Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology

Plants, Год журнала: 2021, Номер 10(12), С. 2751 - 2751

Опубликована: Дек. 14, 2021

There are more than 30 species of Glycyrrhiza genus extensively spread worldwide. It was the most prescribed herb in Ancient Egyptian, Roman, Greek, East China, and West from Former Han era. various beneficial effects licorice root extracts, such as treating throat infections, tuberculosis, respiratory, liver diseases, antibacterial, anti-inflammatory, immunodeficiency. On other hand, traditional medicines getting attraction to treat many diseases. Therefore, it is vital screen medicinal plants find potential new compounds chronic diseases cardiovascular, anticancer, hepatoprotective, etc. This work comprehensively reviews ethnopharmacological uses, phytochemistry, biological activities, clinical evidence, toxicology licorice, which will serve a resource for future fundamental studies. An attempt has been made establish pharmacological effect different In addition, focus this review article on molecular mechanism extracts their four flavonoids (isoliquiritigenin, liquiritigenin, lichalocone, glabridin) pharmacologic activities. Licorice could be natural alternative current therapy exterminate emerging disorders with mild side effects. provide systematic insights into ancient drug further development use.

Язык: Английский

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A review of the phytochemical and pharmacological characteristics of Moringa oleifera

Journal of Pharmacy And Bioallied Sciences, Год журнала: 2018, Номер 10(4), С. 181 - 181

Опубликована: Янв. 1, 2018

Moringa oleifera is a valued medicinal plant in traditional folk medicine. Many pharmacological studies have shown the ability of this to exhibit analgesic, anti-inflammatory, antipyretic, anticancer, antioxidant, nootropic, hepatoprotective, gastroprotective, anti-ulcer, cardiovascular, anti-obesity, antiepileptic, antiasthmatic, antidiabetic, anti-urolithiatic, diuretic, local anesthetic, anti-allergic, anthelmintic, wound healing, antimicrobial, immunomodulatory, and antidiarrheal properties. This review comprehensive summary phytochemical activities as well therapeutic uses plant. M. has wide various pathophysiological conditions. We will properties (drumstick tree) focus on its think that it an attractive subject for further experimental clinical investigations.

Язык: Английский

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Neuroprotective Herbs for the Management of Alzheimer’s Disease

Biomolecules, Год журнала: 2021, Номер 11(4), С. 543 - 543

Опубликована: Апрель 8, 2021

Background-Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative that characterized by memory loss, personality changes, and decline in cognitive function. While the exact cause of AD still unclear, recent studies point to lifestyle, diet, environmental, genetic factors as contributors progression. The pharmaceutical approaches developed date do not alter More than two hundred promising drug candidates have failed clinical trials past decade, suggesting its causes may be highly complex. Medicinal plants herbal remedies are now gaining more interest complementary alternative interventions valuable source for developing AD. Indeed, several scientific described use various medicinal their principal phytochemicals treatment This article reviews subset herbs anti-inflammatory, antioxidant, cognitive-enhancing effects. Methods-This systematically investigated role neuroprotective bioactive compounds dementia associated with Alzheimer's pre-Alzheimer's disease. PubMed Central, Scopus, Google Scholar databases articles were collected, abstracts reviewed relevance subject matter. Conclusions-Medicinal great potential part an overall program prevention It hoped these can used discovery programs identifying safe efficacious small molecules

Язык: Английский

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Neuroprotective Natural Products for Alzheimer’s Disease

Cells, Год журнала: 2021, Номер 10(6), С. 1309 - 1309

Опубликована: Май 25, 2021

Alzheimer's disease (AD) is the number one neurovegetative disease, but its treatment options are relatively few and ineffective. In efforts to discover new strategies for AD therapy, natural products have aroused interest in research community pharmaceutical industry their neuroprotective activity, targeting different pathological mechanisms associated with AD. A wide variety of from origins been evaluated preclinically clinically preventing attenuating multifactorial pathologies This review mainly focuses on possible that may be beneficial product mixtures or extracts sources demonstrated activity preclinical and/or clinical studies. It believed containing multiple bioactive compounds can work additively synergistically exhibit might an effective approach drug discovery.

Язык: Английский

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A strategy of monitoring acetylcholinesterase and screening of natural inhibitors from Uncaria for Alzheimer's disease therapy based on near-infrared fluorescence probe

Sensors and Actuators B Chemical, Год журнала: 2024, Номер 424, С. 136895 - 136895

Опубликована: Ноя. 4, 2024

Язык: Английский

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Phyto-Therapeutic and Nanomedicinal Approaches to Cure Alzheimer’s Disease: Present Status and Future Opportunities

Frontiers in Aging Neuroscience, Год журнала: 2018, Номер 10

Опубликована: Окт. 23, 2018

Alzheimer disease (AD) is characterized by cognitive inability manifested through the accumulation of β-amyloid, formation hyper phosphorylated neurofibrillary tangles (NFT’s) and malfunctioned cholinergic system. The degeneration integrity neuronal network can appear long after onset disease. Nanotechnology based interventions has opened an exciting area via theranostics AD in terms tailored nanomedicine, which are able to target deliver drugs across blood brain barrier (BBB). interface medicinal plants nanotechnology emerging feat medicine, delivered promising results treatment AD. In order assess potential applications plants, their derived components various nanomedicinal approaches, a review literature was deemed as necessary. present review, numerous phytochemicals feats nanomedicine for been discussed mechanistically first time. Furthermore, recent trends like green synthesis metal nanoparticles with reference have elaborated. Foreseeing progress, we hope that will result highly effective theranostic strategies near future.

Язык: Английский

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Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases

Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 137, С. 111377 - 111377

Опубликована: Фев. 16, 2021

Neurodegenerative diseases (NDs) represent a common neurological pathology that determines progressive deterioration of the brain or nervous system. For treating NDs, comprehensive and alternative medicines have attracted scientific researchers' attention recently. Edible mushrooms are essential for preventing several age-based neuronal dysfunctions such as Parkinson's Alzheimer's diseases. Mushroom Grifola frondosa, Lignosus rhinocerotis, Hericium erinaceus, may improve cognitive functions. It has also been reported edible (basidiocarps/mycelia extracts isolated bioactive compounds) reduce beta-amyloid-induced neurotoxicity. Medicinal being used novel natural compounds help modulate immune responses possess anti-cancer, anti-microbial, anti-oxidant properties. Compounds polyphenols, terpenoids, alkaloids, sesquiterpenes, polysaccharides, metal chelating agents validated in different ND treatments. This review aims to assess mushrooms' role their biomolecules utilization kinds NDs. The action mechanisms, presented here, including reducing oxidative stress, neuroinflammation, modulation acetylcholinesterase activity, protecting neurons stimulation, regulating neurotrophins synthesis. We provide background about neurodegenerative in-silico techniques drug research. High costs associated with experiments current ethical law imply efficient alternatives limited cost value. In silico approaches an method low successfully implemented cure disorders recent days. describe applications computational procedures molecular docking, virtual high-throughput screening, dynamic (MD) simulation, quantum-mechanical methods design. They were against various targets

Язык: Английский

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Green Tea Epigallocatechin-3-gallate (EGCG) Targeting Protein Misfolding in Drug Discovery for Neurodegenerative Diseases

Biomolecules, Год журнала: 2021, Номер 11(5), С. 767 - 767

Опубликована: Май 20, 2021

The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now suggest that EGCG targets protein misfolding and aggregation, a common cause pathological mechanism in many NDs. Several studies have shown interacts with misfolded proteins such as amyloid beta-peptide (Aβ), linked Alzheimer’s disease (AD), α-synuclein, Parkinson’s (PD). To date, NDs constitute serious public health problem, causing financial burden for care systems worldwide. Although current treatments provide symptomatic relief, they do not stop or even slow progression these devastating disorders. Therefore, there an urgent need develop effective drugs incurable ailments. It expected targeting can serve therapeutic strategy since neurodegeneration. In this context, may offer great opportunities drug discovery review critically discusses role provides updated information on scientific evidence potentially be used fatal brain

Язык: Английский

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Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease

Oxidative Medicine and Cellular Longevity, Год журнала: 2022, Номер 2022, С. 1 - 22

Опубликована: Апрель 11, 2022

Alzheimer’s disease (AD) is a common neurodegenerative brain disorder that causes cellular response alterations, such as impaired cholinergic mechanism, amyloid-beta (Aβ) AD aggregation, neuroinflammation, and several other pathways. still the most prevalent form of dementia affects many individuals across globe. The exact cause obscure. There are yet no effective medications for halting, preventing, or curing AD’s progress. Plenty natural products isolated from sources analyzed in preclinical clinical settings neuroprotective effects preventing treating AD. In addition, their derivatives have been promising Natural bioactive compounds play an active modulatory role pathological molecular mechanisms development. This review focuses on plant demonstrated activities maybe to treat prevent this article summarizes literature pertaining agents treatment Rapid metabolism, nonspecific targeting, low solubility, lack BBB permeability, limited bioavailability shortcomings molecules We can use nanotechnology nanocarriers based different types approaches.

Язык: Английский

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Pharmacotherapy Evolution in Alzheimer’s Disease: Current Framework and Relevant Directions

Cells, Год журнала: 2022, Номер 12(1), С. 131 - 131

Опубликована: Дек. 28, 2022

Alzheimer’s disease (AD), once considered a rare disease, is now the most common form of dementia in elderly population. Current drugs (cholinesterase inhibitors and glutamate antagonists) are safe but limited benefit to patients, offering symptomatic relief without successful cure disease. Since last several decades, there has been great need for development treatment that might underlying causes AD thereby slow its progression vulnerable individuals. That why phase I, II, III studies act on fronts, such as cognitive improvement, symptom reduction, enhancing basic biology AD, imperative stop This review discusses current strategies, summarizing clinical features pharmacological properties, along with molecular docking analyses existing medications.

Язык: Английский

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