Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Апрель 4, 2025
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(20), С. 15352 - 15352
Опубликована: Окт. 19, 2023
Ocular diseases profoundly impact patients’ vision and overall quality of life globally. However, effective ocular drug delivery presents formidable challenges within clinical pharmacology biomaterial science, primarily due to the intricate anatomical physiological barriers unique eye. In this comprehensive review, we aim shed light on features eye, emphasizing natural it administration. Our goal is provide a thorough overview various characteristics inherent each nano-based system. These encompass nanomicelles, nanoparticles, nanosuspensions, nanoemulsions, microemulsions, nanofibers, dendrimers, liposomes, niosomes, nanowafers, contact lenses, hydrogels, microneedles, innovative gene therapy approaches employing techniques. We delve into biology methodology these systems, introducing their applications over past decade. Furthermore, discuss advantages illuminated by recent studies. While systems for ophthalmic formulations are gaining increasing attention, further research imperative address potential safety toxicity concerns.
Язык: Английский
Процитировано
53
Pharmaceutics, Год журнала: 2023, Номер 15(1), С. 205 - 205
Опубликована: Янв. 6, 2023
Therapeutic proteins, including monoclonal antibodies, single chain variable fragment (ScFv), crystallizable (Fc), and antigen binding (Fab), have accounted for one-third of all drugs on the world market. In particular, these medicines been widely used in ocular therapies treatment various diseases, such as age-related macular degeneration, corneal neovascularization, diabetic retinopathy, retinal vein occlusion. However, formulation biomacromolecules is challenging due to their high molecular weight, complex structure, instability, short half-life, enzymatic degradation, immunogenicity, which leads failure therapies. Various efforts made overcome barriers, providing effective delivery therapeutic altering protein structure or it new systems. These strategies are not only cost-effective beneficial patients but also shown allow fewer drug side effects. this review, we discuss several factors that affect design formulations proteins tissues, use injectable micro/nanocarriers, hydrogels, implants, iontophoresis, cell-based therapy, combination techniques. addition, other approaches briefly discussed, related structural modification improving bioavailability posterior segments eye without affecting stability. Future research should be conducted toward development more effective, stable, noninvasive, proteins. insights into preclinical clinical translation needed.
Язык: Английский
Процитировано
24
AAPS PharmSciTech, Год журнала: 2024, Номер 25(2)
Опубликована: Фев. 1, 2024
Abstract Cyclosporine A (CsA) is a cyclic peptide immunosuppressant drug that beneficial in the treatment of various ocular diseases. However, its bioavailability posterior eye limited due to poor aqueous solubility. Conventional CsA formulations such as solution or emulsion permeate poorly across static and dynamic barriers eye. Dissolvable microneedle (MN)-based patches can be used overcome barrier properties and, thus, enhance CsA-loaded dissolvable MN were fabricated using polyvinylpyrrolidone (PVP) characterized for uniformity sharpness SEM. Further characterization failure force, penetration depth analyzed texture analyzer. Finally, dissolution time, ex vivo permeation, distribution cyclosporine determined isolated porcine eyes. PVP MNs sharp, uniform with good mechanical properties, dissolved within 5 min. Ocular whole perfusion model showed significant increase levels segment tissues compared topically applied ophthalmic (Restasis®) ( P < 0.001). Dissolving prepared, arrays deliver back offering potential treating inflammatory
Язык: Английский
Процитировано
10
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 296, С. 139726 - 139726
Опубликована: Янв. 11, 2025
Язык: Английский
Процитировано
2
Journal of Ocular Pharmacology and Therapeutics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
Posterior segment ocular diseases, such as diabetic retinopathy, age-related macular degeneration, and retinal vein occlusion, are leading causes of vision impairment blindness worldwide. Effective management these conditions remains a formidable challenge due to the unique anatomical physiological barriers eye, including blood-retinal barrier rapid drug clearance mechanisms. To address hurdles, nanostructured delivery systems proposed overcome barriers, target retina, enhance permeation while ensuring controlled release. Traditional therapeutic approaches, intravitreal injections, pose significant drawbacks, patient discomfort, poor compliance, potential complications. Therefore, understanding physiology mechanism eye could aid in design novel formulations that be noninvasive deliver drugs reach site is pivotal for effective treatment strategies. This review focuses on recent advances formulation strategies posterior delivery, highlighting their limitations. Furthermore, nanocarrier in-situ gel, niosomes, hydrogels, dendrimers, liposomes, nanoparticles, nanoemulsions more effectively selectively explored, supplemented with illustrative examples, figures, tables. aims provide insights into current state emphasizing need interdisciplinary approaches develop patient-centric, minimally invasive, solutions.
Язык: Английский
Процитировано
1
Methods, Год журнала: 2025, Номер 235, С. 100 - 117
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
1
The Ocular Surface, Год журнала: 2023, Номер 30, С. 3 - 13
Опубликована: Авг. 3, 2023
Язык: Английский
Процитировано
20
Pharmaceutics, Год журнала: 2023, Номер 15(7), С. 1862 - 1862
Опубликована: Июль 1, 2023
Innovative and new drug delivery systems (DDSs) have recently been developed to vehicle treatments drugs the ocular posterior segment retina. New formulations technological developments, such as nanotechnology, novel matrices, non-traditional treatment strategies, open perspectives in this field. The aim of mini-review is highlight promising strategies reported current literature based on innovative routes overcome anatomical physiological barriers vitreoretinal structures. paper also describes challenges finding appropriate pertinent that provide safety efficacy problems related patient compliance, acceptability, effectiveness, sustained delivery. clinical application these experimental approaches can help pave way for standardizing use DDSs developing enhanced personalized therapeutic options pathologies.
Язык: Английский
Процитировано
18
Hardware, Год журнала: 2024, Номер 2(1), С. 1 - 32
Опубликована: Янв. 26, 2024
Three-dimensional (3D) printing is a process in which materials are added together layer-by-layer manner to construct customized products. Many different techniques of 3D exist, vary used, cost, advantages, and drawbacks. Medicine increasingly benefiting from this transformative technology, the field ophthalmology no exception. The possible applications eyecare vast have been explored literature, such as 3D-printed ocular prosthetics, orbital implants, educational anatomical models, well surgical planning training. Novel drug-delivery platforms also emerged because printing, offering improved treatment modalities for several pathologies. Innovative research bioprinting viable tissues, including cornea, retina, conjunctiva, presenting an avenue regenerative ophthalmic therapies future. Although further development capabilities suitable required, represents powerful tool enhancing eye health.
Язык: Английский
Процитировано
8
Gels, Год журнала: 2024, Номер 10(1), С. 65 - 65
Опубликована: Янв. 15, 2024
Microneedles are of great interest in diverse fields, including cosmetics, drug delivery systems, chromatography, and biological sensing for disease diagnosis. Self-dissolving ultrafine microneedles pure sodium hyaluronate hydrogels were fabricated using a UV-curing TiO
Язык: Английский
Процитировано
7