Indian Journal of Clinical Biochemistry, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 18, 2024
Язык: Английский
Frontiers in Endocrinology, Год журнала: 2025, Номер 15
Опубликована: Янв. 9, 2025
Oxidative stress (OS) is established as a key factor in the etiology of both male and female infertility, arising from an imbalance between reactive oxygen species (ROS) production endogenous antioxidant (AOX) defenses. In men, OS adversely affects sperm function by inducing DNA damage, reducing motility, significantly impairing vitality through plasma membrane peroxidation loss integrity, ultimately compromising overall quality. women, implicated various reproductive disorders, including polycystic ovary syndrome, endometriosis, premature ovarian failure, leading to diminished oocyte quality, disrupted folliculogenesis, poorer outcomes. Antioxidant therapy represents promising intervention mitigate harmful effects ROS on health additions its easy accessibility, safety, low cost. Despite several findings suggesting improvements fertility potential with AOX therapy, data remains inconclusive regarding optimal dosage combination, duration treatment, specific patient populations most likely benefit. this review, we discuss role AOXs management infertile couples, focusing their biological mechanisms, adverse effects, therapeutic efficacy, clinical applications improving outcomes natural conception medically assisted reproduction. Additionally, highlight current practice patterns recommendations for supplementation during course infertility treatment. Further, provide overview limitations research topic insights future studies establish standardized regimens assess long-term impact such live birth rates miscarriage rates.
Язык: Английский
Процитировано
3
BioMolecular Concepts, Год журнала: 2024, Номер 15(1)
Опубликована: Янв. 1, 2024
In the past two decades, oxidative stress (OS) has drawn a lot of interest due to revelation that individuals with many persistent disorders including diabetes, polycystic ovarian syndrome (PCOS), cardiovascular, and other often have aberrant oxidation statuses. OS close interplay PCOS features such as insulin resistance, hyperandrogenism, chronic inflammation; there is belief might contribute development PCOS. currently recognized not only one most prevalent endocrine but also significant contributor female infertility, affecting considerable proportion women globally. Therefore, understanding relationship between crucial therapeutic preventive strategies for Moreover, mechanistic study intracellular reactive oxygen species/ nitrogen species formation its possible interaction women's reproductive health required, which includes complex enzymatic non-enzymatic antioxidant systems. Apart from that, our current review regulation pathogenesis OS. A change in lifestyle, physical activity, various supplements boost levels, particularly vitamins, usage medicinal herbs, thought be best way combat this occurrence improve pathophysiologic conditions associated
Язык: Английский
Процитировано
14
Cells, Год журнала: 2024, Номер 13(16), С. 1354 - 1354
Опубликована: Авг. 14, 2024
Autophagy, an evolutionarily conserved cellular mechanism essential for maintaining internal stability, plays a crucial function in female reproductive ability. In this review, we discuss the complex interplay between autophagy and several facets of health, encompassing pregnancy, ovarian functions, gynecologic malignancies, endometriosis, infertility. Existing research emphasizes significance embryo implantation, specifically endometrium, highlighting its necessity ensuring proper fetal development. Although some knowledge has been gained, there is still lack on specific molecular impacts quality oocytes, growth follicles, general health. Autophagy role maturation, quality, development oocytes. It also involved aging, contributing to reductions that occur with age. This review explores physiological functions system, participation toxicity, important connections endometrium embryo. addition, study investigates possibility emerging treatment approaches aim modify autophagy, using both natural substances synthetic molecules, improve fertility outcomes. Additionally, intends inspire future exploration into intricate health by reviewing recent studies pinpointing areas where current lacking. Subsequent investigations should prioritize conversion these discoveries practical uses medical field, which could potentially result groundbreaking therapies infertility other difficulties related reproduction. Therefore, gaining comprehensive understanding many effects would not only further field biology but open new possibilities diagnostic methods.
Язык: Английский
Процитировано
5
Nature Reviews Endocrinology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 28, 2024
Язык: Английский
Процитировано
5
Journal of Ovarian Research, Год журнала: 2024, Номер 17(1)
Опубликована: Окт. 16, 2024
Polycystic ovary syndrome (PCOS) affects 6-20% of women worldwide, with insulin resistance and hyperinsulinemia occurring in 50-70% patients. Hyperinsulinemia exacerbates oxidative stress, contributing to PCOS pathogenesis. N-acetylcysteine (NAC) is an antioxidant sensitizer that shows promise as a therapeutic for PCOS. Our current study aimed investigate the effects NAC supplementation on endocrine-metabolic parameters mice its effect ovulation induction (OI) efficacy
Язык: Английский
Процитировано
3
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
European journal of medical research, Год журнала: 2025, Номер 30(1)
Опубликована: Апрель 28, 2025
Infertility has emerged as a significant global health concern, affecting nearby 8-12% of couples in reproductive age worldwide. Increasing evidence suggests potential link between human papillomavirus (HPV) and infertility both men women. Some research indicate that HPV can infect various components semen, potentially sperm quality by decreasing motility, viability, increasing DNA fragmentation, all which may contribute to male infertility. The virus attach the equatorial region head, enabling infected transmit oocyte or placenta. Consequently, induces apoptosis trophoblastic cells disrupts their adhesion endometrial cells, raises risk miscarriage. also affect ovarian reserve causing chronic inflammation, impair granulosa cell function lower serum anti-Müllerian hormone (AMH) levels. Besides, HPV-related immune responses producing anti-sperm antibodies (ASAs), cause clumping, reduce motility through cervical mucus, activate complement system damages female tract interfere with sperm-egg interactions. Moreover, infection been linked reduced success rates assisted technologies (ART), disrupting critical processes such acrosome reaction, sperm-oocyte interaction, fusion. One mechanism contributes is oxidative stress (OS). Triggered OS negatively impact damage system, ultimately contributing Despite these associations, precise mechanisms strength relationship remain uncertain. Thus, this review seeks investigate on infertility, particularly its effects OS. A clearer understanding could inform future strategies for addressing
Язык: Английский
Процитировано
0
International Journal of Current Innovations in Advanced Research, Год журнала: 2024, Номер unknown, С. 1 - 10
Опубликована: Май 27, 2024
Polycystic Ovarian Disorder (PCOD) is a prevalent endocrine illness in women of reproductive age which and metabolic disorder. It shows hormonal abnormalities there an excessive production androgens that one the main causes infertility, diabetes, irregular menstrual periods, hirsutism, hair loss, obesity acne. One features PCOD presence cysts on ovaries, can affect their ability to release eggs regularly Anti-Müllerian hormone (AMH) plays inhibitory role follicular development recruitment, contributing arrest. AMH action FSH-induced aromatase likely contributes hyperandrogenism PCOD. Some factors cause such as lack exercise, skipping breakfast, fast food, unbalanced sleep, obesity, genetic, environmental stress level. Lifestyle nutrition maintenance be done by lifestyle changes diet regulation (in taking vitamins, antioxidant Creatine) well medications regulate hormones, improve fertility sleep play vital management.
Язык: Английский
Процитировано
2
Hormone Molecular Biology and Clinical Investigation, Год журнала: 2024, Номер unknown
Опубликована: Сен. 4, 2024
Women with PCOS often experience significant difficulties in achieving spontaneous pregnancy. Intracytoplasmic sperm injection (ICSI) is a viable treatment option for these patients, offering an acceptable success rate. This study purposes to identify factors that may positively or negatively influence pregnancy rates women undergoing ICSI and explore potential modifications enhance successful outcomes.
Язык: Английский
Процитировано
1
ChemistrySelect, Год журнала: 2024, Номер 9(38)
Опубликована: Окт. 1, 2024
Abstract Polycystic Ovary Syndrome (PCOS) is a widespread and complex hormonal disorder occurs in women of reproductive age, characterized by imbalances ovarian dysfunction. Current approaches to treating PCOS often address specific symptoms, highlighting the demand for innovative therapeutic agents that can tackle its multifaceted nature. The present study endeavors investigate potential new chromen‐2‐one derivatives management PCOS. A total 30 have been synthesized evaluated their vitro inhibitory effects on 5‐α reductase antioxidant activities. Based promising activity acute toxicity profile 4‐methoxy‐ N ‐(3‐(4‐methoxyphenyl)‐2‐oxo‐2 H ‐chromen‐6‐yl) benzamide ( 29 ), it was selected subsequent vivo investigation experimental animal models also includes molecular interaction analysis through docking dynamic studies compound ).
Язык: Английский
Процитировано
1