International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138143 - 138143
Опубликована: Ноя. 1, 2024
Язык: Английский
Redox Biology, Год журнала: 2024, Номер 75, С. 103211 - 103211
Опубликована: Май 30, 2024
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark ferroptosis uncontrolled overwhelming peroxidation polyunsaturated fatty acids contained membrane phospholipids, which eventually leads to rupture the plasma membrane. unique that it essentially spontaneous, uncatalyzed chemical process based on perturbed iron redox homeostasis contributing process, but nonetheless modulated by many metabolic nodes impinge cells' susceptibility ferroptosis. Among affecting sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets treatment numerous currently incurable diseases. Herein, current members Germany-wide research consortium focusing research, well key external experts who made seminal contributions this rapidly growing exciting field gathered provide comprehensive, state-of-the-art review Specific topics include: basic mechanisms, vivo relevance, specialized methodologies, tools, potential contribution disease etiopathology progression. We hope article will not only established scientists newcomers with an overview multiple facets ferroptosis, also encourage additional efforts characterize further molecular pathways modulating ultimate goal develop novel pharmacotherapies tackle associated - or caused
Язык: Английский
Процитировано
62
International Journal of Medical Sciences, Год журнала: 2025, Номер 22(3), С. 508 - 527
Опубликована: Янв. 1, 2025
Background: Recent research emphasizes the significant regulatory functions of epigenetic alterations and post-translational modifications (PTMs) in ferroptosis process. Despite existing volume literature, there is a remarkable shortage comprehensive analyses that systematically trace evolution research, map key investigative routes, evaluate current situation field, determine central themes, predict future directions. This study intends to offer summary progress achieved during past 12 years comprehending how PTMs regulate ferroptosis. Methods: The dataset originated from Web Science, covering period January 1, 2012, May 21, 2024. By employing advanced analytical tools, we carried out an extensive scientometric assessment combination with detailed visual data analysis. Results: results emphasize crucial role China, which contributes 69.59% global output, thereby demonstrating its influence on trajectory this domain. Remarkable productivity manifested at institutions such as Central South University, Shanghai Jiao Tong Zhejiang University. Liu Shuang Tang Daolin stand most productive authors field. journal Cell Death & Disease leads terms publication volume, having published greatest number articles related area. identified hepatocellular carcinoma, mitochondrial diseases, iron overload prominent diseases explored Conclusion: meticulous beneficial both experienced researchers newcomers by providing essential information facilitating derivation innovative concepts
Язык: Английский
Процитировано
2
APOPTOSIS, Год журнала: 2024, Номер unknown
Опубликована: Июнь 17, 2024
Abstract Disulfidptosis is a novel form of cell death that distinguishable from established programmed pathways such as apoptosis, pyroptosis, autophagy, ferroptosis, and oxeiptosis. This process characterized by the rapid depletion nicotinamide adenine dinucleotide phosphate (NADPH) in cells high expression solute carrier family 7 member 11 (SLC7A11) during glucose starvation, resulting abnormal cystine accumulation, which subsequently induces andabnormal disulfide bond formation actin cytoskeleton proteins, culminating network collapse disulfidptosis. review aimed to summarize underlying mechanisms, influencing factors, comparisons with traditional pathways, associations related diseases, application prospects, future research directions
Язык: Английский
Процитировано
9
Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 2485 - 2529
Опубликована: Июнь 1, 2024
Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,
Язык: Английский
Процитировано
8
Environmental Pollution, Год журнала: 2024, Номер 359, С. 124531 - 124531
Опубликована: Июль 10, 2024
Язык: Английский
Процитировано
8
Cell Death Discovery, Год журнала: 2025, Номер 11(1)
Опубликована: Янв. 24, 2025
Abstract Environmental pollution represents a significant public health concern, with the potential risks associated environmental pollutants receiving considerable attention over an extended period. In recent years, substantial body of research has been dedicated to this topic. Since discovery ferroptosis, iron-dependent programmed cell death typically characterized by lipid peroxidation, in 2012, there have advances study its role and mechanism various diseases. A growing number studies also demonstrated involvement ferroptosis damage caused organism pollutants, molecular mechanisms involved partially elucidated. The targeting be effective means ameliorating PM2.5, organic inorganic ionizing radiation. This review begins providing summary most important ferroptosis. It then proceeds offer critical analysis effects induced pollutants. Furthermore, as is case all rapidly evolving areas, are numerous unanswered questions challenges pertaining pollutant-induced which we discuss attempt provide some directions clues for future field.
Язык: Английский
Процитировано
1
Biomolecules, Год журнала: 2024, Номер 14(11), С. 1443 - 1443
Опубликована: Ноя. 13, 2024
Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a critical pathway in cancer biology. This review delves into the epigenetic mechanisms that modulate ferroptosis cells, focusing on how DNA methylation, histone modifications, and non-coding RNAs influence expression function essential genes involved this process. By unraveling complex interplay between these ferroptosis, article sheds light novel gene targets functional insights could pave way for innovative treatments to enhance therapeutic efficacy overcome resistance therapy.
Язык: Английский
Процитировано
6
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Фев. 5, 2025
Aortic dissection (AD) is a life-threatening vascular condition marked by the separation or tearing of aortic media. Ferroptosis, form iron-dependent programmed cell death, occurs alongside lipid peroxidation and accumulation reactive oxygen species (ROS). The relationship between ferroptosis AD lies in its damaging effect on cells. In AD, worsens damage to smooth muscle cells (VSMCs) endothelial (ECs), thereby weakening wall’s structural integrity accelerating onset progression condition. However, molecular mechanisms through which regulates remain poorly understood. This article explores AD.
Язык: Английский
Процитировано
0
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 175, С. 116753 - 116753
Опубликована: Май 17, 2024
Ferroptosis is a form of cell death mediated by iron and lipid peroxidation (LPO). Recent studies have provided compelling evidence to support the involvement ferroptosis in pathogenesis various neurodegenerative diseases (NDDs), such as Alzheimer's disease (AD), Parkinson's (PD). Therefore, understanding mechanisms that regulate NDDs may improve management. regulated multiple mechanisms, different degradation pathways, including autophagy ubiquitinproteasome system (UPS), orchestrate complex response directly or indirectly regulating accumulation peroxidation. Ubiquitination plays crucial role protein posttranslational modification driving ferroptosis. Notably, E3 ubiquitin ligases (E3s) deubiquitinating enzymes (DUBs) are key system, their dysregulation closely linked progression NDDs. A growing body highlights sensitivity. However, reports on interaction between signaling scarce. In this review, we first provide brief overview biological processes roles UPS, summarize core molecular potential functions ferroptosis, explore pathophysiological relevance therapeutic implications addition, reviewing E3s DUBs aims new insights strategies for treatment These include E3- DUB-targeted drugs inhibitors, which can be used prevent ameliorate
Язык: Английский
Процитировано
4
Non-coding RNA Research, Год журнала: 2024, Номер 9(4), С. 1159 - 1177
Опубликована: Май 20, 2024
Ferroptosis, a recently identified type of non-apoptotic cell death, triggers the elimination cells in presence lipid peroxidation and an iron-dependent manner. Indeed, ferroptosis-stimulating factors have ability suppressing antioxidant capacity, leading to accumulation reactive oxygen species (ROS) subsequent oxidative death cells. Ferroptosis is involved pathophysiological basis different maladies, such as multiple cancers, among which female-oriented malignancies attracted much attention recent years. In this context, it has also been unveiled that non-coding RNA transcripts, including microRNAs, long RNAs, circular RNAs regulatory interconnections with ferroptotic flux, controls pathogenic development diseases. Furthermore, potential employing these transcripts therapeutic targets during onset female-specific neoplasms modulate ferroptosis become research hotspot; however, molecular mechanisms functional alterations still require further investigation. The current review comprehensively highlights its association focus on how crosstalk affects pathogenesis malignancies, from breast cancer ovarian, cervical, endometrial neoplasms, suggesting novel decelerate even block expansion tumors.
Язык: Английский
Процитировано
4