Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 19, 2024
Background
The
transcription
factor,
SOX13
is
part
of
the
SOX
family.
proteins
are
crucial
in
progression
many
cancers,
and
some
correlate
with
carcinogenesis.
Nonetheless,
biological
clinical
implications
human
breast
cancer
(BC)
remain
rarely
known.
Methods
We
evaluated
survival
expression
data
BC
patients
via
UNLCAL,
GEPIA,
TIMER,
Kaplan-Meier
plotter
databases.
Immunohistochemistry
(IHC)
was
used
to
verify
specimens.
gene
alteration
rates
were
acquired
on
online
web
cBioportal.
With
aid
TCGA
data,
association
between
mRNA
copy
number
alterations
(CNA)
methylation
determined.
LinkedOmics
identify
genes
that
co-expressed
regulators.
Immune
infiltration
tumor
microenvironment
evaluations
assessed
by
ImmuCellAI
TIMER2.0
correlated
drug
resistance
analysis
performed
using
GDSC2
database.
Results
Higher
discovered
tissues
comparison
normal
tissues.
Moreover,
increased
mutation
amplification
found
BC.
Patients
levels
showed
worse
overall
(OS).
Cox
independently
served
as
a
prognostic
indicator
for
poor
Further,
also
confirmed
be
diverse
immune
cells.
In
terms
sensitivity
analysis,
we
higher
level
predicts
high
IC50
value
most
198
drugs
which
resistance.
Conclusion
present
findings
demonstrated
negatively
relates
prognosis
plays
an
important
role
immunity.
Therefore,
may
potentially
adopted
biomarker
predicting
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 5, 2024
Breast
cancer,
one
of
the
most
prevalent
malignancies
among
women
worldwide,
has
rising
incidence
rates.
Physical
activity,
particularly
exercise,
emerged
as
a
significant
modifier
cancer
prognosis,
influencing
both
tumor
biology
and
patient
outcomes.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(11), С. 7556 - 7573
Опубликована: Ноя. 6, 2024
Triple-negative
breast
cancer
(TNBC)
is
recognized
as
a
major
aggressive
subtype
of
due
to
its
expeditious
worsening
growth,
extensive
metastatic
capability,
and
recalcitrance
standard
current
treatments.
Hesperetin
(HSP),
natural
bioflavonoid
from
citrus
fruits,
demonstrates
pronounced
anticancer
efficacy,
but
hydrophobicity
limits
clinical
development.
The
present
study
reports
the
fabrication
biocompatible
pH-responsive
transferrin
(TF)
receptor-targeted
HSP-loaded
poly(lactic-co-glycolic
acid)
(PLGA)
nanobioconjugate
(PLGA-HSP-TF
NPs)
exploration
in
vitro
vivo
antineoplastic
potential.
PLGA
nanoparticles
(NPs),
PLGA-HSP
NPs,
PLGA-HSP-TF
NPs
were
synthesized
characterized
by
DLS,
FTIR,
FE-SEM,
1H
NMR
spectroscopy.
stability
release
profile
inspected,
efficacy
was
scrutinized
terms
cytotoxicity,
oxidative
stress
apoptosis
biomarkers,
cell
cycle
arrest.
In
tumor
regression
host
survival
studies
executed
Ehrlich
ascites
carcinoma
(EAC)
cell-bearing
Swiss
albino
mice.
drug
uptake
highly
stable
accomplished
effectively
MDA-MB-231
cells
showed
pH-dependent
intracellular
HSP,
which
generated
excessive
reactive
oxygen
species
(ROS)
that
led
assault
TNBC
cells.
This
elevated
ROS
dropped
mitochondrial
membrane
potential
triggered
apoptosis-mediated
death
arresting
at
G0/G1
phase.
Furthermore,
unveiled
significant
compared
free
HSP
with
minimum
toxicity
dose
20
mg/kg
body
weight.
divulges
may
be
an
astounding
nanocandidate
for
triple-negative
therapy.
Triple-negative
breast
cancer
(TNBC)
is
the
most
aggressive
subtype
of
cancer.
Previous
studies
have
found
that
fibroblast
growth
factor
receptor
4
(FGFR4)
plays
a
crucial
role
in
tumor
development
and
metastasis.
However,
potential
underlying
mechanisms
FGFR4
progression
TNBC
remain
unclear.
Transfer
RNA-derived
small
RNAs,
a
recently
identified
class
of
noncoding
play
crucial
role
in
regulating
gene
expression
and
are
implicated
cerebrovascular
diseases.
However,
the
specific
biological
roles
mechanisms
transfer
RNAs
intracranial
aneurysms
(IAs)
remain
unclear.
In
this
study,
we
that
RNA-Asp-GTC
derived
fragment
(tRF-AspGTC)
is
highly
expressed
IA
tissues
both
humans
mice.
tRF-AspGTC
promotes
formation
by
facilitating
phenotypic
switching
vascular
smooth
muscle
cells,
increasing
matrix
metalloproteinase
9
expression,
inducing
oxidative
stress
inflammatory
responses.
Mechanistically,
binds
to
galectin-3,
inhibiting
tripartite
motif
29-mediated
ubiquitination
stabilizing
galectin-3.
This
stabilization
activates
toll-like
receptor
4/MyD88/nuclear
factor
kappa
B
pathway,
further
driving
inflammation.
Clinically,
circulating
exosomal
demonstrates
strong
diagnostic
efficacy
for
IAs
as
an
independent
risk
occurrence.
These
findings
highlight
potential
promising
biomarker
therapeutic
target
IAs.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 19, 2024
Background
The
transcription
factor,
SOX13
is
part
of
the
SOX
family.
proteins
are
crucial
in
progression
many
cancers,
and
some
correlate
with
carcinogenesis.
Nonetheless,
biological
clinical
implications
human
breast
cancer
(BC)
remain
rarely
known.
Methods
We
evaluated
survival
expression
data
BC
patients
via
UNLCAL,
GEPIA,
TIMER,
Kaplan-Meier
plotter
databases.
Immunohistochemistry
(IHC)
was
used
to
verify
specimens.
gene
alteration
rates
were
acquired
on
online
web
cBioportal.
With
aid
TCGA
data,
association
between
mRNA
copy
number
alterations
(CNA)
methylation
determined.
LinkedOmics
identify
genes
that
co-expressed
regulators.
Immune
infiltration
tumor
microenvironment
evaluations
assessed
by
ImmuCellAI
TIMER2.0
correlated
drug
resistance
analysis
performed
using
GDSC2
database.
Results
Higher
discovered
tissues
comparison
normal
tissues.
Moreover,
increased
mutation
amplification
found
BC.
Patients
levels
showed
worse
overall
(OS).
Cox
independently
served
as
a
prognostic
indicator
for
poor
Further,
also
confirmed
be
diverse
immune
cells.
In
terms
sensitivity
analysis,
we
higher
level
predicts
high
IC50
value
most
198
drugs
which
resistance.
Conclusion
present
findings
demonstrated
negatively
relates
prognosis
plays
an
important
role
immunity.
Therefore,
may
potentially
adopted
biomarker
predicting
