The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke

Molecular Neurobiology, Год журнала: 2020, Номер 58(1), С. 329 - 347

Опубликована: Сен. 17, 2020

Abstract Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family growth factors that plays crucial role in development nervous system while supporting survival existing neurons and instigating neurogenesis. Altered levels BDNF, both circulation central (CNS), have been reported to be involved pathogenesis neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s (PD), amyotrophic lateral sclerosis (ALS), Huntington’s (HD), multiple (MS), ischemic stroke. MicroRNAs (miRNAs) are class non-coding RNAs found body fluids such as peripheral blood cerebrospinal fluid. Several different miRNAs, their target genes, recognized pathophysiology neurovascular diseases. Thus, they present promising biomarkers novel treatment approach for CNS disorders. Currently, limited studies provide viable evidence miRNA-mediated post-transcriptional regulation BDNF. The aim this review comprehensive assessment current knowledge regarding potential diagnostic prognostic values miRNAs affecting BDNF expression its disorders biomarker. Moreover, therapeutic diseases stroke targeting associated with will discussed.

Язык: Английский

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Monitoring the Redox Status in Multiple Sclerosis

Biomedicines, Год журнала: 2020, Номер 8(10), С. 406 - 406

Опубликована: Окт. 12, 2020

Worldwide, over 2.2 million people suffer from multiple sclerosis (MS), a multifactorial demyelinating disease of the central nervous system. MS is characterized by wide range motor, autonomic, and psychobehavioral symptoms, including depression, anxiety, dementia. The blood, cerebrospinal fluid, postmortem brain samples patients provide evidence on disturbance reduction-oxidation (redox) homeostasis, such as alterations oxidative antioxidative enzyme activities presence degradation products. This review article discusses components redox reactive chemical species, enzymes, species cover frequently discussed oxygen/nitrogen infrequently featured chemicals sulfur, carbonyl, halogen, selenium, nucleophilic that potentially act reductive, well pro-oxidative stressors. systems nuclear factor erythroid-2-related 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1) signaling pathway. NRF2 other transcriptional factors become biomarker sensitive to initial phase stress. Altered homeostasis in were search diagnostic, prognostic, predictive, and/or therapeutic biomarker. Finally, monitoring battery products helps evaluate status expedite building personalized treatment plans for sake better quality life.

Язык: Английский

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Non-coding RNAs in the regulation of blood–brain barrier functions in central nervous system disorders

Fluids and Barriers of the CNS, Год журнала: 2022, Номер 19(1)

Опубликована: Март 26, 2022

Abstract The blood–brain barrier (BBB) is an essential component of the neurovascular unit that controls exchanges various biological substances between blood and brain. BBB damage a common feature different central nervous systems (CNS) disorders plays vital role in pathogenesis diseases. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNA (lncRNAs), circular (circRNAs), are important regulatory molecules involved almost all cellular processes normal development diseases, including CNS Cumulative evidences have demonstrated ncRNA regulation functions In this review, we summarized miRNAs, lncRNAs, circRNAs can be served diagnostic prognostic biomarkers for injuries, involvement underlying mechanisms ncRNAs modulating structure function ischemic stroke, hemorrhagic traumatic brain injury (TBI), spinal cord (SCI), multiple sclerosis (MS), Alzheimer's disease (AD), vascular cognitive impairment dementia (VCID), tumors, infections, diabetes, sepsis-associated encephalopathy (SAE), others. We also discussed pharmaceutical drugs regulate via ncRNAs-related signaling cascades disorders, along with challenges, perspective, therapeutic potential

Язык: Английский

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Spatiotemporally Controllable MicroRNA Imaging in Living Cells via a Near-Infrared Light-Activated Nanoprobe

ACS Applied Materials & Interfaces, Год журнала: 2020, Номер 12(32), С. 35958 - 35966

Опубликована: Июль 15, 2020

In situ spatiotemporal microRNA (miRNA) imaging in mammal cells plays an essential role illustrating its structures and biological functions. Herein, we proposed a near-infrared (NIR) light-activated nanoprobe for high-sensitive controllable miRNA living cells. The NIR-activated employed upconversion nanoparticle that acted as NIR-to-UV transducer to trigger the following photocleavage toward dumbbell DNA probe tethered on surface of nanoparticle. structure change then induced catalytic hairpin assembly target miRNAs, by which readout amplified fluorescence signal was enabled. Additionally, both intracellular accurate quantification live were realized without damaging cell membranes. Compared with conventional strategies, approach remarkedly increases efficiency eliminating those unfavored intercellular molecular backgrounds. We assured sensing strategy will add advancement bioanalysis systems, is crucial importance diagnosis various human diseases, especially cancers.

Язык: Английский

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Non-Coding RNA as Biomarkers for Type 2 Diabetes Development and Clinical Management

Frontiers in Endocrinology, Год журнала: 2021, Номер 12

Опубликована: Сен. 17, 2021

Diabetes, a metabolic disease characterized by high blood glucose and other complications, has undefined causes multiple risk factors, including inappropriate diet, unhealthy lifestyles, genetic predisposition. The two most distinguished types of diabetes are type 1 2 diabetes, resulting from the autoimmune impairment insulin-generating pancreatic β cells insulin insensitivity, respectively. Non-coding RNAs (ncRNAs), cohort with little transcriptional value, have been found to exert substantial importance in epigenetic posttranscriptional modulation gene expression such as messenger RNA (mRNA) silencing. This review mainly focuses on pathology (T2D) ncRNAs potential biomarkers T2D development clinical management. We consolidate pathogenesis, diagnosis, current treatments T2D, present existing evidence changes response various pathological dysfunctions different stages T2D.

Язык: Английский

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Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applications

Frontiers in Molecular Neuroscience, Год журнала: 2022, Номер 15

Опубликована: Ноя. 9, 2022

Central nervous system (CNS) disease is a general term for series of complex and diverse diseases, including Alzheimer’s (AD), Parkinson’s (PD), multiple sclerosis (MS), CNS tumors, stroke, epilepsy, amyotrophic lateral (ALS). Interneuron neuron-glia cells communicate with each other through their homeostatic microenvironment. Exosomes in the microenvironment have crucial impacts on interneuron by transferring contents, such as proteins, lipids, ncRNAs, constituting novel form cell-to-cell interaction communication. Exosomal noncoding RNAs (ncRNAs), microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), PIWI-interacting (piRNAs), regulate physiological functions maintain homeostasis. are regarded extracellular messengers that transfer ncRNAs between neurons body fluids due to ability cross blood-brain barrier. This review aims summarize current understanding exosomal prospective diagnostic biomarkers, pathological regulators, therapeutic strategies clinical applications. We also provide an all-sided discussion comparison some similar diseases main limitations challenges

Язык: Английский

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Cerebrospinal fluid-derived extracellular vesicles after spinal cord injury promote vascular regeneration via PI3K/AKT signaling pathway

Journal of Orthopaedic Translation, Год журнала: 2023, Номер 39, С. 124 - 134

Опубликована: Март 1, 2023

The cerebrospinal fluid (CSF), which surrounds the brain and spinal cord, is predominantly produced by choroid plexus of ventricle. Although CSF-derived extracellular vesicles (CSF-EVs) may be utilized as diagnostic prognostic indicators for illnesses central nervous system (CNS), it uncertain if CSF-EVs have an impact on neurological function after cord injury (SCI). Here, we isolated EVs using ultracentrifugation extracting CSF from Bama miniature pigs. We then combined with hydrogel put cord's surface. To determine had mice's neurofunctional recovery, behavioral evaluations were employed. Both in vitro vivo, effect angiogenesis was assessed. investigated whether stimulated PI3K/AKT pathway to alter PI3K inhibitor LY294002. successfully identified transmission electron microscope (TEM), nano-tracking analysis (NTA), western blot. could ingested vascular endothelial cells proved vivo imaging immunofluorescence. demonstrated that derived pigs SCI (SCI-EVs) showed a better promoting regeneration compared receiving laminectomy (Sham-EVs). Behavioral assessments SCI-EVs dramatically enhance motor sensory mice SCI. Western blot suggested promote activating signaling pathway, pro-angiogenetic attenuated application LY294002 (PI3K inhibitor). Our study revealed hence improving recovery SCI, offer potential novel therapeutic options acute This promotion exosomes, provide approach treatment injury.

Язык: Английский

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Potential of Circulating miRNAs as Molecular Markers in Mood Disorders and Associated Suicidal Behavior

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(5), С. 4664 - 4664

Опубликована: Фев. 28, 2023

Mood disorders are the most prevalent psychiatric associated with significant disability, morbidity, and mortality. The risk of suicide is severe or mixed depressive episodes in patients mood disorders. However, increases severity often presented higher incidences bipolar disorder (BD) than major depression (MDD). Biomarker study neuropsychiatric critical for developing better treatment plans by facilitating more accurate diagnosis. At same time, biomarker discovery also provides objectivity to develop state-of-the-art personalized medicine increased accuracy through clinical interventions. Recently, colinear changes miRNA expression between brain systemic circulation have added great interest examining their potential as molecular markers mental disorders, including MDD, BD, suicidality. A present understanding circulating miRNAs body fluids implicates role managing conditions. Most notably, use prognostic diagnostic response significantly advanced our knowledge base. review discusses circulatory underlying possibilities be used a screening tool assessing conditions, suicidal behavior.

Язык: Английский

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Noncoding RNAs in Diabetic Nephropathy: Pathogenesis, Biomarkers, and Therapy

Journal of Diabetes Research, Год журнала: 2020, Номер 2020, С. 1 - 10

Опубликована: Июнь 22, 2020

The correlation between diabetes and systematic well-being on human life has long established. As a common complication of diabetes, the prevalence diabetic nephropathy (DN) been increasing globally. DN is known to be major cause end-stage kidney disease (ESKD). Till now, molecular mechanisms for have not fully explored effective therapies are still lacking. Noncoding RNAs class produced by genome transcription that cannot translated into proteins. It documented ncRNAs participate in pathogenesis regulating inflammation, apoptosis, autophagy, cell proliferation, other pathological processes. In this review, roles diagnostic therapeutic potential three types (microRNA, noncoding RNA, circular RNA) progression summarized illustrated.

Язык: Английский

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Diagnostic and Prognostic Value of Circulating CircRNAs in Cancer

Frontiers in Medicine, Год журнала: 2021, Номер 8

Опубликована: Март 18, 2021

Cancer has been regarded as one of the leading causes mortality worldwide. Diagnostic and prognostic biomarkers with high sensitivity specificity for cancer play a crucial role in preventing or treating cancer. Circular RNAs (circRNAs), which hold great potential management patients due to their abundance, stable property, serum, plasma, other body fluids, can be used non-invasive blood-based diagnosis prognosis. There are four types circRNAs including exonic (ecircRNA), intronic circRNAs, exon-intron (EIciRNA), intergenic circRNAs. CircRNAs act miRNA sponges, affect protein translation, interplay RNA binding proteins, regulate recruitment, modulate scaffolding assembly. Therefore, multifunctionalities make them ideal detecting predicting Indeed, manifest more than ten This review aims consolidate functions well discuss diagnostic value circulating

Язык: Английский

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