Sleep Disturbances as a Consequence of Long COVID-19: Insights from Actigraphy and Clinimetric Examinations—An Uncontrolled Prospective Observational Pilot Study

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(3), С. 839 - 839

Опубликована: Фев. 1, 2024

The COVID-19 pandemic represents a global health and social challenge. However, the impact of SARS-CoV-2 infection itself on mental sleep quality remains poorly understood. purpose present uncontrolled prospective observational pilot study was to evaluate past disease incidence quantitative qualitative disturbances. A group 61 subjects (37 female, 24 male) reported disturbances that had lasted for at least one month started after recovery from COVID-19. used self-reported instruments: Epworth Sleepiness Scale (ESS) Insomnia Severity Index (ISI), as well an objective method—actigraphy—for analysis architecture. It shown most commonly (68.3%, n = 41) more than (83.6%, 51). ESS scores 7.8 ± 5.0 points indicate moderate daytime sleepiness, ISI 16.3 5.8 denote insomnia. were negatively correlated with total time in bed (r −0.3780, p 0.003), −0.2969, 0.020), wakefulness onset −0.2654, 0.039). In addition, respondents’ age (B −0.17, 0.000) onset. positive correlation found between −0.05, positively 0.3275, 0.010). Female gender be significant predictor insomnia’s severity 2.159, t 3.04, 0.004). conclusion, patients history report long-lasting do not subside spontaneously. patient studied, levels sleepiness insomnia found. frequently problems included irregular sleep, frequent awakenings, difficulty maintaining while normal duration preserved. These findings underscore need continued attention long-term consequences emphasize importance targeted interventions address these enduring affected individuals.

Язык: Английский

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Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID

npj Science of Food, Год журнала: 2024, Номер 8(1)

Опубликована: Март 30, 2024

Язык: Английский

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What is current care for people with Long COVID in England? A qualitative interview study

BMJ Open, Год журнала: 2024, Номер 14(5), С. e080967 - e080967

Опубликована: Май 1, 2024

Objective To investigate current care for people with Long COVID in England. Design In-depth, semistructured interviews living and healthcare professionals; data analysed using thematic analysis. Setting National Health Service England post-COVID-19 services six clinics from November 2022 to July 2023. Participants 15 professionals 21 currently attending or discharged (18 female; 3 male). Results lived experience highlighted the multifaceted nature of COVID, including its varied symptoms, impact on people’s lives complexity involved managing this condition. These impacts encompass physical, social, mental environmental dimensions. People reported barriers accessing primary care, as well negative general practitioner consultations where they felt unheard invalidated, though some positive interactions were also noted. Peer support systems proved highly valuable beneficial individuals, aiding their recovery well-being. Post-COVID-19 viewed spaces overlooked voices found validation, offering more than medical expertise. Despite initial challenges, providers’ increasing expertise diagnosing treating has helped refine approaches Conclusion is not uniform across all locations. Effective communication, specialised comprehensive are crucial. A patient-centred approach considering unique complexities health, social aspects needed. Sustained access imperative, success dependent continuous rehabilitation beyond rapid recovery, acknowledging condition’s enduring complexities.

Язык: Английский

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Prevalence and risk factors for long COVID in China: a systematic review and meta-analysis of observational studies

Journal of Infection and Public Health, Год журнала: 2025, Номер 18(3), С. 102652 - 102652

Опубликована: Янв. 5, 2025

With the outbreak of COVID-19 in China, a large number patients are at risk long COVID after recovery. The purpose our research is to systematically review existing clinical studies understand current prevalence and related factors China. protocol this systematic was registered on PROSPERO (CRD42024519375). We searched six electronic databases from 1st January 2020-1st March 2024. Literature screening, data extraction, bias assessment were independently carried out by two reviewers. Quality included evaluated AHRQ NOS. meta-analysis performed R software 4.2.3 derive factors. Overall, 50 with 65880 participants included. results showed that (with least one symptom) among approximately % (95 %Confidence Interval (CI) 42-58 %) Although we conducted meta-regression subgroup analysis, heterogeneity study high. But Omicron BA.2 variant had statistically significant effect (P = 0.0004). three most common symptoms fatigue (0.33, 95 %CI 0.28-0.39), cognitive decline (0.30, 0.14-0.46) shortness breath (0.29, 0.15-0.43). Patients severe acute phase (Odds Ratio (OR) 1.57, CI 1.39-1.77), combined 2 comorbidities (OR 1.80, 1.40-2.32), 3 2.13, 1.64-2.77), advanced age 1.02, 1.01-1.04), female 1.58, 1.44-1.73) for prevalence. Current found nearly half may suffering Establishing recovery-support platform regular follow-up would help long-term monitor manage patients, especially those high-risk population.

Язык: Английский

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Endothelial Dysfunction in COVID-19: Potential Mechanisms and Possible Therapeutic Options

Life, Год журнала: 2022, Номер 12(10), С. 1605 - 1605

Опубликована: Окт. 14, 2022

SARS-CoV-2, a novel coronavirus found in Wuhan (China) at the end of 2019, is etiological agent current pandemic that heterogeneous disease, named disease 2019 (COVID-19). SARS-CoV-2 affects primarily lungs, but it can induce multi-organ involvement such as acute myocardial injury, myocarditis, thromboembolic eventsandrenal failure. Hypertension, chronic kidney diabetes mellitus and obesity increase risk severe complications COVID-19. There no certain explanation for this systemic COVID-19 involvement, could be related to endothelial dysfunction, due direct (endothelial cells are infected by virus) indirect damage (systemic inflammation) factors. Angiotensin-converting enzyme 2 (ACE2), expressed human endothelium, has fundamental role respiratory syndrome (SARS-CoV-2) infection. In fact, ACE2 used receptor leading downregulation these receptors on cells; once inside, virus reduces integrity tissue, with exposure prothrombotic molecules, platelet adhesion, activation coagulation cascades and, consequently, vascular damage. Systemic microangiopathy thromboembolism lead failure an elevated death. Considering crucial immunological response developing form COVID-19, review, we will attempt clarify underlying pathophysiological mechanisms.

Язык: Английский

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Overview of the potential use of fluvoxamine for COVID-19 and long COVID

Discover Mental Health, Год журнала: 2023, Номер 3(1)

Опубликована: Март 21, 2023

Abstract Coronavirus disease 2019 (COVID-19) has presented a serious worldwide threat to public health since its emergence in late 2019. From safety point of view, drug repurposing received particular attention. Several clinical studies have demonstrated that the use fluvoxamine, selective serotonin reuptake inhibitor with potent sigma-1 receptor agonism, early-stage infection might be associated prevention deterioration individuals SARS-CoV-2 infection, although several reports shown low dose fluvoxamine may ineffective. There is increasing evidence can cross blood–brain barrier, resulting number psychiatric and neurologic symptoms COVID-19 survivors. Importantly, about half survivors experience variety long-term sequelae, including symptoms, known as long COVID. In this priority review, author presents an overview potential treatment

Язык: Английский

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Long COVID in Children, Adults, and Vulnerable Populations: A Comprehensive Overview for an Integrated Approach

Diseases, Год журнала: 2024, Номер 12(5), С. 95 - 95

Опубликована: Май 6, 2024

Long COVID affects both children and adults, including subjects who experienced severe, mild, or even asymptomatic SARS-CoV-2 infection. We have provided a comprehensive overview of the incidence, clinical characteristics, risk factors, outcomes persistent COVID-19 symptoms in encompassing vulnerable populations, such as pregnant women oncological patients. Our objective is to emphasize critical significance adopting an integrated approach for early detection appropriate management long COVID. The incidence severity can significant impact on quality life patients course disease case pre-existing pathologies. Particularly, fragile patients, presence PASC related significantly worse survival, independent from vulnerabilities treatment. It important try achieve recognition management. Various mechanisms are implicated, resulting wide range presentations. Understanding specific factors involved crucial tailoring effective interventions support strategies. Management approaches involve biopsychosocial assessments treatment comorbidities, autonomic dysfunction, well multidisciplinary rehabilitation. overall one gradual improvement, with recovery observed majority, though not all, As research long-COVID continues evolve, ongoing studies likely shed more light intricate relationship between chronic diseases, status, cardiovascular psychiatric disorders, effects This information could guide healthcare providers, researchers, policymakers developing targeted interventions.

Язык: Английский

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Assessing the Quality of Life, Coping Strategies, Anxiety and Depression Levels in Patients with Long-COVID-19 Syndrome: A Six-Month Follow-Up Study

Diseases, Год журнала: 2024, Номер 12(1), С. 21 - 21

Опубликована: Янв. 11, 2024

This longitudinal study investigates the psychosocial effects of long-COVID Syndrome, a domain still not extensively researched. It specifically evaluates quality life, coping mechanisms, anxiety and depression levels in COVID-19 survivors, differentiating between those with without Syndrome. Conducted at Victor Babes Hospital for Infectious Diseases Pulmonology Timisoara, Romania, utilized cohort patients diagnosed mild to moderate COVID-19. The following standardized tools: WHOQOL-BREF COPE-60 strategies, Anxiety Depression Scale (HADS), were employed assessment. sample consisted 86 displaying persistent post-acute symptoms 432 asymptomatic 6-month post-discharge mark. Patients frequent reported significantly higher fatigue (8.2 ± 1.4), cognitive difficulties (7.5 1.6), respiratory challenges (7.8 1.3), along markedly lower overall life (7.0 1.5) compared their counterparts. HADS scores revealed elevated (6.8 1.9) (7.1 2.3) symptomatic group. Quality as evaluated through use WHOQOL-BREF, showed across physical (58.8 15.8), mental (56.3 16.4), social domains (50.2 17.5). findings indicated prevalence disengagement (56.4%) emotion-focused strategies (61.8%) group, contrast 30.1% 37.0%, respectively, highlights that Syndrome deteriorates is associated increased levels. prevalent among suggests need enhanced support tailored this subgroup.

Язык: Английский

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The Aftermath of COVID-19: Exploring the Long-Term Effects on Organ Systems

Biomedicines, Год журнала: 2024, Номер 12(4), С. 913 - 913

Опубликована: Апрель 20, 2024

Background: Post-acute sequelae of SARS-CoV-2 infection (PASC) is a complicated disease that affects millions people all over the world. Previous studies have shown PASC impacts 10% infected patients which 50–70% are hospitalised. It has also been 10–12% those vaccinated against COVID-19 were affected by and its complications. The severity later development symptoms positively associated with early intensity infection. Results: generated health complications caused involve vast variety organ systems. Patients diagnosed neuropsychiatric neurological symptoms. cardiovascular system involved several diseases such as myocarditis, pericarditis, coronary artery reported. Chronic hematological problems thrombotic endothelialitis hypercoagulability described conditions could increase risk clotting disorders coagulopathy in patients. Chest pain, breathlessness, cough respiratory long-COVID causing distress syndrome. observed immune notable, involving diseases. renal was impacted, resulted raising issues, fibrosis, sepsis. Endocrine gland malfunction can lead to diabetes, thyroiditis, male infertility. Symptoms diarrhea, nausea, loss appetite, taste among reported observations due gastrointestinal disorders. Skin abnormalities might be an indication long-term implications persistent cutaneous complaints linked PASC. Conclusions: Long-COVID multidimensional syndrome considerable public implications, affecting physiological systems demanding thorough medical therapy, more study address underlying causes effects needed.

Язык: Английский

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The functional and structural changes in the hippocampus of COVID-19 patients

Acta Neurologica Belgica, Год журнала: 2023, Номер 123(4), С. 1247 - 1256

Опубликована: Май 25, 2023

Язык: Английский

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