Design of Synthetic Strategies towards Sulfur Containing Scaffolds DOI
Sambasivarao Kotha, Priti Khedkar

Synthesis, Journal Year: 2024, Volume and Issue: 57(02), P. 275 - 295

Published: Aug. 28, 2024

Abstract The utilization of sulfur heterocycles in organic synthesis has attracted significant attention due to their wide-ranging applications. This review showcases the syntheses diverse embedded with amino acid derivatives, polycycles, spirocycles, cyclophanes, and other complex scaffolds. reported methods extend beyond compound highlight use different reagents for constructing heterocycles. Review also discusses utility a variety sulfur-containing starting materials generation target molecules. 1 Introduction 2 Potassium Thioacetate 3 Thiazolidine-2,4-dione 4 Rhodanines 5 Sodium Sulfide 6 Thiotetronic Acid 7 Thiadiazoles 8 Thiophene 9 Rongalite 10 Sulfur Dioxide 11 Divinyl Sulfone 12 Heterocycles Based on Boronic Acids 13 Miscellaneous 14 Summary

Language: Английский

Design, synthesis, anti-inflammatory evaluation, and molecular docking studies of novel quinazoline-4(3H)-one-2-carbothioamide derivatives DOI Creative Commons

Le Thanh Hang Nguyen,

Vũ Đình Hoàng, Phạm Minh Quân

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(4), P. 2850 - 2861

Published: Jan. 1, 2025

In this study, we reported the design, synthesis, anti-inflammatory evaluation, and molecular docking studies of novel quinazoline-4( 3H )-one-2-carbothioamide derivatives.

Language: Английский

Citations

0
Dichloroacetylene Formation from Azoles in the UV/Chlorine Process DOI

Baoqiang Hao,

Renyuan Zhang,

Genye He

et al.

ACS ES&T Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Language: Английский

Citations

0
Iodine and DMSO as Surrogate of Hazardous Metal and Non‐Metal Reagents in Organic Synthesis DOI
Reetu Reetu,

Sangita Kalita,

Sonali Prava Dash

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(3)

Published: Jan. 17, 2024

Abstract Organic synthesis involves the production of important chemical structures using scalable and cost‐effective methods that are also environmentally friendly. In this review, a detailed analysis use iodine DMSO in various synthetic routes for preparation valuable targets presented. These reduce acceptance on expensive additives reagents, offer more sustainable solution these scaffolds.

Language: Английский

Citations

3
Multicomponent synthesis of novel functionalized spiroindenopyridotriazine-4H-pyrans DOI Creative Commons

Atefeh Homaee,

Mohammad Bayat,

Hajar Hosseini

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(9), P. 7103 - 7110

Published: Jan. 1, 2025

A very convenient one-pot method for the synthesis of new biologically active compounds, spiro-4H-pyran derivatives, has been developed. This approach, enables incorporation three pharmacophoric cores: pyran, pyridine and triazine scaffolds, within a single molecular skeleton using an efficient sequential multicomponent reaction. The starting materials include ninhydrin, cyanoacetohydrazide, ethyl cyanoacetate, aromatic aldehydes, pyrazolone malononitrile. In this process, spiropyran derivatives were produced with high efficiency through consecutive reactions. first step involves 1,6-diaminopyridinone via three-component approach readily available materials. second step, pyridotriazine, occurs in domino way without need to separate intermediate product step. Finally, third offers several advantages, including fast simple purification products, use safe solvents, no metallic toxic catalysts, atomic economy excellent chemoselectivity

Language: Английский

Citations

0
Exploitation of pyrazole C-3/5 carbaldehydes towards the development of therapeutically valuable scaffolds: a review DOI
Shubham Sharma, Pooja Sharma, Virender Singh

et al.

Chemical Papers, Journal Year: 2024, Volume and Issue: 78(11), P. 6287 - 6314

Published: May 31, 2024

Language: Английский

Citations

2
Easy Access to α-Ketothioamides via Oxidative Amidation of Bunte Salts Using Electrolysis or Hypervalent Iodine DOI

Neha Sharma Prabhakar,

Kaushal Kishor,

Krishna Nand Singh

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(18), P. 13329 - 13337

Published: Sept. 10, 2024

Two new protocols leveraging electrochemical and hypervalent iodine-mediated synthesis of α-ketothioamides have been developed by using easily accessible cost-effective Bunte salts secondary amines. The methods are efficient, simple, straightforward, showcase the formation C-N bonds across diverse substrates under ambient conditions.

Language: Английский

Citations

2
Synthesis of pyrazolo-azepinone derivatives via Morita–Baylis–Hillman chemistry as potent antimicrobial agents DOI
Nisha Devi, Virender Singh,

Arun Singh Pathania

et al.

New Journal of Chemistry, Journal Year: 2023, Volume and Issue: 48(6), P. 2608 - 2623

Published: Dec. 26, 2023

A new MBH reaction mediated approach has been unfolded toward an efficient synthesis of pyrazolo[3,4- c ]azepinone derivatives as potential antimicrobial agents.

Language: Английский

Citations

4
Facile synthesis of substituted 2-aroylbenzo[b]thiophen-3-ols to form novel triazole hybrids using click chemistry DOI Creative Commons

Asma Mukhtar,

Arif Hussain, Faiza Younas

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(15), P. 10270 - 10279

Published: Jan. 1, 2024

In the presence of triethylamine, 2-mercaptobenzoic acid (6) reacts with aryl bromomethyl ketones (8) to produce benzothiophenes (5), which can be subjected a click reaction construct benzothiophene-triazole hybrids (14).

Language: Английский

Citations

1
An efficient and practical approach for the synthesis of indoloquinolines and indolo/pyrroloquinoxalines via a Cu-catalyzed Ugi-C/Ugi-N-arylation sequence DOI Creative Commons

Sheiva Iranfar,

Morteza Shiri, Yazdanbakhsh Lotfi Nosood

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(26), P. 18271 - 18276

Published: Jan. 1, 2024

A Cu-catalyzed tandem transformation of Ugi adducts through CH/NH bond functionalization reactions was reported for synthesizing a broad spectrum indolo/pyrrolo-[1,2- ]quinoxaline and indolo[2,3- c ]quinoline derivatives in good to excellent yields.

Language: Английский

Citations

1
Design of Synthetic Strategies towards Sulfur Containing Scaffolds DOI
Sambasivarao Kotha, Priti Khedkar

Synthesis, Journal Year: 2024, Volume and Issue: 57(02), P. 275 - 295

Published: Aug. 28, 2024

Abstract The utilization of sulfur heterocycles in organic synthesis has attracted significant attention due to their wide-ranging applications. This review showcases the syntheses diverse embedded with amino acid derivatives, polycycles, spirocycles, cyclophanes, and other complex scaffolds. reported methods extend beyond compound highlight use different reagents for constructing heterocycles. Review also discusses utility a variety sulfur-containing starting materials generation target molecules. 1 Introduction 2 Potassium Thioacetate 3 Thiazolidine-2,4-dione 4 Rhodanines 5 Sodium Sulfide 6 Thiotetronic Acid 7 Thiadiazoles 8 Thiophene 9 Rongalite 10 Sulfur Dioxide 11 Divinyl Sulfone 12 Heterocycles Based on Boronic Acids 13 Miscellaneous 14 Summary

Language: Английский

Citations

0