Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(16)
Опубликована: Март 12, 2024
Abstract
Cancer
stem
cells
(CSCs)
are
essential
for
tumor
initiation,
recurrence,
metastasis,
and
resistance.
However,
targeting
CSCs
as
a
therapeutic
approach
remains
challenging.
Here,
stemness
signature
based
on
22‐gene
is
developed
to
predict
prognosis
in
esophageal
squamous
cell
carcinoma
(ESCC).
Staurosporine
(STS)
identified
radioresistance
suppressor
by
high‐throughput
screening
of
library
2131
natural
compounds,
leading
dramatically
improved
radiotherapy
efficacy
subcutaneous
models.
Mechanistically,
STS
inhibits
proliferation
through
the
mTOR/AKT
signaling
pathway
suppressed
ATP‐binding
cassette
A1
(ABCA1),
which
transcriptionally
regulated
liver
X
receptor
alpha
(LXRα).
can
selectively
bind
nucleotide‐binding
domain
(NBD)
ABCA1
compete
ATP,
blocking
ABCA1‐mediated
drug
efflux
facilitating
intracellular
accumulation
STS.
Considering
cytotoxicity
STS,
an
extracellular
vesicle‐encapsulated
system
(EV‐STS)
established
effective
delivery.
EV‐STS
shows
remarkable
growth
inhibition,
even
at
half
dose
with
superior
safety
efficacy.
These
findings
indicate
that
may
serve
predictor
response
neoadjuvant
chemotherapy
and/or
ESCC
patients.
has
shown
antitumor
low
systemic
toxicity,
offering
promising
ESCC.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Авг. 12, 2024
Cancer
remains
a
significant
risk
to
human
health.
Nanomedicine
is
new
multidisciplinary
field
that
garnering
lot
of
interest
and
investigation.
shows
great
potential
for
cancer
diagnosis
treatment.
Specifically
engineered
nanoparticles
can
be
employed
as
contrast
agents
in
diagnostics
enable
high
sensitivity
high-resolution
tumor
detection
by
imaging
examinations.
Novel
approaches
labeling
are
also
made
possible
the
use
nanoprobes
nanobiosensors.
The
achievement
targeted
medication
delivery
therapy
accomplished
through
rational
design
manufacture
nanodrug
carriers.
Nanoparticles
have
capability
effectively
transport
medications
or
gene
fragments
tissues
via
passive
active
targeting
processes,
thus
enhancing
treatment
outcomes
while
minimizing
harm
healthy
tissues.
Simultaneously,
context
radiation
sensitization
photothermal
enhance
therapeutic
efficacy
malignant
tumors.
This
review
presents
literature
overview
summary
how
nanotechnology
used
According
oncological
diseases
originating
from
different
systems
body
combining
pathophysiological
features
cancers
at
sites,
we
most
recent
developments
applications.
Finally,
briefly
discuss
prospects
challenges
cancer.
Abstract
Immune
checkpoint
inhibitors
(ICIs)
have
shown
remarkable
success
in
cancer
treatment.
However,
patients
without
sufficient
antitumor
immunity,
numerous
data
indicate
that
blocking
the
negative
signals
elicited
by
immune
checkpoints
is
ineffective.
Drugs
stimulate
activation‐related
pathways
are
emerging
as
another
route
for
improving
immunotherapy.
In
addition,
development
of
nanotechnology
presents
a
promising
platform
tissue
and
cell
type‐specific
delivery
improved
uptake
immunomodulatory
agents,
ultimately
leading
to
enhanced
immunotherapy
reduced
side
effects.
this
review,
we
summarize
discuss
latest
developments
nanoparticles
(NPs)
immuno‐oncology
therapy
with
focus
on
lipid‐based
NPs
(lipid‐NPs),
including
characteristics
advantages
various
types.
Using
agonists
targeting
stimulation
interferon
genes
(STING)
transmembrane
protein
an
exemplar,
review
potential
lipid‐NPs
augment
STING
agonist
therapy.
Furthermore,
present
recent
findings
underlying
mechanisms
how
pathway
activation
fosters
immunity
regulates
tumor
microenvironment
provide
summary
distinct
preclinical
studies
clinical
trials.
Ultimately,
conduct
critical
assessment
obstacles
future
directions
utilization
enhance
Cancer
vaccines
offer
a
promising
avenue
in
cancer
immunotherapy
by
inducing
systemic,
tumor-specific
immune
responses.
Tumor
extracellular
vesicles
(TEVs)
are
nanoparticles
naturally
laden
with
tumor
antigens,
making
them
appealing
for
vaccine
development.
However,
their
inherent
malignant
properties
from
the
original
cells
limit
direct
therapeutic
use.
This
study
introduces
novel
approach
to
repurpose
TEVs
as
potent
personalized
vaccines.
The
shows
that
inhibition
of
both
YAP
and
autophagy
not
only
diminishes
malignancy-associated
traits
but
also
enhances
immunogenic
attributes
enriching
load
antigens
adjuvants.
These
revamped
TEVs,
termed
attenuated
yet
immunogenically
potentiated
(AI-TEVs),
showcase
potential
inhibiting
growth,
preventive
measure
possible
treatment
recurrent
cancers.
They
prompt
enduring
memory.
In
addition,
showing
AI-TEVs
can
counteract
growth
approach,
strategy
is
presented
developing
postoperative
that's
tailored
individual
patients.
Molecular Pharmaceutics,
Год журнала:
2024,
Номер
21(6), С. 2625 - 2636
Опубликована: Май 21, 2024
Extracellular
vesicle
(EV)
research
is
rapidly
advancing
from
fundamental
science
to
translational
applications
in
EV-based
personalized
therapeutics
and
diagnostics.
Yet,
questions
persist
regarding
EV
biology
mechanisms,
particularly
concerning
the
heterogeneous
interactions
between
EVs
cells.
While
we
have
made
strides
understanding
virus
delivery
intracellular
transport,
our
comprehension
of
trafficking
remains
limited.
are
believed
mediate
intercellular
communication
through
cargo
transfer,
but
uncertainties
occurrence
quantification
EV-cargo
within
acceptor
This
ambiguity
crucial
address,
given
significant
impact
on
perspective
article
does
not
seek
provide
exhaustive
recommendations
guidance
EV-related
studies,
as
these
well-articulated
position
papers
statements
by
International
Society
for
Vesicles
(ISEV),
including
'Minimum
Information
Studies
Vesicles'
(MISEV)
2014,
MISEV2018,
recent
MISEV2023.
Instead,
recognizing
multilayered
heterogeneity
both
a
challenge
an
opportunity,
this
emphasizes
novel
approaches
facilitate
diverse
biology,
address
uncertainties,
leverage
knowledge
advance
diagnostics
therapeutics.
Specifically,
synthesizes
current
insights,
identifies
opportunities,
highlights
exciting
technological
advancements
ultrasensitive
single
or
"digital"
profiling
developed
author's
multidisciplinary
group.
These
newly
technologies
technical
gaps
dissecting
molecular
contents
subsets,
contributing
evolution
next-generation
liquid
biopsies
providing
better
quality
control
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Авг. 23, 2022
Abstract
Small
extracellular
vesicles
(SEVs)
are
containing
DNA,
RNA,
and
proteins
involved
in
intercellular
communication
function,
playing
an
essential
role
the
growth
metastasis
of
tumors.
SEVs
present
various
body
fluids
can
be
isolated
extracted
from
blood,
urine,
cerebrospinal
fluid.
Under
both
physiological
pathological
conditions,
released
by
some
cells,
such
as
immune,
stem,
tumor
a
cytosolic
manner.
secreted
cells
called
tumor-derived
exosomes
(TEXs)
because
their
origin
corresponding
parent
cells.
Glioma
is
most
common
intracranial
tumor,
accounting
for
approximately
half
primary
tumors,
characterized
insidious
onset,
high
morbidity,
mortality
rate.
Complete
removal
tissues
surgery
difficult.
Chemotherapy
improve
survival
quality
patients
to
certain
extent;
however,
gliomas
prone
chemoresistance,
which
seriously
affects
prognosis
patients.
In
recent
years,
TEXs
have
played
vital
occurrence,
development,
associated
immune
response,
chemotherapy
resistance,
radiation
therapy
glioma.
This
article
reviews
glioma
progression,
drug
clinical
diagnosis.
Abstract
Exosomes
are
extracellular
vesicles
that
actively
secreted
by
most
live
cells
via
endosome
pathway.
They
distribute
ubiquitously
in
body
fluids
and
play
important
roles
physiological
pathological
processes.
Recent
studies
have
revealed
exosomes
carry
cell‐specific
cargoes,
such
as
proteins
nucleic
acids,
which
been
recognized
emerging
noninvasive
biomarkers
liquid
biopsy.
Therefore,
the
molecular
profiling
of
tumor‐derived
is
crucial
facilitating
discovery
cancer‐related
biomarkers.
Recently,
various
techniques
proposed
for
sensitive,
accurate,
rapid
characterization
these
small
vesicles.
To
meet
growing
demands
multiplexed
detection,
microfluidics
has
integrated
with
diverse
traditional
analytical
methods
powerful
components
analysis.
Taking
advantages
their
inherent
merits
great
sensitivity,
high
analysis
performance
system
integration,
short
time,
low
cost,
volume
sample,
improved
potential
control,
automation,
disposability,
microfluidic
systems
significantly
exosomes.
In
this
review,
we
summarized
recent
progresses
technologies
exosomes,
including
proteins,
metabolites,
lipids.
Furthermore,
discussed
major
challenges
offered
a
perspective
strategy‐based
exosomal
discovery.
We
expected
in‐depth
summary
devices–assisted
will
greatly
facilitate
biomarkers,
thereby
realizing
highly
efficient
accurate
diagnosis,
prediction
cancers.
Moreover,
view
significance
interesting
approach
exosomes‐based
biopsy,
review
contribute
to
translation
technology
into
clinical
applications.
European Journal of Cancer,
Год журнала:
2023,
Номер
189, С. 112919 - 112919
Опубликована: Май 23, 2023
Growing
evidence
suggests
that
acquired
resistance
to
targeted
therapy
in
non-small
cell
lung
cancer
patients
is
linked
the
mutual
domestication
between
tumour
and
its
surrounding
microenvironment.Our
study
aims
explore
remodelling
of
microenvironment
after
osimertinib
treatment
resistance.We
took
RNA-seq-based
immune
infiltration
analysis
using
TIMER
2.0.
We
carried
out
flow
cytometry
assay
real-time
interaction
cells
cells.
In
addition,
we
analysed
exosomes
via
miRNA-seq
label-free
proteomics.Immune
estimation
showed
a
significant
decrease
score
(P
<
0.001),
0.001)
CD8+
T
0.05),
but
an
increase
M0
macrophages
0.01)
at
compared
pre-treatment
patients.
It
was
demonstrated
from
H1975OR
could
be
taken
up
by
drove
their
polarisation
towards
M2
phenotype,
polarised
reduce
inhibitory
effect
on
proliferation.
Pre-activated
peripheral
blood
mononuclear
exhibited
more
potent
killing
also
detected
CD4+HLA-DR-
CD4+PD1+
being
co-cultured
with
derived
or
conditioned
medium.
Further
proteomics
mir-1258-3p
miR-17-5p
might
participate
this
interaction.An
immunosuppressive
environment,
characterised
decreased
activation,
whereas
increased
macrophage
polarisation,
identified
resistance.
This
may
tumour-derived
exosomes.
Nanoscale,
Год журнала:
2024,
Номер
16(18), С. 8791 - 8806
Опубликована: Янв. 1, 2024
This
review
explores
the
potential
of
integrating
nano-delivery
systems
with
traditional
Chinese
herbal
medicine,
acupuncture,
and
medical
theory.
It
highlights
intersections
in
enhancing
effectiveness
medicine
acupuncture
treatments.
In
addition,
it
discusses
how
integration
theory
can
modernize
make
more
readily
accessible
on
a
global
scale.
Finally,
analyzes
challenges
future
directions
this
field.
Membranes,
Год журнала:
2022,
Номер
12(12), С. 1244 - 1244
Опубликована: Дек. 8, 2022
Extracellular
vesicles
(EV)
are
membrane
surrounded
by
a
lipid
bilayer
and
include
microvesicles,
apoptotic
bodies,
exosomes,
exomeres.
Exosome-encapsulated
microRNAs
(miRNAs)
released
from
cancer
cells
involved
in
the
proliferation
metastasis
of
tumor
via
angiogenesis.
On
other
hand,
mesenchymal
stem
cell
(MSC)
therapy,
which
is
being
employed
regenerative
medicine
owing
to
ability
MSCs
differentiate
into
various
cells,
due
humoral
factors,
including
messenger
RNA
(mRNA),
miRNAs,
proteins,
lipids,
encapsulated
exosomes
derived
transplanted
cells.
New
treatments
that
advocate
cell-free
therapy
using
MSC-derived
will
significantly
improve
clinical
practice.
Therefore,
highly
purified
perform
their
original
functions
desirable.
In
this
review,
we
summarized
advances
purification,
modification,
application
EVs
as
novel
strategies
treat
some
diseases.
