BioMed Research International,
Год журнала:
2019,
Номер
2019, С. 1 - 16
Опубликована: Апрель 7, 2019
Aging
is
related
to
a
number
of
functional
and
morphological
changes
leading
progressive
decline
the
biological
functions
an
organism.
Reactive
Oxygen
Species
(ROS),
released
by
several
endogenous
exogenous
processes,
may
cause
important
oxidative
damage
DNA,
proteins,
lipids,
cellular
dysfunctions.
The
imbalance
between
ROS
production
antioxidant
defenses
brings
stress
conditions
and,
accumulation
ROS,
aging-associated
diseases.
purpose
this
review
provide
overview
most
relevant
data
reported
in
literature
on
natural
compounds,
mainly
phytochemicals,
with
activity
their
potential
protective
effects
age-related
diseases
such
as
metabolic
syndrome,
diabetes,
cardiovascular
disease,
cancer,
neurodegenerative
chronic
inflammation,
possibly
lower
side
effects,
when
compared
other
drugs.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2021,
Номер
2021(1)
Опубликована: Янв. 1, 2021
As
an
antioxidant,
lycopene
has
acquired
importance
as
it
prevents
autoxidation
of
fats
and
related
products.
Tomatoes
are
important
agricultural
product
that
is
a
great
source
lycopene.
It
contains
many
vitamins
minerals,
fiber,
carbohydrates
associated
with
various
positive
effects
on
health.
The
antioxidant
potential
tomatoes
substantially
explained
compounds.
Diet
major
risk
factor
for
heart
diseases
which
shown
the
most
cause
death
in
world.
been
observed
taken
diet
stages
atherosclerosis.
serum
lipid
levels,
endothelial
dysfunction,
inflammation,
blood
pressure,
antioxidative
mainly
affected
by
These
natural
antioxidants,
can
also
enhance
nutritional
value
foods,
may
lead
to
new
ways
if
used
food
preservation.
In
this
review
study,
cardiovascular
protection
mechanism
discussed.
Biomedicine & Pharmacotherapy,
Год журнала:
2020,
Номер
129, С. 110459 - 110459
Опубликована: Июнь 30, 2020
Studying
prostate
cancer
is
important
due
to
its
high
annual
incidences
and
mortality
rates
in
the
world.
Although
are
reduced
using
new
therapy,
complicated
routes
side
effects
of
these
current
drugs
require
a
daily
available
treatment
for
prevention.
Lycopene
natural,
prominent,
effective
product
which
has
value
diet.
The
anti-cancer
effect,
non-toxicity,
safety
preventive
or
therapeutic
roles
lycopene
have
been
investigated
several
studies.
In
review,
we
collected
information
about
anti-cancer,
anti-progressive
apoptotic
on
cancer.
This
article
summary
most
original
review
articles
anticancer
that
systematically
categorized
presents
molecular
structure,
different
sources,
biological
functions,
in-vivo
in-vitro
variety
cancerous
normal
cells.
clinical
studies
provide
clear
image
continuous
use
this
adjunctive
dietary
type
cancers,
especially
men.
addition,
discusses
various
pathways
activated
by
eventually
prevent
suppress
found
effectively
progression
proliferation,
arrest
in-cell
cycle,
induce
apoptosis
cells
both
conditions.
Additionally,
showed
it
could
modulate
signaling
their
protein
prevention
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
161, С. 114428 - 114428
Опубликована: Фев. 24, 2023
The
potent
relation
between
lycopene
intake
and
reduced
incidence
of
a
variety
cancers
has
an
increasing
interest.
This
comprehensive
review
aims
to
highlight
the
in
vivo
vitro
research
evaluating
anticancer
mechanisms
by
underlining
experiment
conditions.
In
addition
these,
general
characterization
been
explained.
A
collection
relevant
scientific
pharmacological
articles
from
following
databases
PubMed/MedLine,
Web
Science,
Scopus,
TRIP
database,
Google
Scholar
on
molecular
action
cellular
effects
various
types
tumors
was
performed.
potential
described
cells,
animal
studies,
some
clinical
trials.
It
revealed
that
is
mainly
due
its
powerful
singlet-oxygen
quencher
characteristics,
simulation
detoxifying/antioxidant
enzymes
production,
initiation
apoptosis,
inhibition
cell
proliferation
cycle
progression
as
well
modulations
gap
junctional
communication,
growth
factors,
signal
transduction
pathways.
highlighted
properties
are
primarily
linked
factors
including;
dose,
presence
drug
delivery
systems,
type
cancer,
tumor
size,
treatment
time.
Molecules,
Год журнала:
2021,
Номер
26(13), С. 3888 - 3888
Опубликована: Июнь 25, 2021
Lycopene
is
a
well-known
compound
found
commonly
in
tomatoes
which
brings
wide
range
of
health
benefits
against
cardiovascular
diseases
and
cancers.
From
an
anti-cancer
perspective,
lycopene
often
associated
with
reduced
risk
prostate
cancer
people
look
for
it
as
dietary
supplement
may
help
to
prevent
cancer.
Previous
scientific
evidence
exhibited
that
the
activity
relies
on
its
ability
suppress
oncogene
expressions
induce
proapoptotic
pathways.
To
further
explore
real
potential
prevention,
this
review
discusses
new
insights
perspectives
activities
could
drive
direction
research.
The
relationship
between
inflammation
being
highlighted,
whereby
suppresses
via
resolution
are
also
discussed
herein.
immune
system
was
be
part
modulates
cells
tumor
growth
progression.
Lycopene,
under
family
carotenoids,
play
special
role
suppressing
lung
Seminars in Cancer Biology,
Год журнала:
2021,
Номер
73, С. 331 - 346
Опубликована: Март 29, 2021
Dietary
interventions
are
key
nutritional
strategies
to
prevent,
improve,
and
prolong
the
survival
of
cancer
patients.
Lycopene,
one
strongest
natural
antioxidants,
its
biologically
active
metabolites,
have
shown
significant
potential
prevent
a
variety
cancers,
including
prostate,
breast,
stomach
making
it
promising
anti-cancer
agent.
We
review
regulatory
mechanisms
epidemiological
evidences
lycopene
metabolites
delay
progression
cancers
at
different
developmental
stages.
Recent
studies
revealed
that
mediate
multiple
molecular
in
treatment
such
as
redox
homeostasis,
selective
anti-proliferation,
apoptosis,
anti-angiogenesis,
tumour
microenvironment
regulation,
anti-metastasis
anti-invasion.
Gut
microbes
cholesterol
metabolism
also
regulation
targets
metabolites.
As
dietary
supplement,
synergistic
interaction
with
other
drugs
nutrients
is
highlighted
especially
due
binding
activity
diet
found
central
fight
against
cancer.
Furthermore,
application
several
novel
delivery
carriers
on
rise
nanoemulsions,
nanostructured
liposomes,
polymer
nanoparticles
for
prevention
discussed
this
future
needed
development.
Moreover,
mechanism
between
or
systems
should
now
be
deeply
investigated
improve
clinical
intervention
future.
Molecules,
Год журнала:
2022,
Номер
27(5), С. 1701 - 1701
Опубликована: Март 4, 2022
Tomato
producing
and
processing
industries
present
undoubted
potential
for
industrial
discarded
products
valorization
whether
due
to
the
overproduction
of
fresh
tomatoes
or
loss
during
processing.
Although
tomato
by-products
are
not
yet
considered
a
raw
material,
several
studies
have
suggested
innovative
profitable
applications.
It
is
often
referred
as
“tomato
pomace”
quite
rich
in
variety
bioactive
compounds.
Lycopene,
vitamin
C,
β-carotene,
phenolic
compounds,
tocopherol
some
bioactives
herein
discussed.
also
minerals.
Many
these
compounds
powerful
antioxidants
with
anti-inflammatory
properties
besides
modulating
immune
system.
Several
researchers
focused
on
possible
application
natural
ingredients,
especially
those
extracted
from
foods,
their
physiological
pharmacological
effects.
Herein,
effects
further
applications
were
carefully
reviewed,
regarding
anti-cancer
The
aim
this
review
was
thus
highlight
existing
opportunities
create
health
context.
Cells,
Год журнала:
2022,
Номер
11(8), С. 1326 - 1326
Опубликована: Апрель 13, 2022
Despite
significant
technological
advancements
in
conventional
therapies,
cancer
remains
one
of
the
main
causes
death
worldwide.
Although
substantial
progress
has
been
made
control
and
treatment
cancer,
several
limitations
still
exist,
there
is
scope
for
further
advancements.
Several
adverse
effects
are
associated
with
modern
chemotherapy
that
hinder
lead
to
other
critical
disorders.
Since
ancient
times,
plant-based
medicines
have
employed
clinical
practice
yielded
good
results
few
side
effects.
The
research
system
advanced
screening
techniques
plants’
bioactive
constituents
enabled
phytochemical
discovery
prevention
challenging
diseases
such
as
cancer.
Phytochemicals
vincristine,
vinblastine,
paclitaxel,
curcumin,
colchicine,
lycopene
shown
promising
anticancer
Discovery
more
plant-derived
compounds
should
be
encouraged
via
exploitation
innovative
techniques,
prevent
treat
advanced-stage
cancers
without
causing
This
review
highlights
numerous
molecules
potential
agents
their
probable
mechanisms
action
provides
an
overview
vitro,
vivo
trial
studies
on
phytochemicals.
