The roles of gut microbiota and its metabolites in diabetic nephropathy

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Июль 27, 2023

Diabetic nephropathy (DN) is a severe microvascular complication of diabetes, which increases the risk renal failure and causes high global disease burden. Due to lack sustainable treatment, DN has become primary cause end-stage worldwide. Gut microbiota its metabolites exert critical regulatory functions in maintaining host health are associated with many pathogenesis aging-related chronic diseases. Currently, theory gut–kidney axis opened novel angle understand relationship between gut multiple kidney In recent years, accumulating evidence revealed that their play an essential role pathophysiologic processes through axis. this review, we summarize current investigations microbial involvement progression DN, further discuss potential microbiota-targeted therapeutic approaches for DN.

Язык: Английский

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Yi-Shen-Hua-Shi granule ameliorates diabetic kidney disease by the “gut-kidney axis”

Journal of Ethnopharmacology, Год журнала: 2023, Номер 307, С. 116257 - 116257

Опубликована: Фев. 12, 2023

Yi-Shen-Hua-Shi (YSHS) granule is an effective prescription widely used in traditional Chinese medicine to treat diabetic kidney disease (DKD), its exact efficacy treating DKD has been confirmed but the underlying regulatory mechanism not fully elucidated.To explore by which YSHS regulates intestinal flora and serum metabolites then renal mRNA expression through "gut-kidney axis", so as improve DKD.40 rats were divided into five groups: Normal group (N) (normal saline), model (M) (STZ + normal low-dose (YL) 2.27 g kg-1 d-1), high-dose (YH) 5.54g d-1) valsartan (V) 7.38mg d-1). After 6 weeks, changes blood glucose, lipids, function related indexes observed, well pathological colon. Intestinal microbiota was sequenced 16S rDNA, differential identified LC-MS/MS, differences observed RNA-seq. Further, association analysis of microbiota, mRNAs, target flora, genes screened verified, "gut-metabolism-transcription" co-expression network constructed.In M, lipid proteinuria increased, inflammation, oxidative stress aggravated, with proliferation mesangial matrix, vacuolar degeneration tubules, accumulation collagen lipid, increased permeability, improved these disorders varying degrees. High dose diversity abundance decreased F/B value, greatly Lactobacillus Lactobacillus_murinus, Prevoella UCG_001. 14 identified, mainly enriched 20 KEGG pathways, such Glycerophospholipid metabolism, Sphingolipid metabolism Phenylalanine, tyrosine tryptophan biosynthesis. 96 mRNAs also identified. The top pathways closely glucose a total 21 expressed. Further correlation revealed that Lactobacillus, Lactobacillus_murinus Prevotella UCG_001 highly correlated biosynthesis pathways. At same time, including Arachidonic acid Purine Primary bile biosynthesis, Ascorbate aldarate Galactose co-enriched granule, 7 phosphatidylethanolamine Adcy3. had high predictive value AUC, validation consistent sequencing results.YSHS could axis". main driving forces. especially may be important follow-up response mechanism.

Язык: Английский

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Dietary Polyphenols and Gut Microbiota Cross-Talk: Molecular and Therapeutic Perspectives for Cardiometabolic Disease: A Narrative Review

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 9118 - 9118

Опубликована: Авг. 22, 2024

The intricate interplay between the gut microbiota and polyphenols has emerged as a captivating frontier in understanding potentially harnessing therapeutic potential of these bioactive compounds. Phenolic compounds, renowned for their antioxidant, anti-inflammatory, antidiabetic, anticancer properties, are subject to transformations within milieu, where diverse microbial ecosystem exerts profound effects on metabolism bioavailability. Conversely, exhibit remarkable capacity modulate composition activity microbiota, fostering bidirectional relationship that extends beyond mere nutrient processing. This symbiotic interaction holds significant implications human health, particularly cardiometabolic diseases such diabetes mellitus, metabolic-dysfunction-associated steatotic liver disease, cardiovascular disease. Through comprehensive exploration molecular interactions, this narrative review elucidates reciprocal dynamics polyphenols, unveiling novel avenues intervention disorders. By unravelling cross-talk two entities, underscores multifaceted roles overall health pivotal role modulation promising strategy mitigating burden diseases.

Язык: Английский

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Traditional Chinese medicine improved diabetic kidney disease through targeting gut microbiota

Pharmaceutical Biology, Год журнала: 2024, Номер 62(1), С. 423 - 435

Опубликована: Май 17, 2024

Context Diabetic kidney disease (DKD) affects nearly 40% of diabetic patients, often leading to end-stage renal that requires replacement therapies, such as dialysis and transplantation. The gut microbiota, an integral aspect human evolution, plays a crucial role in this condition. Traditional Chinese medicine (TCM) has shown promising outcomes ameliorating DKD by addressing the microbiota.

Язык: Английский

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The role and mechanism of the gut microbiota in the development and treatment of diabetic kidney disease

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Апрель 21, 2023

Diabetic kidney disease (DKD) is a common complication in patients with diabetes mellitus (DM). Increasing evidence suggested that the gut microbiota participates progression of DKD, which involved insulin resistance, renin-angiotensin system (RAS) activation, oxidative stress, inflammation and immunity. Gut microbiota-targeted therapies including dietary fiber, supplementation probiotics or prebiotics, fecal transplantation diabetic agents modulate microbiota, such as metformin, glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium-glucose transporter-2 (SGLT-2) inhibitors. In this review, we summarize most important findings about role pathogenesis DKD application therapies.

Язык: Английский

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The therapeutic effects of marine sulfated polysaccharides on diabetic nephropathy

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 261, С. 129269 - 129269

Опубликована: Янв. 9, 2024

Язык: Английский

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Perspective: Multi-omics and Artificial Intelligence for Personalized Nutritional Management of Diabetes in Patients Undergoing Peritoneal Dialysis

Advances in Nutrition, Год журнала: 2025, Номер unknown, С. 100378 - 100378

Опубликована: Янв. 1, 2025

Managing diabetes in patients on peritoneal dialysis (PD) is challenging due to the combined effects of dietary glucose, glucose from dialysate, and other medical complications. Advances technology that enable continuous biological data collection are transforming traditional management approaches. This review explores how multi-omics technologies artificial intelligence (AI) enhancing this patient population. Continuous monitoring (CGM) offers significant advantages over markers like hemoglobin A1c (HbA1c). Unlike HbA1c, which reflects an average level, CGM provides real-time, dynamic allow clinicians make timely adjustments, leading better glycemic control outcomes. Multi-omics approaches valuable for understanding genetic factors influence susceptibility diabetic complications, particularly those related advanced glycation end-products (AGEs). Identifying polymorphisms modify a patient's response AGEs allows personalized treatments, potentially reducing severity diabetes-related pathologies. Metabolomic analyses effluent also promising, as they help identify early biomarkers metabolic dysregulation. Early detection can lead interventions more tailored treatment strategies, improving long-term care. AI integration revolutionizing PD by processing vast datasets CGM, genetic, microbiome profiles. patterns predict outcomes may be difficult humans detect, enabling highly recommendations diet, medication, management. Furthermore, assist automating interpretation, plans education. Despite promise these technologies, there limitations. require investment infrastructure, training validation studies. Additionally, integrating into clinical practice presents logistical financial challenges. Nevertheless, personalized, data-driven strategies offer great potential patients.

Язык: Английский

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Astragalus Mongholicus Polysaccharides Alleviate Kidney Injury in Rats with Type 2 Diabetes Through Modulation of Oxidation, Inflammation, and Gut Microbiota

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1470 - 1470

Опубликована: Фев. 10, 2025

We aimed to uncover the underlying mechanisms contributing therapeutic efficacy of Astragalus mongholicus Polysaccharides (mAPS) in alleviating diabetic nephropathy (DN). The rat model DN was subjected a high-sugar and high-fat diet (HSHFD) coupled with streptozotocin (STZ) injection. Our findings revealed that mAPS administration decreased fasting blood glucose (FBG), BUN, SCR, UA, MDA levels, while elevating serum GSH, GSH-PX, SOD activities rats (p < 0.05). Furthermore, there notable rise mRNA protein expression renal Nrf-2, GCLC, NQO1, HO-1 post treatment Additionally, supplementation led reduced TLR4, NLRP3, p-NF-κB, TGF-β, Smad4. Concurrently, exerted modulatory effect on gut microbiota, as evidenced by increased abundance Muribaculaceae, Ruminococcus_1, Phascolarctobacterium, Lachnoclostridium-related genera. Spearman correlation analysis illustrated negative association between microbiota (Muribaculaceae, Lachnospiraceae_NK4A136, Clostridiales) levels parameters (BUN, CR, TC, TG). In summary, our data robustly attests potential modulating oxidative stress, inflammation, ultimately resulting improved function rats.

Язык: Английский

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The Role and Mechanism of Gut Microbiota in the Development of Diabetic Nephropathy

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(02), С. 215 - 222

Опубликована: Янв. 1, 2025

Язык: Английский

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Alterations of the gut microbiota in patients with diabetic nephropathy and its association with the renin-angiotensin system

Journal of Diabetes & Metabolic Disorders, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 20, 2025

Язык: Английский

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