Multilayered “SMART” hydrogel systems for on-site drug delivery applications

Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 80, P. 104111 - 104111

Published: Dec. 27, 2022

Language: Английский

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A microneedle-based delivery system for broad-protection seasonal influenza A DNA nanovaccines

Cell Reports Physical Science, Journal Year: 2023, Volume and Issue: 4(6), P. 101430 - 101430

Published: May 26, 2023

Seasonal influenza A viruses continue to pose a public health threat, and current vaccines are not sufficiently effective because of virus mutation. There is an urgent need develop broad-protection vaccine. Our team previously designed potential universal hemagglutinin (HA) sequences against seasonal H1N1 H3N2 (mH1 mH3, respectively) through mosaic strategy. In this study, we construct DNA by linking the antigens mH1 mH3 via internal ribosome entry sites then wrap with deoxycholic acid-modified polyetherimide form nanovaccines. microneedle used deliver nanovaccines, data show that better cellular cross-reactivity protective immunity induced compared intramuscular injection method. These results suggest microneedle-based delivery nanovaccines could be promising platform for development

Language: Английский

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Incorporation of Inclusion Complexes in the Dissolvable Microneedle Ocular Patch System for the Efficiency of Fluconazole in the Therapy of Fungal Keratitis

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(20), P. 25637 - 25651

Published: May 10, 2024

Fluconazole (FNL) is one of the first-line treatments for fungal keratitis as it an effective broad-spectrum antimicrobial commonly administered orally or topically. However, FNL has a very low water solubility, limiting its drug formulation, therapeutic application, and bioavailability through tissues. To overcome these limitations, this study aimed to develop inclusion complexes (FNL-IC) with cyclodextrin (α-cyclodextrin, sulfobutylether-β-cyclodextrin, hydroxypropyl-γ cyclodextrin) incorporate into dissolvable microneedle (DMN) system improve solubility penetration. FNL-IC was evaluated saturation Fourier transform infrared spectroscopy, differential scanning calorimetry, in vitro release, minimum inhibitory concentration, fungicidal time-killing assay. DMN-FNL-IC mechanical insertion properties, surface pH, moisture absorption ability, vapor transmission, content recovery. Moreover, ocular kinetic, ex vivo antimicrobial, antifungal, chorioallantoic membrane (HET-CAM) assays were conducted assess overall performance formulation. Mechanical strength properties revealed that great properties. The release significantly improved, exhibiting 9-fold increase compared pure FNL. antifungal activity showed significant inhibition Candida albicans from 6.54 0.73 log cfu/mL 100–0.94%. In numbers colonies 0.87 ± 0.13 (F2), 4.76 0.26 (FNL eye drops), 3.89 0.24 ointments), 8.04 0.58 (control) effectiveness DMN preparations against other standard commercial preparations. HET-CAM assay (F2) did not show any vascular damage. Finally, combination developed appropriately delivery FNL, which safe increased keratitis.

Language: Английский

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Nanozymes for Treating Ocular Diseases

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 13, 2024

Nanozymes, characterized by their nanoscale size and enzyme-like catalytic activities, exhibit diverse therapeutic potentials, including anti-oxidative, anti-inflammatory, anti-microbial, anti-angiogenic effects. These properties make them highly valuable in nanomedicine, particularly ocular therapy, bypassing the need for systemic delivery. Nanozymes show significant promise tackling multi-factored diseases, those influenced oxidation inflammation, like dry eye disease, age-related macular degeneration. Their small size, coupled with ease of modification integration into soft materials, facilitates effective penetration barriers, thereby enabling targeted or prolonged therapy within eye. This review is dedicated to exploring diseases that are intricately linked shedding light on role nanozymes managing these conditions. Additionally, recent studies elucidating advanced applications therapeutics, along materials disease management, discussed. Finally, this outlines directions future investigations aimed at bridging gap between nanozyme research clinical applications.

Language: Английский

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Advancements in Ocular Therapy: A Review of Emerging Drug Delivery Approaches and Pharmaceutical Technologies

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1325 - 1325

Published: Oct. 12, 2024

Eye disorders affect a substantial portion of the global population, yet availability efficacious ophthalmic drug products remains limited. This can be partly ascribed to number factors: (1) inadequate understanding physiological barriers, treatment strategies, and polymer properties, delivery systems; (2) challenges in effectively delivering drugs anterior posterior segments eye due anatomical constraints; (3) manufacturing regulatory hurdles ocular product development. The present review discusses innovative treatments, encompassing implants, liposomes, nanoparticles, nanomicelles, microparticles, iontophoresis, situ gels, contact lenses, microneedles, hydrogels, bispecific antibodies, gene strategies. Furthermore, this also introduces advanced technologies such as 3D printing hot-melt extrusion (HME), aimed at improving bioavailability, reducing therapeutic dosages side effects, facilitating design personalized dosage forms, well enhancing patient compliance. comprehensive lastly offers insights into digital healthcare, market trends, industry perspectives pertaining

Language: Английский

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3D Printed Microneedles for the Transdermal Delivery of NAD⁺ Precursor: Toward Personalization of Skin Delivery

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

3D printing of microneedles (μNDs) for transdermal therapy has the potential to enable patient personalization based on target disease, site application, and dosage requirements. To convert this concept reality, it is necessary that technology can deliver high resolution, an affordable cost, large print volumes. With introduction benchtop 4K 8K printers, now possible manufacture medical devices like μNDs at sufficient resolution low cost. In research, we systematically optimized design parameters such as resin viscosity, angle, layer height, curing time generate customizable μNDs. We have also developed innovative coating microtank device optimize method. applied development novel established NAD

Language: Английский

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Promising role of microneedles in therapeutic and biomedical applications

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 91, P. 105273 - 105273

Published: Dec. 18, 2023

Language: Английский

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Nanotechnology Based On Management of Glaucoma: Review

INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT, Journal Year: 2025, Volume and Issue: 09(01), P. 1 - 9

Published: Jan. 9, 2025

Nanotechnology has transformed medical disciplines, creating tools and materials for molecular control repair of human biological systems. It can improve ocular bioavailability drug residence in glaucoma treatment, increase surgical success, minimize postoperative scarring. Further research is needed to fully understand nanotechnology's therapeutic effects. The purpose this review compile the on nanotechnology advancements, with a focus devices used treat. Glaucoma leading cause blindness, affecting delicate eye. Traditional eye therapies, such as implants, drops, injections, face complications due low or adverse Nanoscience technology offers novel approach disease modifying active molecules react nanocarriers. This explores diagnostic prospects ophthalmology, specifically glaucoma, focusing efficiency, safety, potential applications glaucoma.

Language: Английский

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Formulation Advances in Posterior Segment Ocular Drug Delivery

Journal of Ocular Pharmacology and Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Posterior segment ocular diseases, such as diabetic retinopathy, age-related macular degeneration, and retinal vein occlusion, are leading causes of vision impairment blindness worldwide. Effective management these conditions remains a formidable challenge due to the unique anatomical physiological barriers eye, including blood-retinal barrier rapid drug clearance mechanisms. To address hurdles, nanostructured delivery systems proposed overcome barriers, target retina, enhance permeation while ensuring controlled release. Traditional therapeutic approaches, intravitreal injections, pose significant drawbacks, patient discomfort, poor compliance, potential complications. Therefore, understanding physiology mechanism eye could aid in design novel formulations that be noninvasive deliver drugs reach site is pivotal for effective treatment strategies. This review focuses on recent advances formulation strategies posterior delivery, highlighting their limitations. Furthermore, nanocarrier in-situ gel, niosomes, hydrogels, dendrimers, liposomes, nanoparticles, nanoemulsions more effectively selectively explored, supplemented with illustrative examples, figures, tables. aims provide insights into current state emphasizing need interdisciplinary approaches develop patient-centric, minimally invasive, solutions.

Language: Английский

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Transmucosal drug delivery: prospects, challenges, advances, and future directions

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Introduction Traditional administration routes have limitations including first-pass metabolism and gastrointestinal degradation for sensitive drugs (oral) pain associated with parenteral injections, which also require trained personnel refrigeration, making them expensive. This has increased interest in alternative routes, mucosal surfaces being of high priority.

Language: Английский

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