Cells,
Год журнала:
2022,
Номер
11(24), С. 4071 - 4071
Опубликована: Дек. 15, 2022
Colorectal
cancer
(CRC)
is
a
malignancy
that
seriously
threatens
human
health,
and
metastasis
from
CRC
major
cause
of
death
poor
prognosis
for
patients.
Studying
the
potential
mechanisms
small
extracellular
vesicles
(sEVs)
in
tumor
development
may
provide
new
options
early
effective
diagnosis
treatment
metastasis.
In
this
review,
we
systematically
describe
how
sEVs
mediate
epithelial
mesenchymal
transition
(EMT),
reconfigure
microenvironment
(TME),
modulate
immune
system,
alter
vascular
permeability
angiogenesis
to
promote
We
also
discuss
current
difficulties
studying
propose
ideas.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Сен. 11, 2023
Hepatocellular
carcinoma
(HCC),
the
most
common
primary
malignancy
of
liver,
is
one
leading
causes
cancer-related
death
and
associated
with
a
poor
prognosis.
The
tumor
microenvironment
(TME)
HCC
comprises
immune,
immunosuppressive,
interstitial
cells
hypoxic,
angiogenic,
metabolic
reprogramming,
inflammatory,
immunosuppressive
features.
Exosomes
are
nanoscale
extracellular
vesicles
that
secrete
biologically
active
signaling
molecules
such
as
deoxyribonucleic
acid
(DNA),
messenger
ribonucleic
(mRNA),
microribonucleic
(miRNA),
proteins,
lipids.
These
act
messengers
in
microenvironment,
especially
microenvironment.
Exosomal
circRNAs
reshape
by
prompting
hypoxic
stress
response,
stimulating
angiogenesis,
contributing
to
facilitating
inflammatory
changes
inducing
immunosuppression.
exosomes
secreted
carry
circRNA
into
immune
cells,
which
intervene
activation
promote
overexpression
checkpoints
regulate
acquire
properties.
Furthermore,
immunosuppression
final
result
combination
TME-related
factors,
including
hypoxia,
inflammation
changes.
In
conclusion,
exosomal
accelerates
progression
adjusting
phenotype
ultimately
forming
an
HCC-derived
can
affect
cell
proliferation,
invasion,
metastasis,
induction
chemoresistance.
Therefore,
this
review
aimed
summarize
composition
function
these
exosomes,
role
play
formation,
interactions
between
cells.
This
outlines
malignant
provides
preliminary
exploration
clinical
utility
circRNAs.
Cancers,
Год журнала:
2024,
Номер
16(7), С. 1415 - 1415
Опубликована: Апрель 4, 2024
Hepatocellular
carcinoma
(HCC)
is
the
most
common
primary
liver
cancer.
It
a
major
public
health
problem
worldwide,
and
it
often
diagnosed
at
advanced
stages,
when
no
effective
treatment
options
are
available.
Extracellular
vesicles
(EVs)
nanosized
double-layer
lipid
containing
various
biomolecule
cargoes,
such
as
lipids,
proteins,
nucleic
acids.
EVs
released
from
nearly
all
types
of
cells
have
been
shown
to
play
an
important
role
in
cell-to-cell
communication.
In
recent
years,
many
studies
investigated
cancer,
including
HCC.
Emerging
that
roles
development
progression
modulating
tumor
growth
metastasis
formation.
Moreover,
has
observed
non-coding
RNAs
(ncRNAs)
carried
by
cell-derived
promote
tumorigenesis,
regulating
microenvironment
(TME)
playing
critical
progression,
angiogenesis,
metastasis,
immune
escape,
drug
resistance
EV-related
ncRNAs
can
provide
information
regarding
disease
status,
thus
encompassing
biomarkers.
this
review,
we
discuss
main
present
HCC-derived
EVs,
micro(mi)
RNAs,
long
(lnc)
circular
(circ)
their
potential
clinical
value
biomarkers
therapeutic
targets.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Июнь 29, 2023
Hepatocellular
carcinoma
(HCC),
one
of
the
most
prevalent
cancers,
with
a
high
mortality
rate
worldwide,
seriously
impairs
patient
health.
The
lack
accurate
targets
impedes
early
screening
and
diagnosis
HCC
is
associated
poor
response
to
routine
therapies.
Extracellular
vesicles
(EVs),
comprising
exosomes,
microvesicles,
apoptotic
bodies,
are
lipid
bilayer
membrane-derived
nanometer-sized
vesicles.
EVs
can
be
secreted
from
various
cancer
cells
release
diverse
biomolecules,
such
as
DNA,
RNA,
proteins,
metabolites,
lipids,
making
them
potential
source
biomarkers
regulators
tumor
microenvironment.
Emerging
evidence
suggests
that
involved
in
intercellular
communication
by
carrying
biological
information.
These
elicit
physiological
functions
oncogenesis
HCC,
proliferation,
invasion,
metastasis,
chemoresistance
HCC.
have
also
been
considered
promising
nanotherapeutic
for
Therefore,
this
review
sheds
light
on
current
understanding
interactions
between
propose
strategies.
Cancers,
Год журнала:
2023,
Номер
15(16), С. 4187 - 4187
Опубликована: Авг. 21, 2023
Hepatocellular
carcinoma
(HCC)
is
a
widely
prevalent
and
malignantly
progressive
tumor.
Most
patients
are
typically
diagnosed
with
HCC
at
an
advanced
stage,
posing
significant
challenges
in
the
execution
of
curative
surgical
interventions.
Non-coding
RNAs
(ncRNAs)
represent
distinct
category
RNA
molecules
not
directly
involved
protein
synthesis.
However,
they
possess
remarkable
ability
to
regulate
gene
expression,
thereby
exerting
regulatory
control
over
cellular
processes.
Notably,
ncRNAs
have
been
implicated
modulation
programmed
cell
death
(PCD),
crucial
mechanism
that
various
therapeutic
agents
target
fight
against
HCC.
This
review
summarizes
clinical
significance
ncRNA
regulation
PCD
HCC,
including
patient
diagnosis,
prognosis,
drug
resistance,
side
effects.
The
aim
this
study
provide
new
insights
directions
for
diagnosis
treatment
strategies
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 5, 2024
Osteoarthritis
(OA)
is
a
progressive
degenerative
disorder
impacting
bones
and
joints,
worsened
by
chronic
inflammation,
immune
dysregulation,
mechanical
stress,
metabolic
disturbances,
various
other
contributing
factors.
The
complex
interplay
of
cartilage
damage,
loss,
impaired
repair
mechanisms
remains
critical
formidable
aspect
OA
pathogenesis.
At
the
genetic
level,
multiple
genes
have
been
implicated
in
modulation
chondrocyte
metabolism,
displaying
both
promotive
inhibitory
roles.
Recent
research
has
increasingly
focused
on
influence
non-coding
RNAs
regulation
distinct
cell
types
within
bone
tissue
OA.
In
particular,
an
expanding
body
evidence
highlights
regulatory
roles
microRNAs
chondrocytes.
This
review
aims
to
consolidate
most
relevant
associated
with
chondrocytes,
as
identified
recent
studies,
elucidate
their
involvement
processes
ferroptosis.
Furthermore,
this
study
explores
interactions
between
long
(lncRNAs)
circular
(circRNAs)
OA,
emphasis
microRNA-mediated
mechanisms.
Finally,
gaps
current
are
identified,
offering
strategic
insights
advance
understanding
pathophysiology
guide
therapeutic
developments
field.
Experimental & Molecular Medicine,
Год журнала:
2024,
Номер
56(11), С. 2365 - 2381
Опубликована: Ноя. 11, 2024
Immune
checkpoint
proteins
(ICPs)
serve
as
critical
regulators
of
the
immune
system,
ensuring
protection
against
damage
due
to
overly
activated
responses.
However,
within
tumor
environment,
excessive
ICP
activation
weakens
antitumor
immunity.
Despite
development
numerous
blockade
(ICB)
drugs
in
recent
years,
their
broad
application
has
been
inhibited
by
uncertainties
about
clinical
efficacy.
A
thorough
understanding
regulation
microenvironment
is
essential
for
advancing
more
effective
and
safer
ICB
therapies.
Extracellular
vesicles
(EVs),
which
are
pivotal
mediators
cell-cell
communication,
have
extensively
studied
found
play
key
roles
functionality
ICPs.
Nonetheless,
a
comprehensive
review
summarizing
current
knowledge
crosstalk
between
EVs
ICPs
environment
lacking.
In
this
review,
we
summarize
interactions
several
widely
well
potential
implications,
providing
theoretical
basis
further
investigation
EV-related
therapeutic
approaches.
Abstract
Hepatocellular
carcinoma
(HCC)
is
characterized
by
high
morbidity
and
mortality,
a
low
5-year
survival
rate.
Exploring
the
potential
molecular
mechanisms,
finding
diagnostic
biomarkers
with
sensitivity
specificity,
determining
new
therapeutic
targets
for
HCC
are
urgently
needed.
Circular
RNAs
(circRNAs)
have
been
found
to
play
key
role
in
occurrence
development
of
HCC,
while
exosomes
an
important
intercellular
communication;
thus,
combination
circRNAs
may
inestimable
early
diagnosis
curative
therapy.
Previous
studies
shown
that
can
transfer
from
normal
or
abnormal
cells
surrounding
distant
cells;
thereafter,
influence
target
cells.
This
review
summarizes
recent
progress
regarding
roles
exosomal
diagnosis,
prognosis,
immune
checkpoint
inhibitor
tyrosine
kinase
resistance
provide
inspiration
further
research.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Ноя. 24, 2023
Introduction
Clonorchiasis
remains
a
serious
global
public
health
problem,
causing
various
hepatobiliary
diseases.
However,
there
is
still
lack
of
overall
understanding
regarding
the
molecular
events
triggered
by
Clonorchis
sinensis
(
C.
)
in
liver.
Methods
BALB/c
mouse
models
infected
with
for
5,
10,
15,
and
20
weeks
were
constructed.
Liver
pathology
staining
observation
conducted
to
evaluate
histopathology.
The
levels
biochemical
enzymes,
blood
routine
indices,
cytokines
determined.
Furthermore,
alterations
transcriptome,
proteome,
metabolome
livers
5
analyzed
using
multi-omics
techniques.
Results
results
this
study
indicated
that
adult
can
cause
hepatosplenomegaly
liver
damage,
most
severe
symptoms
observed
at
post-infection.
as
infection
persisted,
Th2
immune
response
increased
relieved.
Multi-omics
analysis
identified
191,
402
232
differentially
expressed
genes
(DEGs),
proteins
(DEPs)
metabolites
(DEMs),
respectively.
Both
DEGs
DEPs
significantly
enriched
fibrosis-related
pathways
such
ECM-receptor
interaction
cell
adhesion
molecules.
Key
molecules
associated
fibrosis
inflammation
(Cd34,
Epcam,
S100a6,
Fhl2,
Itgax,
Retnlg)
up-regulated
both
gene
protein
levels.
top
three
metabolic
pathways,
namely
purine
metabolism,
arachidonic
acid
ABC
transporters,
cirrhosis,
fibrosis,
cholestasis,
promote
LysoPC(P-16:0/0:0),
20-COOH-leukotriene
E4,
14,15-DiHETrE,
up-regulated.
Conclusion
Our
revealed
mice
occurred
Moreover,
uncovered
predominant
related
changes
This
not
only
enhances
our
clonorchiasis
progression
but
also
provides
valuable
insights
into
molecular-level
mechanism
between
its
host
