Design, synthesis, anti-inflammatory evaluation, and molecular docking studies of novel quinazoline-4(3H)-one-2-carbothioamide derivatives
RSC Advances,
Год журнала:
2025,
Номер
15(4), С. 2850 - 2861
Опубликована: Янв. 1, 2025
In
this
study,
we
reported
the
design,
synthesis,
anti-inflammatory
evaluation,
and
molecular
docking
studies
of
novel
quinazoline-4(
3H
)-one-2-carbothioamide
derivatives.
Язык: Английский
Dichloroacetylene Formation from Azoles in the UV/Chlorine Process
ACS ES&T Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
Язык: Английский
Iodine and DMSO as Surrogate of Hazardous Metal and Non‐Metal Reagents in Organic Synthesis
ChemistrySelect,
Год журнала:
2024,
Номер
9(3)
Опубликована: Янв. 17, 2024
Abstract
Organic
synthesis
involves
the
production
of
important
chemical
structures
using
scalable
and
cost‐effective
methods
that
are
also
environmentally
friendly.
In
this
review,
a
detailed
analysis
use
iodine
DMSO
in
various
synthetic
routes
for
preparation
valuable
targets
presented.
These
reduce
acceptance
on
expensive
additives
reagents,
offer
more
sustainable
solution
these
scaffolds.
Язык: Английский
Multicomponent synthesis of novel functionalized spiroindenopyridotriazine-4H-pyrans
RSC Advances,
Год журнала:
2025,
Номер
15(9), С. 7103 - 7110
Опубликована: Янв. 1, 2025
A
very
convenient
one-pot
method
for
the
synthesis
of
new
biologically
active
compounds,
spiro-4H-pyran
derivatives,
has
been
developed.
This
approach,
enables
incorporation
three
pharmacophoric
cores:
pyran,
pyridine
and
triazine
scaffolds,
within
a
single
molecular
skeleton
using
an
efficient
sequential
multicomponent
reaction.
The
starting
materials
include
ninhydrin,
cyanoacetohydrazide,
ethyl
cyanoacetate,
aromatic
aldehydes,
pyrazolone
malononitrile.
In
this
process,
spiropyran
derivatives
were
produced
with
high
efficiency
through
consecutive
reactions.
first
step
involves
1,6-diaminopyridinone
via
three-component
approach
readily
available
materials.
second
step,
pyridotriazine,
occurs
in
domino
way
without
need
to
separate
intermediate
product
step.
Finally,
third
offers
several
advantages,
including
fast
simple
purification
products,
use
safe
solvents,
no
metallic
toxic
catalysts,
atomic
economy
excellent
chemoselectivity
Язык: Английский
Exploitation of pyrazole C-3/5 carbaldehydes towards the development of therapeutically valuable scaffolds: a review
Chemical Papers,
Год журнала:
2024,
Номер
78(11), С. 6287 - 6314
Опубликована: Май 31, 2024
Язык: Английский
Easy Access to α-Ketothioamides via Oxidative Amidation of Bunte Salts Using Electrolysis or Hypervalent Iodine
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(18), С. 13329 - 13337
Опубликована: Сен. 10, 2024
Two
new
protocols
leveraging
electrochemical
and
hypervalent
iodine-mediated
synthesis
of
α-ketothioamides
have
been
developed
by
using
easily
accessible
cost-effective
Bunte
salts
secondary
amines.
The
methods
are
efficient,
simple,
straightforward,
showcase
the
formation
C-N
bonds
across
diverse
substrates
under
ambient
conditions.
Язык: Английский
Synthesis of pyrazolo-azepinone derivatives via Morita–Baylis–Hillman chemistry as potent antimicrobial agents
New Journal of Chemistry,
Год журнала:
2023,
Номер
48(6), С. 2608 - 2623
Опубликована: Дек. 26, 2023
A
new
MBH
reaction
mediated
approach
has
been
unfolded
toward
an
efficient
synthesis
of
pyrazolo[3,4-
c
]azepinone
derivatives
as
potential
antimicrobial
agents.
Язык: Английский
Facile synthesis of substituted 2-aroylbenzo[b]thiophen-3-ols to form novel triazole hybrids using click chemistry
RSC Advances,
Год журнала:
2024,
Номер
14(15), С. 10270 - 10279
Опубликована: Янв. 1, 2024
In
the
presence
of
triethylamine,
2-mercaptobenzoic
acid
(6)
reacts
with
aryl
bromomethyl
ketones
(8)
to
produce
benzothiophenes
(5),
which
can
be
subjected
a
click
reaction
construct
benzothiophene-triazole
hybrids
(14).
Язык: Английский
An efficient and practical approach for the synthesis of indoloquinolines and indolo/pyrroloquinoxalines via a Cu-catalyzed Ugi-C/Ugi-N-arylation sequence
RSC Advances,
Год журнала:
2024,
Номер
14(26), С. 18271 - 18276
Опубликована: Янв. 1, 2024
A
Cu-catalyzed
tandem
transformation
of
Ugi
adducts
through
CH/NH
bond
functionalization
reactions
was
reported
for
synthesizing
a
broad
spectrum
indolo/pyrrolo-[1,2-
]quinoxaline
and
indolo[2,3-
c
]quinoline
derivatives
in
good
to
excellent
yields.
Язык: Английский
Design of Synthetic Strategies towards Sulfur Containing Scaffolds
Synthesis,
Год журнала:
2024,
Номер
57(02), С. 275 - 295
Опубликована: Авг. 28, 2024
Abstract
The
utilization
of
sulfur
heterocycles
in
organic
synthesis
has
attracted
significant
attention
due
to
their
wide-ranging
applications.
This
review
showcases
the
syntheses
diverse
embedded
with
amino
acid
derivatives,
polycycles,
spirocycles,
cyclophanes,
and
other
complex
scaffolds.
reported
methods
extend
beyond
compound
highlight
use
different
reagents
for
constructing
heterocycles.
Review
also
discusses
utility
a
variety
sulfur-containing
starting
materials
generation
target
molecules.
1
Introduction
2
Potassium
Thioacetate
3
Thiazolidine-2,4-dione
4
Rhodanines
5
Sodium
Sulfide
6
Thiotetronic
Acid
7
Thiadiazoles
8
Thiophene
9
Rongalite
10
Sulfur
Dioxide
11
Divinyl
Sulfone
12
Heterocycles
Based
on
Boronic
Acids
13
Miscellaneous
14
Summary
Язык: Английский