Molecules,
Год журнала:
2023,
Номер
28(1), С. 376 - 376
Опубликована: Янв. 2, 2023
In
response
to
stress
factors,
plants
produce
a
wide
range
of
biologically
active
substances,
from
group
secondary
metabolites,
which
are
applied
in
medicine
and
health
prophylaxis.
Chitosan
is
well-known
elicitor
affecting
metabolism
plants,
but
its
effect
on
the
phytochemical
profile
Plectranthus
amboinicus
has
not
been
assessed
yet.
present
experiment,
effectiveness
foliar
application
two
forms
chitosan
(chitosan
suspension
or
lactate)
was
compared
order
evaluate
their
potential
induce
accumulation
selected
polyphenolic
compounds
aboveground
parts
P.
amboinicus.
It
shown
that
lactate
had
substantially
higher
elicitation
efficiency,
as
use
this
form
exerted
beneficial
analysed
quality
parameters
raw
material,
especially
content
(total
polyphenols,
flavonols,
anthocyanins,
caffeic
acid
derivatives)
free
radical-scavenging
activity
extracts
elicited
plants.
Concurrently,
it
no
phytotoxic
effects.
Hence,
lactate-based
can
be
an
effective
method
for
optimisation
production
high-quality
material
characterised
by
increased
concentration
health-promoting
antioxidant
compounds.
Marine Drugs,
Год журнала:
2023,
Номер
21(6), С. 323 - 323
Опубликована: Май 26, 2023
Polyphenols
are
compounds
found
in
various
plants
and
foods,
known
for
their
antioxidant
anti-inflammatory
properties.
Recently,
researchers
have
been
exploring
the
therapeutic
potential
of
marine
polyphenols
other
minor
nutrients
that
algae,
fish
crustaceans.
These
unique
chemical
structures
exhibit
diverse
biological
properties,
including
anti-inflammatory,
antioxidant,
antimicrobial
antitumor
action.
Due
to
these
being
investigated
as
possible
agents
treatment
a
wide
variety
conditions,
such
cardiovascular
disease,
diabetes,
neurodegenerative
diseases
cancer.
This
review
focuses
on
applications
human
health,
also,
phenolic
classes,
extraction
methods,
purification
techniques
future
compounds.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Ноя. 29, 2023
Abstract
Traditional
Chinese
Medicines
(TCMs)
have
been
used
for
centuries
the
treatment
and
management
of
various
diseases.
However,
their
effective
delivery
to
targeted
sites
may
be
a
major
challenge
due
poor
water
solubility,
low
bioavailability,
potential
toxicity.
Nanocarriers,
such
as
liposomes,
polymeric
nanoparticles,
inorganic
nanoparticles
organic/inorganic
nanohybrids
based
on
active
constituents
from
TCMs
extensively
studied
promising
strategy
improve
achieve
higher
therapeutic
effect
with
fewer
side
effects
compared
conventional
formulations.
This
review
summarizes
recent
advances
in
nanocarrier-based
systems
types
TCMs,
including
terpenoids,
polyphenols,
alkaloids,
flavonoids,
quinones,
different
natural
sources.
covers
design
preparation
nanocarriers,
characterization,
vitro/vivo
evaluations.
Additionally,
this
highlights
challenges
opportunities
field
suggests
future
directions
research.
Nanocarrier-based
shown
great
improving
efficacy
serve
comprehensive
resource
researchers
field.
Graphical
abstract
A
primary
concern
about
photodynamic
therapy
(PDT)
is
its
inability
to
regulate
the
generation
levels
of
reactive
oxidative
species
(ROS)
based
on
complex
microenvironment,
resulting
in
impairment
toward
normal
tissues
and
immunosuppression.
Besides,
tumor
metastasis
also
compromises
PDT's
efficacy
drives
mortality.
However,
it
very
challenging
achieve
such
two
goals
within
one
nanosystem.
Here,
nanoassembly
(CPR)
with
self-regulated
antimetastasis
properties
comprises
three
parts:
chlorin
e6-conjugated
β-cyclodextrin
(CD-Ce6)
acts
as
main
PDT
agent
ferrocene
(Fc)-terminated
phenylboronic
acid-containing
conjugates
entering
into
cavity
CD-Ce6,
well
rosmarinic
acid
(RA)-boronic
crosslinked
shell.
Compared
non-crosslinked
counterpart,
CPR
displays
better
stability
enhanced
accumulation.
Under
laser
irradiation,
generates
plenty
ROS
damage
cells
induce
immunogenic
cell
death.
Mildly
acidic
TME
partly
cleaves
crosslinkers
dissociate
antioxidant
RAs
from
micelles,
which
together
Fc
scavenge
PDT-induced
TME.
By
contrast,
under
lysosomal
conditions,
catalyzes
abundant
H2
O2
produce
highly
cytotoxic
•OH,
while
RA
continuously
reduces
ferroptosis-generated
Fc+
Fc,
both
augment
cells.
remarkably
hinders
epithelial-mesenchymal
transition
prevent
lung
metastasis.
Frontiers in Plant Science,
Год журнала:
2024,
Номер
15
Опубликована: Июль 10, 2024
The
interest
in
medicinal
and
aromatic
plants
(MAPs)
has
increased
significantly
recent
years,
driven
by
the
growing
demand
for
natural
products.
MAPs
are
a
valuable
source
of
secondary
metabolites,
which
renders
them
useful
to
number
industries,
including
cosmetics,
pharmaceuticals,
food.
Lamiaceae
family
includes
economically
important
that
produce
metabolites
such
as
essential
oils
(EOs)
phenolic
compounds
(PCs).
quantity
quality
these
affected
abiotic
stress
factors.
In
climate
change
scenario,
is
one
most
families,
especially
due
its
wide
distribution
Mediterranean
region.
present
study,
common
climate-related
environmental
factors,
namely,
drought,
salinity,
temperature,
light,
heavy
metals,
were
reviewed
discussed
order
assess
their
impact
on
chemical
profiles
EOs
PCs,
well
biological
properties
(antioxidant,
antibacterial,
antimelanogenic,
pest-repellent,
UV-protective)
species.
It
can
be
posited
stresses
typically
act
catalyst
metabolism
plants,
resulting
production
EO
(e.g.,
1,8-cineole,
linalool,
camphor,
borneol,
limonene)
PCs
rosmarinic,
caffeic,
salvianolic
acids)
subsequent
enhancement
activities.
view
industrial
applications
bioactive
compounds,
it
explore
changes
induced
factors
possible
increase
accumulation
metabolites.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Март 25, 2024
Abstract
Endophytic
fungi
are
microorganisms
that
considered
as
a
potential
source
of
natural
compounds,
and
can
be
applied
in
various
industries.
The
aims
this
research
were
molecular
identification
endophytic
isolated
from
the
Gundelia
tournefortii
stems,
investigation
their
biological
activities
well
phenolic
fatty
acid
profile.
Surface
sterilized
stems
G.
placed
on
potato
dextrose
agar
(PDA)
to
isolate
fungal
endophytes.
Genomic
DNA
was
extracted
by
CTAB
method,
PCR
amplification
performed
ITS
1
4
primers.
enzyme
production
determined
based
formation
clear
zone
appeared
around
colonies
fungus.
anti-oxidant
activity
evaluated
measuring
amount
free
radicals
DPPH.
Also,
total
phenol
flavonoid
contents
measured
obtained
Folin-Ciocalteu
aluminum
chloride
colorimetric
methods,
respectively.
Moreover,
separation
acids
done
HPLC
GC,
Phylogenetic
analysis
Internal
Transcribed
Spacer
(ITS)
region,
five
isolates
identified
following:
Aspergillus
niger
,
Penicillium
glabrum
Alternaria
alternata
A.
tenuissima
Mucor
circinelloides
.
Evaluation
enzymatic
properties
showed
P.
gabrum
(31
±
1.9
mm),
(23
1.7)
had
more
ability
for
producing
pectinase
cellulase.
extract
(IC
50
=
471
29
µg/mL)
highest
properties,
followed
512
19
µg/mL).
greatest
phenols
flavonoids
(8.2
0.4
mg
GAL/g
2.3
0.3
QE/g,
respectively).
quantification
rosmarinic
acid,
para-coumaric
meta-coumaric
(42.02
1.31,
7.53
0.19,
5.41
0.21
mg/g,
respectively)
main
studied
fungi.
confirmed
that,
all
fungi,
stearic
(27.9–35.2%),
oleic
(11.3–17.3%),
palmitic
(16.9–23.2%),
linoleic
(5.8–11.6%),
caprylic
(6.3–10.9%).
Our
finding
bioactive
which
could
used
This
is
first
report
associated
with
provides
knowledge
future
use
biotechnological
processes.
Archiv der Pharmazie,
Год журнала:
2024,
Номер
357(8)
Опубликована: Май 15, 2024
Various
wound
dressings
have
been
developed
so
far
for
healing,
but
most
of
them
are
ineffective
in
properly
reestablishing
the
skin's
structure,
which
increases
infection
risks
and
dehydration.
Electrospun
membranes
particularly
interesting
dressing
applications
because
they
mimic
extracellular
matrix
healthy
skin.
In
this
study,
a
potential
healing
platform
capable
inducing
synergistic
antibacterial
antioxidation
activities
was
by
incorporating
bio-active
rosmarinic
acid-hydroxyapatite
hybrid
(HAP-RA)
with
different
contents
(0.5,
1,
1.5
wt.%)
into
electrospun
polyamide
6
(PA6)
nanofibers.
Then,
polyethylene
glycol
(PEG)
introduced
to
nanofibrous
composite
improve
biocompatibility
biodegradability
dressing.
The
results
indicated
that
hydrophilicity,
water
uptake,
biodegradability,
mechanical
properties
obtained
PA6/PEG/HAP-RA
enhanced
at
1
wt.%
HAP-RA.
had
excellent
activity.
samples
assessed
vitro.
MTT
assay
performed
on
L929
cell
line
confirmed
positive
effects
scaffold
viability
proliferation.
According
results,
showed
desirable
physiochemical
biological
besides
antioxidative
capabilities,
making
it
promising
candidate
further
studies
applications.
Neuropsychiatric Disease and Treatment,
Год журнала:
2025,
Номер
Volume 21, С. 641 - 661
Опубликована: Март 1, 2025
The
etiology
of
psychiatric
disorders
is
complex
and
results
from
intricate
interactions
among
multiple
neurobiological,
psychological,
environmental,
genetic
factors.
Furthermore,
the
roles
gut
microbiome
dyshomeostasis
in
their
pathogeneses
are
just
beginning
to
be
uncovered,
adding
another
level
complexity.
In
recent
years,
significant
efforts
have
been
directed
toward
discovering
multimodal
yet
safe
therapeutics
counteract
psychological
deficits.
Rosmarinic
acid
(RA),
a
polyphenol
found
several
medicinal
herbs,
has
received
considerable
attention
as
potential
multifaceted
therapeutic
agent,
particularly
for
neuropsychiatric
conditions.
order
critically
evaluate
this
aspect,
data
was
compiled
consolidated
after
extensive
searches
on
scholarly
databases
like
PubMed,
Google
Scholar,
Web
Science.
Peer-reviewed
publications
which
focused
RA
agent
were
included
regardless
year
publication
country
origin.
Based
pre-clinical
clinical
evidence,
review
delves
into
various
mechanistic
aspects
antidepressant,
anxiolytic,
sleep-promoting
functions
RA.
beneficial
effects
gut-microbiome-brain
(GMB)
axis
implications
regulation
neuroprotective
pathways
also
discussed,
with
particular
focus
exploiting
them
ameliorate
Our
assessment
indicated
that
neuroprotectant
against
conditions
beneficially
influences
plethora
targets
related
redox,
inflammatory,
synaptic,
cell
death,
neurotrophic,
signaling
pathways.
As
dietary
may
relevant
favorably
altering
GMB
axis,
indicating
its
prospects
adjuvant
regulating
pathogenic
mechanisms
underlying
However,
more
studies
required
ascertain
neuromodulatory
actions
neuronal
pathophysiologies,
including
ailments.
