Deprivation of methionine inhibits osteosarcoma growth and metastasis via C1orf112-mediated regulation of mitochondrial functions DOI Creative Commons
Xindan Zhang,

Zhenggang Zhao,

Xuepeng Wang

и другие.

Cell Death and Disease, Год журнала: 2024, Номер 15(5)

Опубликована: Май 20, 2024

Abstract Osteosarcoma is a malignant bone tumor that primarily inflicts the youth. It often metastasizes to lungs after chemotherapy failure, which eventually shortens patients’ lives. Thus, there dire clinical need develop novel therapy tackle osteosarcoma metastasis. Methionine dependence special metabolic characteristic of most cells may offer target pathway for such therapy. Herein, we demonstrated methionine deficiency restricted growth and metastasis cultured human cells. A genetically engineered Salmonella , SGN1, capable overexpressing an L-methioninase hydrolyzing led significant reduction S-adenosyl-methionine (SAM) specifically in tissues, drastically subcutaneous xenograft, orthotopic, tail vein-injected metastatic models, prolonged survival model animals. SGN1 also sharply suppressed patient-derived organoid xenograft. restriction initiated severe mitochondrial dysfunction, as evident dysregulated gene expression respiratory chains, increased ROS generation, reduced ATP production, decreased basal maximum respiration, damaged membrane potential. Transcriptomic molecular analysis revealed C1orf112 primary mechanism underlies deprivation-initiated suppression on well functions. Collectively, our findings unraveled linkage between restriction, function, pharmacological agent, can achieve specific deprivation represent promising modality against potentially other types sarcomas well.

Язык: Английский

Complex II ambiguities—FADH2 in the electron transfer system DOI Creative Commons
Erich Gnaiger

Journal of Biological Chemistry, Год журнала: 2023, Номер 300(1), С. 105470 - 105470

Опубликована: Ноя. 22, 2023

The prevailing notion that reduced cofactors NADH and FADH

Язык: Английский

Процитировано

22
Vimentin promotes glioma progression and maintains glioma cell resistance to oxidative phosphorylation inhibition DOI
Yue Liu,

Zhao Shu,

Yi Chen

и другие.

Cellular Oncology, Год журнала: 2023, Номер 46(6), С. 1791 - 1806

Опубликована: Авг. 30, 2023

Язык: Английский

Процитировано

20
Mitochondrial transplantation strategies in multifaceted induction of cancer cell death DOI
Alfredo Cruz‐Gregorio, Ana Karina Aranda‐Rivera, Isabel Amador‐Martínez

и другие.

Life Sciences, Год журнала: 2023, Номер 332, С. 122098 - 122098

Опубликована: Сен. 19, 2023

Язык: Английский

Процитировано

19
Fluorescence microscopy imaging of mitochondrial metabolism in cancer cells DOI Creative Commons
Mónika Göőz, Eduardo N. Maldonado

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Июнь 22, 2023

Mitochondrial metabolism is an important contributor to cancer cell survival and proliferation that coexists with enhanced glycolytic activity. Measuring mitochondrial activity useful characterize patterns, identify metabolic vulnerabilities new drug targets. Optical imaging, especially fluorescent microscopy, one of the most valuable tools for studying bioenergetics because it provides semiquantitative quantitative readouts as well spatiotemporal resolution metabolism. This review aims acquaint reader microscopy imaging techniques currently used determine membrane potential (ΔΨm), nicotinamide adenine dinucleotide (NADH), ATP reactive oxygen species (ROS) are major We describe features, advantages, limitations fluorescence modalities: widefield, confocal multiphoton lifetime (FLIM). also discus relevant aspects image processing. briefly role production NADH, NADHP, flavins various ROS including superoxide hydrogen peroxide discuss how these parameters can be analyzed by microscopy. explain importance, value, label-free autofluorescence NAD(P)H FAD. Practical hints use probes newly developed sensors ΔΨm, described. Overall, we provide updated information about study will interest all investigators regardless their level expertise in field.

Язык: Английский

Процитировано

17
Relevance of Cardiovascular Exercise in Cancer and Cancer Therapy-Related Cardiac Dysfunction DOI Creative Commons
Simon Wernhart, Tienush Rassaf

Current Heart Failure Reports, Год журнала: 2024, Номер 21(3), С. 238 - 251

Опубликована: Май 2, 2024

Abstract Purpose of the Review Cancer therapy-related cardiac dysfunction (CTRCD) has been identified as a threat to overall and cancer-related survival. Although aerobic exercise training (AET) shown improve cardiorespiratory fitness (CRF), relationship between specific regimens cancer survival, heart failure development, reduction CTRCD is unclear. In this review, we discuss impact AET on molecular pathways current literature sports in field cardio-oncology. Recent Findings Cardio-oncological trials have focused variations intensity by using moderate continuous high interval training, which are applicable, safe, effective approaches CRF. Summary increases CRF, reduces cardiovascular morbidity hospitalization should thus be implemented an adjunct standard therapy, although its long-term effect remains unknown. Despite modulating diverse pathways, it unknown regimen, including duration frequency, most suited facilitate peripheral central adaptations survival patients.

Язык: Английский

Процитировано

8
Mitochondrial-related drug resistance lncRNAs as prognostic biomarkers in laryngeal squamous cell carcinoma DOI Creative Commons
Zhimin Wu, Yi Chen,

Dizhi Jiang

и другие.

Discover Oncology, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 18, 2024

Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor of the head and neck that significantly impacts patients' quality life, with chemotherapy resistance notably affecting prognosis. This study aims to identify prognostic biomarkers optimize treatment strategies for LSCC. Using data from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO), combined mitochondrial gene database analysis, we identified lncRNAs associated drug genes. Key long non-coding RNAs (lncRNAs) were selected through univariate Cox regression Lasso regression, multivariate model was constructed predict We further analyzed differences in immune function biological pathway enrichment between high- low-risk groups, developed nomogram, compared sensitivity. Results showed based on seven could serve as an independent factor, Area Under Curve (AUC) values 0.746, 0.827, 0.771 at 1, 3, 5 years, respectively, outperforming some existing models, demonstrating high predictive performance. Significant observed sensitivity groups. risk prediction incorporating resistance-related can accurately independently prognosis LSCC patients.

Язык: Английский

Процитировано

8
Exercise, cancer, and the cardiovascular system: clinical effects and mechanistic insights DOI Creative Commons
Simon Wernhart, Tienush Rassaf

Basic Research in Cardiology, Год журнала: 2024, Номер unknown

Опубликована: Фев. 14, 2024

Abstract Cardiovascular diseases and cancer are the leading causes of death in Western world share common risk factors. Reduced cardiorespiratory fitness (CRF) is a major determinant cardiovascular morbidity survival. In this review we discuss cancer- induced disturbances parenchymal, cellular, mitochondrial function, which limit CRF may be antagonized attenuated through exercise training. We show impact on survival its attenuating effects cardiotoxicity cancer-related treatment. Tailored programs not yet available for each tumor entity as several trials were performed heterogeneous populations without adequate cardiopulmonary testing (CPET) prior to prescription with wide variation modalities. There emerging evidence that crucial pillar treatment tool mitigate cardiotoxic effects. modalities aerobic resistance training their potential improve patients provide an example periodization model cancer.

Язык: Английский

Процитировано

7
Illuminating the immunological landscape: mitochondrial gene defects in pancreatic cancer through a multiomics lens DOI Creative Commons
Hao Chi,

Lanqian Su,

Yalan Yan

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Март 6, 2024

This comprehensive review delves into the complex interplay between mitochondrial gene defects and pancreatic cancer pathogenesis through a multiomics approach. By amalgamating data from genomic, transcriptomic, proteomic, metabolomic studies, we dissected mechanisms by which genetic variations dictate progression. Emphasis has been placed on roles of these genes in altering cellular metabolic processes, signal transduction pathways, immune system interactions. We further explored how findings could refine therapeutic interventions, with particular focus precision medicine applications. analysis not only fills pivotal knowledge gaps about anomalies but also paves way for future investigations personalized therapy options. finding underscores crucial nexus genetics oncological immunology, opening new avenues targeted treatment strategies.

Язык: Английский

Процитировано

6
Decoding mitochondria's role in immunity and cancer therapy DOI Creative Commons
Yu Shrike Zhang, Hong Yan, Yuquan Wei

и другие.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер 1879(4), С. 189107 - 189107

Опубликована: Май 9, 2024

The functions of mitochondria, including energy production and biomolecule synthesis, have been known for a long time. Given the rising incidence cancer, role mitochondria in cancer has become increasingly popular. Activated by components released various pathways interact with each other to induce immune responses protect organisms from attack. However, play dual roles progression cancer. Abnormalities proteins, which are elementary structures closely linked oncogenesis. Both aberrant accumulation intermediates mutations enzymes result generation Therefore, targeting treat may be new strategy. Several drugs aimed at inhibiting mutated accumulated tested clinically. Here, we discuss current understanding interactions between mitochondrial functions, responses, Furthermore, as hopeful targets therapy, providing insights into future therapeutic strategies.

Язык: Английский

Процитировано

6
Exploring the relationship between anastasis and mitochondrial ROS-mediated ferroptosis in metastatic chemoresistant cancers: a call for investigation DOI Creative Commons
Yu Cao, Chang Lu, Narasimha M. Beeraka

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июль 2, 2024

Ferroptosis induces significant changes in mitochondrial morphology, including membrane condensation, volume reduction, cristae alteration, and outer rupture, affecting function cellular fate. Recent reports have described the intrinsic iron metabolism its intricate connection to ferroptosis, a kind of cell death characterized by dependence oxidative stress regulation. Furthermore, updated molecular insights elucidated significance mitochondria ferroptosis implications various cancers. In context cancer therapy, understanding dual role anastasis chemoresistance is crucial. Targeting pathways involved may enhance efficacy inducers, providing synergistic approach overcome chemoresistance. Research into how DNA damage response (DDR) proteins, metabolic changes, redox states interact during can offer new designing combinatorial therapeutic regimens against several cancers associated with stemness. These treatments could potentially inhibit while simultaneously inducing thereby reducing likelihood cells evading developing resistance chemotherapy. The objective this study explore interplay between anastasis, EMT chemoresistance, immunotherapeutics better understand their collective impact on therapy outcomes. We searched public research databases google scholar, PubMed, relemed, national library medicine related topic. review, we discussed tricarboxylic acid cycle glycolysis implicated modulating adding complexity regulatory mechanisms. Additionally, reactive oxygen species (ROS) electron transport chain (ETC) has garnered attention. Lipid metabolism, particularly involving GPX4 System Xc- plays both progression cancer. There need investigate clinical Integrating strategies targeting exploring potential synergy immunotherapy represent promising avenues for advancing chemoresistant treatment. Understanding among mitochondria, ROS, vital oncology, revolutionizing personalized treatment drug development.

Язык: Английский

Процитировано

6