutics, Год журнала: 2024, Номер 16(1), С. 127 - 127
Опубликована: Янв. 19, 2024
Cucurbiturils are a family of macrocyclic oligomers capable forming host–guest complexes with various molecules. Due to noncovalent binding drug molecules and low toxicity, cucurbiturils has been extensively investigated as potential carriers for delivery. However, the immune system’s interactions different carriers, including cucurbiturils, still under investigation. In this study, we focused on cucurbiturils’ immunosafety immunomodulation properties in vivo. We measured blood counts lymphocyte subpopulations blood, spleen, bone marrow, assessed vivo toxicity spleen marrow cells after intraperitoneal administration BALB/c mice. When assessing effect cucurbit[6]uril parameters three injections within week laboratory animals, decrease white was found mice cucurbit[6]util, but observed number normal range. At same time, cucurbit[7]uril cucurbit[8]uril did not affect leukocyte injections. Changes platelets, erythrocytes, monocytes, well several other indicators, such hematocrit or erythrocyte volumetric dispersion, were detected. show that do have immunotoxicity vivo, exception cytotoxic сucurbit[7]uril at high dosage. also evaluated cellular humoral responses. founded concentrations system action differs homologues, which is apparently associated internal environment body.
Язык: Английский
Процитировано
3
International Journal of Cancer, Год журнала: 2024, Номер 155(1), С. 159 - 171
Опубликована: Фев. 22, 2024
Abstract Colorectal cancer has the highest mortality rate of all digestive system diseases. Considering debate about cytokines and biases that exist in traditional observational study designs, we performed a two‐sample Mendelian randomization (MR) analysis to explore association circulating with CRC risk. In this study, used cytokine genetic variants from recently published genome‐wide (GWAS) including 14,824 European‐ancestry participants. Summary‐level data for colorectal were obtained analyses FinnGen consortium. addition, conducted independent supplementary using variation large public GWAS 2021. Among 91 factors, only found IL‐12B be significantly associated risk (odds ratio [OR]: 1.19; 95% confidence interval [CI]: 1.00–1.42; p = .046). We 2021 higher Interleukin‐12p70 levels (IL‐12p70) revealed have significant positive (OR: 1.27; CI: 1.13–1.43; < 1.22 × 10 −3 ). Moreover, was suggestively correlated an elevated level vascular endothelial growth factor (VEGF) 1.17; 1.02–1.35; .026), macrophage colony‐stimulating (M‐CSF) 0.85; 0.76–0.96; .005), IL‐13 1.15; 1.02–1.30; .028), IL‐10 1.23; 1.01–1.49; .037), IL‐7 1.02–1.39; .024). Our MR studies support one IL‐12 is five VEGF, M‐CSF, IL‐13, IL‐10, are
Язык: Английский
Процитировано
3
Research, Год журнала: 2024, Номер 7
Опубликована: Янв. 1, 2024
Extracellular vesicles (EVs) are lipid bilayer-enclosed released by cells. EVs encapsulate proteins and nucleic acids of their parental cell efficiently deliver the cargo to recipient These act as mediators intercellular communication thus play a crucial role in various physiological pathological processes. Moreover, hold promise for clinical use. They have been explored drug delivery vehicles, therapeutic agents, targets disease diagnosis. In landscape cancer research, while strides made EV-focused physiopathology, liquid biopsy, delivery, exploration immunotherapeutic agents may not seen substantial progress date. Despite promising findings reported animal studies, translation EV-based immunotherapeutics encounters challenges. Here, we review existing strategies used immunotherapy, aiming propel development this emerging yet field.
Язык: Английский
Процитировано
3
Advanced Science, Год журнала: 2024, Номер 11(29)
Опубликована: Июнь 14, 2024
Abstract Immunosuppression is a major hallmark of tumor progression in non‐small cell lung cancer (NSCLC). Cluster differentiation 147 (CD147), an important pro‐tumorigenic factor, closely linked to NSCLC immunosuppression. However, the role CD147 di‐methylation immunosuppressive microenvironment (TME) remains unclear. Here, at Lys148 (CD147‐K148me2) identified as common post‐translational modification (PTM) that significantly associated with unsatisfying survival outcomes among sufferers, especially those advanced stages disease. The methyltransferase NSD2 catalyzes generate CD147‐K148me2. Further analysis demonstrates CD147‐K148me2 reestablishes TME and promotes progression. Mechanistically, this interaction between cyclophilin A (CyPA) CD147, turn, increases CCL5 gene transcription by activating p38‐ZBTB32 signaling, leading increased cell‐derived secretion. Subsequently, CD147‐K148me2‐mediated upregulation facilitates M2‐like tumor‐associated macrophage (TAM) infiltration tissues via CCL5/CCR5 axis‐dependent intercellular crosstalk cells macrophages, which inhibited blocking targeted antibody 12C8. Overall, study reveals CD147‐K148me2‐driven development immunosuppression, provides potential interventional strategy for PTM‐targeted therapy.
Язык: Английский
Процитировано
3
Frontiers in Oncology, Год журнала: 2024, Номер 14
Опубликована: Май 23, 2024
Background Kidney cancer is a prevalent malignancy with an increasing incidence worldwide. Blood cell indices and inflammation-related markers have shown huge potential as biomarkers for predicting incidences, but that not clear in kidney cancer. Our study aims to investigate the correlations of blood risk. Methods We performed population-based cohort prospective analysis using data from UK Biobank. A total 466,994 participants, free at baseline, were included analysis. The hazard ratios (HRs) 95% confidence intervals (CIs) risk calculated Cox proportional hazards regression models. Restricted cubic spline models used nonlinear longitudinal associations. Stratified analyses identify high-risk populations. results validated through sensitivity analyses. Results During mean follow-up 12.4 years, 1,710 participants developed showed 13 four associated incidence. restricted non-linear relationships Finally, combined stratified analyses, we found corpuscular hemoglobin concentration (MCHC), red distribution width (RDW), platelet (PDW), systemic immune-inflammation index (SII), product count neutrophil (PPN) related enhanced stable results. Conclusion findings identified three (MCHC, RDW, PDW) two (SII PPN) independent factors These indexes may serve predictors aid development targeted screening strategies at-risk individuals.
Язык: Английский
Процитировано
2
International Immunopharmacology, Год журнала: 2024, Номер 136, С. 112184 - 112184
Опубликована: Июнь 1, 2024
Язык: Английский
Процитировано
2
Heliyon, Год журнала: 2024, Номер 10(7), С. e29216 - e29216
Опубликована: Апрель 1, 2024
Cancer-associated fibroblasts (CAFs) provide suitable conditions for growth of tumor cell and facilitate progression. Hence, we aimed to identify a CAFs-related gene signature associated with the prognosis patients breast cancer (BRCA). We downloaded datasets from Gene Expression Omnibus (GEO) confirmed correlation between CAFs infiltration scores prognosis. By performing weighted co-expression network analysis (WGCNA) Lasso Cox regression analysis, constructed four-gene (COL5A3, FN1, POSTN, RARRES2) prognostic model. Based on median risk score CAFs, BRCA were divided into high- low-risk groups. Compared group, in high-risk group exhibited poor limited response immunotherapy. Furthermore, high found have detrimental due induction immunosuppressive infiltration, resulting an microenvironment. Importantly, that overexpressing FN1 POSTN significantly promoted wound healing invasion ability cells vitro validation. Taking together, identified signature, which was proven be reliable indicator therapeutic efficacy BRCA. This study provided evidence novel CAFs-based stromal therapy.
Язык: Английский
Процитировано
1
Research, Год журнала: 2024, Номер 7
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
1
Journal of Controlled Release, Год журнала: 2024, Номер 376, С. 402 - 412
Опубликована: Окт. 21, 2024
Язык: Английский
Процитировано
1