Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Апрель 4, 2025
Язык: Английский
European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2024, Номер 197, С. 114209 - 114209
Опубликована: Фев. 7, 2024
Ocular drug delivery is challenging due to the presence of tissue barriers and clearance mechanisms. Most widely used topical formulations need frequent application because poor permeability, short retention, low bioavailability. Invasive intraocular injections implants that deliver drugs at target site are associated with infections, inflammation, even vision loss post-use. These gaps can be addressed by a platform efficiently minimal damage. Microneedles were introduced as for overcoming dermal After successful clinical transition microneedles in transdermal delivery, they now being extensively studied ocular applications. The attributes minimally invasive capability wide range therapeutics make an attractive candidate delivery. current manuscript provides detailed overview recent advancements field use. This paper reviews research focusing on polymeric their pharmaceutical biopharmaceutical properties. A brief discussion about translation regulatory concerns also covered. multitude articles supports fact potential, ophthalmic
Язык: Английский
Процитировано
7
Cell Reports Physical Science, Год журнала: 2023, Номер 4(6), С. 101430 - 101430
Опубликована: Май 26, 2023
Seasonal influenza A viruses continue to pose a public health threat, and current vaccines are not sufficiently effective because of virus mutation. There is an urgent need develop broad-protection vaccine. Our team previously designed potential universal hemagglutinin (HA) sequences against seasonal H1N1 H3N2 (mH1 mH3, respectively) through mosaic strategy. In this study, we construct DNA by linking the antigens mH1 mH3 via internal ribosome entry sites then wrap with deoxycholic acid-modified polyetherimide form nanovaccines. microneedle used deliver nanovaccines, data show that better cellular cross-reactivity protective immunity induced compared intramuscular injection method. These results suggest microneedle-based delivery nanovaccines could be promising platform for development
Язык: Английский
Процитировано
15
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(20), С. 25637 - 25651
Опубликована: Май 10, 2024
Fluconazole (FNL) is one of the first-line treatments for fungal keratitis as it an effective broad-spectrum antimicrobial commonly administered orally or topically. However, FNL has a very low water solubility, limiting its drug formulation, therapeutic application, and bioavailability through tissues. To overcome these limitations, this study aimed to develop inclusion complexes (FNL-IC) with cyclodextrin (α-cyclodextrin, sulfobutylether-β-cyclodextrin, hydroxypropyl-γ cyclodextrin) incorporate into dissolvable microneedle (DMN) system improve solubility penetration. FNL-IC was evaluated saturation Fourier transform infrared spectroscopy, differential scanning calorimetry, in vitro release, minimum inhibitory concentration, fungicidal time-killing assay. DMN-FNL-IC mechanical insertion properties, surface pH, moisture absorption ability, vapor transmission, content recovery. Moreover, ocular kinetic, ex vivo antimicrobial, antifungal, chorioallantoic membrane (HET-CAM) assays were conducted assess overall performance formulation. Mechanical strength properties revealed that great properties. The release significantly improved, exhibiting 9-fold increase compared pure FNL. antifungal activity showed significant inhibition Candida albicans from 6.54 0.73 log cfu/mL 100–0.94%. In numbers colonies 0.87 ± 0.13 (F2), 4.76 0.26 (FNL eye drops), 3.89 0.24 ointments), 8.04 0.58 (control) effectiveness DMN preparations against other standard commercial preparations. HET-CAM assay (F2) did not show any vascular damage. Finally, combination developed appropriately delivery FNL, which safe increased keratitis.
Язык: Английский
Процитировано
6
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Май 13, 2024
Nanozymes, characterized by their nanoscale size and enzyme-like catalytic activities, exhibit diverse therapeutic potentials, including anti-oxidative, anti-inflammatory, anti-microbial, anti-angiogenic effects. These properties make them highly valuable in nanomedicine, particularly ocular therapy, bypassing the need for systemic delivery. Nanozymes show significant promise tackling multi-factored diseases, those influenced oxidation inflammation, like dry eye disease, age-related macular degeneration. Their small size, coupled with ease of modification integration into soft materials, facilitates effective penetration barriers, thereby enabling targeted or prolonged therapy within eye. This review is dedicated to exploring diseases that are intricately linked shedding light on role nanozymes managing these conditions. Additionally, recent studies elucidating advanced applications therapeutics, along materials disease management, discussed. Finally, this outlines directions future investigations aimed at bridging gap between nanozyme research clinical applications.
Язык: Английский
Процитировано
6
Journal of Drug Delivery Science and Technology, Год журнала: 2022, Номер 80, С. 104111 - 104111
Опубликована: Дек. 27, 2022
Язык: Английский
Процитировано
23
Pharmaceutics, Год журнала: 2024, Номер 16(10), С. 1325 - 1325
Опубликована: Окт. 12, 2024
Eye disorders affect a substantial portion of the global population, yet availability efficacious ophthalmic drug products remains limited. This can be partly ascribed to number factors: (1) inadequate understanding physiological barriers, treatment strategies, and polymer properties, delivery systems; (2) challenges in effectively delivering drugs anterior posterior segments eye due anatomical constraints; (3) manufacturing regulatory hurdles ocular product development. The present review discusses innovative treatments, encompassing implants, liposomes, nanoparticles, nanomicelles, microparticles, iontophoresis, situ gels, contact lenses, microneedles, hydrogels, bispecific antibodies, gene strategies. Furthermore, this also introduces advanced technologies such as 3D printing hot-melt extrusion (HME), aimed at improving bioavailability, reducing therapeutic dosages side effects, facilitating design personalized dosage forms, well enhancing patient compliance. comprehensive lastly offers insights into digital healthcare, market trends, industry perspectives pertaining
Язык: Английский
Процитировано
5
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 91, С. 105273 - 105273
Опубликована: Дек. 18, 2023
Язык: Английский
Процитировано
10
Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 155938 - 155938
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
4
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер unknown
Опубликована: Сен. 23, 2024
3D printing of microneedles (μNDs) for transdermal therapy has the potential to enable patient personalization based on target disease, site application, and dosage requirements. To convert this concept reality, it is necessary that technology can deliver high resolution, an affordable cost, large print volumes. With introduction benchtop 4K 8K printers, now possible manufacture medical devices like μNDs at sufficient resolution low cost. In research, we systematically optimized design parameters such as resin viscosity, angle, layer height, curing time generate customizable μNDs. We have also developed innovative coating microtank device optimize method. applied development novel established NAD
Язык: Английский
Процитировано
4
Pharmaceutics, Год журнала: 2024, Номер 16(11), С. 1398 - 1398
Опубликована: Окт. 30, 2024
Microneedle technology revolutionizes ocular drug delivery by addressing challenges in treating diseases. This review explores its potential impact, recent advancements, and clinical uses. minimally invasive technique offers precise control of to the eye, with various microneedle types showing penetrate barriers cornea sclera, ensuring effective delivery. Recent advancements have improved safety efficacy, offering sustained controlled for conditions like age-related macular degeneration glaucoma. While promising, such as regulatory long-term biocompatibility persist. Overcoming these through interdisciplinary research is crucial. Ultimately, presents a revolutionary method significantly enhance disease treatment, marking new era eye care.
Язык: Английский
Процитировано
3