Comparative Effects of Two Forms of Chitosan on Selected Phytochemical Properties of Plectranthus amboinicus (Lour.) DOI Creative Commons
Maria Stasińska-Jakubas, Barbara Hawrylak-Nowak, Magdalena Wójciak

и другие.

Molecules, Год журнала: 2023, Номер 28(1), С. 376 - 376

Опубликована: Янв. 2, 2023

In response to stress factors, plants produce a wide range of biologically active substances, from group secondary metabolites, which are applied in medicine and health prophylaxis. Chitosan is well-known elicitor affecting metabolism plants, but its effect on the phytochemical profile Plectranthus amboinicus has not been assessed yet. present experiment, effectiveness foliar application two forms chitosan (chitosan suspension or lactate) was compared order evaluate their potential induce accumulation selected polyphenolic compounds aboveground parts P. amboinicus. It shown that lactate had substantially higher elicitation efficiency, as use this form exerted beneficial analysed quality parameters raw material, especially content (total polyphenols, flavonols, anthocyanins, caffeic acid derivatives) free radical-scavenging activity extracts elicited plants. Concurrently, it no phytotoxic effects. Hence, lactate-based can be an effective method for optimisation production high-quality material characterised by increased concentration health-promoting antioxidant compounds.

Язык: Английский

Therapeutic Potential of Polyphenols and Other Micronutrients of Marine Origin DOI Creative Commons
Leonel Pereira, João Cotas

Marine Drugs, Год журнала: 2023, Номер 21(6), С. 323 - 323

Опубликована: Май 26, 2023

Polyphenols are compounds found in various plants and foods, known for their antioxidant anti-inflammatory properties. Recently, researchers have been exploring the therapeutic potential of marine polyphenols other minor nutrients that algae, fish crustaceans. These unique chemical structures exhibit diverse biological properties, including anti-inflammatory, antioxidant, antimicrobial antitumor action. Due to these being investigated as possible agents treatment a wide variety conditions, such cardiovascular disease, diabetes, neurodegenerative diseases cancer. This review focuses on applications human health, also, phenolic classes, extraction methods, purification techniques future compounds.

Язык: Английский

Процитировано

44

Coordinating caffeic acid and salvianic acid A pathways for efficient production of rosmarinic acid in Escherichia coli DOI
Lian Wang, Huijing Wang, Jianbin Chen

и другие.

Metabolic Engineering, Год журнала: 2023, Номер 76, С. 29 - 38

Опубликована: Янв. 6, 2023

Язык: Английский

Процитировано

29

Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines DOI Creative Commons
Chong Qiu,

Jun Zhe Zhang,

Bo Wu

и другие.

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Ноя. 29, 2023

Abstract Traditional Chinese Medicines (TCMs) have been used for centuries the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due poor water solubility, low bioavailability, potential toxicity. Nanocarriers, such as liposomes, polymeric nanoparticles, inorganic nanoparticles organic/inorganic nanohybrids based on active constituents from TCMs extensively studied promising strategy improve achieve higher therapeutic effect with fewer side effects compared conventional formulations. This review summarizes recent advances in nanocarrier-based systems types TCMs, including terpenoids, polyphenols, alkaloids, flavonoids, quinones, different natural sources. covers design preparation nanocarriers, characterization, vitro/vivo evaluations. Additionally, this highlights challenges opportunities field suggests future directions research. Nanocarrier-based shown great improving efficacy serve comprehensive resource researchers field. Graphical abstract

Язык: Английский

Процитировано

29

Rosmarinic Acid‐Crosslinked Supramolecular Nanoassembly with Self‐Regulated Photodynamic and Anti‐Metastasis Properties for Synergistic Photoimmunotherapy DOI Open Access
Yang Zhou, Yiwei Zhang,

Chaoqing Jiang

и другие.

Small, Год журнала: 2023, Номер 19(23)

Опубликована: Фев. 8, 2023

A primary concern about photodynamic therapy (PDT) is its inability to regulate the generation levels of reactive oxidative species (ROS) based on complex microenvironment, resulting in impairment toward normal tissues and immunosuppression. Besides, tumor metastasis also compromises PDT's efficacy drives mortality. However, it very challenging achieve such two goals within one nanosystem. Here, nanoassembly (CPR) with self-regulated antimetastasis properties comprises three parts: chlorin e6-conjugated β-cyclodextrin (CD-Ce6) acts as main PDT agent ferrocene (Fc)-terminated phenylboronic acid-containing conjugates entering into cavity CD-Ce6, well rosmarinic acid (RA)-boronic crosslinked shell. Compared non-crosslinked counterpart, CPR displays better stability enhanced accumulation. Under laser irradiation, generates plenty ROS damage cells induce immunogenic cell death. Mildly acidic TME partly cleaves crosslinkers dissociate antioxidant RAs from micelles, which together Fc scavenge PDT-induced TME. By contrast, under lysosomal conditions, catalyzes abundant H2 O2 produce highly cytotoxic •OH, while RA continuously reduces ferroptosis-generated Fc+ Fc, both augment cells. remarkably hinders epithelial-mesenchymal transition prevent lung metastasis.

Язык: Английский

Процитировано

24

How climate change-related abiotic factors affect the production of industrial valuable compounds in Lamiaceae plant species: a review DOI Creative Commons
Inês Mansinhos, Sandra Gonçalves, Anabela Romano

и другие.

Frontiers in Plant Science, Год журнала: 2024, Номер 15

Опубликована: Июль 10, 2024

The interest in medicinal and aromatic plants (MAPs) has increased significantly recent years, driven by the growing demand for natural products. MAPs are a valuable source of secondary metabolites, which renders them useful to number industries, including cosmetics, pharmaceuticals, food. Lamiaceae family includes economically important that produce metabolites such as essential oils (EOs) phenolic compounds (PCs). quantity quality these affected abiotic stress factors. In climate change scenario, is one most families, especially due its wide distribution Mediterranean region. present study, common climate-related environmental factors, namely, drought, salinity, temperature, light, heavy metals, were reviewed discussed order assess their impact on chemical profiles EOs PCs, well biological properties (antioxidant, antibacterial, antimelanogenic, pest-repellent, UV-protective) species. It can be posited stresses typically act catalyst metabolism plants, resulting production EO (e.g., 1,8-cineole, linalool, camphor, borneol, limonene) PCs rosmarinic, caffeic, salvianolic acids) subsequent enhancement activities. view industrial applications bioactive compounds, it explore changes induced factors possible increase accumulation metabolites.

Язык: Английский

Процитировано

17

Investigation the biological activities and the metabolite profiles of endophytic fungi isolated from Gundelia tournefortii L. DOI Creative Commons
Mostafa Ebadi,

Fatemeh Ahmadi,

Hossein Tahmouresi

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Март 25, 2024

Abstract Endophytic fungi are microorganisms that considered as a potential source of natural compounds, and can be applied in various industries. The aims this research were molecular identification endophytic isolated from the Gundelia tournefortii stems, investigation their biological activities well phenolic fatty acid profile. Surface sterilized stems G. placed on potato dextrose agar (PDA) to isolate fungal endophytes. Genomic DNA was extracted by CTAB method, PCR amplification performed ITS 1 4 primers. enzyme production determined based formation clear zone appeared around colonies fungus. anti-oxidant activity evaluated measuring amount free radicals DPPH. Also, total phenol flavonoid contents measured obtained Folin-Ciocalteu aluminum chloride colorimetric methods, respectively. Moreover, separation acids done HPLC GC, Phylogenetic analysis Internal Transcribed Spacer (ITS) region, five isolates identified following: Aspergillus niger , Penicillium glabrum Alternaria alternata A. tenuissima Mucor circinelloides . Evaluation enzymatic properties showed P. gabrum (31 ± 1.9 mm), (23 1.7) had more ability for producing pectinase cellulase. extract (IC 50 = 471 29 µg/mL) highest properties, followed 512 19 µg/mL). greatest phenols flavonoids (8.2 0.4 mg GAL/g 2.3 0.3 QE/g, respectively). quantification rosmarinic acid, para-coumaric meta-coumaric (42.02 1.31, 7.53 0.19, 5.41 0.21 mg/g, respectively) main studied fungi. confirmed that, all fungi, stearic (27.9–35.2%), oleic (11.3–17.3%), palmitic (16.9–23.2%), linoleic (5.8–11.6%), caprylic (6.3–10.9%). Our finding bioactive which could used This is first report associated with provides knowledge future use biotechnological processes.

Язык: Английский

Процитировано

11

A bi‐functional nanofibrous composite membrane for wound healing applications DOI
Mohamadreza Shakiba,

Mehrab Pourmadadi,

Seyede Marzieh Hosseini

и другие.

Archiv der Pharmazie, Год журнала: 2024, Номер 357(8)

Опубликована: Май 15, 2024

Various wound dressings have been developed so far for healing, but most of them are ineffective in properly reestablishing the skin's structure, which increases infection risks and dehydration. Electrospun membranes particularly interesting dressing applications because they mimic extracellular matrix healthy skin. In this study, a potential healing platform capable inducing synergistic antibacterial antioxidation activities was by incorporating bio-active rosmarinic acid-hydroxyapatite hybrid (HAP-RA) with different contents (0.5, 1, 1.5 wt.%) into electrospun polyamide 6 (PA6) nanofibers. Then, polyethylene glycol (PEG) introduced to nanofibrous composite improve biocompatibility biodegradability dressing. The results indicated that hydrophilicity, water uptake, biodegradability, mechanical properties obtained PA6/PEG/HAP-RA enhanced at 1 wt.% HAP-RA. had excellent activity. samples assessed vitro. MTT assay performed on L929 cell line confirmed positive effects scaffold viability proliferation. According results, showed desirable physiochemical biological besides antioxidative capabilities, making it promising candidate further studies applications.

Язык: Английский

Процитировано

10

Evaluation of Antimicrobial Properties and Antioxidant Activity of Rosmarinic Acid-Loaded Resomer RG 502 H-Based Nanoparticles Against Tert-Butyl Hydroperoxide-Induced Oxidative Stress: A detailed formulation, characterization and efficacy determination study DOI

Büşra Solak,

Pervin Soyer, Elif Kaya Tilki

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106721 - 106721

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1

Anxiolytic, Antidepressant and Healthy Sleep-Promoting Potential of Rosmarinic Acid: Mechanisms and Molecular Targets DOI Creative Commons

Vijayan Priya,

Dilip Srinivasan,

Swagatika Priyadarsini

и другие.

Neuropsychiatric Disease and Treatment, Год журнала: 2025, Номер Volume 21, С. 641 - 661

Опубликована: Март 1, 2025

The etiology of psychiatric disorders is complex and results from intricate interactions among multiple neurobiological, psychological, environmental, genetic factors. Furthermore, the roles gut microbiome dyshomeostasis in their pathogeneses are just beginning to be uncovered, adding another level complexity. In recent years, significant efforts have been directed toward discovering multimodal yet safe therapeutics counteract psychological deficits. Rosmarinic acid (RA), a polyphenol found several medicinal herbs, has received considerable attention as potential multifaceted therapeutic agent, particularly for neuropsychiatric conditions. order critically evaluate this aspect, data was compiled consolidated after extensive searches on scholarly databases like PubMed, Google Scholar, Web Science. Peer-reviewed publications which focused RA agent were included regardless year publication country origin. Based pre-clinical clinical evidence, review delves into various mechanistic aspects antidepressant, anxiolytic, sleep-promoting functions RA. beneficial effects gut-microbiome-brain (GMB) axis implications regulation neuroprotective pathways also discussed, with particular focus exploiting them ameliorate Our assessment indicated that neuroprotectant against conditions beneficially influences plethora targets related redox, inflammatory, synaptic, cell death, neurotrophic, signaling pathways. As dietary may relevant favorably altering GMB axis, indicating its prospects adjuvant regulating pathogenic mechanisms underlying However, more studies required ascertain neuromodulatory actions neuronal pathophysiologies, including ailments.

Язык: Английский

Процитировано

1

Therapeutic implications and clinical manifestations of thymoquinone DOI
Manzar Alam, Gulam Mustafa Hasan, Md. Meraj Ansari

и другие.

Phytochemistry, Год журнала: 2022, Номер 200, С. 113213 - 113213

Опубликована: Апрель 25, 2022

Язык: Английский

Процитировано

33