Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 155938 - 155938
Published: Sept. 1, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15352 - 15352
Published: Oct. 19, 2023
Ocular diseases profoundly impact patients’ vision and overall quality of life globally. However, effective ocular drug delivery presents formidable challenges within clinical pharmacology biomaterial science, primarily due to the intricate anatomical physiological barriers unique eye. In this comprehensive review, we aim shed light on features eye, emphasizing natural it administration. Our goal is provide a thorough overview various characteristics inherent each nano-based system. These encompass nanomicelles, nanoparticles, nanosuspensions, nanoemulsions, microemulsions, nanofibers, dendrimers, liposomes, niosomes, nanowafers, contact lenses, hydrogels, microneedles, innovative gene therapy approaches employing techniques. We delve into biology methodology these systems, introducing their applications over past decade. Furthermore, discuss advantages illuminated by recent studies. While systems for ophthalmic formulations are gaining increasing attention, further research imperative address potential safety toxicity concerns.
Language: Английский
Citations
50
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 205 - 205
Published: Jan. 6, 2023
Therapeutic proteins, including monoclonal antibodies, single chain variable fragment (ScFv), crystallizable (Fc), and antigen binding (Fab), have accounted for one-third of all drugs on the world market. In particular, these medicines been widely used in ocular therapies treatment various diseases, such as age-related macular degeneration, corneal neovascularization, diabetic retinopathy, retinal vein occlusion. However, formulation biomacromolecules is challenging due to their high molecular weight, complex structure, instability, short half-life, enzymatic degradation, immunogenicity, which leads failure therapies. Various efforts made overcome barriers, providing effective delivery therapeutic altering protein structure or it new systems. These strategies are not only cost-effective beneficial patients but also shown allow fewer drug side effects. this review, we discuss several factors that affect design formulations proteins tissues, use injectable micro/nanocarriers, hydrogels, implants, iontophoresis, cell-based therapy, combination techniques. addition, other approaches briefly discussed, related structural modification improving bioavailability posterior segments eye without affecting stability. Future research should be conducted toward development more effective, stable, noninvasive, proteins. insights into preclinical clinical translation needed.
Language: Английский
Citations
24
AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(2)
Published: Feb. 1, 2024
Abstract Cyclosporine A (CsA) is a cyclic peptide immunosuppressant drug that beneficial in the treatment of various ocular diseases. However, its bioavailability posterior eye limited due to poor aqueous solubility. Conventional CsA formulations such as solution or emulsion permeate poorly across static and dynamic barriers eye. Dissolvable microneedle (MN)-based patches can be used overcome barrier properties and, thus, enhance CsA-loaded dissolvable MN were fabricated using polyvinylpyrrolidone (PVP) characterized for uniformity sharpness SEM. Further characterization failure force, penetration depth analyzed texture analyzer. Finally, dissolution time, ex vivo permeation, distribution cyclosporine determined isolated porcine eyes. PVP MNs sharp, uniform with good mechanical properties, dissolved within 5 min. Ocular whole perfusion model showed significant increase levels segment tissues compared topically applied ophthalmic (Restasis®) ( P < 0.001). Dissolving prepared, arrays deliver back offering potential treating inflammatory
Language: Английский
Citations
9
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 296, P. 139726 - 139726
Published: Jan. 11, 2025
Language: Английский
Citations
1
Methods, Journal Year: 2025, Volume and Issue: 235, P. 100 - 117
Published: Feb. 13, 2025
Language: Английский
Citations
1
The Ocular Surface, Journal Year: 2023, Volume and Issue: 30, P. 3 - 13
Published: Aug. 3, 2023
Language: Английский
Citations
19
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1862 - 1862
Published: July 1, 2023
Innovative and new drug delivery systems (DDSs) have recently been developed to vehicle treatments drugs the ocular posterior segment retina. New formulations technological developments, such as nanotechnology, novel matrices, non-traditional treatment strategies, open perspectives in this field. The aim of mini-review is highlight promising strategies reported current literature based on innovative routes overcome anatomical physiological barriers vitreoretinal structures. paper also describes challenges finding appropriate pertinent that provide safety efficacy problems related patient compliance, acceptability, effectiveness, sustained delivery. clinical application these experimental approaches can help pave way for standardizing use DDSs developing enhanced personalized therapeutic options pathologies.
Language: Английский
Citations
17
Hardware, Journal Year: 2024, Volume and Issue: 2(1), P. 1 - 32
Published: Jan. 26, 2024
Three-dimensional (3D) printing is a process in which materials are added together layer-by-layer manner to construct customized products. Many different techniques of 3D exist, vary used, cost, advantages, and drawbacks. Medicine increasingly benefiting from this transformative technology, the field ophthalmology no exception. The possible applications eyecare vast have been explored literature, such as 3D-printed ocular prosthetics, orbital implants, educational anatomical models, well surgical planning training. Novel drug-delivery platforms also emerged because printing, offering improved treatment modalities for several pathologies. Innovative research bioprinting viable tissues, including cornea, retina, conjunctiva, presenting an avenue regenerative ophthalmic therapies future. Although further development capabilities suitable required, represents powerful tool enhancing eye health.
Language: Английский
Citations
8
Gels, Journal Year: 2024, Volume and Issue: 10(1), P. 65 - 65
Published: Jan. 15, 2024
Microneedles are of great interest in diverse fields, including cosmetics, drug delivery systems, chromatography, and biological sensing for disease diagnosis. Self-dissolving ultrafine microneedles pure sodium hyaluronate hydrogels were fabricated using a UV-curing TiO
Language: Английский
Citations
7
European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 197, P. 114209 - 114209
Published: Feb. 7, 2024
Ocular drug delivery is challenging due to the presence of tissue barriers and clearance mechanisms. Most widely used topical formulations need frequent application because poor permeability, short retention, low bioavailability. Invasive intraocular injections implants that deliver drugs at target site are associated with infections, inflammation, even vision loss post-use. These gaps can be addressed by a platform efficiently minimal damage. Microneedles were introduced as for overcoming dermal After successful clinical transition microneedles in transdermal delivery, they now being extensively studied ocular applications. The attributes minimally invasive capability wide range therapeutics make an attractive candidate delivery. current manuscript provides detailed overview recent advancements field use. This paper reviews research focusing on polymeric their pharmaceutical biopharmaceutical properties. A brief discussion about translation regulatory concerns also covered. multitude articles supports fact potential, ophthalmic
Language: Английский
Citations
7