The cubosome-based nanoplatforms in cancer therapy: Seeking new paradigms for cancer theranostics

Environmental Research, Год журнала: 2023, Номер 237, С. 116894 - 116894

Опубликована: Авг. 14, 2023

Язык: Английский

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A NIR iridium(III) complex-based reversible probe for assessing AD progression and screening anti-AD drugs through visualization of the “Cu2+-H2S seesaw” phenomenon in Alzheimer’s disease

Sensors and Actuators B Chemical, Год журнала: 2024, Номер 407, С. 135509 - 135509

Опубликована: Фев. 17, 2024

Язык: Английский

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Cell Membrane‐Coated Nanoparticles: A New Frontier in Immunomodulation

Advanced NanoBiomed Research, Год журнала: 2024, Номер 4(8)

Опубликована: Май 31, 2024

Immune dysregulation is a pivotal factor in the onset and progression of various diseases. In cancer, immune system's inability to discern eliminate abnormal cells leads uncontrolled tumor growth. When faced with resilient pathogens or harmful toxins, system encounters challenges clearance neutralization. Achieving delicate balance pro‐inflammatory anti‐inflammatory signals essential managing range disorders Like other biomedical research domains, nanotechnology has provided innovative approaches for rebalancing host immunity. Among plethora nanotechnology‐based interventions, concept cell membrane‐coated nanoparticles holds significant potential immunomodulatory applications owing their biomimetic properties that allow precise interaction compromised system. This review thoroughly examines novel nanosystems modulation. The exploration covers crucial elements, including origins characteristics membranes, methods employed procurement coating, physicochemical/biological characterization techniques, enhancement therapeutic efficacy via functionalization. Subsequently, case studies‐based analysis utilizing these bioinspired tackling different conditions caused by disturbance been comprehensively discussed.

Язык: Английский

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Lipid-Based Nanocarriers: Bridging Diagnosis and Cancer Therapy

Pharmaceutics, Год журнала: 2024, Номер 16(9), С. 1158 - 1158

Опубликована: Сен. 1, 2024

Theranostics is a growing field that matches diagnostics and therapeutics. In this approach, drugs techniques are uniquely coupled to diagnose treat medical conditions synergically or sequentially. By integrating diagnostic treatment functions in single platform, the aim of theranostics improve precision medicine by tailoring treatments based on real-time information. context, lipid-based nanocarriers have attracted great scientific attention due their biodegradability, biocompatibility, targeting capabilities. The present review highlights latest research advances for cancer theranostics, exploring several ways improving vivo performance addressing associated challenges. These significant potential create new perspectives nanomedicine offer promise step towards more personalized precise medicine, reducing side effects clinical outcomes patients. This also presents actual barriers possible challenges use nanoparticles theranostic field, such as regulatory hurdles, high costs, technological integration. Addressing these issues through multidisciplinary collaborative approach among institutions could be essential advancing lipid field. Such collaborations can leverage diverse expertise resources, fostering innovation overcoming complex with translation. will crucial realizing full medicine.

Язык: Английский

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Phytoestrogens: Chemistry, potential health benefits, and their medicinal importance

Phytotherapy Research, Год журнала: 2024, Номер 38(6), С. 3060 - 3079

Опубликована: Апрель 11, 2024

Abstract Phytoestrogens, also known as xenoestrogens, are secondary metabolites derived from plants that have similar structures and biological effects human estrogens. These compounds do not directly affect functions but can act agonists or antagonists depending on the level of endogenous estrogen in body. Phytoestrogens may an epigenetic mechanism action independent receptors. found more than 300 plant species synthesized through phenylpropanoid pathway, with specific enzymes leading to various chemical structures. primarily phenolic compounds, include isoflavonoids, flavonoids, stilbenes, lignans. Extensive research animals humans has demonstrated protective phytoestrogens estrogen‐dependent diseases. Clinical trials shown their potential benefits conditions such osteoporosis, Parkinson's disease, certain types cancer. This review provides a concise overview phytoestrogen classification, diversity, biosynthesis discusses therapeutic phytoestrogens, well preclinical clinical development.

Язык: Английский

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Biomolecule-based engineered nanoparticles for Cancer Theranostics

Coordination Chemistry Reviews, Год журнала: 2025, Номер 530, С. 216489 - 216489

Опубликована: Фев. 3, 2025

Язык: Английский

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Nature meets technology: Harnessing nanotechnology to unleash the power of phytochemicals

Deleted Journal, Год журнала: 2024, Номер 5(2), С. 200139 - 200139

Опубликована: Апрель 10, 2024

Phytochemicals encompass a diverse array of bioactive substances originating from plants, exhibiting broad spectrum possible health-promoting effects. Nonetheless, the clinical uses these compounds are restricted due to their limited solubility, stability, bioavailability, and target selectivity. Nanotechnology-based delivery methods present viable approach address problems enhance properties biological activity phytochemicals. Nanoformulations have potential augment pharmacokinetics phytochemicals by means several methods. One surface area solubility is lowering particle size. The process adsorption surfactants onto phytochemical particles can lead formation micelles, which exhibit in water. uptake across many barriers, including intestinal epithelium. To study nanoformulation enhancing therapeutic action Performed systemic review while considering PRISM guidelines. nanoparticles great delivering could help management various diseases. Although, exhaustive research trials yet demanded provide evidential proof for same. In conclusion, utilisation ligand-functionalized enables precise targeting particular cells or tissues. field nanotechnology has significant promise transforming advancement administration medicinal preventative applications. holds addressing obstacles related physicochemical characteristics phytochemicals, hence enabling development enhanced systems advantageous molecules.

Язык: Английский

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Gold Nanoparticles Downregulate IL-6 Expression/Production by Upregulating microRNA-26a-5p and Deactivating the RelA and NF-κBp50 Transcription Pathways in Activated Breast Cancer Cells

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1404 - 1404

Опубликована: Янв. 24, 2024

MicroRNAs (miRNAs) are involved in the modulation of pathogenic genes by binding to their mRNA sequences’ 3′ untranslated regions (3′UTR). Interleukin-6 (IL-6) is known promote cancer progression and treatment resistance. In this study, we aimed explore therapeutic effects gold nanoparticles (GNP) against IL-6 overexpression miRNA-26a-5p breast (BC) cells. GNP were synthesized using trisodium citrate method characterized through UV-Vis spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM). To predict miR-26a-5p mRNA’s 3′UTR, utilized bioinformatics algorithms. Luciferase reporter clone assays anti-miRNA-26a-5p transfection employed validate miR26a-5p 3′UTR. The activity RelA NF-κBp50 was assessed confirmed Bay 11-7082. spherical with a mean size 28.3 nm, exhibiting high stability, suitable for BC cell treatment. We found that directly regulated MCF-7 cells activated PMA. Treatment resulted inhibition secretion increase miR26a-5p. Furthermore, deactivated NF-κBp65/NF-κBp50 transcription activity. newly engineered demonstrated safety showed promise as approach reducing overexpression. suppressed deactivating upregulating expression These findings suggest have potential intervention targeting associated pathways.

Язык: Английский

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Lanthanide-Based Core-Shell Nanoconstructs for Cancer Theragnostics

Опубликована: Янв. 1, 2025

Язык: Английский

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Nanotheranostics Revolutionizing Gene Therapy: Emerging Applications in Gene Delivery Enhancement

Journal of Nanotheranostics, Год журнала: 2025, Номер 6(2), С. 10 - 10

Опубликована: Апрель 9, 2025

Nanotheranostics—where nanoscale materials serve both diagnostic and therapeutic functions—are rapidly transforming gene therapy by tackling critical delivery challenges. This review explores the design engineering of various nanoparticle systems (lipid-based, polymeric, inorganic, hybrid) to enhance stability, targeting, endosomal escape genetic payloads. We discuss how real-time imaging capabilities integrated into these platforms enable precise localization controlled release genes, improving treatment efficacy while reducing off-target effects. Key strategies overcome barriers (such as proton sponge effect photothermal disruption) achieve nuclear are highlighted, along with recent advances in stimuli-responsive that facilitate spatiotemporal control expression. Clinical trials preclinical studies demonstrate expanding role nanotheranostics managing cancer, inherited disorders, cardiovascular neurological diseases. further address regulatory manufacturing hurdles must be for widespread clinical adoption nanoparticle-based therapies. By synthesizing progress ongoing challenges, this underscores transformative potential effective, targeted, image-guided delivery.

Язык: Английский

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