Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota

Biomolecules, Год журнала: 2025, Номер 15(2), С. 270 - 270

Опубликована: Фев. 12, 2025

The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.

Язык: Английский

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Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related Diseases

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Abstract This article provides an overview of the advancements in application fecal microbiota transplantation (FMT) treating diseases related to intestinal dysbiosis. FMT involves transfer healthy donor into patient's body, aiming restore balance and thereby treat a variety such as recurrent Clostridioides difficile infection (rCDI), inflammatory bowel disease (IBD), constipation, short syndrome (SBS), irritable (IBS). While has shown high efficacy treatment rCDI, further research is needed for its other chronic conditions. elaborates on mechanisms dysbiosis, well discusses key factors influencing effectiveness FMT, including selection, recipient characteristics, protocols, methods assessing microbiota. Additionally, it emphasizes successful FMT. Future should focus optimizing process ensure long‐term safety explore potential broader range medical

Язык: Английский

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Interactions between Dietary Antioxidants, Dietary Fiber and the Gut Microbiome: Their Putative Role in Inflammation and Cancer

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8250 - 8250

Опубликована: Июль 28, 2024

The intricate relationship between the gastrointestinal (GI) microbiome and progression of chronic non-communicable diseases underscores significance developing strategies to modulate GI microbiota for promoting human health. administration probiotics prebiotics represents a good strategy that enhances population beneficial bacteria in intestinal lumen post-consumption, which has positive impact on In addition, dietary fibers serve as significant energy source inhabiting cecum colon. Research articles reviews sourced from various global databases were systematically analyzed using specific phrases keywords investigate these relationships. There is clear association fiber intake improved colon function, gut motility, reduced colorectal cancer (CRC) risk. Moreover, state health reflected reciprocal bidirectional relationships among food, antioxidants, inflammation, body composition. They are known their antioxidant properties ability inhibit angiogenesis, metastasis, cell proliferation. Additionally, they promote survival, immune inflammatory responses, inactivate pro-carcinogens. These actions collectively contribute role prevention. different investigations, supplements containing vitamins have been shown lower risk types. contrast, some evidence suggests taking can increase cancer. Ultimately, collaborative efforts immunologists, clinicians, nutritionists, dietitians imperative designing well-structured nutritional trials corroborate clinical efficacy therapy managing inflammation preventing carcinogenesis. This review seeks explore interrelationships fiber, microbiome, with particular focus potential implications

Язык: Английский

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Berberine: Potential preventive and therapeutic strategies for human colorectal cancer

Cell Biochemistry and Function, Год журнала: 2024, Номер 42(4)

Опубликована: Май 14, 2024

Colorectal cancer (CRC) is a common digestive tract tumor, with incidences continuing to rise. Although modern medicine has extended the survival time of CRC patients, its adverse effects and financial burden cannot be ignored. multi-step process can caused by disturbance gut microbiome chronic inflammation's stimulation. Additionally, presence precancerous lesions also risk factor for CRC. Consequently, scientists are increasingly interested in identifying multi-target, safe, economical herbal natural products. This paper summarizes berberine's (BBR) regulatory mechanisms occurrence development The findings indicate that BBR regulates homeostasis controls mucosal inflammation prevent In stage, inhibits cell proliferation, invasion, metastasis, blocks cycle, induces apoptosis, metabolism, angiogenesis, enhances chemosensitivity. plays role overall management Therefore, using as an adjunct prevention treatment could become future trend oncology.

Язык: Английский

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Cancer, deuterium, and gut microbes: A novel perspective

Endocrine and Metabolic Science, Год журнала: 2025, Номер unknown, С. 100215 - 100215

Опубликована: Янв. 1, 2025

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Gut Microbiome Modulation in Hepatocellular Carcinoma: Preventive Role in NAFLD/NASH Progression and Potential Applications in Immunotherapy-Based Strategies

Cells, Год журнала: 2025, Номер 14(2), С. 84 - 84

Опубликована: Янв. 9, 2025

Hepatocellular carcinoma (HCC) is a heterogeneous tumor associated with several risk factors, non-alcoholic fatty liver disease (NAFLD) emerging as an important cause of tumorigenesis. Due to the obesity epidemics, occurrence NAFLD has significantly increased nearly 30% prevalence worldwide. HCC often arises in background chronic (CLD), such nonalcoholic steatohepatitis (NASH) and cirrhosis. Gut microbiome (GM) alterations have been linked progression development, investigations reporting crucial role for gut-liver axis microbial metabolites promoting CLD. Moreover, GM affects homeostasis, energy status, immune microenvironment, influencing response immunotherapy interesting therapeutic implications. In this review, we summarize main changes derived (e.g., short-chain acids bile acids) occurring patients progression, emphasizing their potential early diagnostic biomarkers prognostic tools. We discuss weight loss effects diet-based interventions healthy lifestyles treatment patients, highlighting impact on restoration intestinal barrier structure. also describe encouraging preclinical findings modulation improve functions CLD, boost antitumor probiotic supplementations or anti-hypercholesterolemic drug treatment), ultimately delay HCC. The development safe effective strategies that target holds promise cancer prevention treatment, especially if personalized options will be considered.

Язык: Английский

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The dual role of gut microbiota in pancreatic cancer: new insights into onset and treatment

Therapeutic Advances in Medical Oncology, Год журнала: 2025, Номер 17

Опубликована: Янв. 1, 2025

Pancreatic cancer ranks among the most lethal digestive malignancies, exhibiting a steadily increasing incidence and mortality worldwide. Despite significant advances in research, 5-year survival rate remains below 10%, predominantly due to delayed diagnosis limited therapeutic options. Concurrently, gut microbiota—an integral component of host physiology—has emerged as crucial player pathogenesis pancreatic cancer. Mounting evidence indicates that alterations microbial composition function may influence tumor initiation, progression, response therapy. This review provides an in-depth examination intricate interplay between microbiome cancer, highlighting potential diagnostic biomarkers exploring microbiome-targeted strategies improve patient outcomes.

Язык: Английский

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The role of short-chain fatty acids in cancer prevention and cancer treatment

Archives of Biochemistry and Biophysics, Год журнала: 2024, Номер 761, С. 110172 - 110172

Опубликована: Окт. 4, 2024

Язык: Английский

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Complex Probiotics Ameliorate Fecal Microbiota Transplantation-Induced IBS in Mice via Gut Microbiota and Metabolite Modulation

Nutrients, Год журнала: 2025, Номер 17(5), С. 801 - 801

Опубликована: Фев. 26, 2025

Background/Objectives: Irritable bowel syndrome (IBS) is a highly prevalent functional gastrointestinal disorder. Emerging evidence implicates gut microbiota dysbiosis in IBS pathogenesis, and probiotic interventions targeting microbial modulation hold therapeutic promise. Methods: this study used fecal transplantation to establish mouse model of before evaluating the effects complex by using metagenomics targeted metabolomics explore potential mechanism. Results: After 14 days, relieved constipation, reduced inflammation intestinal permeability, lowered 5-HT levels increased serotonin transporter (SERT) expression tissues. Metagenomic analysis showed inflammation-related species abundance. It also decreased butyric acid, acetic acid tryptophan mice. Conclusions: The effectively alleviated symptoms mice modulating metabolites, providing insights for future research treatment.

Язык: Английский

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Emerging Role of Gut Microbiota in Breast Cancer Development and Its Implications in Treatment

Metabolites, Год журнала: 2024, Номер 14(12), С. 683 - 683

Опубликована: Дек. 5, 2024

Background: The human digestive system contains approximately 100 trillion bacteria. gut microbiota is an emerging field of research that associated with specific biological processes in many diseases, including cardiovascular disease, obesity, diabetes, brain rheumatoid arthritis, and cancer. Emerging evidence indicates the affects response to anticancer therapies by modulating host immune system. Recent studies have explained a high correlation between breast cancer: dysbiosis cancer may regulate systemic inflammatory response, hormone metabolism, tumor microenvironment. Some bacteria are related estrogen which increase or decrease risk changing number hormones. Further, has been seen modulate respect its ability protect against treat cancers, focus on receptor-positive Probiotics other claiming control microbiome bacterial means might be useful prevention, even treatment, Conclusions: present review underlines various aspects clinical application, warranting individualized microbiome-modulated therapeutic approaches treatment.

Язык: Английский

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