Advances in researches on long coronavirus disease in children: a narrative review DOI Open Access

Jiaqian Zhang,

Taiji Kuang,

Xinglou Liu

и другие.

Translational Pediatrics, Год журнала: 2024, Номер 13(2), С. 318 - 328

Опубликована: Фев. 1, 2024

In the context of global pandemic coronavirus disease 2019 (COVID-19), more than 700 million infections and millions deaths have occurred in countries around world. Currently, two main sequelae this are considered to occur children, namely, multi-system inflammatory syndrome children long COVID. Among these two, incidence COVID is higher its impact on population extensive, which focus us. However, due lack relevant studies limitations most studies, COVID-19 infection lag behind those adults, but they begun attract attention some clinicians researchers. We aim summarize current knowledge helping pediatricians researchers better understand providing guidance research clinical treatment it.

Язык: Английский

Epidemiology, clinical presentation, pathophysiology, and management of long COVID: an update DOI

Sizhen Su,

Yi‐Miao Zhao, Na Zeng

и другие.

Molecular Psychiatry, Год журнала: 2023, Номер 28(10), С. 4056 - 4069

Опубликована: Июль 25, 2023

Язык: Английский

Процитировано

62
The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches DOI Creative Commons
Roxana Gheorghiţă, Iuliana Șoldănescu, Andrei Lobiuc

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Март 4, 2024

The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has been defined as the greatest global health and socioeconomic crisis of modern times. While most people recover after being infected with virus, a significant proportion them continue to experience issues weeks, months even years acute infection SARS-CoV-2. This persistence clinical symptoms in individuals for at least three onset or emergence new lasting more than two months, without any other explanation alternative diagnosis have named long COVID, long-haul post-COVID-19 conditions, chronic post-acute sequelae (PASC). Long COVID characterized constellation disorders that vary widely their manifestations. Further, mechanisms underlying are not fully understood, which hamper efficient treatment options. review describes predictors common related COVID's effects on central peripheral nervous system organs tissues. Furthermore, transcriptional markers, molecular signaling pathways risk factors such sex, age, pre-existing condition, hospitalization during phase COVID-19, vaccination, lifestyle presented. Finally, recommendations patient rehabilitation management, well therapeutical approaches discussed. Understanding complexity this disease, its across multiple organ systems overlapping pathologies possible paramount developing diagnostic tools treatments.

Язык: Английский

Процитировано

23
Higher Prevalence of Long COVID Observed in Cancer Survivors: Insights from a US Nationwide Survey DOI

Lingchen Wang,

Wei Yang

Annals of Epidemiology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

2
Long COVID: Clinical Framing, Biomarkers, and Therapeutic Approaches DOI Open Access
Valeria Conti, Graziamaria Corbi, Francesco Sabbatino

и другие.

Journal of Personalized Medicine, Год журнала: 2023, Номер 13(2), С. 334 - 334

Опубликована: Фев. 15, 2023

More than two years after the onset of COVID-19 pandemic, healthcare providers are facing an emergency within emergency, so-called long COVID or post-COVID-19 syndrome (PCS). Patients diagnosed with PCS develop extended range persistent symptoms and/or complications from COVID-19. The risk factors and clinical manifestations many various. Advanced age, sex/gender, pre-existing conditions certainly influence pathogenesis course this syndrome. However, absence precise diagnostic prognostic biomarkers may further complicate management patients. This review aimed to summarize recent evidence on influencing PCS, possible biomarkers, therapeutic approaches. Older patients recovered approximately one month earlier younger patients, higher rates symptoms. Fatigue during acute phase appears be important factor for symptom persistence. Female sex, older active smoking associated a developing PCS. incidence cognitive decline death in controls. Complementary alternative medicine improvement symptoms, particularly fatigue. heterogeneous nature post-COVID complexity who often polytreated due concomitant conditions, suggest holistic integrated approach provide useful guidance treatment overall COVID.

Язык: Английский

Процитировано

30
Incidence of Epstein-Barr virus reactivation is elevated in COVID-19 patients DOI Creative Commons

Keishanne Danielle E. Bernal,

Christopher B. Whitehurst

Virus Research, Год журнала: 2023, Номер 334, С. 199157 - 199157

Опубликована: Июнь 26, 2023

COVID-19, an infectious respiratory illness, is caused by infection with the SARS-CoV-2 virus. Individuals underlying medical conditions are at increased risk of developing serious illnesses such as long COVID. Recent studies have observed Epstein-Barr virus (EBV) reactivation in patients severe illness or COVID, which may contribute to associated symptoms. We determined frequency EBV COVID-19 positive compared negative patients. 106 blood plasma samples were collected from and was detection DNA antibodies against lytic genes individuals previous infection. 27.1% (13/48) reactivations, based on qPCR genomes, COVID group while only 12.5% (6/48) reactivations belonged group. 20/52 (42.30%) PCR had detectable nucleoprotein (Np); indicative past A significantly higher Np protein level found In conclusion, experienced comparison

Язык: Английский

Процитировано

30
Cardiovascular autonomic dysfunction in “Long COVID”: pathophysiology, heart rate variability, and inflammatory markers DOI Creative Commons

Karina Carvalho Marques,

Juarez Antônio Simões Quaresma, Luiz Fábio Magno Falcão

и другие.

Frontiers in Cardiovascular Medicine, Год журнала: 2023, Номер 10

Опубликована: Сен. 1, 2023

Long COVID is characterized by persistent signs and symptoms that continue or develop for more than 4 weeks after acute COVID-19 infection. Patients with experience a cardiovascular autonomic imbalance known as dysautonomia. However, the underlying pathophysiological mechanisms behind this remain unclear. Current hypotheses include neurotropism, cytokine storms, inflammatory persistence. Certain immunological factors indicate autoimmune dysfunction, which can be used to identify patients at higher risk of COVID. Heart rate variability imbalances in individuals suffering from COVID, measurement non-invasive low-cost method assessing modulation. Additionally, biochemical markers are diagnosing monitoring These improve understanding driving response its effects on sympathetic parasympathetic pathways nervous system. Autonomic may result lower heart variability, impaired vagal activity, substantial sympathovagal imbalance. New research subject must encouraged enhance long-term risks cause

Язык: Английский

Процитировано

27
A Multi-Center Study Investigating Long COVID-19 in Healthcare Workers from North-Eastern Italy: Prevalence, Risk Factors and the Impact of Pre-Existing Humoral Immunity—ORCHESTRA Project DOI Creative Commons
Luca Cegolon, Marcella Mauro,

Donatella Sansone

и другие.

Vaccines, Год журнала: 2023, Номер 11(12), С. 1769 - 1769

Опубликована: Ноя. 27, 2023

Introduction: The impact of long-COVID-19 syndrome is rather variable, since it influenced by several residual confounders. This study aimed to investigate the prevalence long COVID-19 in healthcare workers (HCWs) from four university hospitals north-eastern Italy: Trieste, Padua, Verona, and Modena-Reggio Emilia. Methods: During period June 2022-August 2022, HCWs were surveyed for past infections, medical history, any acute as well post-COVID-19 symptoms. was estimated at 30-60 days or 61+ first negative swab following second episode. Furthermore, risk investigated multivariable logistic regression. Results expressed adjusted odds ratio (aOR) with a 95% confidence interval (95%CI). Results: 5432 returned usable questionnaire: 2401 infected SARS-CoV-2 least once, 230 twice, 8 three times. after primary infection 24.0% versus 16.3% days, 10.5% against 5.5% event. most frequent symptoms event asthenia (30.3%), followed myalgia (13.7%), cough (12.4%), dyspnea (10.2%), concentration deficit (8.1%), headache (7.3%), anosmia (6.5%), decreasing order prevalence. significantly higher hospitalized (aOR = 3.34; 95%CI: 1.62; 6.89), those during early pandemic waves-namely Wuhan 2.16; 1.14; 4.09) Alpha (aOR= 2.05; 1.25; 3.38) transmission periods-and progressively increasing viral shedding time (VST), especially 15+ 3.20; 2.07; 4.94). Further determinants female sex 1.91; 1.30; 2.80), age >40 years, abnormal BMI, administrative services (reference category). In contrast, vaccinated two doses before their 0.57; 0.34; 0.94), undergraduate students, postgraduate trainees less likely experience days. Apart waves, main confirmed Conclusions: increased severity disease VST, initial when more virulent strains circulating, susceptibility had not been yet, vaccines still available, and/or vaccination coverage building up. therefore decreased inversely humoral immunity individual level. Nevertheless, remarkably lower reinfections regardless status, suggesting that hybrid did increase protection compared mounted either natural separately. Since currently low Omicron patients who developed waves tend return state full health time, cost-effective approach screen could be restricted vulnerable individuals developing severe prolonged VST.

Язык: Английский

Процитировано

26
The lived experience of long COVID: A qualitative study of mental health, quality of life, and coping DOI Creative Commons

C Kennelly,

Anh T. P. Nguyen,

Natasha Y. Sheikhan

и другие.

PLoS ONE, Год журнала: 2023, Номер 18(10), С. e0292630 - e0292630

Опубликована: Окт. 13, 2023

The majority of people who contract COVID-19 experience a short period symptomatic infection. However, symptoms persist for months or years following initial exposure to the virus in some cases. This has been described as long COVID. Little is known about lived this condition, it only recently emerged. study aimed explore experiences mental health, quality life, and coping among living with A sample 47 adults participated web-based focus groups. Separate groups were held 24 individuals pre-existing health conditions 23 without conditions. Data analyzed using codebook thematic analysis approach. Five themes identified integral COVID experience: Emotional Landscape Long COVID, New Limits Daily Functioning, Grief Loss Former Identity, COVID-related Stigmatization, Learning Cope Persisting Symptoms. These findings illustrate immense impact on life. Minimal differences found between those conditions, both substantially impacted by condition. Attention perspectives necessary inform future directions research clinical practice.

Язык: Английский

Процитировано

23
Effect of Pulmonary Rehabilitation on Exercise Capacity, Dyspnea, Fatigue, and Peripheral Muscle Strength in Patients With Post-COVID-19 Syndrome: A Systematic Review and Meta-analysis DOI
Murilo Rezende Oliveira, Mariana Hoffman, Arwel W. Jones

и другие.

Archives of Physical Medicine and Rehabilitation, Год журнала: 2024, Номер 105(8), С. 1559 - 1570

Опубликована: Фев. 3, 2024

Язык: Английский

Процитировано

15
Long COVID Definition, Symptoms, Risk Factors, Epidemiology and Autoimmunity: A Narrative Review DOI Creative Commons
Paweł Kozłowski, Aleksandra Leszczyńska, Olga Ciepiela

и другие.

American Journal of Medicine Open, Год журнала: 2024, Номер 11, С. 100068 - 100068

Опубликована: Фев. 14, 2024

The virus called SARS-CoV-2 emerged in 2019 and quickly spread worldwide, causing COVID-19. It has greatly impacted on everyday life, healthcare systems, the global economy. In order to save as many lives possible, precautions such social distancing, quarantine, testing policies were implemented, effective vaccines developed. A growing amount of data collected worldwide allowed characterization this new disease, which turned out be more complex than other common respiratory tract infections. An increasing number convalescents presented with a variety non-specific symptoms emerging after acute infection. This possible health problem was identified labelled long COVID. Since then, great effort been made by clinicians scientific community understand underlying mechanisms develop preventive measures treatment. role autoimmunity induced infection development COVID is discussed review. We aim deliver description several conditions an autoimmune background observed COVID-19 convalescents, including Guillain-Barré syndrome, antiphospholipid syndrome related thrombosis, Kawasaki disease highlighting relationship between autoimmunity. However, further studies are required determine its true clinical significance.

Язык: Английский

Процитировано

14