Green and clean synthesis of 4-arylideneisoxazol-5-ones using NaCl aqueous solution
Sustainable Chemistry for the Environment,
Год журнала:
2024,
Номер
5, С. 100066 - 100066
Опубликована: Янв. 6, 2024
The
one-pot,
three-component
cyclization
reaction
a
wide
variety
of
aryl/heteroaryl
aldehydes,
hydroxylamine
hydrochloride,
and
β-keto
ester
compounds
was
performed
in
simple
manner.
reactions
carried
out
the
presence
sodium
chloride
(NaCl)
as
profitable,
green,
efficient
catalyst
at
room
temperature.
Optimization
experiments
indicate
that
amount
17
mol%
loaded
NaCl
is
sufficient
to
catalyze
reaction.
Among
advantages
this
NaCl-catalyzed
method
are
availability
catalyst,
no
need
for
synthesis
several
steps,
commercially
available
reactants,
use
aqueous
conditions,
clean
synthesis,
non-inflammable
medium,
environmental
pollution,
safety,
cost-effectiveness,
pot-economy,
optimum
efficiency,
carbon
economy
steps.
Due
absence
harmful
solvents,
an
abundant,
low-cost,
useful
water
solvent,
considered
green
synthesis.
Язык: Английский
Rapid synthesis of fully substituted arylideneisoxazol-5(4H)-one using zinc oxide nanoparticles
Research on Chemical Intermediates,
Год журнала:
2023,
Номер
49(10), С. 4603 - 4619
Опубликована: Июль 9, 2023
Язык: Английский
An efficient, green and micellar catalyzed preparative-scale synthesis of 3,4-Disubstituted isoxazole-5(4H)-ones in the water
Sustainable Chemistry for the Environment,
Год журнала:
2024,
Номер
5, С. 100070 - 100070
Опубликована: Янв. 9, 2024
The
one-pot
three-component
synthesis
of
3,4-Disubstituted
isoxazole-5(4H)-ones
has
been
developed
using
an
aqueous
micellar
medium
as
a
catalyst
under
milder
reaction
conditions.
was
completed
by
25
mol%
sodium
lauryl
sulfate
in
at
room
temperature.
employs
green
solvent,
eco-friendly
reagent,
and
non-chromatographic
method
for
purification.
present
tolerates
several
substituted
aldehydes
proved
to
be
efficient
along
with
excellent
yield.
Moreover,
the
recovered
reused
times
without
significantly
losing
its
catalytic
activity.
Язык: Английский
Synthesis of Isoxazol-5-One Derivatives Catalyzed by Amine-Functionalized Cellulose
Опубликована: Авг. 27, 2024
In
this
contribution,
the
propylamine-functionalized
cellulose
(Cell-Pr-NH2)
was
employed
as
catalyst
in
three-component
reaction
between
hydroxylamine
hydrochloride,
various
type
of
aryl/heteroaryl
aldehydes,
ethyl
acetoacetate/ethyl
4-chloroacetoacetate/
or
3-oxohexanoate.
The
results
these
experiments
were
formation
3,4-disubstituted
isoxazol-5(4H)-one
heterocycles.
desired
five-membered
heterocyclic
compounds
obtained
good
to
high
yields
at
room
temperature.
investigation
different
solvents
led
us
conclusion
that
water
is
best
solvent
perform
current
one-pot,
reactions.
Attempts
find
optimum
loading
clearly
showed
14
mg
Cell-Pr-NH2
seems
be
sufficient
carry
out
This
method
has
highlighted
some
principles
green
chemistry
including
less
waste
generation,
atom
economy,
use
an
environmentally
friendly
solvent,
and
energy
saving.
Purification
without
chromatographic
methods,
mild
conditions,
simple
work-up,
low-cost
medium,
saving
time,
obtainable
precursors
are
other
notable
features
one-pot
fashion.
Язык: Английский
Green Synthesis of Arylideneisoxazol-5-Ones Catalyzed by Silicon Dioxide Nanoparticles
Polycyclic aromatic compounds,
Год журнала:
2023,
Номер
44(8), С. 5022 - 5037
Опубликована: Сен. 21, 2023
Abstract4-Arylideneisoxazol-5(4H)-ones
were
obtained
via
a
simple
and
efficient
one-pot,
three-component
cyclocondensation
of
diverse
aldehydes
with
hydroxylamine
hydrochloride
β-keto
esters
in
water.
This
one-pot
heterocyclization
has
been
performed
the
presence
catalytic
amounts
silicon
dioxide
nanoparticles
(SiO2
NPs)
at
room
temperature.
approach
is
economical
for
synthesis
potentially
bioactive
4-arylideneisoxazol-5(4H)-one
derivatives.
The
products
formed
86–94%
isolated
reaction
yields
using
5
mol%
nanocatalyst.
reactions
completed
temperature
under
aqueous
conditions.
significant
features
present
procedure
are
uncomplicated
product
isolation,
purification
without
chromatographic
methods,
great
biocompatibility
SiO2
NPs,
straightforward
conditions,
easy
workup,
environmentally
friendly,
readily
available
starting
materials,
reusability
catalyst,
as
well
inexpensive
green
medium.Keywords:
Isoxazol-5(4H)-onessilicon
nanoparticlesgreen
synthesiscyclocondensation
AcknowledgementsWe
would
to
express
our
thankfulness
Damghan
University
Research
Council.
corresponding
author
also
like
thank
Shahrekord
University.Disclosure
statementNo
potential
conflict
interest
was
reported
by
author(s).
Язык: Английский