Assessing body composition through anthropometry: Implications for diagnosing and managing polycystic ovary syndrome (PCOS) DOI
Suparna Parua, Arnab Das, Anukona Hazra

и другие.

Clinical Physiology and Functional Imaging, Год журнала: 2024, Номер unknown

Опубликована: Сен. 25, 2024

Abstract Polycystic ovary syndrome (PCOS) is a multifaceted endocrine disorder with profound implications for the reproductive and metabolic health of women. The utilization anthropometric measures in diagnosis management PCOS has gained increasing attention due to their practicality predictive capacity associated conditions such as obesity insulin resistance. This review rigorously explores application various indices, including body mass index, waist‐to‐hip ratio, advanced metrics shape index roundness wrist circumference, neck circumference. These indices offer critical insights into fat distribution its association hormonal perturbations characteristic PCOS. underscores necessity addressing obesity, prevalent comorbidity PCOS, through lifestyle modifications personalized therapeutic approaches. By incorporating evaluations routine clinical practice, healthcare professionals can enhance diagnostic precision, optimize treatment strategies, ultimately improve patient outcomes. integrative approach not only facilitates challenges inherent but also contributes development more individualized interventions, thereby enhancing overall quality life women affected by

Язык: Английский

Exploring Small-Molecule Inhibitors Targeting MAPK Pathway Components: Focus on ERK, MEK1, and MEK2 Kinases in Cancer Treatment DOI Creative Commons
Tuhin Mukherjee, Satyajit Mohanty, Jasleen Kaur

и другие.

Chemical Biology Letters, Год журнала: 2024, Номер 11(2), С. 659 - 659

Опубликована: Апрель 18, 2024

Mitogen-activated protein kinases (MAPKs), also known as extracellular signal regulated (ERKs), are found in numerous transduction pathways and triggered by kinase cascades. This article will review the present state of MAPK pathway inhibitors, with an emphasis on characteristics tiny molecule blockers p38, MEK1, MEK2 kinases. Many these inhibitors have showed potential experimental animal models disease, they now being investigated people for inflammatory cancer diseases. Clinical trials currently evaluating targeting a subset cellular signaling cascades that control pleiotropic activity. These activities far-reaching consequences management wide range disorders. The Ras-Raf-MEK-ERK (ERK) pathway, other hand, is clear therapeutic target because it common downstream route critical growth factor tyrosine receptors frequently changed or overexpressed human malignancies. Several new medicines this been discovered tested clinical studies. BAY 43-9006 one most intriguing agents. Although was initially created Raf inhibitor, has ability to Flt-3, c-Kit, VEGFR-2, which helps explain its antiproliferative antiangiogenic characteristics. ERK system normal malignant tissue be discussed paper, focus emerging treatments cascade at level.

Язык: Английский

Процитировано

6
Randomized clinical trial of astaxanthin supplement on serum inflammatory markers and ER stress‐apoptosis gene expression in PBMCs of women with PCOS DOI Creative Commons
Masoome Jabarpour, Fardin Amidi,

Ashraf Aleyasin

и другие.

Journal of Cellular and Molecular Medicine, Год журнала: 2024, Номер 28(14)

Опубликована: Июль 1, 2024

Abstract Polycystic ovarian syndrome (PCOS) is related to pro‐apoptotic and pro‐inflammatory conditions generated by Endoplasmic reticulum (ER) stress. This study aimed determine the effect of Astaxanthin (ASX), as carotenoid with potent antioxidant anti‐inflammatory properties, on serum inflammatory markers, apoptotic factors ER stress‐apoptotic genes in peripheral blood mononuclear cells (PBMCs) women PCOS. randomized, double‐blind clinical trial included 56 PCOS patients aged 18–40. For 8 weeks, subjects were randomly assigned one two groups: either 12 mg ASX ( n = 28) or placebo 28). Real‐time PCR was used quantify gene expression associated stress‐apoptosis women's PBMCs. The levels TNF‐α, IL18, IL6 CRP determined obtaining samples from all before after intervention using Enzyme‐linked immunosorbent assay (ELISA). Also, active caspase‐3 caspase‐8 detected PBMC ELISA kit. Furthermore, we evaluated efficacy disease symptoms. Following 8‐week intervention, supplementation able reduce GRP78 p 0.051), CHOP 0.008), XBP1 0.002), ATF4 (0.038), ATF6 (0.157) DR5 (0.016) when compared placebo. However, this decrease not statistically significant for 0.067) marginally 0.051). TNF‐α 0.009), IL‐18 0.003), IL‐6 0.013) 0.012) also lower therapy group. there no difference 0.177) 0.491) between treatment control groups. In our study, had positive BMI, hirsutism, hair loss regularity menstrual cycle. It appears that may benefit changing pathway reducing markers; however, additional research required compound's potential relevance.

Язык: Английский

Процитировано

5
Polycystic ovary syndrome as a metabolic disease DOI
Nafiye Helvacı, Bülent Okan Yıldız

Nature Reviews Endocrinology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

Язык: Английский

Процитировано

5
Exploring the therapeutic impact of Salvia officinalis on lipid and oxidative stress markers in patients with polycystic ovary syndrome – a randomized placebo-controlled clinical trial DOI Creative Commons
Arezoo Maleki‐Hajiagha, Faraz Mojab, Fardin Amidi

и другие.

BMC Complementary Medicine and Therapies, Год журнала: 2025, Номер 25(1)

Опубликована: Март 26, 2025

Salvia.officinalis (S. officinalis), is recognized for its antihyperlipidemic, metabolism-regulating, and antioxidant properties in diabetic hyperlipidemic disorders. This study examining effects on lipid oxidative stress (OS) markers patients with Polycystic Ovary Syndrome (PCOS), thereby substantiating role managing metabolic In this randomized placebo-controlled trial was performed gynecology clinics affiliated to Iran University of Medical Sciences. Accordingly, 70 Iranian married women aged 15–40 years newly diagnosed PCOS were included. They receive either 330 mg S. officinalis extract or placebo daily eight weeks. The outcomes included profile OS markers. found a significantly lower triglyceride levels malondialdehyde after weeks intake compared placebo. Also, the mean change triglyceride, high-density lipoprotein cholesterol, malondialdehyde, total capacity statistically significant intervention group. demonstrates that can reduce PCOS, suggesting potential as an adjunctive natural therapy imbalances associated condition. While did not alter other markers, observed improvements highlight therapeutic promise officinalis. These findings support further investigation into clinical applications benefits health. IRCT201504146917N2 2015–10-03 (registered while recruiting).

Язык: Английский

Процитировано

0
Alpha-lipoic acid regulates pro-inflammatory cytokines and hormones in letrozole-induced polycystic ovary syndrome in rats DOI

Fehintoluwa Joy Femi-Olabisi,

Olawunmi Rashidat Oyerinde,

Opeyemi Faokunla

и другие.

Endocrine and Metabolic Science, Год журнала: 2025, Номер 18, С. 100245 - 100245

Опубликована: Май 3, 2025

Язык: Английский

Процитировано

0
FSH, LH, Lipid and Adipokines in Polycystic Ovary Syndrome: Clinical Biochemistry Insights for Diagnosis and Management DOI

Wafa M. Merza,

Abeer Khalid Yaseen,

Maha Adel Mahmood

и другие.

The Journal of Steroid Biochemistry and Molecular Biology, Год журнала: 2025, Номер 251, С. 106773 - 106773

Опубликована: Май 5, 2025

Язык: Английский

Процитировано

0
МЕХАНІЗМИ ВПЛИВУ ІНСУЛІНОРЕЗИСТЕНТНОСТІ ПРИ СИНДРОМІ ПОЛІКІСТОЗНИХ ЯЄЧНИКІВ НА ПРОЦЕС ІМПЛАНТАЦІЇ ЕМБРІОНА DOI
S. V. Khmil, Ю. Б. Правак, Svitlana Halnykina

и другие.

Здобутки клінічної і експериментальної медицини, Год журнала: 2025, Номер 1, С. 39 - 48

Опубликована: Апрель 11, 2025

РЕЗЮМЕ. Безпліддя є однією з основних проблем репродуктивної медицини. Зокрема, у жінок із СПКЯ це супроводжується інсулінорезистентністю та метаболічними порушеннями, що негативно впливають на овуляцію, якість ооцитів імплантаційну здатність ендометрія. Допоміжні репродуктивні технології, а саме екстракорпоральне запліднення, провідними методиками лікування таких пацієнток, однак їх ефективність часто знижується через порушення рецептивності Мета роботи – проаналізувати вплив метаболічних порушень при імплантацію ембріона, зокрема гормональні запальні механізми, основі сучасних наукових досліджень. Матеріал і методи. Проведено аналіз публікацій баз даних PubMed, Scopus, Web of Science Google Scholar за останні 10 років. Відбиралися рецензовані статті, висвітлюють молекулярні механізми інсулінорезистентності, зміни ендометріального мікрооточення їхній імплантацію. Результати. Імплантація ембріона складний процес, залежить від злагодженої взаємодії ендокринної, імунної судинної систем, також При синдромі полікістозних яєчників імплантації зумовлені гормональним дисбалансом, інсулінорезистентністю, дефектами ангіогенезу хронічним запаленням, знижує ймовірність успішного прикріплення ембріона; додатково метаболічний синдром погіршує рецептивність ендометрія оксидативний стрес толерантності. Рандомізовані дослідження мета-аналізи свідчать, не лише якісні характеристики й адекватна корекція імплантаційних індивідуалізовані підходи до підготовки перед імплантацією в програмах ЕКЗ ключовими факторами успішності безпліддя даній когорті пацієнтів. Висновки. Мультифакторний підхід пацієнток метаболічним синдромом включає корекцію способу життя, метаболічну антиоксидантну терапію, сприяє покращенню гормонального балансу, фолікулогенезу Персоналізований визначення вікна застосування тесту ERA дозволяє підвищити ЕКЗ, знижуючи ризики невдалих імплантацій.

Процитировано

0
Exploring the role of rare earth elements (praseodymium, samarium, lanthanum, and terbium) and oxidative stress in polycystic ovary syndrome: A case-control study DOI Creative Commons
Manal Abudawood

Human & Experimental Toxicology, Год журнала: 2025, Номер 44

Опубликована: Май 1, 2025

Background Praseodymium (Pr), Samarium (Sm), Lanthanum (La), and Terbium (Tb) are rare earth elements (REEs) that can accumulate in the body induce oxidative stress (OS), which may contribute to polycystic ovary syndrome (PCOS), a condition affecting 116 million women worldwide. With increasing use of REEs, understanding their role PCOS is crucial. Design This case-control study included 56 cases 50 healthy controls, with confounding factors such as age, BMI, hormones controlled. Inductively Coupled Plasma Mass Spectrometry (ICP-MS) was used measure serum levels Pr, Sm, La, Tb, Pearson correlation performed explore relationship markers malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD). Result A significant increase Tb observed compared controls ( p < 0.05). The 95% confidence intervals (CIs) for differences were [0.0008, 0.0032], [0.0002, 0.0091], [0.0019, 0.0073], 0.0129], respectively. Additionally, MDA significantly elevated, accompanied by reduction antioxidant markers-GSH SOD 0.001). Elevated REE positively correlated increased negatively GSH SOD, indicating stress. Conclusion These findings suggest stress-induced metal intoxication play critical development PCOS. Future studies should clinical significance exposure its potential target preventive strategies management.

Язык: Английский

Процитировано

0
The underlying causes, treatment options of gut microbiota and food habits in type 2 diabetes mellitus: a narrative review DOI
Krishnendu Adhikary, Riya Sarkar,

Sriparna Maity

и другие.

Journal of Basic and Clinical Physiology and Pharmacology, Год журнала: 2024, Номер 35(3), С. 153 - 168

Опубликована: Май 1, 2024

Type 2 diabetes mellitus is a long-lasting endocrine disorder characterized by persistent hyperglycaemia, which often triggered an entire or relative inadequacy of insulin production resistance. As result resistance to (IR) and overall lack in the body, type (T2DM) metabolic illness that hyperglycaemia. Notably, occurrence vascular complications advancement IR T2DM are accompanied dysbiosis gut microbiota. Due difficulties managing disease dangers multiple accompanying complications, chronic, progressive immune-mediated condition plays significant clinical health burden on patients. The frequency incidence among young people have been rising worldwide. relationship between microbiota composition physio-pathological characteristics proposes novel way monitor enhance effectiveness therapies. Our knowledge how it affects has changed over last 20 years. Species genus Eubacterium, make up portion core animal microbiome, some recently discovered 'generation' possibly helpful bacteria. In this article, we focused pathogenesis therapeutic approaches towards T2DM, with special reference bacteria from ancient times present day.

Язык: Английский

Процитировано

2
The modern pathogenetic challenges of polycystic ovary syndrome DOI Creative Commons
Л. В. Пахаренко, N.Ya. Zhylka, О.S. Shcherbinska

и другие.

Reproductive health of woman, Год журнала: 2024, Номер 2, С. 75 - 80

Опубликована: Март 9, 2024

Polycystic ovary syndrome (PCOS) is one of the neuroendocrine syndromes in women reproductive age. In pathogenesis its development a great importance paid to hormonal disbalance, metabolic changes, overweight and obesity, diabetes mellitus, insulin resistance, genetic factors, etc. Very often, PCOS accompanied by infertility, cardiovascular risks, mellitus.The article devoted review modern scientific literature about last researches mechanisms disorders which are connected with also, psychological disturbance stress. The describes specific conditions patients. On basis analyzed publications connection between disorders, overweight, obesity lipidogram parameters presented.Also, gut vaginal microbiota described this paper. studies demonstrate significant changes human microbiome course polycystic syndrome. presents concepts difference composition vagina syndrome.The pathogenetic role processes pathogenesis, namely, regulation immune response inflammation pathology, described. It has been shown that there differences microflora intestines, manifested decreased concentration Lactobacillus presence variety other microorganisms compared healthy women.Thus, main links closely each other. That why multimodal approaches for study management patients extremely important.

Язык: Английский

Процитировано

2