Palladium-catalyzed asymmetric [4 + 3] cycloaddition of acyclic α,β-unsaturated imines with trimethylenemethane donors: access to chiral non-fused azepines
Ting-Peng Li,
S. Su,
Jia‐Huan Shen
и другие.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(8), С. 2326 - 2331
Опубликована: Янв. 1, 2024
An
efficient
approach
for
the
construction
of
non-fused
azepines
in
good
yields
with
high
enantioselectivity
via
Pd-catalyzed
asymmetric
[4
+
3]
cycloaddition
was
developed.
Язык: Английский
Palladium-catalyzed [6 + 4] cycloaddition with π-allyl all-carbon 1,6-dipole for the synthesis of ten-membered heterocycles
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
11(5), С. 1299 - 1304
Опубликована: Дек. 25, 2023
This
work
introduces
a
novel
α,α-diester-δ-vinylvalerolactone
as
dipolar
precursor
in
palladium-catalyzed
[6
+
4]
cycloaddition
reaction
with
azadienes,
resulting
the
production
of
ten-membered
heterocycles.
Язык: Английский
Palladium-catalyzed (Z)-selective allylation of phosphine oxides with vinylethylene carbonates to construct phosphorus allyl alcohols
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(15), С. 3068 - 3072
Опубликована: Янв. 1, 2024
Allylphosphine
oxide
compounds
are
important
building
blocks
with
broad
applications
in
organic
synthesis
and
pharmaceutical
science.
Herein,
we
report
an
unprecedented
palladium-catalyzed
allylation
of
phosphine
oxides
vinylethylene
carbonates,
producing
various
phosphorus
allyl
alcohols
excellent
yields
high
Язык: Английский
Synthesis of Indole‐Fused Eight‐Membered Oxa‐Rings via Palladium‐Catalyzed Asymmetric [4+4] Cycloaddition of Indole‐2,3‐Quinodimethanes with 2‐Alkylidenetrimethylene Carbonates
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 16, 2024
Comprehensive
Summary
We
report
a
palladium‐catalyzed
asymmetric
[4+4]
cycloaddition
reaction
between
2‐alkylidenetrimethylene
carbonate
and
electron‐deficient
indole‐2,3‐quinodimethanes
(
IQDMs
).
This
features
exclusive
regioselectivity,
high
yield
(up
to
98%),
excellent
enantioselectivity
95%
ee),
easy
scale‐up
without
any
loss
of
efficiency,
making
it
valuable
for
the
synthesis
indole‐fused
eight‐membered
oxa‐rings.
Язык: Английский
Type of Tetrahydronaphthalene-Fused 1,5-Dipoles and Their Application in Polycyclic Compounds Synthesis
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(15), С. 10551 - 10556
Опубликована: Июль 17, 2024
Palladium-catalyzed
dipolar
cycloaddition
reactions
represent
an
efficient
strategy
for
the
construction
of
cyclic
compounds,
with
development
novel
precursors
being
a
key
focus.
In
this
study,
new
type
precursor
was
synthesized
through
assembly
vinylethylene
carbonate
unit
and
tetrahydronaphthalene
skeleton.
This
can
undergo
[3
+
2],
[5
4],
2]
reactions,
leading
to
tetrahydronaphthalene-fused
oxazolidin-2-ones,
1,5-oxazonines,
tetrahydrooxepines.
general,
all
these
exhibited
good
reaction
efficiency
functional
group
tolerance.
Язык: Английский